Tue.Mar 18, 2025

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Duchenne patient dies after receiving Sarepta gene therapy

BioPharma Drive: Drug Pricing

A young man treated with Elevidys died of acute liver failure. The case may give doctors pause before prescribing the treatment in the future, some analysts wrote.

Therapies 356
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Genetic study reveals hidden chapter in human evolution

Science Daily: Pharmacology News

Modern humans descended from not one, but at least two ancestral populations that drifted apart and later reconnected, long before modern humans spread across the globe.

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Stoke CEO exits; Medicare drug price talks advance

BioPharma Drive: Drug Pricing

Ed Kaye, Stoke’s longtime leader, will be replaced by former Vertex executive Ian Smith. Elsewhere, all 12 drugmakers targeted for second round of Medicare price talks agreed to participate.

Drugs 260
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Stroke rehabilitation drug repairs brain damage

Science Daily: Pharmacology News

A new study has discovered what researchers say is the first drug to fully reproduce the effects of physical stroke rehabilitation in model mice, following from human studies.

Drugs 284
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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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IV Bags Might Flood Bloodstream With Microplastics

Drugs.com

TUESDAY, March 18, 2025 -- Microplastics that invade and burrow deep within the human body are becoming an increasing concern among doctors and health experts.Now, a new study shows that even medical care is causing increased exposure to the tiny.

Doctors 259

More Trending

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Non‐Hydroxamate Inhibitors of IspC Enzyme in the MEP Pathway: Structural Insights and Drug Development Potential

Chemical Biology and Drug Design

The review provides a comprehensive analysis of non-hydroxamate inhibitors for IspC, an enzyme crucial in the MEP pathway, highlighting its structural diversity and improved drug development potential. It details the design strategies for lipophilic and bisubstrate non-hydroxamate inhibitors, emphasizing their enhanced metal-ion coordination and increased inhibitory potency against IspC.

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When did human language emerge?

Science Daily: Pharmacology News

Humans' unique language capacity was present at least 135,000 years ago, according to a survey of genomic evidence. As such, language might have entered social use 100,000 years ago.

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Makers Drag Feet Reporting Medical Device Side Effects: Study

Drugs.com

TUESDAY, March 18, 2025 -- Other people could be having problems with the same insulin pump, dental implant or glucose monitor that you use -- and you might not find out in a timely manner.Thats because medical device manufacturers frequently fail.

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How to stop being surprised by extreme weather

Science Daily: Pharmacology News

A team of scientists have brought together methods to see beyond the limitations of conventional weather records, which typically only cover the past century.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Prime sets sights on liver, lung disease as next target for its gene editing tech

BioPharma Drive: Drug Pricing

The biotech unveiled a new research program in alpha-1 antitrypsin deficiency, a disease that’s also a focus for rival Beam Therapeutics.

Disease 209
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Revolutionary blueprint to fuse wireless technologies and AI

Science Daily: Pharmacology News

Virginia Tech researchers say a true revolution in wireless technologies is only possible through endowing the system with the next generation of artificial intelligence (AI) that can think, imagine, and plan akin to humans. Doing so will allow networks to break free from traditional enablers, deliver unprecedented quality, and usher in a new phase of the AI evolution.

Research 210
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Glucose Monitors Improve Traffic Safety For Diabetic Drivers

Drugs.com

TUESDAY, March 18, 2025 -- Continuous glucose monitors dont just help people with diabetes maintain healthy blood sugar levels, a new study says -- the devices also can help them be safer drivers.Diabetics who use glucose monitors have fewer i.

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Innovative infant wearable uses artificial intelligence for at-home assessments of early motor development

Science Daily: Pharmacology News

The smart MAIJU jumpsuit offers a novel approach to at-home monitoring of infants' early motor development. The wearable device combines expertise in medicine, measuring technology and AI, enabling objective and accurate assessment of children's motor skills without the presence of researchers.

Research 201
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Chatbots Show Signs of Anxiety, Study Finds

Drugs.com

TUESDAY, March 18, 2025 -- Turns out, even artificial intelligence (AI) needs to take a breather sometimes.A new study suggests that chatbots like ChatGPT may get stressed when exposed to upsetting stories about war, crime or accidents -- just lik.

