Drug Discovery World

JANUARY 5, 2024

Kyverna Therapeutics has revealed plans to progress to Phase II trials of KYV-101 for multiple sclerosis (MS) following a green light from the US Food and Drug Administration (FDA). KYV-101 is an autologous, fully human CD19 chimeric antigen receptor (CAR) T-cell product candidate for use in B cell-driven autoimmune diseases. “This approval is a critically necessary step that paves the way to enrol patients with treatment-refractory progressive MS for whom there are no currently available

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Therapies Treatment Protein Expression Trials 313

Antidote

JANUARY 5, 2024

Though clinical trial patient recruitment is an integral part of the medical research process, it is often one of the most difficult aspects of conducting a study. There are various reasons for this challenge, and among them is the widespread existence of misconceptions about participating in research that many patients may see as a barrier to entry.

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Clinical Trials Trials Research 124

Drug Discovery World

JANUARY 5, 2024

Massachusetts Institute of Technology (MIT) researchers have used deep learning to identify a new class of antibiotic candidates that can kill methicillin-resistant Staphylococcus aureus (MRSA). The study represents more good news in the battle against antimicrobial resistance, as researchers from Harvard University and Roche also recently announced the discovery of a novel class of antibiotics.

Engineering 148

Engineering Government Science Pharmaceuticals 148

BioPharma Drive: Drug Pricing

JANUARY 5, 2024

The clearance is a major shift for the agency, which described its decision as a “first step” in allowing Florida to bulk purchase lower-cost Canadian medicines.

FDA 125

FDA Drugs 125

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

JANUARY 5, 2024

Techbio SimBioSys and the Mayo Clinic have entered into a strategic collaboration to develop novel digital precision medicine solutions for breast cancer. The aim of the collaboration is to develop cloud-based clinical software tools that will support the end-to-end decision-making process for early-stage breast cancer patients, including drug selection and risk stratification.

Treatment 148

Treatment Clinical Trials Trials Disease 148

Chemical Biology and Drug Design

JANUARY 5, 2024

Remimazolam suppressed NLRP3 activity to reduce inflammation level in model of bronchopneumonia by the inhibition of PDPK1 ubiquitination by interlinked PDPK1 protein, as a novel drug for inflammation in model of bronchopneumonia or other pulmonary disease. Abstract Bronchopneumonia is the most common pneumonia in childhood. Therefore, we tested the effects of Remimazolam presented Bronchopneumonia and its possible mechanisms.

Protein Expression 100

Protein Expression Disease Drugs Research 100

Chemical Biology and Drug Design

JANUARY 5, 2024

Thalidomide dwindled CRC cell migration and invasion. HOXB7 upregulation was detected in CRC cells, which promoted CRC cell migration, invasion, and β-catenin expression. Also, HOXB7 upregulation abrogated the effects of thalidomide on CRC cells. Collectively, thalidomide inhibits migration and invasion of CRC cells, which is achieved by suppressing HOXB7-mediated activation of Wnt/β-catenin signaling pathway.

Bioinformatics 100

Bioinformatics Cell Biology Treatment Research 100

Drug Discovery World

JANUARY 5, 2024

AbbVie and Umoja Biopharma have entered into two exclusive option and license agreements to develop multiple in-situ generated CAR-T cell therapy candidates in oncology. The first agreement provides AbbVie an exclusive option to license Umoja’s CD19 directed in-situ generated CAR-T cell therapy candidates. This includes UB-VV111, Umoja’s lead clinical programme for haematologic malignancies currently at the IND-enabling phase.

Therapies 130

Therapies Licensing Licensing Research 130

Chemical Biology and Drug Design

JANUARY 5, 2024

The mechanism schematic model by matrine/miR-495-3p/miR-543/PDK1/Wnt/β-catenin pathway in AML. Abstract Acute myeloid leukemia (AML) is a commonly hematological malignancy with feature of rapidly increased immature myeloid cells in bone marrow. The anti-tumor activity of matrine has been reported in various cancers. However, the functional role of matrine in AML progression still needs to be studied.

Regulations 100

Regulations Production Research 100

Drugs.com

JANUARY 5, 2024

FRIDAY, Jan. 5, 2024 -- The U.S. Food and Drug Administration on Friday gave the nod to a Florida plan to import drugs from Canada at much lower prices than in the United States.The approval could prove to be a major turning point for the United.

