Broad Institute

MARCH 22, 2024

Messenger RNAs with multiple “tails” could lead to more effective therapeutics By Corie Lok March 22, 2024 Breadcrumb Home Messenger RNAs with multiple “tails” could lead to more effective therapeutics Scientists have engineered long lasting mRNAs that increased therapeutic protein production in cells and animals. By Kat J. McAlpine March 22, 2024 Credit: Catherine Boush, Broad Communications Related news New method tracks gene expression in single cells over space and time Messenger RNA (mRNA)

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Engineering Protein Production RNA Vaccine 140

Science Daily: Pharmacology News

MARCH 22, 2024

How much time do planets have to form from a swirling disk of gas and dust around a star? A new study gives scientists a better idea of how our own solar system came to be.

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BioPharma Drive: Drug Pricing

MARCH 22, 2024

The approval of Italfarmaco’s Duvyzat is the first for an oral, non-steroidal Duchenne drug and was issued for all patients at least six years of age, regardless of their genetic underpinnings.

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FDA Drugs 120

Science Daily: Pharmacology News

MARCH 22, 2024

It's no surprise that your dog can learn to sit when you say 'sit' and come when called. But a new study has made the unexpected discovery that dogs generally also know that certain words 'stand for' certain objects. When dogs hear those words, brain activity recordings suggest they activate a matching mental representation in their minds.

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Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Drugs.com

MARCH 22, 2024

FRIDAY, March 22, 2024 -- Medicare will now cover the popular weight-loss drug Wegovy if patients using it also have heart disease, U.S. officials announced Thursday.The move comes after the U.S. Food and Drug Administration approved drugmaker Novo.

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Disease Drugs 119

Science Daily: Pharmacology News

MARCH 22, 2024

Imagine if every time you saw a face, it appeared distorted. Well, for those who have a very rare condition known as prosopometamorphopsia (PMO), which causes facial features to appear distorted, that is reality. A new study reports on a unique case of a patient with PMO. The research is the first to provide accurate and photorealistic visualizations of the facial distortions experienced by an individual with PMO.

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Research 128

Science Daily: Pharmacology News

MARCH 22, 2024

Archaeological analysis of a near unique animal cemetery discovered in London nearly 30 years ago has revealed there was an international horse trading network, orchestrated by the elites of late medieval and Tudor England, which brought superior physical specimens to the UK for jousting and for use as status symbols.

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International 122

Drugs.com

MARCH 22, 2024

FRIDAY, March 22, 2024 -- Working stiffs in the United States are dying at higher rates than those in other wealthy nations, a new study finds.Death rates among working-age Americans are 2.5 times higher than the average of other high-income.

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Science Daily: Pharmacology News

MARCH 22, 2024

Ground-based measuring devices and aircraft radar operated in the far northeast of Greenland show how much ice the 79 N-Glacier is losing. According to recent measurements, the thickness of the glacier has decreased by more than 160 meters since 1998. Warm ocean water flowing under the glacier tongue is melting the ice from below. High air temperatures cause lakes to form on the surface, whose water flows through huge channels in the ice into the ocean.

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Drugs.com

MARCH 22, 2024

FRIDAY, March 22, 2024 -- Cuddly, friendly, fun: Your pet brings so much to your life, but experts warn that, in rare cases, they can also bring illness.The health benefits of pet ownership are many, noted Dr. Stacey Rose, an associate professor of.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Science Daily: Pharmacology News

MARCH 22, 2024

Engineers have discovered a new way to manufacture solar cells using perovskite semiconductors. It could lead to lower-cost, more efficient systems for powering homes, cars, boats and drones.

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Research Engineering 119

Drugs.com

MARCH 22, 2024

FRIDAY, March 22, 2024 -- Catherine, Princess of Wales, announced Friday that she has been diagnosed with cancer and has begun chemotherapy treatments.The news, which she disclosed in a video released by Kensington Palace, came after days of.

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Science Daily: Pharmacology News

MARCH 22, 2024

Could life be found in frozen sea spray from moons orbiting Saturn or Jupiter? New research finds that life can be detected in a single ice grain containing one bacterial cell or portions of a cell. The results suggest that if life similar to that on Earth exists on these planetary bodies, that this life should be detectable by instruments launching in the fall.

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Research 115

Drugs.com

MARCH 22, 2024

FRIDAY, March 22, 2024 -- A surgical treatment used to treat conditions like carpal tunnel syndrome and back sciatica might also help relieve the pain of patients with diabetic neuropathy, a new study finds.Surgical nerve decompression.

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Treatment 105

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Perficient: Drug Development

MARCH 22, 2024

Cloud modernization is the primary driver of digital transformation and impactful business value. Cloud platforms have evolved from core technology to disruptive ecosystems of strategic advantage. Migration and modernization are vital to reach new markets, deliver innovative products, improve resiliency, reduce costs, and improve customer experiences.

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Government Compliance Engineering Production 105

Drugs.com

MARCH 22, 2024

FRIDAY, March 22, 2024 -- Some people diagnosed with schizophrenia might instead be suffering from a rare visual condition that can cause other people’s faces to appear “demonic,” a new study argues.The condition, called prosopometamorphopsia.

