Tue.Jan 14, 2025

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Gene editing extends lifespan in mouse model of prion disease

Broad Institute

Gene editing extends lifespan in mouse model of prion disease By Allessandra DiCorato January 14, 2025 Breadcrumb Home Gene editing extends lifespan in mouse model of prion disease A single-letter edit in DNA reduces levels of the disease-causing prion protein in the brain and could lead to a preventative, one-time treatment for the deadly neurodegenerative disorder.

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Scientific workflow for hypothesis testing in drug discovery: Part 2 of 3

Drug Target Review

Drug discovery scientists spend their days developing and testing complex hypotheses, leveraging data and expertise through workflows that utilise available tools. Operating a workflow, such as the one described in Figure 1, involves several key considerations that affect both the accuracy of results and the efficiency of the research process. Defining the research question A well-defined research question is the cornerstone of an effective scientific workflow in drug discovery.

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This metaphorical cat is both dead and alive -- and it will help quantum engineers detect computing errors

Science Daily: Pharmacology News

Engineers have demonstrated a well-known quantum thought experiment in the real world. Their findings deliver a new and more robust way to perform quantum computations and they have important implications for error correction, one of the biggest obstacles standing between them and a working quantum computer.

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5 questions facing emerging biotech in 2025

BioPharma Drive: Drug Pricing

Young drugmakers confront several harsh realities this year, among them a contracting sector and competition from China.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Updated Guidelines for Preventing Osteoporosis-Related Fractures Released

Drugs.com

TUESDAY, Jan. 14, 2025 -- All women 65 and older should continue to be screened for osteoporosis, the nation’s leading preventive health panel says in an updated recommendation. The U.S. Preventive Services Task Force also recommends.

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Lilly blames slower-than-expected growth for 2024 sales miss

BioPharma Drive: Drug Pricing

The company said it overestimated demand of its obesity and diabetes drugs in the fourth quarter, but projected a further ramp-up in sales this year.

Drugs 65

More Trending

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JPM25: Amgen’s defense, Merck’s patent ‘hill’ and Viking’s long-term planning

BioPharma Drive: Drug Pricing

Executives at Amgen made the case for MariTide's differentiation, while Merck's CEO contended that Keytruda's coming loss of exclusivity can be managed.

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Bird Flu Kills 20 Million Chickens in U.S., Driving Egg Prices Sky-High

Drugs.com

TUESDAY, Jan. 14, 2025 -- A deadly bird flu outbreak has wreaked havoc on U.S. chicken farms, claiming the lives of over 20 million egg-laying chickens last quarter, marking the worst impact on America's egg supply since the outbreak began in.

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Regenxbio licenses gene therapies to Japan’s Nippon Shinyaku

BioPharma Drive: Drug Pricing

Nippon Shinyaku will pay Regenxbio $110 million upfront for U.S. and Asia rights to treatments for Hunter and Hurler syndromes.

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Drug Patent Expirations for the Week of January 12, 2025

Drug Patent Watch

UZEDY (risperidone) Teva Patent: 10,736,965 Expiration: Jan 12, 2025 See More … For more information on how DrugPatentWatch can help with your pharmaceutical business intelligence needs, contact admin@DrugPatentWatch.com or visit www.DrugPatentWatch.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Sleep Deprivation Lets Intrusive Memories, Bad Thoughts Into the Mind

Drugs.com

TUESDAY, Jan. 14, 2025 -- People with post-traumatic stress disorder (PTSD) are plagued by unwanted and distressing memories over which they have little to no control.Doctors now think they understand why PTSD patients and others arent able to k.

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Mastering Database.SaveResult in Batch Class: A Beginner-Friendly Guide

Perficient: Drug Development

Imagine youre a skilled craftsman working in a massive warehouse. Every day, your task is to process thousands of unique items and ensure that each one is properly logged and stored. But lets face it mistakes happen. Sometimes an item gets mislabeled or damaged, and you need to know which ones to fix, and which ones made it safely through. In Salesforce, when working with a batch class that processes thousands or even millions of records, Database.SaveResult acts as your trusty supervisor, keep

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Diabetes Drug Protects Against Skin Cancer, New Research Says

Drugs.com

TUESDAY, Jan. 14, 2025 -- A popular diabetes drug can provide protection against skin cancers, a new study says.Metformin significantly reduces peoples risk of developing basal cell cancers or squamous cell cancers, the two most common skin c.

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Pharmaceutical Negotiations Decoded: Lessons from the Trenches

Drug Patent Watch

In the fast-paced world of pharmaceuticals, negotiations play a pivotal role in shaping the industry’s landscape. From mergers and acquisitions to licensing agreements and pricing discussions, these complex interactions demand a unique blend of scientific knowledge, business acumen, and interpersonal skills. Let’s dive into the intricacies of pharmaceutical negotiations, exploring valuable lessons, current trends, and strategies for success.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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It May Be Easier to Quit Smoking With Holistic or Integrated Health Approach

Drugs.com

TUESDAY, Jan. 14, 2025 -- It takes a village to help a smoker quit. And a new study published recently in JAMA Internal Medicine shows that smokers had a nearly doubled success rate quitting when supported by an integrated approach that included.

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Kristen Quick Explains the Impact of Salesforce Life Sciences Cloud

Perficient: Drug Development

Kristen Quick, Director at Perficient, shared her insights on the transformative potential of Salesforce Life Sciences Cloud for pharmaceutical and med tech organizations, highlighting its ability to drive innovation and improve outcomes. As the healthcare landscape continues to evolve, innovative solutions like Life Sciences Cloud are becoming essential for driving efficiency, improving patient care, and accelerating time to market: Introduction to Kristen Quick Kristen Quick is a director i

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Men Are 3 Times As Likely to Die from Traumatic Brain Injury Compared to Women

Drugs.com

TUESDAY, Jan. 14, 2025 -- Men are more than three times as likely to die from a traumatic brain injury compared to women, a new study says. About 30 brain injury-related deaths occurred for every 100,000 U.S. men in 2021, while only 9 such deaths.

