ASPET

SEPTEMBER 16, 2024

Post-traumatic stress disorder (PTSD) is a debilitating psychiatric condition that develops following exposure to a traumatic event. Individuals with this condition experience numerous physiological and behavioral alterations, including intrusive memories, avoidance of trauma-related stimuli, heightened anxiety, hypervigilance, impaired cognition, elevated resting heart rate and blood pressure, and altered neuroendocrine function, to name a few.

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Treatment Research 189

Chemical Biology and Drug Design

SEPTEMBER 16, 2024

This study identified MAPK9 as the directly binding target of baicalein by the DNA-programmed affinity labeling method and tested the binding affinity as 89.7 nM by surface plasmon resonance. Baicalein stabilized MAPK9 to induce apoptosis in hepatocarcinoma cells, which would be helpful to understand and use baicalein in hepatocarcinoma therapy. ABSTRACT Hepatocellular carcinoma (HCC) is a significant global health concern.

DNA 100

DNA Therapies Treatment Production 100

ASPET

SEPTEMBER 16, 2024

Clinical reports suggest that the most effective strategies for managing opioid use disorder comprise a comprehensive treatment program of both pharmacological and non-pharmacological approaches. However, the conditions under which these combinations are most effective are not well characterized. This study examined whether the presence of an alternative reinforcer could alter the efficacy of FDA-approved opioid antagonist or agonist medications, as well as the non-opioid flumazenil, in decreasi

FDA Approval 100

FDA Approval Treatment FDA 100

Drugs.com

SEPTEMBER 16, 2024

MONDAY, Sept. 16, 2024 -- Tiny puffs from asthma inhalers could be causing big climate problems for Mother Earth, a new study warns.Each inhaler dose contains some of the most potent greenhouse gases known, and they are adding up, researchers.

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Research 119

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

ASPET

SEPTEMBER 16, 2024

Glioblastoma (GBM) is a disease of the whole brain, with infiltrative tumor cells protected by an intact BBB. GBM has a poor prognosis despite aggressive treatment, in part due to lack of adequate drug permeability at the BBB. Standard of care GBM therapies include radiation and cytotoxic chemotherapy that lead to DNA damage. Subsequent activation of DNA damage response (DDR) pathways can induce resistance.

Pharmacogenetics 100

Pharmacogenetics DNA Pharmacokinetics Treatment 100

Antidote

SEPTEMBER 16, 2024

Receiving a Parkinson’s diagnosis is a life-altering event that nearly 1 million people in the United States have experienced. Parkinson’s disease symptoms can vary from person to person. Receiving a diagnosis often requires several steps. In this blog, we’ll be sharing more details about the disease and discussing opportunities for individuals to get involved in Parkinson’s research.

Disease 114

Disease Research 114

Drugs.com

SEPTEMBER 16, 2024

MONDAY, Sept. 16, 2024 -- For the first time, scientists have detected microscopic microplastics lodged in the human brain.Researchers in Germany and Brazil say that 8 out of 15 autopsied adults had microplastics detected within their brain's smell.

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ASPET

SEPTEMBER 16, 2024

Mitochondrial dysfunction is a hallmark of many genetic neurodegenerative diseases, but therapeutic options to reverse mitochondrial dysfunction are limited. While recent studies support the possibility of improving mitochondrial fusion/fission dynamics and motility to correct mitochondrial dysfunction and resulting neurodegeneration in Charcot-Marie-Tooth disease (CMT) and other neuropathies, the clinical utility of reported compounds and relevance of pre-clinical models are uncertain.

Small Molecule 100

Small Molecule Pharmacokinetics Engineering Disease 100

Drugs.com

SEPTEMBER 16, 2024

MONDAY, Sept. 16, 2024 -- Fatty liver disease linked to diabetes and obesity can easily progress to liver cirrhosis, but new research suggests that GLP-1 medicines like Ozempic can help stop that. In a new decades-long study, veterans with diabetes.

