Tue.Dec 05, 2023

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CRUK and Guardant Health collaborate on precision cancer drugs

Drug Discovery World

Cancer Research UK (CRUK), Cancer Research Horizons, and precision oncology company Guardant Health have launched a collaboration to advance cancer treatment. The agreement will enable the parties to discuss opportunities for collaboration to support the charity’s research and clinical development activities, focusing primarily on its clinical trials run by its Centre for Drug Development.

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Harvesting water from air with solar power

Science Daily: Pharmacology News

Researchers have developed a promising new solar-powered atmospheric water harvesting technology that could help provide enough drinking water for people to survive in difficult, dryland areas: They synthesized a super hygroscopic gel capable of absorbing and retaining an unparalleled amount of water. One kilogram of dry gel could adsorb 1.18 kilograms of water in arid atmospheric environments and up to 6.4 kilograms in humid atmospheric environments.

Research 118
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HuPK: A Humanised Platform for therapeutic antibody PK evaluation

Drug Discovery World

Download the guide to learn more about:  How JAX’s HuPK™ Humanised FcRn Platform offers a validated and cost-effective solution for assessing the in vivo  preclinical pharmacokinetics and stability of Fc-based biologics and therapeutics carried by albumin.   JAX’s portfolio of FcRn humanised mouse models.  Study design templates, expected results, and troubleshooting tips for the most common applications of JAX’s HuPK™ Platform.

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Top 10 climate science insights unveiled

Science Daily: Pharmacology News

A new report equips policymakers with the latest and most pivotal climate science research from the previous 18 months, synthesized to help inform negotiations at COP28 and policy implementation through 2024 and beyond.

Science 116
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Guide: Assessing preclinical PK in therapeutic antibodies

Drug Discovery World

A new Guide is now available from The Jackson Laboratory (JAX) entitled ‘HuPK: A Humanised Platform for therapeutic antibody PK evaluation’ Download the Guide to learn more about:  How JAX’s HuPK™ Humanised FcRn Platform offers a validated and cost-effective solution for assessing the in vivo  preclinical pharmacokinetics and stability of Fc-based biologics and therapeutics carried by albumin.

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Cognitive Decline May Come Earlier for People With Epilepsy

Drugs.com

TUESDAY, Dec. 5, 2023 -- People with epilepsy suffer quicker declines in thinking than people without the brain disorder, particularly if they also have risk factors like high blood pressure or diabetes, a new study finds.The difference was.

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Pfizer, after delay, completes enrollment in Lyme vaccine trial

BioPharma Drive: Drug Pricing

The announcement ends a lengthy setback that began when the company and partner Valneva accused a clinical trial site operator of study misconduct.

Trials 113
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Any Kind of Drug Abuse Treatment Can Help Gay Men Kick Meth Habit

Drugs.com

TUESDAY, Dec. 5, 2023 -- Methamphetamine abuse has long plagued the gay community, but a new study finds that any form of substance abuse treatment can help users quit. In a news release, University of California, Los Angeles researchers explained.

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Exploring Selenium 4: Dive into the Actions API

Perficient: Drug Development

Selenium 4, the latest iteration of the Selenium WebDriver, introduces several enhancements to streamline web automation. One notable improvement is the revamped Actions API. This low-level interface provides virtualized device input actions to the web browser, offering granular control over keyboard, mouse, pen, touch devices, and even scroll wheel interactions.

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Drug Wholesalers and Brand-Name Drug Prices: Understanding CVS Health/McKesson and Why Pharmacies Lose Money on GLP-1s

Drug Channels

Consider two apparently unrelated drug channel anomalies: In McKesson’s 2023 fiscal year, CVS bought $75 billion in pharmaceuticals from McKesson’s wholesale business—a jump of more than 35% compared with the previous year. Despite skyrocketing sales for anti-obesity GLP-1 drugs, many retail pharmacies are losing money on every prescription. The common factor behind these two disparate situations: Pharmaceutical wholesalers’ unusual pricing for brand-name drugs sold to pharmacies, hospitals, and

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Newborns' Brains Aren't 'Undeveloped' Compared to Those of Infant Monkeys, Chimps

Drugs.com

TUESDAY, Dec. 5, 2023 -- New research challenges a long-held notion that human newborns enter the world with brains that are significantly less developed than those of other primates.Babies are born extremely helpless and with poor muscle.

