Tue.Oct 15, 2024

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Good physical fitness from childhood protects mental health

Science Daily: Pharmacology News

A recent study found that good physical fitness from childhood to adolescence is linked to better mental health in adolescence. These results are significant and timely, as mental health problems are currently a major societal challenge, affecting up to 25%--30% of young people. These findings suggest that improving physical fitness from childhood can help prevent mental health problems.

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3 Years of Med School Might Be Enough to Produce Quality Doctors

Drugs.com

TUESDAY, Oct. 15, 2024 -- It’s typically thought that medical school requires four years of study after graduating college.But doctors might be able to shave a year off their medical education and still do a great job treating patients, a new study.

Doctors 246
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Major step toward fully 3D-printed active electronics

Science Daily: Pharmacology News

Researchers produced 3D-printed, semiconductor-free logic gates, which perform computations in active electronic devices. As they don't require semiconductor materials, they represent a step toward 3D printing an entire active electronic device.

Research 311
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Gene Therapy Might Tweak Fats, Help Prevent Arthritis in Overweight Kids

Drugs.com

TUESDAY, Oct. 14, 2024 -- Gene therapy could help obese kids avoid health problems associated with excess weight, including arthritis, a new, preliminary study in mice suggests.The gene therapy prompts cells to convert inflammation-causing omega-6.

Therapies 246
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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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NASA, NOAA: Sun reaches maximum phase in 11-year solar cycle

Science Daily: Pharmacology News

Experts have announced that the Sun has reached its solar maximum period, which could continue for the next year. Scientists will not be able to determine the exact peak of this solar maximum period for many months because it's only identifiable after they've tracked a consistent decline in solar activity after that peak. However, scientists have identified that the last two years on the Sun have been part of this active phase of the solar cycle, due to the consistently high number of sunspots d

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New electrophiles targeting thiols in a reversible covalent manner

Covalent Modifiers

Xingyu Ma, Manyi Xu, Fengge Wang, Tingting Hu, Xinyuan Chena and Chong-Jing Zhang Chem. Commun. , 2024 DOI [link] Reversible covalent electrophiles with the advantages of both reversible and covalent interactions receive much attention in the fields of chemical biology and medicinal chemistry. Here, we report two electron-deficient olefins activated by amide and ester, amide-substituted acrylamide and methyl ester-substituted acrylamide, targeting thiols in a reversible covalent manner.

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Homeless Americans' Death Rate Rises on Hot Days

Drugs.com

TUESDAY, Oct. 15, 2024 -- As temperatures soar in some of America's hottest spots, death rates among local homeless people rise as well, new research shows.Data from 2015 through 2022 finds a big bump in deaths among unhoused people in Clark County.

Research 246
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Forbion follows string of startup exits with $2.2B fundraise

BioPharma Drive: Drug Pricing

The amount surpassed the firm’s targets, allowing it to increase the size and number of company financings it plans to do in the future.

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Could Dad's Sperm Raise Odds for Common Complications of Pregnancy?

Drugs.com

TUESDAY, Oct. 15, 2024 -- Some men might have damaged sperm that will increase the risk of pregnancy complications and health problems in newborns, a new study finds.DNA defects in sperm can double the risk of preeclampsia, a dangerous pregnancy.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Redirecting the pioneering function of FOXA1 with covalent small molecules

Covalent Modifiers

Sang Joon Won, Yuxiang Zhang, Christopher J. Reinhardt,Lauren M. Hargis, Nicole S. MacRae,Kristen E. DeMeester,Evert Njomen,Jarrett R. Remsberg,Bruno Melillo, Benjamin F. Cravatt, Michael A. Erb Molecular Cell, 2024 [link] Pioneer transcription factors (TFs) bind to and open closed chromatin, facilitating engagement by other regulatory factors involved in gene activation or repression.

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Certain Women May Need Mammograms Before Age 40 -- An Expert Explains Why

Drugs.com

TUESDAY, Oct. 15, 2024 -- Women typically are urged to start receiving regular mammograms at age 40, but some might need to start even sooner, experts say.Specific risk factors that increase risk of early breast cancer might prompt young women to.

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Potent Inhibition and Rapid Photoactivation of Endogenous Bruton’s Tyrosine Kinase Activity in Native Cells via Opto-Covalent Modulators

Covalent Modifiers

Weizhi Weng, Ping Zhang, and Zhengying Pan Journal of the American Chemical Society 2024 DOI: 10.1021/jacs.4c06459 Naturally, kinases exert their activities in a highly regulated fashion. A number of ingenious approaches have been developed to artificially control kinase activity by external stimuli, such as the incorporation of unnatural amino acids or the fusion of additional protein domains; however, methods that directly modulate endogenous kinases in native cells are lacking.

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Parents or Ambulance: How a Child Reaches an ER Could Matter

Drugs.com

TUESDAY, Oct. 15, 2024 -- It’s natural for a parent to bundle an injured child into a car and rush their kid to the emergency room.But that decision could actually delay their child’s emergency care, a new study shows.Severely injured children bro.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Pfizer invests in molecular glue; Jazz, MeiraGTx shares rise on drug data

BioPharma Drive: Drug Pricing

The pharma will work with Triana Biomedicines on molecular glue degraders. Elsewhere, Akeso raised $250 million and a MASH drug developer got a well-known board chair.