Disease 119

Disease Research 119

ASPET

SEPTEMBER 16, 2024

The development of TGFβR inhibitors (TGFβRi) as new medicines have been affected by cardiac valvulopathy and arteriopathy toxicity findings in nonclinical toxicology studies. PF-06952229 (MDV6058) selected using rational drug design is a potent and selective TGFβRI inhibitor (TGFβRIi) with a relatively clean off-target selectivity profile and good pharmacokinetic properties across species.

Pharmacokinetics 100

Pharmacokinetics Packaging Drugs 100

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Science Daily: Pharmacology News

SEPTEMBER 16, 2024

An experiment tested six generative large language models against students in an online introductory biomedical and health informatics course. The models scored higher than as many as three quarters of the real-world students in the class.

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Research 115

ASPET

SEPTEMBER 16, 2024

The disruption of dopamine neurotransmission by the HIV-1 Transactivator of transcription (Tat) during HIV-1 infection has been linked to the development of neurocognitive disorders, even under combined antiretroviral therapy (cART) treatment. We have demonstrated that SRI-32742, a novel allosteric modulator of dopamine (DA) transporter (DAT), attenuates cocaine- and Tat-binding to DAT, alleviates Tat-induced cognitive deficits and potentiation of cocaine reward in inducible Tat transgenic mice.

Therapies 100

Therapies Treatment 100

Drugs.com

SEPTEMBER 16, 2024

MONDAY, Sept. 16, 2024 -- People should prepare for the fall cold and flu season by getting the updated influenza and COVID-19 vaccinations, an infectious diseases expert says.“When my patients ask me if they should be getting a COVID vaccine this y.

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Vaccine Disease 116

Science Daily: Pharmacology News

SEPTEMBER 16, 2024

Astronomers have used the NASA/ESA James Webb Space Telescope to confirm that supermassive black holes can starve their host galaxies of the fuel they need to form new stars.

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Drugs.com

SEPTEMBER 16, 2024

MONDAY, Sept. 16, 2024 -- Vaping may look cool when you're young, but it appears to be dulling the brains of college students, a new study warns.College students who vape have lower cognitive function scores than those who don't, researchers.

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Research 111

NIOSH Science Blog: Drugs

SEPTEMBER 16, 2024

As part of Fungal Disease Awareness Week, we are highlighting fungal diseases that can affect workers. Coccidioidomycosis (Valley fever), blastomycosis, and histoplasmosis are fungal diseases caused by fungi that live in the environment in certain regions. Infections are caused by breathing in fungal spores that get into the air. Some jobs and work activities that disturb soil in areas where the fungi live can release fungal spores into the air and put workers at higher risk.

Disease 100

Disease 100

Drugs.com

SEPTEMBER 16, 2024

MONDAY, Sept. 16, 2024 (Healthday News) -- In a disclosure that can't eliminate the possibility that bird flu may have spread from one human to another for the first time, U.S. health officials have reported that a person who lived with a Missouri.

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BioPharma Drive: Drug Pricing

SEPTEMBER 16, 2024

Legislation that passed the House of Representatives passed the Biosecure Act last week would forced U.S. biotechs to cut ties with five Chinese contract partners.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drugs.com

SEPTEMBER 16, 2024

MONDAY, Sept 16, 2024 -- A decade of patient follow-up finds a combo of two immunotherapy drugs can greatly extend survival for people with advanced melanomas.In 2011, a diagnosis of advanced, metastatic melanoma typically meant death within 6.5.

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Drugs 105

Science Daily: Pharmacology News

SEPTEMBER 16, 2024

New research examines thousands of years of Arctic sled dog ancestry and reveals when and how Siberian and Alaskan sled dogs' DNA mixed.

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DNA Research 111

Drugs.com

SEPTEMBER 16, 2024

MONDAY, Sept. 16, 2024 -- People with rare genetic variants linked to degenerative brain disorders like Parkinson’s disease are at increased risk of developing ALS, a new study finds.Further, having these genetic variants increases the risk of a p.

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Disease 98

Science Daily: Pharmacology News

SEPTEMBER 16, 2024

If seabirds can catch avian flu by stealing food from infectious birds, it gives scientists a clue where to monitor for outbreaks among these vulnerable birds.