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Why 340B Reform Could Happen in 2025 (video)

Drug Channels

During my recent Drug Channels Outlook 2025 video webinar, I tackled a wide range of crucial topicsincluding the controversial 340B Drug Pricing Program. As I explain in this video excerpt, we may finally see reform of this rapidly expanding program. Whats more, implementing the Inflation Reduction Act will disrupt the current operations of the 340B programand could shift program oversight from Health Resources and Services Administration to the Centers for Medicare & Medicaid Services.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Are Young People With Eating Disorders Predisposed to Them?

Drugs.com

TUESDAY, Jan. 14, 2025 -- Eating disorders appear to be linked to differences in brain structure among teenagers.Young adults who develop eating disorders appear to have delayed brain maturation as teenagers, MRI scans show in a new study published.

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Cell and Gene Therapies for CNS and Ocular Delivery

Alta Sciences

Cell and Gene Therapies for CNS and Ocular Delivery tchichekian Tue, 01/14/2025 - 15:04 Image Website_Webinar_GACT.

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U.S. Dementia Cases Expected to Double By 2060

Drugs.com

TUESDAY, Jan. 14, 2025 -- Seniors risk of dementia is more than double what was previously thought.The risk of developing dementia after age 55 is more than 42% among Americans, researchers reported in a study published Jan. 13 in the journal N.

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Webinar-A Square Peg in a Round Hole

Alta Sciences

Webinar-A Square Peg in a Round Hole tchichekian Tue, 01/14/2025 - 15:09 Image Website_Webinar_PSYCH.

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Innovative Approaches to Generic Drug Development: Case Studies

Drug Patent Watch

The Generic Drug Revolution: Setting the Stage Before we dive into the nitty-gritty, let’s take a moment to appreciate the impact of generic drugs. Did you know that generic drugs now make up about 90% of all prescription drug purchases in the United States, while accounting for only 20% of prescription drug spending[1]? That’s right, these unsung heroes are saving our healthcare system trillions of dollars!

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Webinar-A Square Peg in a Round Hole

Alta Sciences

Webinar-A Square Peg in a Round Hole tchichekian Tue, 01/14/2025 - 15:09 Image Social-Media_Webinar_PSYCH_OnDemand_V2.

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Residents of unburned homes reported health symptoms months after Marshall Fire

Science Daily: Pharmacology News

Wildfires that burn homes and vehicles could expose people to dangerous airborne compounds through ash and smoke. Research has shown that people returning to their unburned homes may also experience health symptoms months after a nearby fire is extinguished. Through a survey of people affected by the 2021 Marshall Fire in Boulder, Colorado, researchers found that headaches, sore throats and coughs were frequently self-reported by residents living near burned structures.

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The Altascientist - Psychedelics and Entactogens

Alta Sciences

The Altascientist - Psychedelics and Entactogens tchichekian Tue, 01/14/2025 - 15:17 Image Social media_Audio book_The Altascientist_issue 19_CNS Hallucinogens.

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Unlock the Future of Integration with IBM ACE

Perficient: Drug Development

Have you ever wondered about integration in API development or how to become familiar with the concept? In this blog, we will discuss one of the integration technologies that is very easy and fun to learn, IBM ACE. What is IBM ACE? IBM ACE stands for IBM App Connect Enterprise. It is an integration platform that allows businesses to connect various applications, systems, and services, enabling smooth data flow and communication across diverse environments.

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The Altascientist - The Effects of Drugs on Driving

Alta Sciences

The Altascientist - The Effects of Drugs on Driving tchichekian Tue, 01/14/2025 - 15:20 Image Resource-Center_e-bulletin_The_Altascientist_issue_1.

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Four B2B E-Commerce Trends for 2025

Perficient: Drug Development

Its that time of year when everyone comes out with their trends to watch for 2025. While it may seem a bit of a cliche, 2025 has several innovations taking hold that should prove exciting for anyone willing to grab the opportunity. The way businesses buy and sell is changing faster than ever, and B2B companies are at a tipping point. Its a segment of business that is often slow to change and adopt new practices.

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The Altascientist - Human Abuse Potential Studies

Alta Sciences

The Altascientist - Human Abuse Potential Studies tchichekian Tue, 01/14/2025 - 15:22 Image 1200x627_The-Altascientist_issue-3_HAP.

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Key Insights from the Front-End Meetup by the Front-End Meetup Group

Perficient: Drug Development

Let me take you through the event that perfectly wrapped up 2024! Perficient’s Front-End Team concluded the year with a memorable meetup filled with inspiring sessions and networking, setting the stage for an exciting 2025. We’re already excited about the next one! Event Overview The Front-End Meetup, hosted by the Front-end Meetup Group and sponsored by Perficient, began at 10:00 AM with great energy as developers, designers, and tech enthusiasts gathered.

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The Altascientist - Critical Consideration for the Manufacture of HPAPIs

Alta Sciences

The Altascientist - Critical Consideration for the Manufacture of HPAPIs tchichekian Tue, 01/14/2025 - 15:23 Image 2064x1080_e-bulletin_The-Altascientist-issue35.

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How to Remove Strikethrough Text from PDFs Using Python

Perficient: Drug Development

In this blog post, I will share my journey of developing a Python-based solution to remove strikethrough text from PDFs. This solution is specifically designed for PDFs where strikethrough is applied as a style rather than an annotation. The Challenge Strikethrough text in PDFs can be tricky to handle, mainly when applied as a style. Standard PDF manipulation libraries often fall short in these cases.