Thu.Sep 12, 2024

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Three biotechs raise $700M in rare burst of IPO activity

BioPharma Drive: Drug Pricing

The offerings by Bicara, Zenas and MBX give a glimpse into what industry insiders describe as a backlog of mature startups waiting for the right opportunity to test public markets.

Marketing 130
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Climate-change-triggered 2023 mega-landslide caused Earth to vibrate for nine days

Science Daily: Pharmacology News

A landslide in a remote part of Greenland caused a 200 meter (650 foot) mega-tsunami that sloshed back and forth across a fjord for nine days, generating vibrations throughout Earth, according to a new study. The study concluded that this movement of water was the cause of a mysterious, global seismic signal that lasted for nine days and puzzled seismologists in September 2023.

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Twice-Yearly Injection Cuts HIV Risk by 96%, But Will Cost Cut Access?

Drugs.com

THURSDAY, Sept. 12, 2024 -- It could be a real breakthrough for people at risk for HIV infection: A shot given every six months that reduces their risk by a whopping 96%.That's according to new trial results released Thursday by Gilead Sciences.

Science 119
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Path to prosperity for planet and people shrinking rapidly, scientists warn

Science Daily: Pharmacology News

Our planet will only remain able to provide even the most basic standard of living for everyone in the future if economic systems and technologies are dramatically transformed and critical resources are more fairly used, managed and shared, a new report shows.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Gene therapy startup emerges with green light for first-of-its-kind trial

BioPharma Drive: Drug Pricing

Spun out of research at Nationwide Children’s Hospital, Vironexis claims it will be the first company to start a study testing a cancer drug delivered via the adeno-associated viruses commonly used in genetic medicines.

Therapies 111
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Powered by renewable energy, microbes turn CO2 into protein and vitamins

Science Daily: Pharmacology News

Researchers can harvest protein and vitamin B9 from microbes by feeding them nothing much more than hydrogen, oxygen, and CO2. The technology runs on renewable energy to produce a sustainable, micronutrient-enriched protein alternative that may one day make it to our plates.

Research 116

More Trending

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How El Nino and mega ocean warming caused the greatest-ever mass extinction

Science Daily: Pharmacology News

Mega ocean warming El Nino events were key in driving the largest extinction of life on planet Earth some 252 million years ago, according to new research. The study has shed new light on why the effects of rapid climate change in the Permian-Triassic warming were so devastating for all forms of life in the sea and on land.

Research 111
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High Doses of ADHD Meds Could Trigger Psychosis

Drugs.com

THURSDAY, Sept. 12, 2024 -- Prescriptions for amphetamine stimulants to treat ADHD have increased significantly in recent years, particularly during the pandemic.Unfortunately, high doses of stimulants like Adderall can increase the risk of.

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Ignore antifungal resistance in fungal disease at your peril, warn top scientists

Science Daily: Pharmacology News

Without immediate action, humanity will potentially face further escalation in resistance in fungal disease, a group of scientists from the around the world has warned. According to the scientists most fungal pathogens identified by the World Health Organization -- accounting for around 3.8 million deaths a year -- are either already resistant or rapidly acquiring resistance to antifungal drugs.

Disease 105
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Weight-Loss Drug Zepbound May Work Better in Women Than Men

Drugs.com

THURSDAY, Sept. 12, 2024 -- The injectable weight-loss drug Zepbound appears to work better in women than in men, according to a new analysis of the clinical trials that led to its approval.All doses of tirzepatide consistently reduced weight in.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Invisibility cloaks? Wave scattering simulation unlocks potential for advanced metamaterials

Science Daily: Pharmacology News

Could invisibility cloaks become a reality? New research brings this science fiction concept a step closer, with a breakthrough software package that simulates how waves interact with complex materials.

Packaging 102
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Ingredient in Hair Dye Led to Woman's Vision Loss

Drugs.com

THURSDAY, Sept. 12, 2024 -- An ingredient in the hair dye a French woman used caused her to develop a vision-robbing retinopathy, researchers report. When she switched to a dye without these ingredients, called aromatic amines, her vision troubles.