FDA 122

FDA Drugs 122

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

BioPharma Drive: Drug Pricing

JANUARY 5, 2024

Lykos Therapeutics, formerly known as MAPS Public Benefit Corp., recently submitted its MDMA capsules for FDA approval, following two positive studies.

FDA Approval 117

FDA Approval Therapies FDA 117

Drugs.com

JANUARY 5, 2024

FRIDAY, Jan. 5, 2024 -- Folks who take Ozempic or Wegovy for diabetes and weight loss need not worry about a higher risk of suicidal thoughts or feelings while on the medications, a new, large review finds.In the study, which was funded by the U.S.

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Science Daily: Pharmacology News

JANUARY 5, 2024

Animal ecologists developed an analytical approach to better understand one of the latest threats to feathered creatures: the rise of wind and solar energy facilities.

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Drugs.com

JANUARY 5, 2024

FRIDAY, Jan. 5, 2024 -- Drugs already used by millions to lower cholesterol might someday have a new role: Relieving asthma and COPD.That's the hope of a new line of research underway at the University of California, Davis. A study funded by the.

Research 105

Research Drugs 105

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drug Target Review

JANUARY 5, 2024

Scientists from the Centre for Genomic Regulation and the Wellcome Sanger Institute have found the allosteric control sites in the KRAS protein, the highly sought after targets for drug development. This study is the first complete control map for any protein. One of the most commonly mutated genes in many types of cancer is KRAS. Named the ‘Death Star’ protein because of its spherical shape and a lack of an ideal site to target with drugs, it has a higher prevalence in deadly cancer types like

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Regulations Pharmaceutical Companies DNA Treatment 98

Drugs.com

JANUARY 5, 2024

FRIDAY, Jan. 5, 2024 -- A salmonella outbreak that's already sickened 24 people is triggering the recall of charcuterie meats sent to Sam's Club distribution centers nationwide."On January 3, 2024, Fratelli Beretta USA Inc., recalled approximately.

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Science Daily: Pharmacology News

JANUARY 5, 2024

Creating a functional lung using interspecies chimeric animals is an attractive albeit challenging option for lung transplantation, requiring more research on the viable conditions needed for organ generation. A new study uses reverse-blastocyst complementation and tetraploid-based organ complementation methods to first determine these conditions in lung-deficient mice and then to generate rat-derived lungs in these mice.

Research 98

Research 98

Drugs.com

JANUARY 5, 2024

FRIDAY, Jan. 5, 2024 -- How much a person believes in the strength of a drug might influence how powerfully that drug influences brain activity, a new study has found.Smokers told to expect a low, medium or high dose of nicotine from an e-cigarette.

Drugs 98

Drugs 98

SCIENMAG: Medicine & Health

JANUARY 5, 2024

The pathogenic potential of inhaling the inert fibrous nanomaterials used in thermal insulation (such as asbestos or fibreglass) is actually connected not to their chemical composition, but instead to their geometrical characteristics and size.

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Drugs.com

JANUARY 5, 2024

FRIDAY, Jan. 5, 2024 -- Tejocote weight-loss supplements sold through online through Amazon or Etsy could contain a highly toxic substance, the U.S. Food and Drug Administration is warning.FDA tests revealed that capsules labeled as tejocote.

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FDA Drugs 98

SCIENMAG: Medicine & Health

JANUARY 5, 2024

When the body encounters bacteria, viruses or harmful substances, its innate immune cells, neutrophils, assemble at the site to combat the invader. Credit: UofL photo. When the body encounters bacteria, viruses or harmful substances, its innate immune cells, neutrophils, assemble at the site to combat the invader.

Virus 84

Virus Disease Research 84

Drugs.com

JANUARY 5, 2024

FRIDAY, Jan. 5, 2024 -- Migraines are not only extremely painful, but they also appear to pose a driving risk for seniors, a new study warns.Older adult drivers recently diagnosed with migraines are three times more likely to be involved in a car.

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SCIENMAG: Medicine & Health

JANUARY 5, 2024

A bit of weed before a workout can boost motivation and make exercise more enjoyable. But if performance is the goal, it may be best to skip that joint. Credit: Patrick Campbell/CU Boulder A bit of weed before a workout can boost motivation and make exercise more enjoyable.