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Mice pass the mirror test, a classic indicator of self-recognition

Science Daily: Pharmacology News

Researchers report that mice display behavior that resembles self-recognition when they see themselves in the mirror. When the researchers marked the foreheads of black-furred mice with a spot of white ink, the mice spent more time grooming their heads in front of the mirror -- presumably to try and wash away the ink spot. However, the mice only showed this self-recognition-like behavior if they were already accustomed to mirrors, if they had socialized with other mice who looked like them, and

Research 104
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Opioid Crisis May Be Driving Surge in Youth Suicides

Drugs.com

TUESDAY, Dec 5, 2023 -- Suicide rates for Americans under the age of 18 are rising at unprecedented rates, and a new report points to a likely culprit: The ongoing epidemic of opioid abuse.It's not that more kids and teens became abusers of.

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Standardizing software: Supporting small pharma with SAP

Fierce BioTech

SAP’s technology reaches almost every corner of our economy and society, the company providing vital software that helps countless companies and organizations from a huge array of sectors to functi | Aparna Seksaria and Kevin Brophy sit down with Fierce Biotech’s Rebecca Williamson to talk about the importance of levelling the playing field by offering leading-edge software solutions to the smaller businesses in the pharma sphere.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Surgery Helps Kids With Drug-Resistant Epilepsy, But Race Could Hinder Access

Drugs.com

TUESDAY, Dec. 5, 2023 -- Black, Hispanic and low-income kids are less likely to receive surgery that can treat their drug-resistant epilepsy, a new study finds.Researchers discovered that children on anti-seizure drugs who received vagus nerve.

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Exposure to soft robots decreases human fears about working with them

SCIENMAG: Medicine & Health

VANCOUVER, Wash. – Seeing robots made with soft, flexible parts in action appears to lower people’s anxiety about working with them or even being replaced by them. Credit: Dean Hare, Washington State University Photo Services VANCOUVER, Wash.

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It's Hunting Season: Keep Safety in Your Sights

Drugs.com

TUESDAY, Dec. 5, 2023 (Healthday News) -- Hunting season has begun in many parts of the United States, with millions of Americans heading into the woods in hopes of bagging a big buck. But with the season comes tragic accidents.

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CVS overhauls how its retail pharmacies charge for prescription drugs

BioPharma Drive: Drug Pricing

Under the new model, CVS’ pharmacy network will price drugs based on the amount the company paid for them, plus a defined markup and additional pharmacist fee.

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High Blood Pressure in Pregnancy Tied to Long-Term Heart Trouble for Hispanic Women

Drugs.com

TUESDAY, Dec. 5, 2023 -- Hispanic women who experience spikes in blood pressure while pregnant may also face higher heart risks years later, new research shows.

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UofL secures $6.5 million to enhance training for nursing professionals

SCIENMAG: Medicine & Health

The University of Louisville has received $6.5 million through two federal grants to help increase Kentuckians’ access to health care, particularly in underserved rural and urban areas.

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Wasabi Shows Memory-Boosting Powers in Study

Drugs.com

TUESDAY, Dec. 5, 2023 -- Wasabi, that green condiment that spices up your sushi, may possess memory-boosting powers, a new Japanese study suggests.

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Dorothee Dormann receives an ERC Consolidator Grant to support her research into neurodegenerative diseases

SCIENMAG: Medicine & Health

The protein TDP-43 is present in all cells of our body and important for their biochemical processes. However, this protein can aggregate into large clumps in the brain, which can cause degenerative diseases such as Alzheimer’s and other dementias.

