Drug Discovery Today
OCTOBER 15, 2024
Pioneer Group, the specialist life science infrastructure and venture-building company, welcomed 425 school children from 29 schools to eight of its sites across the UK last week to mark Ada Lovelace Day, an international celebration of the achievements of women in STEM.
Perficient: Drug Development
OCTOBER 15, 2024
This post is the third in a series of four about estimating project hours. Part 1: Sandbagging & Lowballing Part 2: Dependencies & Creep Part 3: Assumptions & Uncertainty Coming Soon: Part 4: The Emotional Conclusion In this third installment of my blog series on project estimates, let’s dive headfirst into the murky waters of assumptions and uncertainty!
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Drugs.com
OCTOBER 15, 2024
TUESDAY, Oct. 15, 2024 -- People sense millisecond shifts in odor as quickly as they might spot a change in color, new research shows.The study discounts the notion that smell is a "slower" sense than sight or hearing, scientists say. "A sniff of.
Drug Channels
OCTOBER 15, 2024
A new survey of plan sponsors sheds light on their satisfaction with transparency at large and small pharmacy benefit managers (PBMs). As you will see, clients remain slightly more satisfied with the perceived transparency of smaller PBMs compared with the Big Three PBMs—CVS Caremark, Express Scripts, and Optum Rx. However, plan sponsors are dissatisfied with transparency about how both large and small PBMs make money.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Drugs.com
OCTOBER 15, 2024
TUESDAY, Oct. 15, 2024 -- Some men might have damaged sperm that will increase the risk of pregnancy complications and health problems in newborns, a new study finds.DNA defects in sperm can double the risk of preeclampsia, a dangerous pregnancy.
Broad Institute
OCTOBER 15, 2024
#WhyIScience Q&A: A microbiologist and immunologist finds links between our own microbes and disease mechanisms By Ari Navetta October 15, 2024 Breadcrumb Home #WhyIScience Q&A: A microbiologist and immunologist finds links between our own microbes and disease mechanisms Eric Brown discusses finding purpose in the unpredictability of research and his personal connection to his work.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Science Daily: Pharmacology News
OCTOBER 15, 2024
Researchers produced 3D-printed, semiconductor-free logic gates, which perform computations in active electronic devices. As they don't require semiconductor materials, they represent a step toward 3D printing an entire active electronic device.
Drugs.com
OCTOBER 15, 2024
TUESDAY, Oct. 14, 2024 -- Gene therapy could help obese kids avoid health problems associated with excess weight, including arthritis, a new, preliminary study in mice suggests.The gene therapy prompts cells to convert inflammation-causing omega-6.
addgene Blog
OCTOBER 15, 2024
We’re very excited to announce that we are expanding our viral vector service to include a Packaged on Request option. Through this expansion, scientists will be able to request an AAV composed of an AAV plasmid in the Addgene repository and their choice of five different serotypes.
Drugs.com
OCTOBER 15, 2024
TUESDAY, Oct. 15, 2024 -- Half of people who develop blood poisoning, otherwise known as sepsis, are dead within a couple of years, a new study finds.A little more than 50% of patients admitted to an ER with sepsis died within two years, Danish.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Drug Patent Watch
OCTOBER 15, 2024
Have you ever found yourself scratching your head at the pharmacy counter, wondering why your “3-month supply” of medication doesn’t quite match up with the calendar? You’re not alone. Many people are puzzled by the discrepancy between a 92-day supply of pills and the actual number of days in a three-month period.
Drugs.com
OCTOBER 15, 2024
TUESDAY, Oct. 15, 2024 -- Pharmacists may continue making compounded versions of the weight-loss medication tirzepatide while the U.S. Food and Drug Administration revisits its Oct. 2 decision to remove the medicine from a national drug shortage.