Research 105
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Impact of climate change on agriculture suggests even greater challenges to the environment, global food supply and public health

Science Daily: Pharmacology News

A sweeping global research review of the links between climate and agriculture reveals the likelihood of an emergent feedback loop whereby, as climate change puts more pressure on the global food supply, agriculture will, by necessity, adopt practices that may exacerbate its environmental impact. The paper also identifies new agricultural practices that have the potential to increase efficiency and stabilize our food supply in the decades to come.

Research 101
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In Every U.S. State, at Least 1 in 5 People Is Now Obese

Drugs.com

THURSDAY, Sept. 12, 2024 -- Statistics from 2023 on U.S. obesity rates bring no good news: In every state in the nation, 1 in every 5 people is now obese, the new tally shows.In 2013, not one state had an adult obesity rate topping 35%, but 10.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Quantum researchers cause controlled 'wobble' in the nucleus of a single atom

Science Daily: Pharmacology News

Researchers have been able to initiate a controlled movement in the very heart of an atom. They caused the atomic nucleus to interact with one of the electrons in the outermost shells of the atom. This electron could be manipulated and read out through the needle of a scanning tunneling microscope. The research offers prospects for storing quantum information inside the nucleus, where it is safe from external disturbances.

Research 100
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Alzheimer's Drugs May Work in Whole New Way, Study Finds

Drugs.com

THURSDAY, Sept. 11, 2024 -- Two monoclonal antibody treatments to slow Alzheimer's disease, lecanemab (Leqembi) and donanemab (Kisunla), have been approved by the U.S. Food and Drug Administration over the past two years. It's thought the drugs.

Drugs 98
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Researchers discover building blocks that could 'revolutionize computing'

Science Daily: Pharmacology News

A research team has made a major discovery by designing molecules that could revolutionize computing.

Research 125
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Many Americans Wary of Vaccines as Fall Flu, COVID Season Looms: Survey

Drugs.com

THURSDAY, Sept. 12, 2024 -- A lot of Americans are on the fence regarding annual flu and COVID shots, a new survey finds.More than one-third of those polled (37%) said they’d gotten vaccines in the past but don’t plan to this year, according to res.

Vaccine 98
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Fulcrum shares collapse as Sanofi-partnered muscular dystrophy drug fails key test

BioPharma Drive: Drug Pricing

The biotech will now suspend development of a drug prospect that Sanofi acquired partial rights to just four months ago.

Drugs 114
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Sleep Changes Common for Stroke Survivors

Drugs.com

THURSDAY, Sept. 12, 2024 -- Less than half of people who've survived a stroke will go on to have a healthy, normal sleep pattern, new research shows.Normal sleep is defined as six to eight hours of shuteye nightly. However, a majority of the.

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Targeted immune intervention and stopping ART in model of SIV infection leads to control of viral replication and reservoirs

Science Daily: Pharmacology News

Researchers have shown unprecedented control of SIV replication and decay of viral reservoirs by combining a stringent model of infection with the interruption of antiretroviral therapy (ART). The success of this immune-based approach follows the research team's identification of the mechanisms of action for PD1 and IL-10, molecules known to regulate HIV persistence and immune dysfunction.

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A-Fib May Be 3 Times More Common Than Thought

Drugs.com

THURSDAY, Sept. 12, 2024 -- The number of Americans with a potentially dangerous heart rhythm condition is three times greater than previously thought, a new study claims.An estimated 5% of the population -- 10.5 million U.S. adults -- have atrial.

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Hair-thin wire to help simulate cosmic conditions

Science Daily: Pharmacology News

Extreme conditions prevail inside stars and planets. The pressure reaches millions of bars, and it can be several million degrees hot. Sophisticated methods make it possible to create such states of matter in the laboratory -- albeit only for the blink of an eye and in a tiny volume. So far, this has required the world's most powerful lasers, and the opportunities for experiments are correspondingly rare.

