ASPET

NOVEMBER 17, 2023

Heart failure with preserved ejection fraction (HFpEF) is a major health problem with limited treatment options. Although optimizing cardiac energy metabolism is a potential approach to treating heart failure, it is poorly understood what alterations in cardiac energy metabolism actually occur in HFpEF. To determine this, we used mice in which HFpEF was induced using an obesity and hypertension HFpEF protocol for 10 weeks.

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Treatment Regulations 100

Antidote

NOVEMBER 17, 2023

Achondroplasia, also known as achondroplastic dwarfism or ACH, is a rare disorder characterized by short stature, a large head, and short arms and legs. It is the most common type of skeletal dysplasia, the umbrella term that identifies hundreds of conditions , and occurs in about one in 15,000 to 35,000 births.

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ASPET

NOVEMBER 17, 2023

Ketamine is a new, potent and rapid-acting antidepressant approved for therapy of treatment-resistant depression, which has a different mechanism of action than currently-available antidepressant therapies. It owes its uniquely potent antidepressant properties to a complex mechanism of action, which currently remains unclear. However, it is thought that it acts by modulating the functioning of the glutamatergic system, which plays an important role in the process of neuroplasticity associated wi

Therapies 100

Therapies Treatment Drugs 100

Drugs.com

NOVEMBER 17, 2023

WEDNESDAY, Nov. 15, 2023 -- Retatrutide, an experimental weight-loss drug that could compete against blockbusters Wegovy and Zepbound, may work wonders for obese folks with liver disease, new research shows. A wider study, published in June, found.

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Drugs Disease Research 111

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

ASPET

NOVEMBER 17, 2023

Creatinine, a clinical marker for kidney function, is predominantly cleared by glomerular filtration, with active tubular secretion contributing to about 30% of its renal clearance. Recent studies suggested the potential involvement of organic anion transporter (OAT)2, in addition to the previously known organic cation transporter (OCT)2-mediated basolateral uptake, in creatinine active secretion.

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Pharmacogenetics Pharmacokinetics Disease Drugs 100

Drugs.com

NOVEMBER 17, 2023

THURSDAY, Nov. 16, 2023 -- The first home test for chlamydia and gonorrhea will soon hit the market, following its approval Wednesday by the U.S. Food and Drug Administration. People will be able to buy the Simple 2 Test over-the-counter at a.

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FDA Approval FDA Marketing Drugs 111

Drug Patent Watch

NOVEMBER 17, 2023

Researchers from West Virginia University College of Law have conducted a study examining the frequency of drug patent invalidations based on inequitable conduct. The findings, published in JAMA, shed light… The post Navigating Legal Waters: Study Delves into Inequitable Conduct in Drug Patent Cases appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs Research 102

ASPET

NOVEMBER 17, 2023

Botulinum neurotoxin (BoNT) is a potent protein toxin that causes muscle paralysis and death by asphyxiation. Treatments for symptomatic botulism are intubation and supportive care until respiratory function recovers. Aminopyridines have recently emerged as potential treatments for botulism. The clinically approved drug 3,4-diaminopyridine (3,4-DAP) rapidly reverses toxic signs of botulism and has antidotal effects when continuously administered in rodent models of lethal botulism.

Treatment 100

Treatment Drugs 100

Drugs.com

NOVEMBER 17, 2023

THURSDAY, Nov. 16, 2023 -- Measles deaths are surging worldwide, prompted by a wave of infections among unvaccinated children, public health experts say. Deaths from measles increased by 43% globally in 2022 compared to the year before, resulting.

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ASPET

NOVEMBER 17, 2023

Children are highly vulnerable to the neurotoxic effects of organophosphates (OP), which can cause neuronal developmental defects, including intellectual disability, autism, epilepsy, and related comorbidities. Unfortunately, no specific pediatric OP neurotoxicity model currently exists. In this study, we developed and characterized a pediatric rat model of status epilepticus (SE) induced by the OP diisopropylfluorophosphate (DFP) and examined its impact on long-term neurological outcomes.

