Broad Institute
JANUARY 22, 2024
Q&A: New approaches are needed to find better cancer drug targets By Allessandra DiCorato January 22, 2024 Breadcrumb Home Q&A: New approaches are needed to find better cancer drug targets Bill Sellers, head of Broad’s Cancer Program, talks about how to discover new classes of genetic dependencies that could move therapies closer to curing cancer patients.
ASPET
JANUARY 22, 2024
The NOD-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome is a central regulator of innate immunity, essential for processing and release of interleukin-1β and pyroptotic cell death. As endogenous NLRP3 activating triggers are hallmarks of many human chronic inflammatory diseases, inhibition of NLRP3 has emerged as a therapeutic target.
BioPharma Drive: Drug Pricing
JANUARY 22, 2024
New details of the proposed acquisitions show there were multiple interested buyers, which, according to some analysts, could set the stage for more dealmaking.
ASPET
JANUARY 22, 2024
Nuclear factor-B (NF-B) plays a central role in inflammatory responses, while its physiological functions are essential for cell survival and proliferation. Currently, drugs targeting NF-B inhibition have not yet been applied in clinical practice. We investigated the physiological effect of a novel NF-kB inhibitory compound, 1 H -pyrazolo[3,4- d ]pyrimidin-4-amine derivative (INH #1) on three inflammatory animal models.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Drugs.com
JANUARY 22, 2024
MONDAY, Jan. 22, 2024 -- Depression affects half of the 6 million Americans who struggle with debilitating heart failure. Now, research shows that two leading modes of treatment -- antidepressants and an approach called behavioral activation.
BioPharma Drive: Drug Pricing
JANUARY 22, 2024
Trodelvy didn’t outperform chemotherapy in a large study of people with a common lung tumor, a setback that sent company shares down by double digits.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Drug Patent Watch
JANUARY 22, 2024
A recent article published in Health Affairs, delves into the Federal Trade Commission’s (FTC) concerns regarding the inclusion of improper patents in the FDA’s Orange Book by pharmaceutical manufacturers. The… The post Legislative Proposals to Tackle Improper Pharmaceutical Patents in the Orange Book appeared first on DrugPatentWatch - Make Better Decisions.
Drugs.com
JANUARY 22, 2024
MONDAY, Jan. 22, 2024 — Back pain is a double-edged sword.In most cases, it disappears within about six weeks. But when it doesn't, low back pain is likely to bother you for the long haul, researchers warn."The good news is that most episodes of.
Science Daily: Pharmacology News
JANUARY 22, 2024
Gliding winged-reptiles were amongst the ancient crocodile residents of the Mendip Hills in Somerset, England, researchers at the have revealed.
Collaborative Drug
JANUARY 22, 2024
Import File Parser We're excited to announce a significant update to the CDD Vault Import Data wizard. This update introduces a flexible parser to accommodate a wider range of data file formats beyond the traditional tabular ("long and skinny") layout. Now, you can easily import data files organized in various formats, including those resembling a Plate layout.
Advertisement
Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Eye on FDA
JANUARY 22, 2024
Last week FDA’s Office of Prescription Drug Promotion issued its first regulatory action letter of the year. This was an Untitled Letter – a/k/a Notice of Violation Letter (NOV) – sent by the agency to Novartis in relation to promotional content regarding the cancer treatment KISQALI(r) (ribociclib). The communications vehicle that was the subject of the letter was a Direct-to-Consumer (DTC) television advertisement that had been submitted for agency review.
Science Daily: Pharmacology News
JANUARY 22, 2024
Scientists have developed 'supramolecular ink,' a new 3D-printable OLED (organic light-emitting diode) material made of inexpensive, Earth-abundant elements instead of costly scarce metals. The advance could enable more affordable and environmentally sustainable OLED flat-panel displays as well as 3D-printable wearable technologies and lighting.
SCIENMAG: Medicine & Health
JANUARY 22, 2024
A team of scientists from Nanyang Technological University, Singapore (NTU Singapore) has demonstrated that communication among memory-coding neurons – nerve cells in the brain responsible for maintaining working memory – is disrupted with ageing and that this can begin in middle age.
Science Daily: Pharmacology News
JANUARY 22, 2024
A research team has developed a novel catalyst for the high-efficiency and stable production of high-purity green hydrogen.
Advertisement
Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
SCIENMAG: Medicine & Health
JANUARY 22, 2024
MADISON, WI.– Cleft lip and palate are the most common craniofacial birth defects in humans, affecting more than 175,000 newborns around the world each year. Yet despite decades of research, it’s still not known what causes most cases or what can be done to prevent them.
NIOSH Science Blog: Drugs
JANUARY 22, 2024
Some individuals with COVID-19 do not recover to their usual state of health, experiencing a broad array of new or continuing debilitating symptoms collectively referred to as “long COVID.” Long COVID can have a significant impact on a worker’s return to work. In June 2023, the Centers for Disease Control and Prevention hosted the webinar Evaluating and Supporting Patients with Long COVID in Returning to Work.
SCIENMAG: Medicine & Health
JANUARY 22, 2024
Air conditioning in our workplaces and homes doesn’t just cool the air – it can also help trap particles from wildfire smoke and reduce our exposure to potentially harmful elements like soluble mercury, sulfate and nitrate, new research shows.
