Broad Institute

OCTOBER 29, 2024

New drug triggers rapid cell death in cancer models By Karen Zusi-Tran October 29, 2024 Breadcrumb Home New drug triggers rapid cell death in cancer models BRD-810 inhibits the MCL1 protein and reactivates apoptosis in tumor cells, displaying therapeutic potential in animal models. By Karen Zusi-Tran October 29, 2024 Credit: National Cancer Institute Human cells with acute myelocytic leukemia (AML) in the pericardial fluid.

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Drugs.com

OCTOBER 29, 2024

TUESDAY, Oct. 29, 2024 -- Artificial intelligence might be able to help doctors detect the prostate cancers most likely to be life-threatening to men, a new study suggests. An AI program successfully identified and outlined 85% of the most.

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Perficient: Drug Development

OCTOBER 29, 2024

The 2024 InsureTech Connect (ITC) conference was truly exhilarating, with key takeaways impacting the insurance industry. Each year, it continues to improve, offering more relevant content, valuable industry connections, and opportunities to delve into emerging technologies. This year’s event was no exception, showcasing the importance of personalization to the customer, tech-driven relationship management, and AI-driven underwriting processes.

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Drugs.com

OCTOBER 29, 2024

TUESDAY, Oct. 29, 2024 -- Middle-aged folks facing a colon cancer screening now have a blood test they can choose over a standard colonoscopy.However, the blood test isn't as effective as colonoscopy at detecting and preventing colon cancer, a new.

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Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

BioPharma Drive: Drug Pricing

OCTOBER 29, 2024

Daniel Quirk, an immunology and neuroscience executive at Bristol Myers Squibb, will be Biogen’s next chief medical officer, while Robin Kramer will replace retiring CFO Michael McDonnell.

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Science Daily: Pharmacology News

OCTOBER 29, 2024

Researchers used laser-guided imaging to uncover vast unexplored Maya settlements in Campeche, Mexico, revealing more than 6,500 pre-Hispanic structures, including a previously unknown large city with stone pyramids. Their study enhances our understanding of the ancient civilization's extent and complexity in an area largely overlooked by archaeologists.

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Research 107

Science Daily: Pharmacology News

OCTOBER 29, 2024

Paleobiologists have found that the sinuses of ocean dwelling relatives of modern-day crocodiles prevented them from evolving into deep divers like whales and dolphins.

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Drugs.com

OCTOBER 29, 2024

TUESDAY, Oct. 29, 2024 -- Artificial intelligence can accurately detect heart murmurs in dogs, a new study finds.The AI program detects heart murmurs in canines with 90% accuracy, similar to the accuracy of expert cardiologists, researchers.

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Science Daily: Pharmacology News

OCTOBER 29, 2024

Weddell seals in Erebus Bay, Antarctica, may look like couch potatoes when they are resting on ice. However, these seals, which are the southernmost population of the southernmost living mammals, are exceptional divers that can reach depths of more than 900 meters and recorded dives lasting 96 minutes, which is well beyond their aerobic threshold. Scientists have identified an optimal and novel dive foraging strategy the seals employ to capture prey in the highly seasonal Antarctic environment w

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Research 102

Drugs.com

OCTOBER 29, 2024

TUESDAY, Oct. 29, 2024 -- For many reasons, bodybuilders and others involved in weight training might have to take a break from the gym.However, new Finnish research finds that even weeks-long interruptions in training won't hamper muscle-building.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Science Daily: Pharmacology News

OCTOBER 29, 2024

Military musicians returning from the Napoleonic wars established Britain's first brass bands earlier than previously thought, new research reveals. The study undermines the idea that brass bands were a civilian and exclusively northern creation.

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Research 102

Drugs.com

OCTOBER 29, 2024

TUESDAY, Oct. 29, 2024 -- Researchers looking at the sweltering European summer of 2022 estimated that more than half of the heat-linked deaths occurring on the continent would not have happened if human-led climate change wasn't in place."Without.

