Mon.May 13, 2024

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Today's world: Fastest rate of carbon dioxide rise over the last 50,000 years

Science Daily: Pharmacology News

Today's rate of atmospheric carbon dioxide increase is 10 times faster than at any other point in the past 50,000 years, researchers have found through a detailed chemical analysis of ancient Antarctic ice.

Research 329
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Ajax, aiming for a better JAK drug, raises $95M to begin first tests

BioPharma Drive: Drug Pricing

Goldman Sachs and Eli Lilly are among those backing the startup, which claims its prospect could be more potent than the myelofibrosis therapies that have come to market in recent years.

Therapies 319
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Plant virus treatment shows promise in fighting metastatic cancers in mice

Science Daily: Pharmacology News

An experimental treatment made from a plant virus is effective at protecting against a broad range of metastatic cancers in mice, shows a new study. The treatment, composed of nanoparticles fashioned from the cowpea mosaic virus -- a virus that infects black-eyed pea plants -- showed remarkable success in improving survival rates and suppressing the growth of metastatic tumors across various cancer models, including colon, ovarian, melanoma and breast cancer.

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Wegovy Can Help Heart Failure Patients Reduce Meds: Study

Drugs.com

MONDAY, May 13, 2024 -- People with heart failure are often prescribed what are known as loop diuretic medications to help reduce the fluid buildup that's a hallmark of the disease.Now, research suggests that taking the blockbuster weight loss drug.

Research 278
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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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What makes a memory? It may be related to how hard your brain had to work

Science Daily: Pharmacology News

The human brain filters through a flood of experiences to create specific memories. Why do some of the experiences in this deluge of sensory information become 'memorable,' while most are discarded by the brain? A computational model and behavioral study developed by Yale scientists suggests a new clue to this age-old question, they report in the journal Nature Human Behavior.

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First case of highly pathogenic avian influenza transmitted from cow to human confirmed

Science Daily: Pharmacology News

in March a farm worker who reported no contact with sick or dead birds, but who was in contact with dairy cattle, began showing symptoms in the eye and samples were collected by the regional health department to test for potential influenza A. Experts have now confirmed the first case of highly pathogenic avian influenza transmission from a mammal (dairy cow) to a human.

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First Pig Kidney Recipient Dies Almost Two Months After Transplant

Drugs.com

MONDAY, May 13, 2024 -- Rick Slayman, the first person to receive a kidney transplant from a genetically modified pig, has died nearly two months after having the historic surgery.In a statement released Saturday, Slayman's family said they were.

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Nature's 3D printer: Bristle worms form bristles piece by piece

Science Daily: Pharmacology News

Molecular biologists provide exciting insights into the bristles of the marine annelid worm Platynereis dumerilii. Specialized cells, so-called chaetoblasts, control the formation of the bristles. Their mode of operation is astonishingly similar to that of a technical 3D printer.

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Takeda nabs option to license Alzheimer’s immunotherapies from AC Immune

BioPharma Drive: Drug Pricing

The deal — worth $100 million up front and potentially billions more later on — gives Takeda an exclusive option to license an Alzheimer’s vaccine and other “active immunotherapies.

Licensing 188
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Ophiobolin A Covalently Targets Mitochondrial Complex IV Leading to Metabolic Collapse in Cancer Cells

Covalent Modifiers

Flor A. Gowans, Danny Q. Thach, Zhouyang Zhu, Yangzhi Wang, Belen E. Altamirano Poblano, Dustin Dovala, John A. Tallarico, Jeffrey M. McKenna, Markus Schirle, Thomas J. Maimone, and Daniel K. Nomura ACS Chemical Biology 2024 DOI: 10.1021/acschembio.4c00064 Ophiobolin A (OPA) is a sesterterpenoid fungal natural product with broad anticancer activity.

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Sanofi gambles $80M on Fulcrum’s muscular dystrophy drug

BioPharma Drive: Drug Pricing

The deal gives the pharma partial rights to a medicine GSK once developed for heart disease but could soon become the first therapy for facioscapulohumeral muscular dystrophy.

Therapies 183
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Police Seizures of Pills With Fentanyl Have Skyrocketed

Drugs.com

MONDAY, May 13, 2024 -- Police seizures of illicit fentanyl pills have soared in recent years, a new study has found.The number of pills containing fentanyl seized by law enforcement was 2,300 times greater in 2023 than in 2017 – more than 115.

