Antidote
JANUARY 5, 2024
Though clinical trial patient recruitment is an integral part of the medical research process, it is often one of the most difficult aspects of conducting a study. There are various reasons for this challenge, and among them is the widespread existence of misconceptions about participating in research that many patients may see as a barrier to entry.
Chemical Biology and Drug Design
JANUARY 5, 2024
Remimazolam suppressed NLRP3 activity to reduce inflammation level in model of bronchopneumonia by the inhibition of PDPK1 ubiquitination by interlinked PDPK1 protein, as a novel drug for inflammation in model of bronchopneumonia or other pulmonary disease. Abstract Bronchopneumonia is the most common pneumonia in childhood. Therefore, we tested the effects of Remimazolam presented Bronchopneumonia and its possible mechanisms.
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ASPET
JANUARY 5, 2024
The primary response of proliferating BPAEC (bovine pulmonary artery endothelial cells) after x-ray irradiation ({less than or equal to} 10 Gy) is shown to be transient cell-cycle arrest. Accompanying oxidant-linked functional changes within the mitochondria are readily measured, but not increased autophagy. Radiation-induced apoptosis is negligible in this line - important, because cells undergoing apoptosis release oxygen-derived species that can overwhelm/mask the radiation-associated species
Chemical Biology and Drug Design
JANUARY 5, 2024
Thalidomide dwindled CRC cell migration and invasion. HOXB7 upregulation was detected in CRC cells, which promoted CRC cell migration, invasion, and β-catenin expression. Also, HOXB7 upregulation abrogated the effects of thalidomide on CRC cells. Collectively, thalidomide inhibits migration and invasion of CRC cells, which is achieved by suppressing HOXB7-mediated activation of Wnt/β-catenin signaling pathway.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
ASPET
JANUARY 5, 2024
There do not appear to be any established therapeutics for treating azide poisoning at this time and presently available antidotes to cyanide poisoning are far from ideal, being particularly impractical for use if multiple victims present. The cobalt (II/III) complex of the Schiff-base ligand trans -[14]-diene (5,7,7,12,14,14-hexamethyl-1,4,8,11-tetraazacyclotetradeca-4,11-diene (or "CoN 4 [14]") first synthesized by Curtis(Curtis, 1968) for other purposes, is shown to act as an effective antido
Chemical Biology and Drug Design
JANUARY 5, 2024
The mechanism schematic model by matrine/miR-495-3p/miR-543/PDK1/Wnt/β-catenin pathway in AML. Abstract Acute myeloid leukemia (AML) is a commonly hematological malignancy with feature of rapidly increased immature myeloid cells in bone marrow. The anti-tumor activity of matrine has been reported in various cancers. However, the functional role of matrine in AML progression still needs to be studied.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
BioPharma Drive: Drug Pricing
JANUARY 5, 2024
Lykos Therapeutics, formerly known as MAPS Public Benefit Corp., recently submitted its MDMA capsules for FDA approval, following two positive studies.
Drugs.com
JANUARY 5, 2024
FRIDAY, Jan. 5, 2024 -- Folks who take Ozempic or Wegovy for diabetes and weight loss need not worry about a higher risk of suicidal thoughts or feelings while on the medications, a new, large review finds.In the study, which was funded by the U.S.
Science Daily: Pharmacology News
JANUARY 5, 2024
Animal ecologists developed an analytical approach to better understand one of the latest threats to feathered creatures: the rise of wind and solar energy facilities.
Drugs.com
JANUARY 5, 2024
FRIDAY, Jan. 5, 2024 -- Drugs already used by millions to lower cholesterol might someday have a new role: Relieving asthma and COPD.That's the hope of a new line of research underway at the University of California, Davis. A study funded by the.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Science Daily: Pharmacology News
JANUARY 5, 2024
Creating a functional lung using interspecies chimeric animals is an attractive albeit challenging option for lung transplantation, requiring more research on the viable conditions needed for organ generation. A new study uses reverse-blastocyst complementation and tetraploid-based organ complementation methods to first determine these conditions in lung-deficient mice and then to generate rat-derived lungs in these mice.