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Research 98

Science Daily: Pharmacology News

OCTOBER 29, 2024

What if a microbe could help curb the climate crisis? Meet UTEX-3222, aka 'Chonkus,' a cyanobacterium discovered living in the volcanic CO2 seeps off the coast of Vulcano, Sicily. Chonkus is like other photosynthetic cyanobacteria in that it consumes CO2 and incorporates it into its cells. However, what sets UTEX-3222 apart is its rapid, high-density growth, which allows it to consume CO?

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Drugs.com

OCTOBER 29, 2024

TUESDAY, Oct. 29, 2024 -- Weed use among U.S. teenagers fell dramatically over the past decade, a new study shows.By 2021, only about 16% of teens said they were currently using marijuana, down from 23% in 2011, researchers found.All grades.

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Research 95

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Clinical Trials

Science Daily: Pharmacology News

OCTOBER 29, 2024

Paleontologists have identified fossils of an ancient species of bug that spent the past 450 million years covered in fool's gold in central New York. The new species, Lomankus edgecombei, is a distant relative of modern-day horseshoe crabs, scorpions, and spiders. It had no eyes, and its small front appendages were best suited for rooting around in dark ocean sediment, back when what is now New York state was covered by water.

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Drugs.com

OCTOBER 29, 2024

TUESDAY, Oct. 29, 2024 -- Health officials are investigating the case of an Iowa resident who died of Lassa fever after traveling recently to West Africa.The Ebola-like virus is rarely seen in the United States, according to the U.S. Centers for.

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Virus 92

Science Daily: Pharmacology News

OCTOBER 29, 2024

In the largest predation event ever recorded, researchers observed capelin shoaling off the coast of Norway, where a swarm of cod overtook them, consuming over 10 million fish in a few hours. The team hopes to deploy their technique to monitor the large-scale dynamics among other species of fish and track vulnerable keystone species.

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Research 91

NIOSH Science Blog: Drugs

OCTOBER 29, 2024

Forest operations, which include logging and other forestry activities (e.g., planting, thinning, fuels reduction, and wildland fire fighting), are a vital component of forest management. It is also one of the most dangerous places to work in the United States (U.S.). In 2022, there were 54 fatalities to logging workers. The work-related fatality rate for logging workers is 100.7 per 100,000 FTE,* which is more than 27 times higher than the rate for all occupations at 3.7 per 100,000 FTE.

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Regulations 85

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Conversations in Drug Development Trends

OCTOBER 29, 2024

By: Juliane Mills, Senior Director, Therapeutic Strategy Lead, Rare Disease The rise of patient-led clinical research, particularly in rare disease, represents a significant shift in the clinical trial landscape. Increasingly, patients and patient-led organizations are playing a pivotal role in shaping drug development, underscoring the importance of collaboration between patient organizations, CROs, and pharmaceutical and biotechnology companies.

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Clinical Research Disease Research Clinical Trials 72

Drug Channels

OCTOBER 29, 2024

Eeek! It's time for Drug Channels’ Halloween roundup of terrifying tales to share with your ghoulish fiends. This month’s tricks and treats: Spooky! Blue Shield of California frightens away the gross-to-net bubble with its Humira biosimilar strategy Vampiric! Prior authorization sinks its fangs into providers’ time Wicked! How the IRA will put a stake through specialty physician practices Eerie!

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Biosimilars Drugs 72

BioPharma Drive: Drug Pricing

OCTOBER 29, 2024

The licensing deal with China’s Chimagen Biosciences is the latest example of drugmaker interest in exploring the potential of “T cell engagers” in autoimmune disease.

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Licensing Licensing Treatment Disease 67

Perficient: Drug Development

OCTOBER 29, 2024

I’ve been working with Next.Js for a quite a while and have been watching its development with interest all this time. Last week I was happy attended Next.js Conf in San Francisco. Perficient was proudly sponsoring of this event therefore I represented our Sitecore Practice along with David Lewis – my peer colleague from the Optimizely Practice Vercel released new version 15 of Next.js framework.

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Packaging International Production 52

BioPharma Drive: Drug Pricing

OCTOBER 29, 2024

Crescent Biopharma is advancing a drug its CEO claims is “purpose-built” to be a perfected version of Summit Therapeutics’ ivonescimab, which recently beat Merck’s Keytruda in a Phase 3 trial.