Science Daily: Pharmacology News
OCTOBER 15, 2024
Experts have announced that the Sun has reached its solar maximum period, which could continue for the next year. Scientists will not be able to determine the exact peak of this solar maximum period for many months because it's only identifiable after they've tracked a consistent decline in solar activity after that peak. However, scientists have identified that the last two years on the Sun have been part of this active phase of the solar cycle, due to the consistently high number of sunspots d
Drugs.com
OCTOBER 15, 2024
TUESDAY, Oct. 15, 2024 -- As temperatures soar in some of America's hottest spots, death rates among local homeless people rise as well, new research shows.Data from 2015 through 2022 finds a big bump in deaths among unhoused people in Clark County.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Covalent Modifiers
OCTOBER 15, 2024
Xingyu Ma, Manyi Xu, Fengge Wang, Tingting Hu, Xinyuan Chena and Chong-Jing Zhang Chem. Commun. , 2024 DOI [link] Reversible covalent electrophiles with the advantages of both reversible and covalent interactions receive much attention in the fields of chemical biology and medicinal chemistry. Here, we report two electron-deficient olefins activated by amide and ester, amide-substituted acrylamide and methyl ester-substituted acrylamide, targeting thiols in a reversible covalent manner.
Science Daily: Pharmacology News
OCTOBER 15, 2024
A recent study found that good physical fitness from childhood to adolescence is linked to better mental health in adolescence. These results are significant and timely, as mental health problems are currently a major societal challenge, affecting up to 25%--30% of young people. These findings suggest that improving physical fitness from childhood can help prevent mental health problems.
Covalent Modifiers
OCTOBER 15, 2024
Sang Joon Won, Yuxiang Zhang, Christopher J. Reinhardt,Lauren M. Hargis, Nicole S. MacRae,Kristen E. DeMeester,Evert Njomen,Jarrett R. Remsberg,Bruno Melillo, Benjamin F. Cravatt, Michael A. Erb Molecular Cell, 2024 [link] Pioneer transcription factors (TFs) bind to and open closed chromatin, facilitating engagement by other regulatory factors involved in gene activation or repression.
Drugs.com
OCTOBER 15, 2024
TUESDAY, Oct. 15, 2024 -- It’s typically thought that medical school requires four years of study after graduating college.But doctors might be able to shave a year off their medical education and still do a great job treating patients, a new study.
Covalent Modifiers
OCTOBER 15, 2024
Weizhi Weng, Ping Zhang, and Zhengying Pan Journal of the American Chemical Society 2024 DOI: 10.1021/jacs.4c06459 Naturally, kinases exert their activities in a highly regulated fashion. A number of ingenious approaches have been developed to artificially control kinase activity by external stimuli, such as the incorporation of unnatural amino acids or the fusion of additional protein domains; however, methods that directly modulate endogenous kinases in native cells are lacking.
Drugs.com
OCTOBER 15, 2024
TUESDAY, Oct. 15, 2024 -- Women typically are urged to start receiving regular mammograms at age 40, but some might need to start even sooner, experts say.Specific risk factors that increase risk of early breast cancer might prompt young women to.
BioPharma Drive: Drug Pricing
OCTOBER 15, 2024
The pharma will work with Triana Biomedicines on molecular glue degraders. Elsewhere, Akeso raised $250 million and a MASH drug developer got a well-known board chair.
thought leadership
OCTOBER 15, 2024
Our Nordic region features world-class healthcare. Understanding the Nordic healthcare and market access landscape is crucial for successful pricing and reimbursement of your pharmaceutical product. After reading this, you will have a basic knowledge of the key steps to create a s uccessful pricing and reimbursement strategy for your product as you navigate the Nordic markets - Sweden, Norway, Denmark, Finland, and Iceland.
BioPharma Drive: Drug Pricing
OCTOBER 15, 2024
The amount surpassed the firm’s targets, allowing it to increase the size and number of company financings it plans to do in the future.