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Bacteria invade brain after implanting medical devices

Science Daily: Pharmacology News

Brain implants hold immense promise for restoring function in patients with paralysis, epilepsy and other neurological disorders. But a team of researchers has discovered that bacteria can invade the brain after a medical device is implanted, contributing to inflammation and reducing the device's long-term effectiveness.

Research 192
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Hormone Therapy May Protect Transgender Patients From Depression

Drugs.com

TUESDAY, March 18, 2025 -- Gender-affirming hormone therapy may not only help transgender and nonbinary individuals physically -- it could also improve their mental health, new research suggests.A study published March 17 in JAMA Network Open found.

Therapies 179
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Arbor raises $74M amid genetic medicine’s funding slump

BioPharma Drive: Drug Pricing

The round will fund a “one-and-done” treatment for a rare kidney condition that its CEO says can address concerns patients have with therapies from Alnylam and Novo Nordisk.

Therapies 171
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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A rubber hand alleviates pain

Science Daily: Pharmacology News

If a person hides their own hand and focuses on a rubber hand instead, they may perceive it as part of their own body under certain conditions. What sounds like a gimmick could one day be used to help patients who suffer from chronic pain: Researchers have shown that pain caused by heat is experienced as less severe thanks to the rubber hand illusion.

Research 165
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Chest CT Scans Can Help Diagnose Pneumonia

Drugs.com

TUESDAY, March 18, 2025 -- Low-dose CT chest scans could help detect pneumonia in at-risk patients while exposing them to small amounts of radiation, a new study says.Ultra-low-dose scans can effectively detect pneumonia in patients with.

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The Issue with Reissue: PTE Edition

FDA Law Blog: Biosimilars

By Sara W. Koblitz Integral to the careful balance Congress struck when passing the Hatch-Waxman Amendments, the patent term extension (PTE) is intended to restore patent life that was consumed during regulatory review of an FDA-regulated product. Even though the PTE provisions established in the Drug Price Competition and Patent Restoration Act are forty-plus years old, courts are still grappling with questions about how to best implement the Patent Term Extension.

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Prompt CPR Saves Lives, Regardless Of Who Performs It

Drugs.com

TUESDAY, March 18, 2025 -- It doesnt matter if CPR is performed by a doctor, a paramedic or an unskilled, unpracticed passerby -- when performed promptly, it will increase a persons odds of survival, a new study says.The speed of CPR initiation is.

Doctors 162
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Sofinnova’s latest biotech fund sprouts three new startups

BioPharma Drive: Drug Pricing

As part of its “pan-European” plans, Sofinnova is backing startups developing treatments for fibrosis, cancer and Alzheimer’s.

Treatment 148
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Babies With Heart Defects Also Prone To Cancer

Drugs.com

TUESDAY, March 18, 2025 -- Newborns with a heart defect may have two strikes against their future health, rather than one.Babies with heart birth defects appear to have a higher risk of developing childhood cancer, compared to those without a heart.

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Enhancing Business Efficiency with AI: An Introduction to Copilot Agents

Perficient: Drug Development

Introduction to Copilot Agents In today’s fast-paced digital landscape, efficiency and productivity are paramount. Customizing AI to meet your business needs is key to maintaining a competitive edge. Enter Copilot Agents specialized intelligent AI assistants designed to streamline workflows by automating repetitive tasks, providing actionable insights, and seamlessly integrating with your existing tools and data sources.

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Artesunate Suppresses the Migration and Invasion of Thyroid Cancer Cells via Upregulating PTEN to Block M2 Polarization of Tumor‐Associated Macrophages

Chemical Biology and Drug Design

Artesunate suppressed the migration and invasion of thyroid cancer cells via inhibiting the PI3K/Akt pathway by PTEN upregulation-blocked M2 polarization of tumor-associated macrophages. ABSTRACT Immunotherapy holds promise for thyroid cancer (TC) treatment. In the context of our previous findings that artesunate (ART) could inhibit the migration and invasion of TC cells through phosphoinositide 3-kinase/protein kinase B (PI3K/Akt), this study was engineered to investigate whether ART regulates

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Typing CRISPR Systems

addgene Blog

Whats in a type? That which we call CRISPR, by any other name wouldprobably still edit genomes.

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