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Trials Drugs 64

Common Sense for Drug Policy Blog

OCTOBER 29, 2024

Limited Evidence for Nalfmefene "In 2021, due to the widespread availability of high-potency synthetic opioids like fentanyl, the US FDA approved two high-dose naloxone products, an 8 mg IN spray (Kloxxado) and a 5 mg IM injectable (Zimhi). The only studies reported in the FDA package inserts for both products are pharmacokinetic studies in healthy volunteers, which demonstrated substantially higher naloxone plasma levels than standard doses of naloxone (0.4 mg IM vs. 8 mg IN and 2 mg IM vs. 5 m

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Pharmacokinetics FDA Approval Packaging FDA 52

Perficient: Drug Development

OCTOBER 29, 2024

Data isn’t just an asset—it’s the lifeblood of most organizations. As businesses continue to amass vast amounts of information, the exposure to potential breaches grows exponentially. According to IBM , the global cost of data breaches continues to rise, with the average incident now costing companies $4.88 million in 2024, up 10% from the previous year.

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Government Regulations Marketing 52

Common Sense for Drug Policy Blog

OCTOBER 29, 2024

Standard Dose Naloxone Effective "Studies in two states in the US have found that there is no association between the introduction of fentanyl into the drug supply and naloxone dosing required to reverse opioid overdoses. This conclusion emerged from data collected over four years at a SSP in Pittsburgh, PA, that distributed primarily 0.4 mg IM naloxone to people who use drugs (Bell et al., 2019; Bell & Dasgupta, 2024).

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Production Drugs 52

Drugs.com

OCTOBER 29, 2024

TUESDAY, Oct. 29, 2024 -- Most kids with attention issues won't go on to develop serious psychiatric conditions like psychosis or schizophrenia. However, a new study finds poor attention spans in childhood, plus certain genes, could play a role in.

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Common Sense for Drug Policy Blog

OCTOBER 29, 2024

Evidence Lacking for Higher Dose Naloxone "Around the world, there is no evidence of the need or benefit of higher dose products, particularly from people to whom they would be administered (Saari et al., 2024). People who used opioids, in one qualitative study, preferred lower dose IN products (Neale et al., 2022). In 2024, the Michigan Drug User Health Alliance surveyed 108 people who use drugs about their reversal product preferences.

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Production Drugs 52

Fierce BioTech

OCTOBER 29, 2024

Virtual agents: The future of pharma education, engagement and insights This exclusive whitepaper dives into the cutting-edge applications of virtual agents, revealing how they’re enhancing patient education, delivering real-time engagement, and providing actionable insights that shape better healthcare outcomes. Download now to explore the strategic advantages and practical steps for implementing virtual agents in your organization. smarcus Tue, 10/29/2024 - 11:01 This exclusive whitepaper dive

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Perficient: Drug Development

OCTOBER 29, 2024

Upgrades to Drupal versions have been significantly more efficient since Drupal 8 (symfony framework), meaning that site rebuilds are mostly not required. List of Modifications to Platform Specifications: Symfony: Ensure that you have symfony 7 PHP: PHP 8.3 installed with the zlib extension enabled is required for PHP Drupal 11. This extension will often be enabled by default on most platforms.

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Trials Production 52

addgene Blog

OCTOBER 29, 2024

Addgene is very excited to share the very first edition of our Antibodies 101 eBook! The latest addition to our eBook collection is a handy resource for anyone looking to use antibody-based applications in their research.

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Research 52

Perficient: Drug Development

OCTOBER 29, 2024

SNOWFLAKE’S STREAM STREAM: Stream is a CHANGE DATA CAPTURE methodology in snowflake, it records the DML changes made to tables including (Insert/Update/delete). When a stream is created for a table, it will be creating a pair of hidden columns to track the metadata. create or replace stream s_emp on table emp append_only=false; I have two tables emp and emp_hist , emp is my source table and emp_hist will be my my target.

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BioPharma Drive: Drug Pricing

OCTOBER 29, 2024

New guidelines and the timing of COVID vaccinations impacted uptake of Abrysvo this year, according to a company executive.

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