Drug Discovery World

SEPTEMBER 25, 2024

Antibody drug conjugates (ADCs) are among the hottest properties in pharma, powerful anticancer drugs that target tumours and deliver a lethal payload that destroys them, while leaving healthy tissues untouched. But there’s much more to come from this technology. DDW’s Megan Thomas explores the topic and speaks with experts in the industry. Early days of ADC drug development The first ADC was approved around the turn of the century, with Pfizer’s Mylotarg (gemtuzumab ozogamicin) becoming the fi

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Therapies Pharma Companies FDA Approval FDA 162

Science Daily: Pharmacology News

SEPTEMBER 25, 2024

Scientists successfully extracted and analyzed DNA from ancient cheese samples found alongside the Tarim Basin mummies in China, dating back approximately 3,600 years. The research suggests a new origin for kefir cheese and sheds light on the evolution of probiotic bacteria.

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Drug Discovery World

SEPTEMBER 25, 2024

Vicebio has announced a $100 million Series B financing, which will be used to develop next-generation vaccines for respiratory viruses. The development will utilise Vicebio’s Molecular Clamp technology, discovered at The University of Queensland. The technology stabilises viral glycoproteins in their highly immunogenic ‘prefusion’ conformation, crucial for eliciting strong protective immune responses.

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Clinical Trials Vaccine Trials Virus 147

Science Daily: Pharmacology News

SEPTEMBER 25, 2024

Large expansion of carbon capture and storage is necessary to fulfill the Paris Climate Agreement. Yet a new study shows that without major efforts, the technology will not expand fast enough to meet the 2 C target and even with major efforts it is unlikely to expand fast enough for the 1.5 C target.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

SEPTEMBER 25, 2024

Insilico Medicine has shared positive preliminary results from its Phase IIa clinical trial evaluating ISM001-055, a first-in-class small molecule targeting TNIK (Traf2- and Nck-interacting kinase). The drug was designed utilising generative AI to treat idiopathic pulmonary fibrosis (IPF). The study met both its primary endpoint of safety and its secondary efficacy endpoints, demonstrating dose-dependent response in forced vital capacity (FVC), a critical measure of lung function in IPF patients

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Small Molecule Clinical Trials Drugs Trials 147

Science Daily: Pharmacology News

SEPTEMBER 25, 2024

The discovery of a 'weird' and unprecedented galaxy in the early Universe could 'help us understand how the cosmic story began', astronomers say. GS-NDG-9422 (9422) was found approximately one billion years after the Big Bang and stood out because it has an odd, never-before-seen light signature -- indicating that its gas is outshining its stars. The 'totally new phenomena' is significant, researchers say, because it could be the missing-link phase of galactic evolution between the Universe's fi

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Research 111

Drugs.com

SEPTEMBER 25, 2024

WEDNESDAY, Sept. 25, 2024 -- In a finding that suggests Ozempic and Wegovy have powers that extend beyond weight loss, a new study finds the medications might also lower people’s risk of opioid overdose. People with type 2 diabetes prescribed.

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Drug Discovery World

SEPTEMBER 25, 2024

The DDW Fall issue is out now and asks if the gut microbiome can unlock new therapeutics for mental health disorders, places a spotlight on oncology and includes a market report on the North American drug discovery hotspots. It also features an exclusive guide on the benefits and advances in cell line development. The guide covers the value and impact cell line development is having on drug discovery, looks at how biotechnologies are enhancing the precision and efficiency of therapeutic protein

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Protein Production Production Treatment Disease 130

Science Daily: Pharmacology News

SEPTEMBER 25, 2024

A new study could change the way scientists view microbial processes in the deep ocean. The unexpected findings expand our understanding of the impacts of climate change, including how and where the ocean stores carbon.

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Drugs.com

SEPTEMBER 25, 2024

WEDNESDAY, Sept. 25, 2024 -- As Americans get ready for fall and winter, the U.S. government is offering another round of free COVID tests, available by the end of this month."U.S. households will be eligible to order 4 free COVID-19 tests at.

