Drug Discovery World

MAY 30, 2024

A new research paper has validated the mechanism of action of the Atrogi’s first-in-class, small molecule, ATR-127, in combating obesity and metabolic complications. Unlike existing anti-obesity therapies that compromise lean muscle mass, ATR-127 induces significant weight loss while preserving crucial lean body mass. ATR-127 binds to both the beta-2 and beta-3 adrenergic receptors in a unique manner, allowing for precise modulation of downstream signalling cascades.

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Drug Discovery Today

MAY 30, 2024

London, 25/04/2024: The lab industry’s largest annual trade show is returning to the NEC, Birmingham, on October 30 and 31, 2024, to showcase sustainability and the latest innovations from the lab industry. The highly anticipated event will see thousands of attendees from across the lab sector descend on the NEC to meet with over 200 of the industry’s leading companies and enjoy the show’s world-leading conference programme, hosted across four free-to-attend theatres.

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Drug Discovery World

MAY 30, 2024

DDW Editor Reece Armstrong speaks to Dr Katrina Pollock from the Oxford Vaccine Group at the University of Oxford. Dr Pollock is the Chief Investigator of the LEGACY03 clinical trial, a study aiming to investigate lymph nodes and vaccination responses across age groups. RA: Could you tell us about the LEGACY03 trial? KP: The LEGACY03 study aims to understand how we respond to vaccines and how this changes as we age.

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Science Daily: Pharmacology News

MAY 30, 2024

When we're told 'This coffee is hot' upon being served a familiar caffeinated beverage at our local diner or cafe, the message is clear. But what about when we're told 'This coffee is not hot'? Does that mean we think it's cold? Or room temperature? Or just warm? A team of scientists has now identified how our brains work to process phrases that include negation (i.e., 'not'), revealing that it mitigates rather than inverts meaning -- in other words, in our minds, negation merely reduces the tem

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

MAY 30, 2024

In this free webinar , hosted by DDW and sponsored by Benchling, you will learn about technology through the lens of artificial intelligence (AI), machine learning and lab automation. It will take place on 11 June from 3:00 PM – 4:00 PM BST. You will hear from Jonathan Wingfield, Principal Scientist at AstraZeneca; Abraham Heifets, CEO at Atomwise; Raminderpal Singh, AI Expert at HitchhikersAI; and a joint presentation from Helen Liu-Mayo, Product Manager, Machine Learning at Benchling, an

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Antidote

MAY 30, 2024

One may choose to participate in a clinical trial for many reasons. Volunteering often has multiple benefits, from advancing medical research to gaining access to cutting-edge medical care. However, deciding to enroll in a clinical trial is only one part of the process.

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Clinical Trials Trials Research 119

Science Daily: Pharmacology News

MAY 30, 2024

Fossils found on the shoreline of Lake Kariba in Zimbabwe represent a completely new dinosaur species. This remarkable find, named Musankwa sanyatiensis, marks only the fourth dinosaur species named from Zimbabwe.

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Drug Discovery World

MAY 30, 2024

Join DDW and Thermo Fisher Scientific on 20 June, 11AM EDT/4PM BST, for an exclusive webinar, ‘ Advancing biotherapy manufacturing: innovative strategies for residual DNA and viral titre quantitation using dPCR ’. This free event will feature insight from Thermo Fisher Scientific’s Jonas Buege, Senior Manager, Product Management, as well as Viki Mahen, Scientist III, Molecular Biology.

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DNA Molecular Biology Compliance Production 130

Science Daily: Pharmacology News

MAY 30, 2024

Reaserchers have created a prototype for what they call 'living bioelectronics': a combination of living cells, gel, and electronics that can integrate with living tissue. Tests in mice found that the devices could continuously monitor and improve psoriasis-like symptoms, without irritating skin.

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Perficient: Drug Development

MAY 30, 2024

Quality innovation is not for the weak at heart! Innovation myths may have you thinking it is for the lucky or the extremely talented – that’s not true. Pablo Picasso said, “Inspiration exists, but it has to find you working.” Thomas Edison quipped, “Opportunity is missed by most people because it is dressed in overalls and looks like work.” In this blog post, I want to focus on a different quote with the same intent.

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Production 116

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Science Daily: Pharmacology News

MAY 30, 2024

Over the last two years, scientists have used NASA's James Webb Space Telescope to explore what astronomers refer to as Cosmic Dawn -- the period in the first few hundred million years after the big bang where the first galaxies were born.

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Drugs.com

MAY 30, 2024

THURSDAY, May 30, 2024 -- Newer epilepsy drugs taken while pregnant won’t affect the creative thinking of children, an effect that had been observed in older medications, a new study reports.Researchers found no difference in creativity scores at a.

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Drugs 105

Science Daily: Pharmacology News

MAY 30, 2024

Humans may be accelerating the rate at which organic matter decomposes in rivers and streams on a global scale, according to a new study. That could pose a threat to biodiversity in waterways around the world and increase the amount of carbon in Earth's atmosphere, potentially exacerbating climate change. The study is the first to combine a global experiment and predictive modeling to illustrate how human impacts to waterways may contribute to the global climate crisis.

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Drugs.com

MAY 30, 2024

THURSDAY, May 30, 2024 -- Cancer patients receive less effective treatment at hospitals that mainly serve minority communities, a new study shows.More than 9% of cancer patients are treated at hospitals where a significant percentage of patients.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Science Daily: Pharmacology News

MAY 30, 2024

New research sheds light on how individual neurons in the hippocampus of rats stabilize and tune spatial representations during periods of rest following the animals' first time running a maze, offering first proof of neuroplasticity during sleep.