BioPharma Drive: Drug Pricing
JANUARY 22, 2024
The medicine, called donidalorsen, reduced hereditary angioedema-related attacks in the Phase 3 trial. Several competing options to it are already available or in advanced testing, however.
Advertisement
Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
SCIENMAG: Medicine & Health
JANUARY 22, 2024
Non-alcoholic fatty liver disease (NAFLD), recently renamed metabolic dysfunction-associated fatty liver disease (MAFLD), is spectrum of diseases that ranges from non-alcoholic fatty liver (NAFL) to non-alcoholic steatohepatitis (NASH). Credit: Sha, T.T.
Drugs.com
JANUARY 22, 2024
MONDAY, Jan. 22, 2024 -- A newly developed “brush biopsy” allows dentists to screen for the most common form of mouth cancer, a new study reports.Dentists use a small brush to gently collect cells from potentially cancerous lesions inside the.
Drug Patent Watch
JANUARY 22, 2024
This chart shows the pharmaceutical companies with patents in the most countries. Patents must be filed in each country (or, in some cases regional patent office) where patent protection is… The post Which pharmaceutical companies have the greatest global patent coverage? appeared first on DrugPatentWatch - Make Better Decisions.
Cytel
JANUARY 22, 2024
Regulatory guidelines outline all crucial studies and documentation that should be in place before a drug product can be tested in humans for the first time. However, such guidelines do not tell you when different studies are ideally run or how to best prioritize between studies. Here, I share ways to save time and limit costs on your way to clinical trials.
Drug Patent Watch
JANUARY 22, 2024
Annual Drug Patent Expirations for EVOCLIN Evoclin is a drug marketed by Mylan and is included in one NDA. There are two patents protecting this drug and one Paragraph IV… The post New patent expiration for MYLAN drug EVOCLIN appeared first on DrugPatentWatch - Make Better Decisions.
Drugs.com
JANUARY 22, 2024
MONDAY, Jan. 22, 2024 (HealthDay New) -- Sarah Ferguson, the Duchess of York, announced Monday that she has been diagnosed with melanoma, an aggressive form of skin cancer."I have been taking some time to myself as I have been diagnosed with.
Drug Patent Watch
JANUARY 22, 2024
Annual Drug Patent Expirations for DIFICID Dificid is a drug marketed by Cubist Pharms Llc and is included in two NDAs. It is available from one supplier. There are six… The post New patent expiration for Cubist Pharms drug DIFICID appeared first on DrugPatentWatch - Make Better Decisions.
Drugs.com
JANUARY 22, 2024
MONDAY, Jan. 22, 2024 -- Infection in childhood with bacterial meningitis leaves one-third of survivors with long-term neurological damage, often severe, a new study shows.The disease is rare and easily treated with antibiotics. However, as Swedish.
Drug Patent Watch
JANUARY 22, 2024
Annual Drug Patent Expirations for INJECTAFER Injectafer is a drug marketed by Am Regent and is included in one NDA. It is available from one supplier. There are ten patents… The post New patent for Am Regent drug INJECTAFER appeared first on DrugPatentWatch - Make Better Decisions.
Drugs.com
JANUARY 22, 2024
MONDAY, Jan. 22, 2024 -- Breast cancer deaths declined by a dramatic 58% between 1975 and 2019, and researchers think they can pinpoint the exact reasons for the reduction.Advances in medical technology aided by routine breast cancer screening have.
Drug Patent Watch
JANUARY 22, 2024
Annual Drug Patent Expirations for TAZVERIK Tazverik is a drug marketed by Epizyme Inc and is included in one NDA. It is available from one supplier. There are twenty-four patents… The post New patent for Epizyme Inc drug TAZVERIK appeared first on DrugPatentWatch - Make Better Decisions.
Drugs.com
JANUARY 22, 2024
MONDAY, Jan. 22, 2024 -- Microbiomes: You've probably heard of these communities of largely helpful bacteria that colonize the gut or the skin. But a man's semen has a microbiome of its own, and new research suggests it could play a role in.
Drug Patent Watch
JANUARY 22, 2024
Annual Drug Patent Expirations for SUNOSI Sunosi is a drug marketed by Axsome Malta and is included in one NDA. It is available from two suppliers. There are eighteen patents… The post New patent for Axsome Malta drug SUNOSI appeared first on DrugPatentWatch - Make Better Decisions.
Drugs.com
JANUARY 22, 2024
MONDAY, Jan. 22, 2024 -- Sports provides many physical and mental health benefits to children and teens, but many quit due to injury, overtraining and burnout.As many as 7 in 10 kids drop out of youth sports by age 13, according to the American.
Drug Target Review
JANUARY 22, 2024
A new study by scientists at the Cincinnati Children’s Hospital Medical Center elucidates how pioneer transcription factors (TFs) function. The team developed a new CRISPR interference (CRISPRi) model to investigate how the pioneer TF FOXA controls human endoderm differentiation during liver development, as well as how the pioneer TF OCT4 influences the behaviour of pluripotent stem cells.
Expert insights. Personalized for you.
128 
Let's personalize your content