ASPET

SEPTEMBER 20, 2024

Post-traumatic stress disorder (PTSD) is caused by exposure to a traumatic or stressful event. Symptoms related to this disorder include persistent re-experiencing of memories and fear generalization. Current pharmacological treatments for PTSD are insufficient, with fewer than 30% of patients reporting symptom remission. This study aims to determine the efficacy of acute ( R,S) ketamine and chronic fluoxetine (FLX) in reducing fear memory and fear generalization.

Treatment 190

Treatment Research 190

Science Daily: Pharmacology News

SEPTEMBER 20, 2024

A new, wide-ranging exploration of human remains casts doubt on a long-standing theory in archaeology known as the Kurgan hypothesis -- which, among other claims, suggests that humans first domesticated horses as early as the fourth millennium B.C.

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ASPET

SEPTEMBER 20, 2024

Despite considerable efforts, there remains no FDA-approved medications for cocaine use disorder (CUD). One strategy to mitigate cocaine craving and relapse is to elevate dopamine (DA). The DA transport inhibitor and releaser d -amphetamine has been shown to decrease cocaine self-administration (SA), although it has abuse liability. Recently, several modafinil analogues reduced cocaine SA in rats and monkeys, including JJC8-088, characterized as "cocaine like" in rats, and JJC8-091, characterize

FDA Approval 100

FDA Approval Treatment FDA Drugs 100

BioPharma Drive: Drug Pricing

SEPTEMBER 20, 2024

The decision against Syfovre’s approval follows efforts by Apellis to have reviewers reevaluate clinical evidence multiple times and, according to an analyst, will lead to a restructuring of the company’s operations in Europe.

Drugs 117

Drugs 117

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drugs.com

SEPTEMBER 20, 2024

FRIDAY, Sept. 20, 2024 -- The days of waiting for a flu shot at your doctor's office or local pharmacy may be over: The U.S. Food and Drug Administration on Friday approved FluMist nasal spray as the first influenza vaccine that can be.

FDA Approval 116

FDA Approval Vaccine Pharmacy Doctors 116

BioPharma Drive: Drug Pricing

SEPTEMBER 20, 2024

A pill Novo acquired produced modest weight loss but raised safety questions. Elsewhere, Sanofi detailed the silver lining it found in a recent study and a heart drug developer’s shares surged.

Drug Development 62

Drug Development Drugs 62

Drug Target Review

SEPTEMBER 20, 2024

What were the specific results and observations from the 28-day mouse trial conducted by Oxford Drug Design? The trial was a standard mouse xenograft against MCF7 breast cancer cells inserted into the fat pad. There were six mice per arm with the vehicle control and the positive control being the potent immunosuppressor agent rapamycin. We tested the current lead compound in our program and the results demonstrated clear efficacy with significant tumour regression.

Clinical Trials 59

Clinical Trials Treatment Science Trials 59

Drugs.com

SEPTEMBER 20, 2024

FRIDAY, Sept. 20, 2024 -- Whooping cough cases are climbing at the fastest pace in years as students across America return to school, U.S. health officials reported Thursday.In figures published by the U.S. Centers for Disease Control and.

Disease 105

Disease 105

Fierce BioTech

SEPTEMBER 20, 2024

Although childhood cancer is rare, it is the leading cause of disease related death in children.1 2 The diagnosis of cancer in children may be delayed due to the non-specific nature of t | Navigate current legislation and FDA guidance for pediatric oncology clinical trials with expert guidance from WCG.

Clinical Trials 52

Clinical Trials Trials Therapies Research 52

Drugs.com

SEPTEMBER 20, 2024

FRIDAY, Sept. 20, 2024 -- Doctors sometimes turn to antidepressants as a means of easing older people's physical pain, but a new expert review finds there's little evidence to support the practice.Antidepressants may even come with hazards for.

Doctors 110

Doctors 110

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Perficient: Drug Development

SEPTEMBER 20, 2024

One of the biggest challenges product development teams face is bridging the gap between high-level product goals and the specific tasks needed to achieve them. How do you ensure that the broader vision is effectively translated into actionable steps? This is where features come into play. What is a Feature? A feature is a logical functionality or a grouping mechanism that is used in between the high-level epics and tactical user stories.

Production 52

Production 52

Drugs.com

SEPTEMBER 20, 2024

FRIDAY, Sept. 20, 2024 -- Controversial fentanyl lollipops and similar products will no longer be made by drug makers, the U.S. Food and Drug Administration has announced.Known as TIRF medications, these products contain fentanyl and are used to.

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FDA Drugs Production 110

Crucial Data Solutions

SEPTEMBER 20, 2024

The Challenge of Device Provisioning in Clinical Trials In clinical trials, gathering timely and accurate data from patients is essential. The post Simplifying ePRO Data Collection: The Benefits of BYOD with TrialKit appeared first on Crucial Data Solutions.

Clinical Trials 52

Clinical Trials Trials 52

Drugs.com

SEPTEMBER 20, 2024

FRIDAY, Sept. 20, 2024 -- A cavalry of sorts can come to the rescue of combat veterans suffering from post-traumatic stress disorder (PTSD), a new study says.Combat veterans who regularly care for horses experience an easing of their PTSD symptoms.

