Tue.Oct 29, 2024

article thumbnail

New drug triggers rapid cell death in cancer models

Broad Institute

New drug triggers rapid cell death in cancer models By Karen Zusi-Tran October 29, 2024 Breadcrumb Home New drug triggers rapid cell death in cancer models BRD-810 inhibits the MCL1 protein and reactivates apoptosis in tumor cells, displaying therapeutic potential in animal models. By Karen Zusi-Tran October 29, 2024 Credit: National Cancer Institute Human cells with acute myelocytic leukemia (AML) in the pericardial fluid.

Drugs 133
article thumbnail

Sinuses prevented prehistoric croc relatives from deep diving

Science Daily: Pharmacology News

Paleobiologists have found that the sinuses of ocean dwelling relatives of modern-day crocodiles prevented them from evolving into deep divers like whales and dolphins.

307
307
Insiders

Sign Up for our Newsletter

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

article thumbnail

How AI Might Help Men Fighting Prostate Cancer

Drugs.com

TUESDAY, Oct. 29, 2024 -- Artificial intelligence might be able to help doctors detect the prostate cancers most likely to be life-threatening to men, a new study suggests. An AI program successfully identified and outlined 85% of the most.

Doctors 279
article thumbnail

Have we found all the major Maya cities? Not even close, new research suggests

Science Daily: Pharmacology News

Researchers used laser-guided imaging to uncover vast unexplored Maya settlements in Campeche, Mexico, revealing more than 6,500 pre-Hispanic structures, including a previously unknown large city with stone pyramids. Their study enhances our understanding of the ancient civilization's extent and complexity in an area largely overlooked by archaeologists.

Research 288
article thumbnail

Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

article thumbnail

Colonoscopy Still Beats New Blood Tests at Spotting Colon Cancer

Drugs.com

TUESDAY, Oct. 29, 2024 -- Middle-aged folks facing a colon cancer screening now have a blood test they can choose over a standard colonoscopy.However, the blood test isn't as effective as colonoscopy at detecting and preventing colon cancer, a new.

279
279

More Trending

article thumbnail

Biogen refreshes its C-suite; Novartis writes down MorphoSys assets

BioPharma Drive: Drug Pricing

Daniel Quirk, an immunology and neuroscience executive at Bristol Myers Squibb, will be Biogen’s next chief medical officer, while Robin Kramer will replace retiring CFO Michael McDonnell.

273
273
article thumbnail

Britain's brass bands older than we thought and invented by soldiers from the Napoleonic Wars

Science Daily: Pharmacology News

Military musicians returning from the Napoleonic wars established Britain's first brass bands earlier than previously thought, new research reveals. The study undermines the idea that brass bands were a civilian and exclusively northern creation.

Research 281
article thumbnail

You Can Take Weeks-Long Breaks in Weight Training and Muscles Bounce Back

Drugs.com

TUESDAY, Oct. 29, 2024 -- For many reasons, bodybuilders and others involved in weight training might have to take a break from the gym.However, new Finnish research finds that even weeks-long interruptions in training won't hamper muscle-building.

Research 246
article thumbnail

GSK to pay $300M to license drug it sees as potential lupus treatment

BioPharma Drive: Drug Pricing

The licensing deal with China’s Chimagen Biosciences is the latest example of drugmaker interest in exploring the potential of “T cell engagers” in autoimmune disease.

Licensing 164
article thumbnail

From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

article thumbnail

AI Might Help Pick Up Heart Trouble in Dogs

Drugs.com

TUESDAY, Oct. 29, 2024 -- Artificial intelligence can accurately detect heart murmurs in dogs, a new study finds.The AI program detects heart murmurs in canines with 90% accuracy, similar to the accuracy of expert cardiologists, researchers.

Research 246
article thumbnail

Pfizer sales of RSV vaccine ebb, but company gains market share

BioPharma Drive: Drug Pricing

New guidelines and the timing of COVID vaccinations impacted uptake of Abrysvo this year, according to a company executive.

Vaccine 156
article thumbnail

Iowa Resident Dies of Suspected Lassa Fever After Trip to West Africa

Drugs.com

TUESDAY, Oct. 29, 2024 -- Health officials are investigating the case of an Iowa resident who died of Lassa fever after traveling recently to West Africa.The Ebola-like virus is rarely seen in the United States, according to the U.S. Centers for.

Virus 246
article thumbnail

Paragon spinout joins hunt for new type of cancer immunotherapy

BioPharma Drive: Drug Pricing

Crescent Biopharma is advancing a drug its CEO claims is “purpose-built” to be a perfected version of Summit Therapeutics’ ivonescimab, which recently beat Merck’s Keytruda in a Phase 3 trial.

