Chemical Biology and Drug Design

JANUARY 23, 2024

Emodin is a naturally occurring anthraquinone derivative with a variety of pharmacologic effects, but its role in colorectal cancer (CRC) has hardly been investigated. The current findings showed that emodin repressed the viability, migration, and invasion of CRC cells and suppressed EMT via inhibition of HCP5 expression. Abstract Emodin is a naturally occurring anthraquinone derivative with a variety of pharmacologic effects, but its role and regulatory mechanism in colorectal cancer (CRC) rema

RNA 100

RNA Regulations Research 100

ASPET

JANUARY 23, 2024

Most idiosyncratic drug reactions (IDRs) appear to be immune-mediated, but mechanistic events preceding severe reaction onset remain poorly defined. Damage-associated molecular patterns (DAMPs) may contribute to both innate and adaptive immune phases of IDRs, and changes in extracellular vesicle (EV) cargo have been detected post-exposure to several IDR-associated drugs.

Immune Response 100

Immune Response Bioinformatics Regulations Drugs 100

Chemical Biology and Drug Design

JANUARY 23, 2024

A novel series of chromone and acrylate-based PL inhibitors were designed with the analogue 9a , being potent of the series, exhibiting IC 50 of 3.32 ± 0.224 μM. Also, the fluorescence quenching and enzyme kinetics study proved the competitive nature of inhibition. Abstract By the optimization of previously established pancreatic lipase (PL) inhibitory lead, we have developed novel chromone-containing analogues with embedded acrylate fragment as potential PL inhibitors.

Treatment 100

Treatment Marketing Drugs Research 100

ASPET

JANUARY 23, 2024

Ischemia with non-obstructive coronary arteries (INOCA), caused by coronary artery spasm, has gained increasing attention owing to the poor quality of life of impacted patients. Therapeutic options to address INOCA remain limited, and developing new therapeutic agents is desirable. Herein, we examined whether soluble guanylate cyclase (sGC) activators could be beneficial in preventing coronary spasms.

Clinical Development 100

Clinical Development 100

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Chemical Biology and Drug Design

JANUARY 23, 2024

Human UCP classification and its tissue distribution. Abstract Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease associated with lipid deposition in liver cells and/or subsequent inflammation, excluding other known causes. NAFLD is a subset of metabolic syndrome that ranges from simple steatohepatitis (NASH), fibrosis to cirrhosis and hepatocellular carcinoma (HCC).

Production 100

Production Disease Regulations 100

ASPET

JANUARY 23, 2024

Patients with sickle cell disease (SCD) display priapism, a prolonged penile erection in the absence of sexual arousal. The current pharmacological treatments for SCD-associated priapism are limited and focused on acute interventions rather than prevention. Thus, there is an urgent need for new drug targets and preventive pharmacological therapies for this condition.

Disease 100

Disease Therapies Treatment Research 100

Drug Target Review

JANUARY 23, 2024

What innovative approaches and technologies are anticipated to reshape immuno-oncology treatments in 2024? Immuno-oncology, notably through checkpoint inhibitors, has significantly reshaped cancer treatment over the past decade. The current shift focuses on enhancing their efficacy by addressing the crucial need for robust T cell responses, an apparent bottleneck for broader impact.

Treatment 122

Treatment Immune Response Vaccine Therapies 122

Chemical Biology and Drug Design

JANUARY 23, 2024

Matrine inhibits the growth and metastasis of hepatocellular carcinoma by regulating the ELAVL1/RBM3-mediated Wnt/β-catenin signaling pathway. Abstract Matrine has been reported to exert anti-tumor effects in various cancers, including hepatocellular carcinoma (HCC). Nevertheless, the anti-tumor molecular mechanism of Martine in HCC is still not fully revealed.

Regulations 100

Regulations RNA Treatment Research 100

Drugs.com

JANUARY 23, 2024

TUESDAY, Jan. 23, 2024 -- If you or someone close to you suffers from severe allergic reactions, you have probably heard there are new recommendations out that offer guidance on the diagnosis, management and treatment of anaphylaxis.The latest.