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BioPharma Drive: Drug Pricing

SEPTEMBER 16, 2024

Results for Pfizer’s ponsegromab looked promising, while BioNTech and Instil Bio capitalized on momentum surrounding a kind of bispecific antibody.

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Drugs 86

Science Daily: Pharmacology News

SEPTEMBER 16, 2024

Researchers follow the dramatic changes that occur in the brain throughout the course of pregnancy.

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Research 110

BioPharma Drive: Drug Pricing

SEPTEMBER 16, 2024

There’s no doubt that AI and GenAI can speed up pharmaceutical innovation. But before organizations can jump into the future, it’s crucial to understand the benefits – and the risks – of advanced technology.

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Pharmaceuticals 78

Drugs.com

SEPTEMBER 16, 2024

MONDAY, Sept. 16, 2024 -- Newfangled designs intended to make football helmets more protective have overlooked one key component, a new study suggests.Nearly a third of concussions in pro football involve impacts to the facemask, a part of the.

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BioPharma Drive: Drug Pricing

SEPTEMBER 16, 2024

Applying a systems thinking approach can create improvements in scientific integrity, operational feasibility and scalability.

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Clinical Trials Science Trials 88

Drug Patent Watch

SEPTEMBER 16, 2024

In the high-stakes world of pharmaceuticals, where innovation meets profit, a little-known regulatory program called REMS (Risk Evaluation and Mitigation Strategy) has become a powerful tool for brand-name drug manufacturers to fend off generic competition.

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FDA Pharmaceuticals Drugs 59

BioPharma Drive: Drug Pricing

SEPTEMBER 16, 2024

Warner Biddle and Christi Shaw, two prominent former executives at Gilead’s CAR-T division, will try to turn around an autoimmune cell therapy developer that’s lost most of its value since raising $319 million in a February IPO.

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Therapies 72

Perficient: Drug Development

SEPTEMBER 16, 2024

What is SEO? SEO (Search Engine Optimization) refers to the practice of optimizing websites and content to rank higher in search engine results pages It involves improving on-page and off-page factors to drive organic traffic to your website Why is SEO Important? Increases visibility : Higher rankings lead to increased visibility, helping your target audience find your site.

Engineering 59

Engineering International Research 59

Drug Target Review

SEPTEMBER 16, 2024

Can you tell us about your journey in the field of STEM and the challenges you encountered along the way? First of all, thank you so much for having me. Drug Target Review’s commitment to highlighting diverse experiences resonates deeply with me, and I’m honoured to be a part of this conversation. My love for science truly began at home.

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Science Pharmaceutical Companies Treatment Pharmaceuticals 59

FDA Law Blog: Biosimilars

SEPTEMBER 16, 2024

By Mark I. Schwartz — FDA recently published a Federal Register (FR) Notice [ Docket No. FDA-2024-N-3945 ] announcing the publication of a draft strategy document, for public comment, outlining specific actions FDA plans to take to facilitate the use of innovative manufacturing technologies. This FR Notice and draft strategy document are part of FDA’s commitment under the Prescription Drug User Fee Act (PDUFA) Reauthorization Performance Goals and Procedures for Fiscal Years 2023-2027 (PDUFA VII

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FDA International Production Drugs 57

New Drug Approvals

SEPTEMBER 16, 2024

Atilotrelvir, BDBM622370, GST-HG171 2850365-55-6, ALIGOS THERAPEUTICS, INC 511.5 C 24 H 32 F 3 N 5 O 4 (1 S ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[(2 S )-3,3-dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butanoyl]spiro[2-azabicyclo[2.2.1]heptane-5,1′-cyclopropane]-3-carboxamide Spiro[2-azabicyclo[2.2.1]heptane-5,1′-cyclopropane]-3-carboxamide, N-[(1S)-1-cyano-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]-2-[(2S)-3,3-dimethyl-1-oxo-2-[(2,2,2-trifluoroacetyl)amino]bu

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Production 57