N?methylpiperazinyl and piperdinylalkyl?O?chalcone derivatives as potential polyfunctional agents against Alzheimer's disease: Design, synthesis and biological evaluation
Chemical Biology and Drug Design
AUGUST 20, 2023
3D & 2D poses of chalcone analogues interacted with AChE enzyme. Abstract The series of N -methylpiperazinyl and piperdinylalkyl- O -chalcone derivatives as potential polyfuctional agents against Alzheimer's disease that have been designed, synthesized and then evaluated biologically using in vitro assays for the inhibition of acetylcholinesterase (AChE) activity, AGEs, and free radical formation.
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