Treatment 100

Treatment 100

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Drug Channels

NOVEMBER 17, 2023

Today’s guest post comes from Maria Kirsch, President of Patient Services at EVERSANA. Maria discusses the challenges patients and healthcare providers face accessing specialty therapies. She introduces us to ACTICS ® eAccess , EVERSANA’s technology platform for electronic prior authorization and benefits verification that can be used for both the pharmacy benefit and the medical benefit.

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Pharmacy Therapies Drugs 97

ASPET

NOVEMBER 17, 2023

This article describes recent advances in the use of neurosteroids as novel anticonvulsants for refractory status epilepticus (RSE) and as medical countermeasures (MCs) for organophosphates and chemical nerve agents (OPNAs). We highlight a decade-long journey to bring the synthetic neurosteroid ganaxolone (GX) from bench to clinic. RSE, including when caused by nerve agents, is associated with devastating morbidity and permanent long-term neurological dysfunction.

Treatment 100

Treatment Therapies Trials 100

Drugs.com

NOVEMBER 17, 2023

THURSDAY, Nov. 16, 2023 -- Shrinkage of one of the brain's key memory centers appears to herald thinking declines, a new study finds. The region in question is the hippocampus, a two-sided structure located roughly above each ear and embedded deep.

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ASPET

NOVEMBER 17, 2023

Developing nano-biomaterials with tunable topology, size, and surface characteristics has shown tremendously favorable benefits in various biological and clinical applications. Among various nano-biomaterials, peptide-based drug delivery systems offer multiple merits over other synthetic systems due to their enhanced bio and cytocompatibility and desirable biochemical and biophysical properties.

Therapies 100

Therapies Disease Drugs 100

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drugs.com

NOVEMBER 17, 2023

WEDNESDAY, Nov. 15, 2023 -- Pesticide exposure appears to be linked to lower sperm concentrations in men around the world, a new large-scale evidence review has concluded. A review of 25 studies spanning nearly 50 years found consistent links.

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ASPET

NOVEMBER 17, 2023

Sulfur mustard (SM) is a highly reactive organic chemical has been used as a chemical warfare agent and terrorist threat since WWI. The cornea is highly sensitive to SM toxicity and exposure to low vapor doses can cause incapacitating acute injuries. Exposure to higher doses can elicit persistent secondary keratopathies that cause reduced quality of life and impaired or lost vision.

DNA 100

DNA Treatment Drugs Research 100

Drugs.com

NOVEMBER 17, 2023

WEDNESDAY, Nov. 14, 2023 -- Oral nicotine pouches might be marketed as an alternative to cigarettes, but they do little to curb smokers’ nicotine cravings, a new study finds. The pouches – which contain nicotine powder and other.

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Marketing 105

ASPET

NOVEMBER 17, 2023

The classes of neuropharmaceuticals known as proteins and peptides serve as diagnostic tools and are involved in specific communication in the peripheral and central nervous systems (CNS). However, due to tight junctions resembling epithelial cells found in the blood-brain barrier (BBB) in vivo, they are typically excluded from transport from the blood to the brain.

Pharmaceuticals 100

Pharmaceuticals Treatment Disease Drugs 100

Drugs.com

NOVEMBER 17, 2023

WEDNESDAY, Nov. 15, 2023 (Healthday News) -- As U.S. suicide rates continue to rise, new government data shows older men have become the most susceptible. In a report published Wednesday, researchers from the U.S. Centers for Disease.

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Government Disease Research 98

SCIENMAG: Medicine & Health

NOVEMBER 17, 2023

CAMBRIDGE, MA — Diagnosing sleep disorders such as sleep apnea usually requires a patient to spend the night in a sleep lab, hooked up to a variety of sensors and monitors.

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Research 93

Drugs.com

NOVEMBER 17, 2023

WEDNESDAY, Nov. 15, 2023 -- You likely know that Lyme disease can be spread by ticks, but have you heard of babesiosis? It’s a different disease caused by the bite of a deer tick, and cases are rising in the United States, scientists from the.

