ASPET

SEPTEMBER 16, 2024

Post-traumatic stress disorder (PTSD) is a debilitating psychiatric condition that develops following exposure to a traumatic event. Individuals with this condition experience numerous physiological and behavioral alterations, including intrusive memories, avoidance of trauma-related stimuli, heightened anxiety, hypervigilance, impaired cognition, elevated resting heart rate and blood pressure, and altered neuroendocrine function, to name a few.

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Treatment Research 189

Science Daily: Pharmacology News

SEPTEMBER 16, 2024

An experiment tested six generative large language models against students in an online introductory biomedical and health informatics course. The models scored higher than as many as three quarters of the real-world students in the class.

Research 125

Research 125

Drugs.com

SEPTEMBER 16, 2024

MONDAY, Sept. 16, 2024 -- Tiny puffs from asthma inhalers could be causing big climate problems for Mother Earth, a new study warns.Each inhaler dose contains some of the most potent greenhouse gases known, and they are adding up, researchers.

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Research 119

Science Daily: Pharmacology News

SEPTEMBER 16, 2024

Researchers follow the dramatic changes that occur in the brain throughout the course of pregnancy.

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Research 118

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Drugs.com

SEPTEMBER 16, 2024

MONDAY, Sept. 16, 2024 -- Fatty liver disease linked to diabetes and obesity can easily progress to liver cirrhosis, but new research suggests that GLP-1 medicines like Ozempic can help stop that. In a new decades-long study, veterans with diabetes.

Disease 119

Disease Research 119

Drugs.com

SEPTEMBER 16, 2024

MONDAY, Sept. 16, 2024 -- People should prepare for the fall cold and flu season by getting the updated influenza and COVID-19 vaccinations, an infectious diseases expert says.“When my patients ask me if they should be getting a COVID vaccine this y.

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Vaccine Disease 116

Science Daily: Pharmacology News

SEPTEMBER 16, 2024

Astronomers have used the NASA/ESA James Webb Space Telescope to confirm that supermassive black holes can starve their host galaxies of the fuel they need to form new stars.

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Antidote

SEPTEMBER 16, 2024

Receiving a Parkinson’s diagnosis is a life-altering event that nearly 1 million people in the United States have experienced. Parkinson’s disease symptoms can vary from person to person. Receiving a diagnosis often requires several steps. In this blog, we’ll be sharing more details about the disease and discussing opportunities for individuals to get involved in Parkinson’s research.

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Disease Research 114

Science Daily: Pharmacology News

SEPTEMBER 16, 2024

If seabirds can catch avian flu by stealing food from infectious birds, it gives scientists a clue where to monitor for outbreaks among these vulnerable birds.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drugs.com

SEPTEMBER 16, 2024

MONDAY, Sept. 16, 2024 -- For the first time, scientists have detected microscopic microplastics lodged in the human brain.Researchers in Germany and Brazil say that 8 out of 15 autopsied adults had microplastics detected within their brain's smell.

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Chemical Biology and Drug Design

SEPTEMBER 16, 2024

This study identified MAPK9 as the directly binding target of baicalein by the DNA-programmed affinity labeling method and tested the binding affinity as 89.7 nM by surface plasmon resonance. Baicalein stabilized MAPK9 to induce apoptosis in hepatocarcinoma cells, which would be helpful to understand and use baicalein in hepatocarcinoma therapy. ABSTRACT Hepatocellular carcinoma (HCC) is a significant global health concern.

DNA 100

DNA Therapies Treatment Production 100

Drugs.com

SEPTEMBER 16, 2024

MONDAY, Sept. 16, 2024 -- Vaping may look cool when you're young, but it appears to be dulling the brains of college students, a new study warns.College students who vape have lower cognitive function scores than those who don't, researchers.

Research 111

Research 111

ASPET

SEPTEMBER 16, 2024

Clinical reports suggest that the most effective strategies for managing opioid use disorder comprise a comprehensive treatment program of both pharmacological and non-pharmacological approaches. However, the conditions under which these combinations are most effective are not well characterized. This study examined whether the presence of an alternative reinforcer could alter the efficacy of FDA-approved opioid antagonist or agonist medications, as well as the non-opioid flumazenil, in decreasi

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FDA Approval Treatment FDA 100

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Drugs.com

SEPTEMBER 16, 2024

MONDAY, Sept. 16, 2024 (Healthday News) -- In a disclosure that can't eliminate the possibility that bird flu may have spread from one human to another for the first time, U.S. health officials have reported that a person who lived with a Missouri.

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105

ASPET

SEPTEMBER 16, 2024

Glioblastoma (GBM) is a disease of the whole brain, with infiltrative tumor cells protected by an intact BBB. GBM has a poor prognosis despite aggressive treatment, in part due to lack of adequate drug permeability at the BBB. Standard of care GBM therapies include radiation and cytotoxic chemotherapy that lead to DNA damage. Subsequent activation of DNA damage response (DDR) pathways can induce resistance.