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Research 109

Drugs.com

MAY 30, 2024

THURSDAY, May 30, 2024 -- The old joke holds that fatherhood causes a man’s hair to go prematurely gray.Whether or not that’s true, being a father does appear to put men at greater risk of poor heart health later in life, a new study finds.Dads ten.

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Science Daily: Pharmacology News

MAY 30, 2024

Scientists studying ultra-processed foods have created a new tool for assessing the rewarding and reinforcing properties of foods that make up 58 percent of calories consumed in the United States. The foods have been linked to a wide range of negative health outcomes.

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Drugs.com

MAY 30, 2024

THURSDAY, May 30, 2024 -- Folks typically think of heart disease as a byproduct of modern fast-food living, but a new study shows the condition has plagued humanity for centuries.More than a third (37%) of 237 adult mummies from seven different.

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Disease 97

Science Daily: Pharmacology News

MAY 30, 2024

A great armada entered the North Atlantic, launched from the cold shores of North America. But rather than ships off to war, this force was a fleet of icebergs. And the havoc it wrought was to the ocean current itself. The future of the Atlantic circulation will be determined by a tug-o-war between Greenland's decreasing ice flux and its increasing freshwater runoff.

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Drugs.com

MAY 30, 2024

THURSDAY, May 30, 2024 -- Amid an ongoing outbreak of bird flu in dairy cows, there's been a third case of H5N1 avian flu confirmed in a dairy worker, U.S. health officials reported Thursday. The previous two human cases -- the first in Texas, the.

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Science Daily: Pharmacology News

MAY 30, 2024

Scientists have found that statins -- commonly used cholesterol-lowering drugs -- may block a pathway that leads to the development of cancer in the context of chronic inflammation.

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Therapies Drugs 100

Drugs.com

MAY 30, 2024

THURSDAY, May 30, 2024 -- America's college students seem to be more stressed than ever, with a new report finding a sharp rise in cases of post-traumatic stress disorder (PTSD) and acute stress disorder (ASD) on campuses across the country.In a.

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Drug Patent Watch

MAY 30, 2024

Annual Drug Patent Expirations for KORLYM Korlym is a drug marketed by Corcept Therap and is included in one NDA. It is available from one supplier.

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Drugs.com

MAY 30, 2024

THURSDAY, May 30, 2024 -- Stuttering is a neurological condition, not a psychological one, and scientists in Finland now believe they've found the disrupted network in the brain that may cause it."These findings explain well-known features of.

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Science Daily: Pharmacology News

MAY 30, 2024

A whaler's forgotten aerial photos from 1937 have given researchers the most detailed picture of the ice evolution in East Antarctica to date. The results show that the ice has remained stable and even grown slightly over almost a century, though scientists observe early signs of weakening. The research offers new insights that enhance predictions of ice changes and sea level rise.

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Perficient: Drug Development

MAY 30, 2024

Health insurers from every corner of the country are set to assemble in Las Vegas for the 2024 AHIP conference —and here at Perficient, we’re excited to have two of our colleagues attending as well. At AHIP 2024, thought leaders will address some of the industry’s most pressing questions, and the conference will feature educational sessions, Q&As, and networking opportunities.

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addgene Blog

MAY 30, 2024

If you’re depositing a pooled library with Addgene, you may be surprised to learn that we ask for an amplification protocol with your deposit. This is because repeated amplifications of pooled libraries can lead to issues such as recombination and loss of plasmid diversity, so Addgene strives to distribute aliquots of the original library whenever possible.

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Science Daily: Pharmacology News

MAY 30, 2024

This fossil looks like a lumpy, rounded rock with a couple of exposed teeth that are a little worse for wear, having been submerged and tumbled along the floor of the Gulf of Mexico for thousands of years before washing up on a beach. But when it was X-rayed a doctoral student saw there was more to the fossil that met the eye: a hidden canine tooth that had not yet erupted from the jaw bone.

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BioPharma Drive: Drug Pricing

MAY 30, 2024

The $73 million round for CinRx Pharma, which created a startup AstraZeneca bought last year, will help fund subsidiaries making drugs for obesity, irritable bowel syndrome and gastroparesis.

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Science Daily: Pharmacology News

MAY 30, 2024

Combining a new imaging instrument with the powerful adaptive optics capabilities of the Large Binocular Telescope, astronomers have captured a volcanic event on Jupiter's moon Io at a resolution never before achieved with Earth-based observations.

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BioPharma Drive: Drug Pricing

MAY 30, 2024

The company is prioritizing development of an earlier so-called FcRn inhibitor, a type of medicine that’s shown promise treating multiple inflammatory conditions.

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Drugs 73

Science Daily: Pharmacology News

MAY 30, 2024

New research demonstrated a possible formation mechanism of intermediate-mass black holes in globular clusters, star clusters that could contain tens of thousands or even millions of tightly packed stars. The first ever star-by-star massive cluster-formation simulations revealed that sufficiently dense molecular clouds, the 'birthing nests' of star clusters, can give birth to very massive stars that evolve into intermediate-mass black holes.

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Drugs.com

MAY 30, 2024

THURSDAY, May 30, 2024 -- California skateboarder Jared Hager has become the first person to receive a transparent skull replacement, which allows doctors to better view the function of his brain. The window has allowed doctors to both monitor his.

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BioPharma Drive: Drug Pricing

MAY 30, 2024

With “no playbook out there” to fall back on, the new company is taking a long-term approach as it develops its portfolio, an Otsuka Precision Health exec told MedTech Dive.

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