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Drugs.com

JANUARY 5, 2024

FRIDAY, Jan. 5, 2024 -- Most people have heard of sudden infant death syndrome (SIDS), where babies die during sleep for reasons that aren't always clear.But every year, about 400 cases of similar "sudden unexplained deaths in children" (SUDC).

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Science Daily: Pharmacology News

JANUARY 5, 2024

Researchers have identified microstructures in fossil cells that are 1.75 billion years old. These structures, called thylakoid membranes, are the oldest ever discovered. They push back the fossil record of thylakoids by 1.2 billion years and provide new information on the evolution of cyanobacteria which played a crucial role in the accumulation of oxygen on the early Earth.

Research 85

Research 85

Drugs.com

JANUARY 5, 2024

FRIDAY, Jan. 5, 2024 -- A rare genetic mutation found in 1% of people of European descent appears to cut their odds for Parkinson's disease in half, a new study finds.A better understanding of how this bit of DNA works might lead to better.

Disease 97

Disease DNA 97

SCIENMAG: Medicine & Health

JANUARY 5, 2024

Researchers at the University of Michigan Health Rogel Cancer Center have identified a mechanism that causes severe gastrointestinal problems with immune-based cancer treatment. Credit: Michigan Medicine Researchers at the University of Michigan Health Rogel Cancer Center have identified a mechanism that causes severe gastrointestinal problems with immune-based cancer treatment.

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Research Treatment 73

Drugs.com

JANUARY 5, 2024

FRIDAY, Jan. 5, 2024 -- Teenagers who've packed on extra pounds have a significantly increased risk of developing kidney disease as a young adult, a new study finds.Obesity increased risk of later kidney disease as much as ninefold in boys and.

Disease 94

Disease 94

Science Daily: Pharmacology News

JANUARY 5, 2024

The largest analysis yet of African savannah elephant populations shows that conservationists have successfully protected elephants in southern Africa for the last 25 years. However, the pattern varies regionally, with some elephant populations soaring and others still facing large declines. The key to long-term stability appears to be connecting large core areas with neighboring buffer zones, as opposed to well-protected but isolated protected areas known as 'fortress conservation.

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Perficient: Drug Development

JANUARY 5, 2024

Software is at the core of the modern business model, making quality and performance top priorities to stay competitive. Organizations rely on continuous automation and testing (CAT) services to build business applications faster, with higher quality, and at scale to meet increasing market demands. Organizations looking to modernize testing capabilities with new technologies or fill skill gaps among internal teams seek external testing services providers for support.

Engineering 64

Engineering Government International Production 64

Drugs.com

JANUARY 5, 2024

FRIDAY, Jan. 5, 2024 -- Combining mindfulness with exercise could be the key to managing stress during a potentially turbulent 2024, a new review argues.

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Drug Target Review

JANUARY 5, 2024

Naegleria fowleri , a thermophilic free-living amoeba endemic to warm fresh water, is called ‘the brain-eating amoeba’ because it is the causative agent of primary amoebic meningoencephalitis (PAM). 1 Intranasal exposure to N. fowleri during recreational watersports is a recurring route to PAM infections ( eg , recent ‘splash-pad’ exposures causing paediatric PAM cases) 2.

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Small Molecule Drugs Biochemical Assays Regulations 59

Drug Patent Watch

JANUARY 5, 2024

Annual Drug Patent Expirations for BRYHALI Bryhali is a drug marketed by Bausch and is included in one NDA. It is available from one supplier. There are two patents protecting… The post New patent for Bausch drug BRYHALI appeared first on DrugPatentWatch - Make Better Decisions.

Drugs 59

Drugs Marketing 59

Common Sense for Drug Policy Blog

JANUARY 5, 2024

Growth in Reports of Xylazine in the US 2019-2022 "In 2019, relatively low rates of xylazine NFLIS [National Forensic Laboratory Information System] reports were observed; all states had a rate below 6 xylazine NFLIS reports per 100,000 residents, and 16 states had zero NFLIS xylazine reports ( Figure 1 ; eTable 4 in Supplement 1 ). In contrast, in 2022, only 2 states had zero xylazine NFLIS drug reports, and the highest rates of xylazine NFLIS reports (per 100,000 residents) were observed in Ne

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Laboratories Drugs 52