Treatment 116

Treatment 116

Chemical Biology and Drug Design

JANUARY 23, 2024

Betulinic acid (BA) improved cardiac function, reduced myocardial injury, and attenuated inflammation in the cecal ligation and puncture (CLP) rats, indicating BA as a potential drug for sepsis-induced myocardial dysfunction. The mechanism may related to inhibit TLR4/MyD88/NF-κB signaling and promote M2 macrophage polarization in myocardial tissues.

Biochemical Assays 100

Biochemical Assays Protein Expression Drugs Research 100

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

BioPharma Drive: Drug Pricing

JANUARY 23, 2024

A black box warning for secondary T cell malignancies should be added to the labeling of all six approved CAR-T therapies, the agency said.

Therapies 122

Therapies FDA 122

Chemical Biology and Drug Design

JANUARY 23, 2024

Sodium 2-[(4-oxidobenzylidene)amino]-6H-1,3,4-thiadiazine-5-olate exhibited significant in vivo anticancer agent against Ehrlich ascites carcinoma via dual inhibition of PI3K and mTOR. It displayed an antioxidant effect by decreasing MDA levels and increasing TAC levels. Also, it induced apoptosis by upregulation of caspase-3 and p53. Molecular docking studies had also been performed.

Regulations 100

Regulations Treatment Therapies Research 100

Drugs.com

JANUARY 23, 2024

TUESDAY, Jan. 23, 2024 -- Ever wonder what your dog most likes to watch on TV?Think nature documentaries, Lassie or good old Scooby-Doo, a new study suggests.Dogs are most engaged when watching videos that feature other animals, according to a new.

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Perficient: Drug Development

JANUARY 23, 2024

DI or Dependency Injection is a complex topic, not just in Optimizely CMS, but in general in.net core implementations. Some aspects we get, like the different ways dependencies can be injected and which is better over others, while some leave us scratching our heads. Often times we end up doing a lot of troubleshooting, digging into internal code and finding the right alternatives to DI, to get things to work.

International 104

International Engineering 104

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Drugs.com

JANUARY 23, 2024

TUESDAY, Jan. 23, 2024 -- Flu and COVID are sweeping across the country, posing a particular hazard to people at risk for heart disease.These respiratory infections can trigger heart complications from fever, dehydration and inflammation, experts.

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Science Daily: Pharmacology News

JANUARY 23, 2024

Owls produce negligible noise while flying. While many studies have linked the micro-fringes in owl wings to their silent flight, the exact mechanisms have been unclear. Now, a team of researchers has uncovered the effects of these micro-fringes on the sound and aerodynamic performance of owl wings through computational fluid dynamic simulations. Their findings can inspire biomimetic designs for the development of low-noise fluid machinery.

Research 83

Research 83

Drugs.com

JANUARY 23, 2024

TUESDAY, Jan. 23, 2024 -- Two new strategies using deep brain stimulation can improve symptoms of Parkinson’s disease, Duke University researchers have found.Doctors can efficiently improve symptoms of Parkinson’s by simultaneously targeting to.

Treatment 105

Treatment Disease Research 105

addgene Blog

JANUARY 23, 2024

With renewed energy and optimism that comes at the start of every new year, it is a wonderful opportunity to once again reflect on our achievements in the last year and share the exciting things to come in the new year. I am proud of what we accomplished in 2023 and thrilled to be sharing our plans for 2024.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drugs.com

JANUARY 23, 2024

TUESDAY, Jan. 23, 2024 -- The health dangers posed by colorful detergent pods continues to plague young children, a new study warns.U.S. poison control centers still receive one call every 44 minutes about a young child who’s been harmed through.

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Science Daily: Pharmacology News

JANUARY 23, 2024

Researchers have achieved a major breakthrough in Redox Flow Desalination (RFD), an emerging electrochemical technique that can turn seawater into potable drinking water and also store affordable renewable energy.