Trials 156
article thumbnail

How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

article thumbnail

More Than Half of Heat Deaths Can Be Blamed on Global Warming: Study

Drugs.com

TUESDAY, Oct. 29, 2024 -- Researchers looking at the sweltering European summer of 2022 estimated that more than half of the heat-linked deaths occurring on the continent would not have happened if human-led climate change wasn't in place."Without.

Research 245
article thumbnail

Pfizer answers Starboard challenge with beat-and-raise quarter

BioPharma Drive: Drug Pricing

The company reported higher-than-expected third quarter sales and hiked its revenue forecast for the year by $1.5 billion.

156
156
article thumbnail

Marijuana Use Has Fallen 'Dramatically' Among U.S. Teens

Drugs.com

TUESDAY, Oct. 29, 2024 -- Weed use among U.S. teenagers fell dramatically over the past decade, a new study shows.By 2021, only about 16% of teens said they were currently using marijuana, down from 23% in 2011, researchers found.All grades.

Research 245
article thumbnail

Introducing the Addgene Antibodies 101 eBook!

addgene Blog

Addgene is very excited to share the very first edition of our Antibodies 101 eBook! The latest addition to our eBook collection is a handy resource for anyone looking to use antibody-based applications in their research.

article thumbnail

Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

article thumbnail

Childhood Attention Issues Show Links to Later Risk for Psychosis, Schizophrenia

Drugs.com

TUESDAY, Oct. 29, 2024 -- Most kids with attention issues won't go on to develop serious psychiatric conditions like psychosis or schizophrenia. However, a new study finds poor attention spans in childhood, plus certain genes, could play a role in.

130
130
article thumbnail

STC - 56th Annual Symposium

Alta Sciences

STC - 56th Annual Symposium iianiro Tue, 10/29/2024 - 15:27 Image 147900-Toronto.

40
article thumbnail

Newly discovered cyanobacteria could help sequester carbon from oceans and factories

Science Daily: Pharmacology News

What if a microbe could help curb the climate crisis? Meet UTEX-3222, aka 'Chonkus,' a cyanobacterium discovered living in the volcanic CO2 seeps off the coast of Vulcano, Sicily. Chonkus is like other photosynthetic cyanobacteria in that it consumes CO2 and incorporates it into its cells. However, what sets UTEX-3222 apart is its rapid, high-density growth, which allows it to consume CO?

305
305
article thumbnail

PBSS - San Francisco Bay—Current State of Bioanalysis for Biologics and Cell/Gene Therapy Products

Alta Sciences

PBSS - San Francisco Bay—Current State of Bioanalysis for Biologics and Cell/Gene Therapy Products iianiro Tue, 10/29/2024 - 20:55 Image foster_city_sunset.

article thumbnail

Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

article thumbnail

Fossil hunters strike gold with new species

Science Daily: Pharmacology News

Paleontologists have identified fossils of an ancient species of bug that spent the past 450 million years covered in fool's gold in central New York. The new species, Lomankus edgecombei, is a distant relative of modern-day horseshoe crabs, scorpions, and spiders. It had no eyes, and its small front appendages were best suited for rooting around in dark ocean sediment, back when what is now New York state was covered by water.

286
286
article thumbnail

PBSS - San Francisco Bay—Clinical Pharmacology Studies on Hepatic and Renal Impairments for NDA Filing

Alta Sciences

PBSS - San Francisco Bay—Clinical Pharmacology Studies on Hepatic and Renal Impairments for NDA Filing iianiro Tue, 10/29/2024 - 16:53 Image gettyimages-1330763893-640x640.

article thumbnail

Weddell seals in the Antarctic strategically time their most extreme dives to maximize foraging

Science Daily: Pharmacology News

Weddell seals in Erebus Bay, Antarctica, may look like couch potatoes when they are resting on ice. However, these seals, which are the southernmost population of the southernmost living mammals, are exceptional divers that can reach depths of more than 900 meters and recorded dives lasting 96 minutes, which is well beyond their aerobic threshold. Scientists have identified an optimal and novel dive foraging strategy the seals employ to capture prey in the highly seasonal Antarctic environment w

Research 282
article thumbnail

PBSS - Boston—Preclinical Development and IND Filing for new modalities, ADCs, SiRNA/ASO, Gene and Cell Therapies

Alta Sciences

PBSS - Boston—Preclinical Development and IND Filing for new modalities, ADCs, SiRNA/ASO, Gene and Cell Therapies iianiro Tue, 10/29/2024 - 18:14 Image cambridge-massachusetts.

article thumbnail

Unlocking the Full Potential of Your CDMO Partnership: Strategies for Success

Drug Patent Watch

In the rapidly evolving landscape of biotechnology and pharmaceutical development, contract development and manufacturing organizations (CDMOs) have become essential partners for companies seeking to bring innovative medicines to market. However, navigating the complexities of these partnerships can be daunting, especially for smaller biotech companies.