Disease 85
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New Syndrome May Be Affecting Babies Exposed to Fentanyl

Drugs.com

TUESDAY, Dec. 5, 2023 -- Doctors report they are seeing what they think is a new syndrome in babies who are exposed to fentanyl while in the womb.All of the infants have cleft palates and unusually small heads, and all were born to mothers who said.

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Reliable research and evidence-based recommendations scarce for women who exercise according to menstrual cycle

SCIENMAG: Medicine & Health

Hamilton, ON, December 5, 2023 – There is no shortage of advice for women on what to eat, how to train, or what supplements to take during their menstrual cycles, but a new review by an international team of scientists has found little evidence to support such recommendations.

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'Shocking' discovery: Electricity from electric eels may transfer genetic material to nearby animals

Science Daily: Pharmacology News

Researchers have discovered that electric eels can alter the genes of tiny fish larvae with their electric shock. Their findings help to better understand electroporation, a method by which genes can be transported using electricity.

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Marshall School of Medicine dean recognized on 2023 Highly Cited Researchers List

SCIENMAG: Medicine & Health

HUNTINGTON, W.Va. – David Gozal, M.D., M.B.A., Ph.D. (Hon), vice president of health affairs and dean of the Joan C. Edwards School of Medicine at Marshall University, was named to the 2023 list of Highly Cited Researchers™ list by Clarivate™. Credit: Marshall University Joan C. Edwards School of Medicine HUNTINGTON, W.Va. – David Gozal, M.D.

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BIO names longtime Amicus head John Crowley as its new CEO

BioPharma Drive: Drug Pricing

Crowley, a rare disease advocate who led Amicus for nearly two decades, will take the reins as the industry group seeks to challenge Medicare’s new drug pricing powers.

Disease 76
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Can signs of life be detected from Saturn's frigid moon?

Science Daily: Pharmacology News

Researchers have shown unambiguous laboratory evidence that amino acids transported in the ice plumes of Saturn's moon, Eceladus, can survive impact speeds of up to 4.2 km/s, supporting their detection during sampling by spacecraft.

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J&J pitches investors on sales growth from cancer, immune disease drugs

BioPharma Drive: Drug Pricing

The company expects its pharmaceutical division to deliver 20 new medicines through the end of the decade, including several it believes could earn peak annual sales of more than $5 billion.

Disease 67
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Unlocking neutron star rotation anomalies: Insights from quantum simulation

Science Daily: Pharmacology News

A collaboration between quantum physicists and astrophysicists has achieved a significant breakthrough in understanding neutron star glitches. They were able to numerically simulate this enigmatic cosmic phenomenon with ultracold dipolar atoms. This research establishes a strong link between quantum mechanics and astrophysics and paves the way for quantum simulation of stellar objects from Earth.

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CRISPR eyes autoimmune disease in revamp of cell therapy plans

BioPharma Drive: Drug Pricing

The gene editing biotech is shelving two of its most advanced cancer drugs, and joining a growing group of companies exploring cell-based medicines for inflammatory diseases like lupus.

Disease 67
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Artificial intelligence makes gripping more intuitive

Science Daily: Pharmacology News

Artificial hands can be operated via app or with sensors placed in the muscles of the forearm. New research shows: a better understanding of muscle activity patterns in the forearm supports a more intuitive and natural control of artificial limbs. This requires a network of 128 sensors and artificial intelligence based techniques.

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Wildfires Are Undoing Gains Made Against Air Pollution

Drugs.com

TUESDAY, Dec. 5, 2023 -- Unhealthy air from wildfires is causing hundreds of additional deaths in the western United States every year, a new study claims.Wildfires have undercut progress made in cleaning America’s air, and between 2000 and 2020.

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BrainChild Bio spins out of Seattle Children’s to develop cancer drugs

BioPharma Drive: Drug Pricing

Launched from BrainChild founder Michael Jensen’s lab at the Washington-area hospital, the company is focusing first on pediatric brain tumors.