Quanticate
OCTOBER 15, 2024
As clinical trials grow in complexity, the volume of data collected and the need for advanced statistical techniques, such as Bayesian Analysis and Multiple Imputation (MI), continue to expand. These methods require substantial computational power, leading to increased processing times that can delay critical analysis and reporting stages. Such delays pose challenges in meeting tight project timelines, especially when multiple analyses or quality control (QC) tasks must be performed on large dat
KIF1A
OCTOBER 15, 2024
“We dream of being able to find in Italy the knowledge and trials that are available in the USA today. For this reason we decided to fund a KIF1A association also in Italy, in collaboration with other Italian parents.” A message from Ale’s family in Italy: Hi, I’m Ale and I’m six years old. I’m Italian and I live in Brescia (a middle-size town close to Milan) with my mom Benedetta, my dad Ennio, my older brother Davide and Flash, my little dog.
ACTO
OCTOBER 15, 2024
Improves HCP interactions by providing field professionals with instant access to approved clinical and product information TORONTO and NEW YORK, October 16, 2024 – ACTO, the only AI-powered Intelligent Field Excellence (IFE) platform purpose-built for the life sciences industry, today announced the availability of LAICA RepAssist , the first genAI knowledge assistant designed specifically for pharmaceutical field representatives.
Perficient: Drug Development
OCTOBER 15, 2024
Lets talk about data governance in banking and financial services, one area I have loved working in and in various areas of it … where data isn’t just data, numbers aren’t just numbers … They’re sacred artifacts that need to be protected, documented, and, of course, regulated within an inch of their lives. It’s not exactly the most glamorous part of financial services, but without solid data governance, banks would be floating in a sea of disorganized, chaotic
Fierce BioTech
OCTOBER 15, 2024
Is That Heart Attack Really an Adverse Event? The success of your highly complex clinical trial depends on accurate, reliable assessments of your endpoints. Learn how to accurately identify and attribute adverse events, eliminate conflicts of interest, and ensure the integrity of your studies. jpiatt Tue, 10/15/2024 - 13:52 Discover how independent adjudication can safeguard your clinical trials from misidentified adverse events and enhance the credibility of your results.
Perficient: Drug Development
OCTOBER 15, 2024
Problem Statement: Oracle Fusion Costing Distribution process will treat the Outside Processing (OSP) as ordinary items (Direct Material/Material). If you are procuring direct items to work orders or have an outside service provided in a sub-assembly as a work order step, Oracle Cost Management solution will cost the two “items” as Direct Material given the Cost Component Mappings.
Alta Sciences
OCTOBER 15, 2024
Up Close and Personal with Jason Boehme, Associate Director, Program Management nbartlett Tue, 10/15/2024 - 09:00 Jason Boehme joined Altasciences in 2018 as Senior Project Manager. He was promoted to Associate Director, Program Management , in 2022, and now oversees a team of program managers who guide end-to-end solutions, including preclinical , clinical , CDMO , regulatory , and bioanalytical solutions.
Advarra
OCTOBER 15, 2024
The International Council for Harmonisation (ICH) good clinical practice (GCP) guidelines are critical in ensuring the safety and rights of clinical trial participants. The guidelines also facilitated international harmonization of clinical research making it easier to conduct multi-national trials and bring new therapies to market more efficiently.
Covalent Modifiers
OCTOBER 15, 2024
Weizhi Weng, Ping Zhang, and Zhengying Pan Journal of the American Chemical Society 2024 DOI: 10.1021/jacs.4c06459 Naturally, kinases exert their activities in a highly regulated fashion. A number of ingenious approaches have been developed to artificially control kinase activity by external stimuli, such as the incorporation of unnatural amino acids or the fusion of additional protein domains; however, methods that directly modulate endogenous kinases in native cells are lacking.
Perficient: Drug Development
OCTOBER 15, 2024
Artificial intelligence (AI) has exploded onto the scene in most industries. And the healthcare field is no exception. Faced with growing workloads, shrinking margins and the ever-present “do more with less” mindset, many in healthcare are looking to generative AI as the next revolution in healthcare delivery, management and marketing. We’re bullish on the concept of generative AI.
BioPharma Drive: Drug Pricing
OCTOBER 15, 2024
Biosimilar competition is expected in early January for the company’s second highest-selling drug, putting greater focus on newer products' market trajectory.
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