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Half of Patients With Sepsis Die Within 2 Years, Hospital Study Finds

Drugs.com

TUESDAY, Oct. 15, 2024 -- Half of people who develop blood poisoning, otherwise known as sepsis, are dead within a couple of years, a new study finds.A little more than 50% of patients admitted to an ER with sepsis died within two years, Danish.

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Potent Inhibition and Rapid Photoactivation of Endogenous Bruton’s Tyrosine Kinase Activity in Native Cells via Opto-Covalent Modulators

Covalent Modifiers

Weizhi Weng, Ping Zhang, and Zhengying Pan Journal of the American Chemical Society 2024 DOI: 10.1021/jacs.4c06459 Naturally, kinases exert their activities in a highly regulated fashion. A number of ingenious approaches have been developed to artificially control kinase activity by external stimuli, such as the incorporation of unnatural amino acids or the fusion of additional protein domains; however, methods that directly modulate endogenous kinases in native cells are lacking.

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FDA Says Compounding Pharmacies Can Keep Making Weight-Loss Med Tirzepatide, for Now

Drugs.com

TUESDAY, Oct. 15, 2024 -- Pharmacists may continue making compounded versions of the weight-loss medication tirzepatide while the U.S. Food and Drug Administration revisits its Oct. 2 decision to remove the medicine from a national drug shortage.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Tremfya, Carvykti sales grow as J&J prepares for Stelara patent loss

BioPharma Drive: Drug Pricing

Biosimilar competition is expected in early January for the company’s second highest-selling drug, putting greater focus on newer products' market trajectory.

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#WhyIScience Q&A: A microbiologist and immunologist finds links between our own microbes and disease mechanisms

Broad Institute

#WhyIScience Q&A: A microbiologist and immunologist finds links between our own microbes and disease mechanisms By Ari Navetta October 15, 2024 Breadcrumb Home #WhyIScience Q&A: A microbiologist and immunologist finds links between our own microbes and disease mechanisms Eric Brown discusses finding purpose in the unpredictability of research and his personal connection to his work.

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Pioneer Group’s life sciences campuses host biggest Ada Lovelace Day event to date

Drug Discovery Today

Pioneer Group, the specialist life science infrastructure and venture-building company, welcomed 425 school children from 29 schools to eight of its sites across the UK last week to mark Ada Lovelace Day, an international celebration of the achievements of women in STEM.

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The 92-Day Pill Puzzle: Why Your 3-Month Supply Doesn’t Add Up

Drug Patent Watch

Have you ever found yourself scratching your head at the pharmacy counter, wondering why your “3-month supply” of medication doesn’t quite match up with the calendar? You’re not alone. Many people are puzzled by the discrepancy between a 92-day supply of pills and the actual number of days in a three-month period.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Addgene is Expanding Our Viral Vector Service!

addgene Blog

We’re very excited to announce that we are expanding our viral vector service to include a Packaged on Request option. Through this expansion, scientists will be able to request an AAV composed of an AAV plasmid in the Addgene repository and their choice of five different serotypes.

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Real-World Data Meets Clinical Trial Design: Optimizing Protocols and Site Selection

Fierce BioTech

| Now’s the time to rethink clinical trials with real-world data (RWD). Discover strategies to optimize your protocols and site selection.

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The Advantages of Parallel Processing Clinical Data in SAS/Connect

Quanticate

As clinical trials grow in complexity, the volume of data collected and the need for advanced statistical techniques, such as Bayesian Analysis and Multiple Imputation (MI), continue to expand. These methods require substantial computational power, leading to increased processing times that can delay critical analysis and reporting stages. Such delays pose challenges in meeting tight project timelines, especially when multiple analyses or quality control (QC) tasks must be performed on large dat

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If Plan Sponsors Are So Unhappy with Their PBMs’ Transparency, Why Won’t They Change the Model?

Drug Channels

A new survey of plan sponsors sheds light on their satisfaction with transparency at large and small pharmacy benefit managers (PBMs). As you will see, clients remain slightly more satisfied with the perceived transparency of smaller PBMs compared with the Big Three PBMs—CVS Caremark, Express Scripts, and Optum Rx. However, plan sponsors are dissatisfied with transparency about how both large and small PBMs make money.

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A Pharma Marketers' Roadmap to Data Privacy Compliance : Are You Ready for 2025?

Fierce BioTech

A Pharma Marketers' Roadmap to Data Privacy Compliance : Are You Ready for 2025? swheeler Tue, 10/15/2024 - 19:53 Thu, 11/21/2024 - 13:00 Resource Type Webinar Ben Chapman Duration 60 minutes Join for an insightful webinar on the evolving privacy landscape impacting pharma marketers in 2025. As state laws continue to shape advertising practices, understanding the nuances of compliance and data ethics is crucial.