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Government 105

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Science Daily: Pharmacology News

SEPTEMBER 25, 2024

A new study on ice cores from Alaska and Greenland found that air pollution from the burning of fossil fuels reaches the remote Arctic in amounts large enough to alter its fundamental atmospheric chemistry. The researchers unexpectedly found pollution's footprint in levels of an airborne byproduct of marine phytoplankton activity, which plummeted as soon as widespread fossil fuel usage began in the industrial era.

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Research 106

Drug Target Review

SEPTEMBER 25, 2024

Targeted cancer therapies and treatment resistance mechanisms Targeted cancer therapies such as epidermal growth factor receptor (EGFR), Kirsten rat sarcoma virus (KRAS), or V-Raf Murine Sarcoma Viral Oncogene Homolog B (BRAF) inhibitors have made a significant positive impact in the treatment of solid tumours, specifically for patients exhibiting oncogenic mutations.

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Science Daily: Pharmacology News

SEPTEMBER 25, 2024

Tree-ring data reveal that periodic shifts in strong winds high above the Earth's surface have driven opposite climates in different parts of Europe for the past 700 years and likely much longer, resulting in contrasting patterns in weather, agricultural and societal extremes.

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Drugs.com

SEPTEMBER 25, 2024

WEDNESDAY, Sept. 25, 2024 -- Most Americans don’t plan to get vaccinated against the flu or COVID-19 this season, a new survey has found.Fewer than two in five U.S. adults (38%) say they will definitely get a flu jab, and only one in four (26%) say.

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Vaccine 103

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Science Daily: Pharmacology News

SEPTEMBER 25, 2024

Researchers have discovered that mutations affect protein stability following remarkably simple rules. The discovery has profound implications for accelerating the development of new treatments for diseases or the design of new proteins with industrial applications.

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Treatment Disease Research 104

Drugs.com

SEPTEMBER 25, 2024

WEDNESDAY, Sept. 25, 2024 -- During a tense hearing before a Senate committee on Tuesday, Novo Nordisk CEO Lars Fruergaard Jørgensen faced tough questions over the company's high prices for its blockbuster drugs Ozempic and Wegovy.While testifying.

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Drugs 102

Science Daily: Pharmacology News

SEPTEMBER 25, 2024

The discovery of new cynodont fossils from southern Brazil by a team of palaeontologists has led to a significant breakthrough in understanding the evolution of mammals.

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National Institute on Drug Abuse: Nora's Blog

SEPTEMBER 25, 2024

Commercial interests contribute to drug use and addiction mfleming Wed, 09/25/2024 - 15:00 Nora's Blog September 26, 2024 Image ©Getty Images/ PeopleImages Biomedical sciences are bringing increased focus to social determinants of health, which the World Health Organization (WHO) defines as “the conditions in which people are born, grow, work, live, and age, the systems put in place to deal with illness, and the wider set of forces and systems shaping the conditions of daily life.” 1 Very often,

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Science Daily: Pharmacology News

SEPTEMBER 25, 2024

New research suggests Mars' missing atmosphere -- which dramatically diminished 3.5 billion years ago -- could be locked in the planet's clay-covered crust. Water on Mars could have set off a chain reaction that drew CO2 out of the atmosphere and converted it into methane within clay minerals.

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Research 101

Drugs.com

SEPTEMBER 25, 2024

WEDNESDAY, Sept. 25, 2024 -- A non-drug nasal spray could theoretically help stop the spread of respiratory viruses like the flu and COVID-19 better than wearing a mask, a new study suggests.The spray uses ingredients that are medically inactive to.

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Virus Drugs 98

Science Daily: Pharmacology News

SEPTEMBER 25, 2024

The SAGA Survey just published three new research articles that provide us with new insights into the uniqueness of our own Milky Way Galaxy after completing the census of 101 satellite systems similar to the Milky Way's.