Drug Target Review
JANUARY 5, 2024
Scientists from the Centre for Genomic Regulation and the Wellcome Sanger Institute have found the allosteric control sites in the KRAS protein, the highly sought after targets for drug development. This study is the first complete control map for any protein. One of the most commonly mutated genes in many types of cancer is KRAS. Named the ‘Death Star’ protein because of its spherical shape and a lack of an ideal site to target with drugs, it has a higher prevalence in deadly cancer types like
Drugs.com
JANUARY 5, 2024
FRIDAY, Jan. 5, 2024 -- A salmonella outbreak that's already sickened 24 people is triggering the recall of charcuterie meats sent to Sam's Club distribution centers nationwide."On January 3, 2024, Fratelli Beretta USA Inc., recalled approximately.
SCIENMAG: Medicine & Health
JANUARY 5, 2024
The pathogenic potential of inhaling the inert fibrous nanomaterials used in thermal insulation (such as asbestos or fibreglass) is actually connected not to their chemical composition, but instead to their geometrical characteristics and size.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Drugs.com
JANUARY 5, 2024
FRIDAY, Jan. 5, 2024 -- How much a person believes in the strength of a drug might influence how powerfully that drug influences brain activity, a new study has found.Smokers told to expect a low, medium or high dose of nicotine from an e-cigarette.
SCIENMAG: Medicine & Health
JANUARY 5, 2024
When the body encounters bacteria, viruses or harmful substances, its innate immune cells, neutrophils, assemble at the site to combat the invader. Credit: UofL photo. When the body encounters bacteria, viruses or harmful substances, its innate immune cells, neutrophils, assemble at the site to combat the invader.
Drugs.com
JANUARY 5, 2024
FRIDAY, Jan. 5, 2024 -- Tejocote weight-loss supplements sold through online through Amazon or Etsy could contain a highly toxic substance, the U.S. Food and Drug Administration is warning.FDA tests revealed that capsules labeled as tejocote.
SCIENMAG: Medicine & Health
JANUARY 5, 2024
A bit of weed before a workout can boost motivation and make exercise more enjoyable. But if performance is the goal, it may be best to skip that joint. Credit: Patrick Campbell/CU Boulder A bit of weed before a workout can boost motivation and make exercise more enjoyable.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Drugs.com
JANUARY 5, 2024
FRIDAY, Jan. 5, 2024 -- Migraines are not only extremely painful, but they also appear to pose a driving risk for seniors, a new study warns.Older adult drivers recently diagnosed with migraines are three times more likely to be involved in a car.
Science Daily: Pharmacology News
JANUARY 5, 2024
Researchers have identified microstructures in fossil cells that are 1.75 billion years old. These structures, called thylakoid membranes, are the oldest ever discovered. They push back the fossil record of thylakoids by 1.2 billion years and provide new information on the evolution of cyanobacteria which played a crucial role in the accumulation of oxygen on the early Earth.
Drugs.com
JANUARY 5, 2024
FRIDAY, Jan. 5, 2024 -- Most people have heard of sudden infant death syndrome (SIDS), where babies die during sleep for reasons that aren't always clear.But every year, about 400 cases of similar "sudden unexplained deaths in children" (SUDC).
SCIENMAG: Medicine & Health
JANUARY 5, 2024
Researchers at the University of Michigan Health Rogel Cancer Center have identified a mechanism that causes severe gastrointestinal problems with immune-based cancer treatment. Credit: Michigan Medicine Researchers at the University of Michigan Health Rogel Cancer Center have identified a mechanism that causes severe gastrointestinal problems with immune-based cancer treatment.
Drugs.com
JANUARY 5, 2024
FRIDAY, Jan. 5, 2024 -- A rare genetic mutation found in 1% of people of European descent appears to cut their odds for Parkinson's disease in half, a new study finds.A better understanding of how this bit of DNA works might lead to better.