Research 80

Research 80

Drugs.com

JANUARY 23, 2024

TUESDAY, Jan. 23, 2024 -- Black people are five times as likely as others to develop glaucoma and up to 15 times more likely to be blinded by the degenerative eye disease.Now, a new study reports that genetics appears to be at least one factor.

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SCIENMAG: Medicine & Health

JANUARY 23, 2024

Diabetes mellitus and sarcopenia pose a substantial challenge to public health, especially among the elderly. These conditions share common pathophysiological mechanism and are linked bidirectionally, with each contributing to an increased risk of the other.

Research 80

Research 80

Science Daily: Pharmacology News

JANUARY 23, 2024

A new camera system allows ecologists and filmmakers to produce videos that accurately replicate the colors that different animals see in natural settings.

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SCIENMAG: Medicine & Health

JANUARY 23, 2024

The ability to walk one kilometre comfortably can help predict fracture risk, according to researchers at the Garvan Institute of Medical Research.

Research 89

Research 89

Drug Patent Watch

JANUARY 23, 2024

This chart shows the pharmaceutical drugs with the greatest number of patents still in force. The number of patents covering a drug can be indicative of the value of a… The post Which pharmaceutical drugs have the most patents? appeared first on DrugPatentWatch - Make Better Decisions.

Pharmaceuticals 72

Pharmaceuticals Drugs 72

SCIENMAG: Medicine & Health

JANUARY 23, 2024

(LOS ANGELES) – January 23, 2024 – Vadim Jucaud, Ph.D., Assistant Professor at the Terasaki Institute for Biomedical Innovation, has been awarded a grant from the National Institutes of Health to develop a functional organ-on-a-chip to model allogeneic transplant rejection.

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Chemical Biology and Drug Design

JANUARY 23, 2024

Cover Image © molekuul_be/Shutterstock.

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SCIENMAG: Medicine & Health

JANUARY 23, 2024

Each year, at least 1.7 million adults in the United States develop sepsis, and approximately 350,000 will die from the serious blood infection that can trigger a life-threatening chain reaction throughout the entire body. Credit: UC San Diego Health Each year, at least 1.

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BioPharma Drive: Drug Pricing

JANUARY 23, 2024

The acquisition will give Sanofi an experimental drug for alpha-1 antitrypsin deficiency, while the rest of Inhibrx's assets will be spun out into a new company.

Drugs 67

Drugs 67

SCIENMAG: Medicine & Health

JANUARY 23, 2024

Metabolic dysfunction- associated steatohepatitis, or MASH, is an inflammatory, liver-scarring disease that has reached epidemic proportions, with an estimated 1.5% to 6.5% of U.S. adults afflicted by the condition, and roughly 24% of adults having nonalcoholic fatty liver disease (NAFLD).

Disease 77

Disease Treatment 77

Science Daily: Pharmacology News

JANUARY 23, 2024

New research conducted by nuclear physicists is using a method that connects theories of gravitation to interactions among the smallest particles of matter. The result is insight into the strong force, a powerful mediator of particle interactions in the subatomic realm. The research has revealed, for the first time, a snapshot of the distribution of the shear strength of the strong force inside the proton -- or how strong an effort must be to overcome the strong force to move an object it holds

Research 64

Research 64

SCIENMAG: Medicine & Health

JANUARY 23, 2024

A new study finds that very few patients diagnosed with type 2 diabetes are able to achieve normal blood glucose levels through weight loss alone. A team led by Andrea Luk of the Chinese University of Hong Kong, report these findings January 23rd in the open access journal PLOS Medicine.

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BioPharma Drive: Drug Pricing

JANUARY 23, 2024

J&J and Bristol Myers joined the latest funding round for the startup, which was led by the newly launched Mirae Asset Capital Life Science.

RNA 67

RNA Science Drugs 67