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Research 100

Drugs.com

SEPTEMBER 25, 2024

WEDNESDAY, Sept. 25, 2024 -- A raw diet pet food company is recalling cartons of frozen beef and chicken dog food that could be tainted with salmonella or listeria germs.Answers Pet Food announced the recall this week after the U.S. Food and Drug.

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Drugs 98

Science Daily: Pharmacology News

SEPTEMBER 25, 2024

Researchers examined Neptunian exoplanets -- these planets share similar characteristics to our own Neptune, but orbit outside of our solar system. Scientists discovered a new area called the 'Neptunian Ridge' -- in between the 'Neptunian desert' and the 'Neptunian Savannah'. A new 'map' of distant planets shows a ridge of planets in deep space, separating a desert of planets from a more populated savannah.

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Research 98

Drugs.com

SEPTEMBER 25, 2024

WEDNESDAY, Sept. 25, 2024 -- Only 1 in every 4 U.S. adults struggling with schizophrenia receive "minimally adequate treatment," new data shows.Many of these patients also struggle with other mental health issues, such as substance abuse or.

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Quanticate

SEPTEMBER 25, 2024

In rheumatoid arthritis (RA) clinical trials, accurately measuring the effectiveness of treatments is critical for determining their value in managing this chronic and debilitating condition. By evaluating improvements in joint symptoms and overall disease activity, the ACR criteria provide a clear and consistent framework for determining the efficacy of RA therapies.

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Clinical Trials Trials Treatment Therapies 97

Drugs.com

SEPTEMBER 25, 2024

WEDNESDAY, Sept. 24, 2024 -- Millions of Americans are caring for veterans, putting their finances and their mental health on the line to help those who have served the country.More than 14 million Americans now provide daily care to wounded, sick.

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BioPharma Drive: Drug Pricing

SEPTEMBER 25, 2024

The financing will support a technology designed to make delivery of lentiviral gene therapies, which are typically administered through a complex process, more convenient.

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Drugs.com

SEPTEMBER 25, 2024

WEDNESDAY, SEPT. 25, 2024 -- In a move that could mean more Americans in crisis get help and get it quickly, federal officials announced Tuesday that major cellphone carriers now have the technology to direct 988 callers to local mental health.

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Science Daily: Pharmacology News

SEPTEMBER 25, 2024

A landmark study has begun to unravel one of the fundamental mysteries in neuroscience -- how the human brain encodes and makes sense of the flow of time and experiences.

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Drugs.com

SEPTEMBER 25, 2024

WEDNESDAY, Sept. 25, 2024 -- Two key symptoms that can arise soon after a diagnosis of multiple sclerosis (MS) could predict how swiftly the illness will progress and suggest best treatment options, new research shows.The two symptoms -- blurred.

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Treatment Research 96

Drug Patent Watch

SEPTEMBER 25, 2024

Generic drug manufacturers face significant challenges when attempting to navigate around REMS (Risk Evaluation and Mitigation Strategies) imposed by brand-name drug companies. These strategies, intended to ensure drug safety, are sometimes misused to delay generic competition.

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Drugs 92

Drugs.com

SEPTEMBER 25, 2024

WEDNESDAY, Sept. 25, 2024 -- Long-term space travel to Mars could be bad for astronauts’ hearts, a new zero-gravity study shows.After a month at the International Space Station, a set of 48 bioengineered human heart tissue samples beat about half a.

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International 90

Science Daily: Pharmacology News

SEPTEMBER 25, 2024

Drone footage is offering new insight into the acrobatics undertaken by gray whales foraging in the waters off the coast of Oregon.

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BioPharma Drive: Drug Pricing

SEPTEMBER 25, 2024

The offering, which was upsized twice, will support development of a drug the company believes can boost the effects of popular weight loss medicines like Eli Lilly’s Zepbound.

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Drug Research Research Drugs 67