Science Daily: Pharmacology News
JANUARY 5, 2024
The largest analysis yet of African savannah elephant populations shows that conservationists have successfully protected elephants in southern Africa for the last 25 years. However, the pattern varies regionally, with some elephant populations soaring and others still facing large declines. The key to long-term stability appears to be connecting large core areas with neighboring buffer zones, as opposed to well-protected but isolated protected areas known as 'fortress conservation.
Drugs.com
JANUARY 5, 2024
FRIDAY, Jan. 5, 2024 -- Teenagers who've packed on extra pounds have a significantly increased risk of developing kidney disease as a young adult, a new study finds.Obesity increased risk of later kidney disease as much as ninefold in boys and.
Perficient: Drug Development
JANUARY 5, 2024
Software is at the core of the modern business model, making quality and performance top priorities to stay competitive. Organizations rely on continuous automation and testing (CAT) services to build business applications faster, with higher quality, and at scale to meet increasing market demands. Organizations looking to modernize testing capabilities with new technologies or fill skill gaps among internal teams seek external testing services providers for support.
Drugs.com
JANUARY 5, 2024
FRIDAY, Jan. 5, 2024 -- Combining mindfulness with exercise could be the key to managing stress during a potentially turbulent 2024, a new review argues.
Drug Patent Watch
JANUARY 5, 2024
This chart shows the drugs with the most patents in Cyprus. Patents must be filed in each country (or, in some cases regional patent office) where patent protection is desired.… The post Which pharmaceutical drugs have the most drug patents in Cyprus? appeared first on DrugPatentWatch - Make Better Decisions.
Common Sense for Drug Policy Blog
JANUARY 5, 2024
Growth in Reports of Xylazine in the US 2019-2022 "In 2019, relatively low rates of xylazine NFLIS [National Forensic Laboratory Information System] reports were observed; all states had a rate below 6 xylazine NFLIS reports per 100,000 residents, and 16 states had zero NFLIS xylazine reports ( Figure 1 ; eTable 4 in Supplement 1 ). In contrast, in 2022, only 2 states had zero xylazine NFLIS drug reports, and the highest rates of xylazine NFLIS reports (per 100,000 residents) were observed in Ne
Drug Patent Watch
JANUARY 5, 2024
Annual Drug Patent Expirations for BRYHALI Bryhali is a drug marketed by Bausch and is included in one NDA. It is available from one supplier. There are two patents protecting… The post New patent for Bausch drug BRYHALI appeared first on DrugPatentWatch - Make Better Decisions.
Common Sense for Drug Policy Blog
JANUARY 5, 2024
"Dry January," One-Month Alcohol Abstinence Campaigns and Harm Reduction "Each year, OMACs [One-Month Alcohol Abstinence Campaigns] attract an increasing number of participants. For example, even if it still represents less than one percent of the Australian adult population in 2019, 44,000 people officially registered for Dry July [ 28 ], while they were 16,787 in 2016 and 9,532 in 2010 [ 34 ].
Perficient: Drug Development
JANUARY 5, 2024
This series is my Next.js study resume, and despite it’s keen to a vanilla Next.js, all the features are applicable with Sitecore SDK. It is similar to the guide I recently wrote about GraphQL and aims to reduce the learning curve for those switching to it from other tech stacks. In part 1 we covered some fundamentals of Next.js – rendering strategies along with the nuances of getStaticProps, getStaticPaths, getServerSideProps as well as data fetching.
Common Sense for Drug Policy Blog
JANUARY 5, 2024
The Gig Economy, Nightwork, and Stimulant Use "Nightwork—meaning all jobs that are executed during nighttime—increased as cities became connected to electricity in the early twentieth century, and as economies became more connected globally through the internet. In the current 'gig economy' — dominated by those jobs in which people are paid by the task, rather than receiving a fixed salary — work never stops.
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