Pharmacogenetics 100

Pharmacogenetics DNA Treatment Pharmacokinetics 100

Drugs.com

SEPTEMBER 16, 2024

MONDAY, Sept 16, 2024 -- A decade of patient follow-up finds a combo of two immunotherapy drugs can greatly extend survival for people with advanced melanomas.In 2011, a diagnosis of advanced, metastatic melanoma typically meant death within 6.5.

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Drugs 105

ASPET

SEPTEMBER 16, 2024

We previously identified a small molecule, UM101, predicted to bind to the substrate-binding groove of p38aMitogen-activated Protein Kinase (MAPK) near the binding site of its proinflammatory substrate, MAPK-activated protein kinase (MK2). UM101 exhibited anti-inflammatory, endothelial-stabilizing, and lung-protective effects. To overcome its limited aqueous solubility and p38a binding affinity, we designed an analog of UM101, GEn-1124, with improved aqueous solubility, stability, and p38a bindi

Small Molecule 100

Small Molecule Drugs 100

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

BioPharma Drive: Drug Pricing

SEPTEMBER 16, 2024

Legislation that passed the House of Representatives passed the Biosecure Act last week would forced U.S. biotechs to cut ties with five Chinese contract partners.

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ASPET

SEPTEMBER 16, 2024

Mitochondrial dysfunction is a hallmark of many genetic neurodegenerative diseases, but therapeutic options to reverse mitochondrial dysfunction are limited. While recent studies support the possibility of improving mitochondrial fusion/fission dynamics and motility to correct mitochondrial dysfunction and resulting neurodegeneration in Charcot-Marie-Tooth disease (CMT) and other neuropathies, the clinical utility of reported compounds and relevance of pre-clinical models are uncertain.

Small Molecule 100

Small Molecule Pharmacokinetics Engineering Disease 100

Drugs.com

SEPTEMBER 16, 2024

MONDAY, Sept. 16, 2024 -- People with rare genetic variants linked to degenerative brain disorders like Parkinson’s disease are at increased risk of developing ALS, a new study finds.Further, having these genetic variants increases the risk of a p.

Disease 98

Disease 98

ASPET

SEPTEMBER 16, 2024

The development of TGFβR inhibitors (TGFβRi) as new medicines have been affected by cardiac valvulopathy and arteriopathy toxicity findings in nonclinical toxicology studies. PF-06952229 (MDV6058) selected using rational drug design is a potent and selective TGFβRI inhibitor (TGFβRIi) with a relatively clean off-target selectivity profile and good pharmacokinetic properties across species.

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Pharmacokinetics Packaging Drugs 100

PPD

SEPTEMBER 16, 2024

The pharmaceutical industry is currently experiencing a significant transformation. The convergence of real-world data (RWD), technology and artificial intelligence (AI) is playing a vital role in accelerating drug development. In a recent panel discussion at DIA Global , our experts explored how these elements are reshaping clinical research and drug discovery.

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Clinical Development Clinical Trials Clinical Research Trials 97

ASPET

SEPTEMBER 16, 2024

The disruption of dopamine neurotransmission by the HIV-1 Transactivator of transcription (Tat) during HIV-1 infection has been linked to the development of neurocognitive disorders, even under combined antiretroviral therapy (cART) treatment. We have demonstrated that SRI-32742, a novel allosteric modulator of dopamine (DA) transporter (DAT), attenuates cocaine- and Tat-binding to DAT, alleviates Tat-induced cognitive deficits and potentiation of cocaine reward in inducible Tat transgenic mice.

Therapies 100

Therapies Treatment 100

Drugs.com

SEPTEMBER 16, 2024

MONDAY, Sept. 16, 2024 -- Newfangled designs intended to make football helmets more protective have overlooked one key component, a new study suggests.Nearly a third of concussions in pro football involve impacts to the facemask, a part of the.

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NIOSH Science Blog: Drugs

SEPTEMBER 16, 2024

As part of Fungal Disease Awareness Week, we are highlighting fungal diseases that can affect workers. Coccidioidomycosis (Valley fever), blastomycosis, and histoplasmosis are fungal diseases caused by fungi that live in the environment in certain regions. Infections are caused by breathing in fungal spores that get into the air. Some jobs and work activities that disturb soil in areas where the fungi live can release fungal spores into the air and put workers at higher risk.

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Disease 92

BioPharma Drive: Drug Pricing

SEPTEMBER 16, 2024

Applying a systems thinking approach can create improvements in scientific integrity, operational feasibility and scalability.

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Clinical Trials Science Trials 86

thought leadership

SEPTEMBER 16, 2024

As the pharmaceutical landscape in the Japan and Asia-Pacific (JAPAC) region continues to evolve, the demand for efficient, high-quality medical information (MI) services has never been greater. Our offshore contact centers in India and the Philippines offer pharmaceutical companies an unparalleled blend of innovation, customer excellence, and cost efficiency.

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Pharmaceutical Companies Pharmaceuticals Marketing 75