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Covalent Modifiers

MARCH 22, 2024

Linqi Cheng Yixian Wang, Yiming Guo, Sophie S. Zhang Han Xiao C ell Chemical Biology, 2024 Volume 31, 3, 428 - 445 [link] j. chembiol. 2023.09.004 Recent years have seen a remarkable growth in the field of protein-based medical treatments. Nevertheless, concerns have arisen regarding the cytotoxicity limitations, low affinity, potential immunogenicity, low stability, and challenges to modify these proteins.

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Small Molecule Engineering Treatment Drugs 94

Drugs.com

MARCH 22, 2024

FRIDAY, March 22, 2024 -- Many teens – especially girls – are affected by body dysmorphic disorder, a condition in which they become obsessed with perceived flaws in their personal appearance, a new study shows.BDD affects about two in every.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Science Daily: Pharmacology News

MARCH 22, 2024

Academics are proposing a new and improved way to help researchers discover when consciousness emerges in human infancy.

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Research 118

Drugs.com

MARCH 22, 2024

FRIDAY, March 22, 2024 -- The weight room is becoming an increasingly dangerous place for folks trying to get into shape, a new study discovers.Head and facial injuries related to weightlifting have increased sharply during the past decade for both.

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Drug Channels

MARCH 22, 2024

Today’s guest post comes from Adam Stotts, SVP of Customer Success at AssistRx. Adam discusses how patients seeking to access specialty therapies can benefit from a digital intake approach. He then explains three ways that specialty pharmaceutical companies can use digital intake strategies to speed patient enrollment. To learn about AssistRx’s digital intake solutions, download Digital Intake for Specialty Drug Programs: Q1 2024 Progress Report.

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SCIENMAG: Medicine & Health

MARCH 22, 2024

Amyotrophic lateral sclerosis (ALS) is a degenerative disease. The neurons responsible for movement begin to die and muscle control is progressively lost, leading to a fatal outcome. The causes of ALS are currently unknown, and there is no effective treatment.

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Treatment Disease Research 87

Covalent Modifiers

MARCH 22, 2024

Sang Joon Won, Yuxiang Zhang, Christopher J. Reinhardt, Nicole S. MacRae, Kristen E. DeMeester, Evert Njomen, Lauren M. Hargis, Jarrett R. Remsberg, Bruno Melillo, Benjamin F. Cravatt, Michael A. Erb bioRxiv 2024.03.21.586158; doi: [link] Pioneer transcription factors (TFs) exhibit a specialized ability to bind to and open closed chromatin, facilitating engagement by other regulatory factors involved in gene activation or repression.

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Small Molecule DNA 79

SCIENMAG: Medicine & Health

MARCH 22, 2024

Researchers at the University of Toronto and Sinai Health have created a new platform to identify proteins that can be co-opted to control the stability of other proteins — a new but largely unrealized approach to the treatment of disease.

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Treatment Disease Research 76

DrugBank

MARCH 22, 2024

There are many obstacles that you have to overcome on the road to success in early-stage drug discovery and drug repurposing research. The sector is constantly evolving and has become an increasingly competitive space to work. Research is emerging at a never before seen rate, and it is causing challenges for researchers and scientists to not only stay on top of the latest publications, but to validate conflicting information.

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Licensing Licensing Research Production 74

Collaborative Drug

MARCH 22, 2024

Recorded Webinar 3-21 24: Interdisciplinary Pathways in Medicine: Neurodegenerative Research and Drug Discovery

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Research Disease Drugs 95

Science Daily: Pharmacology News

MARCH 22, 2024

New mathematical modeling of the Atlantic meridional overturning circulation -- a system of ocean currents -- shows greater complexity than previously thought. Researchers have revealed a hierarchy of irreversible 'tipping points.

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Research 74

SCIENMAG: Medicine & Health

MARCH 22, 2024

There were multiple unsafe sleep practices at play in more than three-quarters of Sudden Unexpected Infant Deaths reported in 23 jurisdictions between 2011 and 2020, a new study reveals. The researchers say the findings underscore the need for more comprehensive safe-sleep education for new parents, including from healthcare providers.

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Research 72

Science Daily: Pharmacology News

MARCH 22, 2024

Spiders that disguise themselves as ants live in many locations around the globe but until now most had been able to avoid detection from fossil researchers as well as predators.

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Research 73

Drugs.com

MARCH 22, 2024

FRIDAY, March 22, 2024 -- An already approved cancer drug could be an effective treatment for women with advanced, recurring uterine cancer, a new clinical trial shows. Rucaparib, which belongs to a class of drugs called PARP inhibitors, extended.

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Clinical Trials Trials Treatment Drugs 69

Collaborative Drug

MARCH 22, 2024

Parser Supports Multiple Plates in a Single Import File The new CDD data parser now handles multiple plates in the same import. You can select a single plate block and assign a fixed value like the name of the plate. Multiple plates can be selected in the same sheet or separate sheets of the file. Be sure to use a consistent ‘field name’ for the associated fixed value (e.g.

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Drug Patent Watch

MARCH 22, 2024

A recent article in Communications of the ACM explores opportunities for “Permissionless innovation” in pharmaceuticals.

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Pharmaceuticals 86

BioPharma Drive: Drug Pricing

MARCH 22, 2024

Two weeks after the FDA updated Wegovy’s label, Medicare changed its stance to allow people with a history of heart disease to receive treatment, a shift that could further boost access to the fast-selling medicine.

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FDA Treatment Disease Drugs 64