Sun.Aug 20, 2023

article thumbnail

N?methylpiperazinyl and piperdinylalkyl?O?chalcone derivatives as potential polyfunctional agents against Alzheimer's disease: Design, synthesis and biological evaluation

Chemical Biology and Drug Design

3D & 2D poses of chalcone analogues interacted with AChE enzyme. Abstract The series of N -methylpiperazinyl and piperdinylalkyl- O -chalcone derivatives as potential polyfuctional agents against Alzheimer's disease that have been designed, synthesized and then evaluated biologically using in vitro assays for the inhibition of acetylcholinesterase (AChE) activity, AGEs, and free radical formation.

Disease 100
article thumbnail

Is Your Child Lagging in Reading Skills? An Expert Offers Tips

Drugs.com

SUNDAY, Aug. 20, 2023 -- Helping a child who struggles with reading can be a rewarding experience. A nationally known expert offers some tips for parents who are trying to help their child work through these difficulties. Patricia Edwards, professor.

98
Insiders

Sign Up for our Newsletter

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

article thumbnail

Exploring calcium channel blocker as a candidate drug for Pseudomonas aeruginosa through network pharmacology and experimental validation

Chemical Biology and Drug Design

Calcium channel blocker (CCB) is known to possess antibacterial effects. We aimed to apply network pharmacology (docking and protein–protein interaction [PPI] analyses) to predict the potential targets and mechanisms of CCB against Pseudomonas aeruginosa as well as to verify the effect of these drugs. Abstract Calcium channel blocker (CCB) is known to possess antibacterial effects.

Drugs 100
article thumbnail

Long-term study reaffirms benefits of COVID-19 vaccination for organ transplant recipients

SCIENMAG: Medicine & Health

FOR IMMEDIATE RELEASE Credit: Both the photomicrograph and model are courtesy of the National Institute of Allergy and Infectious Diseases, National Institutes of Health FOR IMMEDIATE RELEASE Findings from a two-year study of nearly 2,400 solid organ transplant recipients, conducted by the Johns Hopkins Transplant Research Center (TRC) in collaboration with the New York University […]

Vaccine 87
article thumbnail

How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

article thumbnail

Curcumin inhibits malignant behavior of colorectal cancer cells by regulating M2 polarization of tumor?associated macrophages and metastasis associated in colon cancer 1 (MACC1) expression

Chemical Biology and Drug Design

This study reveals the curcumin exerts antiproliferative and anti-migration effects on colorectal cancer cell lines using MACC1 as a target and inhibiting the M2 polarization of TAMs. Curcumin is a promising compound for the treatment of colorectal cancer or a complement of current standard therapy modalities. Abstract The present study was to investigate the underlying mechanism of the antitumor effect of curcumin in colorectal cancer cells, focusing on the M2 polarization of tumor-associated m

article thumbnail

Scientists elaborated the design and application prospect of China’s Tiangong space station

SCIENMAG: Medicine & Health

As a manned spacecraft operating in orbit for a long time, a space station embodies a country’s scientific and technological strength comprehensively. China’s manned space project was approved in 1992 with a 3-step strategic plan, and building a space station is the final goal of this plan.

Science 85

More Trending

article thumbnail

Overuse of social media and devices top parent concerns as kids head back to school

SCIENMAG: Medicine & Health

ANN ARBOR, Mich. – As children head back to school, two issues have climbed higher on their parents’ list of concerns: the role of social media and the internet in kids’ lives. Credit: University of Michigan Health C.S. Mott Children’s Hospital National Poll on Children’s Health. ANN ARBOR, Mich.

article thumbnail

Testing with Burp Suite’s Repeater

Perficient: Drug Development

Burp Suite is a comprehensive toolkit for web application testing and one of its most powerful features is the Repeater. The Repeater is an interactive tool that allows you to manually modify and replay HTTP requests to a web application. It’s an essential feature for testing and debugging web applications and can help you identify potential vulnerabilities.

52
article thumbnail

Citizen scientists reveal how the common wasp spreads across UK

SCIENMAG: Medicine & Health

The Big Wasp Survey, a citizen science project involving thousands of volunteers throughout the UK, has yielded important genetic insights into the common wasp, reports a study led by UCL researchers.

Science 80
article thumbnail

Sitecore Send Full Overview

Perficient: Drug Development

This post is an overview of a composable Sitecore Send offering – an email marketing automation solution with no code campaign automation. Sitecore Send is an intelligent marketing automation platform with thousands of global customers that offers personalized customer experiences through email campaigns, workflows, and web personalization. It aims to be a global leader in the market automation space, with accolades for usability and customer satisfaction.

article thumbnail

Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

article thumbnail

Plans for UK’s first menopause education programme launched by UCL academics

SCIENMAG: Medicine & Health

Experts at UCL have teamed up with leading women’s health charities to design a new education and support programme for women across the country experiencing menopause.

80
article thumbnail

Psychological and Psychiatric Disabilities: Assistive Technologies and Adaptive Strategies Part 8

Perficient: Drug Development

In a world that is becoming increasingly aware of the diverse needs of individuals, it’s important to shed light on an often-overlooked aspect of disabilities – psychological and psychiatric disabilities. These conditions, ranging from anxiety and depression to bipolar disorder and schizophrenia, can significantly impact an individual’s life.

article thumbnail

COVID-19 vaccines are effective against severe cases in children

SCIENMAG: Medicine & Health

Research at a Glance: A Murdoch Children’s Research Institute-led review has found COVID-19 vaccines are effective against severe cases of the disease in children and adolescents.

Vaccine 75
article thumbnail

Navigating the Visual World: Exploring Current Assistive Technologies for Visual Disabilities

Perficient: Drug Development

Living with visual disabilities presents unique challenges that can significantly impact an individual’s daily life. However, with the rapid advancements in technology, a multitude of innovative solutions have emerged to enhance accessibility and independence for those with visual impairments. In this article, we’ll take a closer look at the range of assistive technologies that are currently being employed to empower individuals with visual disabilities.

article thumbnail

Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

article thumbnail

Recreational nitrous oxide use is no laughing matter

SCIENMAG: Medicine & Health

Nitrous oxide is a popular recreational drug, especially among young people, that can cause serious and sometimes permanent neurological defects.

Drugs 72
article thumbnail

Which pharmaceutical companies have the most drug patents in Eurasian Patent Organization?

Drug Patent Watch

This chart shows the pharmaceutical companies with the most patents in Eurasian Patent Organization. Patents must be filed in each country (or, in some cases regional patent office) where patent… The post Which pharmaceutical companies have the most drug patents in Eurasian Patent Organization? appeared first on DrugPatentWatch - Make Better Decisions.

article thumbnail

Testing with Burp Suite’s Intruder

Perficient: Drug Development

Burp Suite is a popular tool for web application testing, and one of its most powerful features is the Intruder. The Intruder allows you to perform automated tests on a target, such as brute-forcing or parameter fuzzing. In this blog, we’ll take a closer look at Intruder in Burp Suite and explore some best practices for using this tool effectively.

52
article thumbnail

Time is right to develop a consensus Human Skin Cell Atlas, according to leading dermatology experts

SCIENMAG: Medicine & Health

Philadelphia, August 21, 2023 – As a single organ, our skin is able to perform a broad repertoire of vital functions. Dermatology experts call for a reference guide to single-cell composition of normal human skin, which is still lacking.

83