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98

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Quanticate

SEPTEMBER 20, 2024

As oncology treatments advance, optimising dose selection has become a key focus for improving patient outcomes. The FDA’s Project Optimus aims to address this need by reshaping traditional dose-finding methods, prioritising both efficacy and long-term tolerability. In this article, we discuss the objectives and implications of Project Optimus, exploring its potential to transform oncology clinical trials and enhance cancer treatment strategies.

Treatment 52

Treatment Clinical Trials Trials 52

Drugs.com

SEPTEMBER 20, 2024

FRIDAY, Sept. 20, 2024 -- Each year, an average of 174 U.S. kids under the age of 5 lose their lives over causes linked to nursery products.Many of these tragedies could be prevented, and the Consumer Product Safety Commission (CPSC) on Thursday.

Production 98

Production 98

Fierce BioTech

SEPTEMBER 20, 2024

Accelerating Timelines to Clinic with GPEx® Lightning Catalent Biologics revolutionary GPEx® Lightning system overcomes the toughest manufacturing challenges by finely tuning multi-chain gene expression resulting in optimal titer & protein quality. Experience faster development, robust processes, superior protein quality, & higher yields. jpiatt Fri, 09/20/2024 - 09:33 Accelerating Timelines to Clinic with GPEx® Lightning Catalent Resource Type Whitepaper 250x190 (4).

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Drugs.com

SEPTEMBER 20, 2024

FRIDAY, Sept. 20, 2024 -- Millions of women struggle with the discomfort and stress of urinary incontinence, and many turn to medications for help.Now, new research suggests that yoga and other exercise regimens might work just as well to control.

Research 104

Research 104

Drug Channels

SEPTEMBER 20, 2024

Today’s guest post comes from Josh Marsh, Vice President and General Manager, Sonexus™ Access and Patient Support at Cardinal Health Josh discusses challenges manufacturers may face when outsourcing patient support programs. He outlines a process that smoothly transitions hubs and minimizes disruptions for patients and healthcare providers. To learn more, download the 3-step guide to patient hub transitions.

Drugs 52

Drugs 52

Drugs.com

SEPTEMBER 20, 2024

FRIDAY, Sept. 20, 2024 -- An arthritis sufferer’s joints start to get ornery when the weather turns colder, getting stiff and achy as the mercury drops.Cold weather doesn’t cause arthritis, but it can make it worse, experts say."Our joints operate b.

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BMG Labtech

SEPTEMBER 20, 2024

The fundamental observation that almost all molecules in nature absorb and emit light at different wavelengths has driven developments in spectroscopy and fueled discoveries across scientific disciplines. 1 Today researchers have access to technologies and instruments that use different forms of light to generate precise measurements of how much of a particular substance is present in a solution.

Research 52

Research 52

Drugs.com

SEPTEMBER 20, 2024

FRIDAY, Sept. 20, 2024 -- Heavy-duty endurance exercise can cause body fat levels to drop without any accompanying weight loss, a new small-scale study indicates.A group of eleven middle-aged men who cycled 710 miles in seven days lost only about.

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BioPharma Drive: Drug Pricing

SEPTEMBER 20, 2024

The agency brought action against Caremark, Express Scripts and Optum Rx on Friday, and warned that all drug manufacturers “should be on notice” as well.

Pharmacy 52

Pharmacy Drugs 52

Drugs.com

SEPTEMBER 20, 2024

FRIDAY, Sept. 20, 2024 -- Pulling your hair out in frustration with your finicky youngster?Don’t blame your parenting style -- genetics likely played a huge role in their eating habits, a new twins study FINDs.Fussy eating is mainly influenced by g.

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NIOSH Science Blog: Drugs

SEPTEMBER 20, 2024

On September 11, 2001, nearly 3,000 people lost their lives and thousands were injured during the events that occurred at the World Trade Center (WTC) in New York City, New York, the Pentagon in Arlington, Virginia, and the plane crash in Shanksville, Pennsylvania. It’s estimated that more than 400,000 people were exposed to harmful contaminants, risks of traumatic injury, and physically and emotionally stressful conditions in the following days, weeks, months, and years.[1] These included emerg

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Drugs.com

SEPTEMBER 20, 2024

FRIDAY, Sept. 20, 2024 -- Would-be dads don’t have to worry that taking the epilepsy drug valproate will result in children with birth defects, a new review concludes. Valproate, an anti-seizure drug, is known to cause birth defects and.

Drugs 59

Drugs 59

Drugs.com

SEPTEMBER 20, 2024

FRIDAY, Sept. 20, 2024 -- Would-be dads don’t have to worry that taking the epilepsy drug valproate will result in children with birth defects, a new review concludes.Valproate, an anti-seizure drug, is known to cause birth defects and d.

Drugs 52

Drugs 52

Drugs.com

SEPTEMBER 20, 2024

FRIDAY, Sept. 20, 2024 -- Stroke rates continue to rise among adults and children living with sickle cell disease, despite new standards of care meant to lower their risk, a new study finds.People with sickle cell are vulnerable to strokes caused.

Disease 52

Disease 52