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NewVale, an unorthodox venture firm, sets out to support biotech’s ‘infrastructure’

BioPharma Drive: Drug Pricing

The firm, which closed a $167 million fund, aims to fill a “crucial gap” by helping to grow the companies startups turn to for outsourced services, founder Todd Holmes told BioPharma Dive.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Olivia Munn Underwent Hysterectomy After Breast Cancer Diagnosis

Drugs.com

MONDAY, May 13, 2024 -- Actress and "X-men" star Olivia Munn has revealed that she underwent egg retrieval and then a hysterectomy after being diagnosed with breast cancer. In an article published on Mother's Day, Munn told Vogue she opted for.

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Biosimilars are gaining ground. The IRA could push them further next year.

BioPharma Drive: Drug Pricing

As commercial momentum builds, coverage incentives for the Medicare market are expected to favor biosimilars in 2025.

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Yoga Can Help Heart Failure Patients Stay Strong

Drugs.com

MONDAY, May 13, 2024 -- Yoga can help improve the long-term health of people with heart failure, a new study has found.“Patients who practiced yoga on top of taking their medications felt better, were able to do more, and had stronger hearts than.

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Acknowledging comorbidities in trial design is essential for successful outcomes

BioPharma Drive: Drug Pricing

Examine why adaptive trials that consider comorbidities are critical for a successful trial outcome.

Trials 139
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Test Might Predict Which Kids Will Outgrow Peanut Allergy

Drugs.com

MONDAY, May 13, 2024 -- About a third of young children who are allergic to peanuts will outgrow the allergy by the age of 10, and an antibody test might predict who those kids might be.

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Partnering for success: Choosing the right CDMO in pharma outsourcing

BioPharma Drive: Drug Pricing

Explore the four most important qualities for choosing a dependable outsourcing partner in pharma.

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Could Having 'Skinny' Fat Cells Encourage Weight Gain?

Drugs.com

MONDAY, May 13, 2024 -- “Skinny” fat cells might actually make it harder to lose weight and easier to pack on extra pounds, a new study says.Researchers say it’s possible to predict if someone’s going to gain weight based solely on the size.

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When Worlds Collide: The Theory of Real-World Evidence Meets Reality

FDA Law Blog: Biosimilars

By Jeffrey N. Gibbs & Ana Loloei & Véronique Li, Senior Medical Device Regulation Expert — FDA has long touted the use of real-world evidence ( RWE ). Extolling RWE, FDA has said “RWE can be leveraged to bring new products to market, evaluate the safety and effectiveness of existing products for new uses, and assess the continued performance and safety of products once on the market.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Microneedle Patches Might Reverse a Form of Hair Loss

Drugs.com

MONDAY, May 13, 2024 -- Early research in mice suggests a new path forward to restoring hair growth in people affected by a form of alopecia. Alopecia areata is an autommune disorder that affects an estimated 6 million Americans and has no.

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New patent expiration for Azurity drug NYMALIZE

Drug Patent Watch

Annual Drug Patent Expirations for NYMALIZE Nymalize is a drug marketed by Azurity and is included in one NDA. It is available from one supplier.

Drugs 59
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Cancer & COVID Drove Him to Double-Lung Transplant

Drugs.com

MONDAY, May 13, 2024 -- Chicago resident Arthur “Art” Gillespie fell ill in early March 2020 with COVID, after he and his father went to visit an uncle in a nursing facility.“I was hospitalized for 12 days with a high fever and cough, and.

Nurses 130
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New patent for Amarin Pharms drug VASCEPA

Drug Patent Watch

Annual Drug Patent Expirations for VASCEPA Vascepa is a drug marketed by Amarin Pharms and is included in one NDA. It is available from two suppliers.

Drugs 59
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Bridging the Genetic Diagnosis Gap: Strategies for Expanding Access to Rare Disease Therapies

Fierce BioTech

Bridging the Genetic Diagnosis Gap: Strategies for Expanding Access to Rare Disease Therapies pesurya Mon, 05/13/2024 - 13:44 Tue, 06/18/2024 - 13:00 Resource Type Webinar Heather McLaughlin, PhD, FACMG, NYCoQ, CGMB Michelle Hearn, CGC Colleen Caleshu, CGC Jeff Haroldson, PharmD Duration 60 Minutes As targeted treatments for rare diseases rapidly emerge, genetic diagnosis plays a crucial role in enabling access to clinical trials and precision therapies with the ultimate benefit of enhancing pat