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Disease 98

LifeSciVC

NOVEMBER 17, 2023

2023 couldn’t end fast enough for most of us in biopharma; its been a tough year in the capital markets, and the industry is facing it’s fair share of headwinds. Fortunately, despite all that, great science and medicine continues to advance. This month we held our 2023 Annual General Meeting for our fund’s investors and our Atlas Venture Retreat with industry executives.

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Science Marketing Production Disease 97

Drugs.com

NOVEMBER 17, 2023

WEDNESDAY, Nov. 15, 2024 -- Record numbers of children and tweens now take melatonin for sleep, potentially doing harm to their development, a new study warns. Nearly one in five school-aged kids are popping melatonin to help them rest, often with.

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SCIENMAG: Medicine & Health

NOVEMBER 17, 2023

This year’s European Antibiotic Awareness Day (EAAD) focuses on the targets outlined in the 2023 Council Recommendation to step up efforts in the European Union (EU) against antimicrobial resistance in a One Health approach.

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Hospitals 87

Drugs.com

NOVEMBER 17, 2023

THURSDAY, Nov. 16, 2023 (Healthday News) -- While childhood cancer is no longer terminal for many, death rates remain higher in Black and Hispanic children, a new government report reveals. Treatments for these rare cancers have improved.

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Government Treatment 104

SCIENMAG: Medicine & Health

NOVEMBER 17, 2023

Scientists have developed an ingestible device that can safely monitor vital signs like breathing and heart rate from inside humans. The tool, described November 17 in the journal Device, has the potential to provide accessible and convenient care for people at risk of opioid overdose.

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Clinical Trials Trials 84

Drugs.com

NOVEMBER 17, 2023

THURSDAY, Nov. 16, 2023 (Healthday News) -- The chances of a woman having two uteruses are rare, but the odds of becoming pregnant at the same time in each uterus are even more rare. But one Alabama woman is experiencing just that. Kelsey Hatcher.

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SCIENMAG: Medicine & Health

NOVEMBER 17, 2023

MOREHEAD, Ky. (Nov. 17, 2023) — In celebration of National Rural Health Day, yesterday the University of Kentucky College of Medicine and Anthem Blue Cross and Blue Shield Medicaid in Kentucky announced new scholarship opportunities for UK’s Rural Physician Leadership Program (RPLP). The Anthem Rural Medicine Scholarships will provide $100,000 to offset the cost of medical school for students in the RPLP.

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Medical Schools 83

BioPharma Drive: Drug Pricing

NOVEMBER 17, 2023

Following the approval of Zepbound, Lilly is adding capacity to avert shortages and restricted access.

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Drugs 112

Science Daily: Pharmacology News

NOVEMBER 17, 2023

New research shows that air filtration systems or 'air cleaners' don't stop you getting sick. Air cleaners are designed to filter pollutants or contaminants out of the air that passes through them.

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Research 97

SCIENMAG: Medicine & Health

NOVEMBER 17, 2023

New Orleans, LA – The American Psychiatric Association (APA) Foundation has selected Rahn Baily, MD, DLFAPA, ACP, Professor and Chair of Psychiatry at LSU Health New Orleans School of Medicine, as the recipient of the 2024 Solomon Carter Fuller Award.

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Drugs.com

NOVEMBER 17, 2023

THURSDAY, Nov. 16, 2023 -- To address a continuing nationwide shortage, more than 77,000 doses of RSV shots for infants were released Thursday by the U.S. Centers for Disease Control and Prevention and the U.S. Food and Drug Administration. The.

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Disease Drugs 85

SCIENMAG: Medicine & Health

NOVEMBER 17, 2023

Migraine is more than just a headache. Often the pain is accompanied by nausea, vomiting, light sensitivity, and sound sensitivity. Chronic migraine can be disabling and may prevent many, especially women, from contributing to working life. Credit: Silje Alvestad Migraine is more than just a headache.

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Collaborative Drug

NOVEMBER 17, 2023

The collaboration's achievements include the discovery of potent antivirals, building open knowledge bases, and functioning as an information-exchange hub,

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Drugs 76