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Black Stroke Patients More Likely to Arrive Late at Hospital, Without Prior ER Notification

Drugs.com

THURSDAY, Sept. 12, 2024 -- Black stroke victims are arriving at emergency rooms much later than white patients, greatly increasing their risk of death or lifelong disability, a new study finds.Every second counts when it comes to treating a.

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Trilobite fossils from upstate New York reveal 'extra' set of legs

Science Daily: Pharmacology News

A new study finds that a trilobite species with exceptionally well-preserved fossils from upstate New York has an additional set of legs underneath its head. The research suggests that having a fifth pair of head appendages might be more widespread among trilobites than once thought and helps researchers better understand how trilobite heads are segmented.

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The ‘Rule of Three’: How the FDA is Hacking Drug Prices

Drug Patent Watch

In the labyrinthine world of pharmaceuticals, where the cost of life-saving medications can often feel like a roll of the dice, the FDA is implementing a strategy that aims to bring some much-needed transparency and affordability to the market. This strategy, known as the ‘Rule of Three,’ is a game-changer in the battle against soaring drug prices.

FDA 81
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Discovery could lead to longer-lasting EV batteries, hasten energy transition

Science Daily: Pharmacology News

Researchers have discovered why lithium-ion batteries, which power most electronic devices, lose capacity overtime. The findings could enable the development of electric vehicles that go far longer without needing a charge.

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Product Highlight: DrugBank Data Dictionary

DrugBank

At DrugBank we’re committed to improving your daily research and drug development operations. Our latest enhancement, the DrugBank Data Dictionary, is designed to streamline how you interact with our extensive data offerings. This tool is designed to bring clarity and precision to your workflows, enabling you to navigate our knowledgebase with ease and confidence.

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NASA's Webb peers into the extreme outer galaxy

Science Daily: Pharmacology News

Astronomers have directed NASA's James Webb Space Telescope to examine the outskirts of our Milky Way galaxy. Scientists call this region the Extreme Outer Galaxy due to its location more than 58,000 light-years away from the Galactic Center. (For comparison, Earth is approximately 26,000 light-years from the center.

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The Addgene Antibody Data Hub

addgene Blog

If you’re using antibodies in your research, you've probably found yourself staring at a browser full of tabs, each open to a different antibody option. Or you may find yourself with only two options, but very little data on which might work in your application. It can be quite difficult to decide on which antibody to request for your experiment!

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Huge gamma-ray burst collection 'rivals 250-year-old Messier catalog'

Science Daily: Pharmacology News

Hundreds of gamma-ray bursts (GRBs) have been recorded as part of an enormous global effort so extensive it 'rivals the catalog of deep-sky objects created by Messier 250 years ago', astronomers say. GRBs are the most violent explosions in the Universe, releasing more energy than the Sun would in 10 billion years. They occur when either a massive star dies or two neutron stars merge.

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ZASTAPRAZAN

New Drug Approvals

ZASTAPRAZAN 2133852-18-1 362.5 g/mol, C 22 H 26 N 4 O 1-Azetidinyl[8-[[(2,6-dimethylphenyl)methyl]amino]-2,3-dimethylimidazo[1,2- a ]pyridin-6-yl]methanone (ACI) azetidin-1-yl-[8-[(2,6-dimethylphenyl)methylamino]-2,3-dimethylimidazo[1,2-a]pyridin-6-yl]methanone JAQBO; JP-1366; OCN-101; Zastaprazan citrate – Onconic Therapeutics, UNII-W9S9KZX5MD Originator Onconic Therapeutics Class Anti-inflammatories; Antiulcers; Azetidines; Imidazoles; Methylamines; Pyridines; Small molecules Mechanism o

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Microbe dietary preferences influence the effectiveness of carbon sequestration in the deep ocean

Science Daily: Pharmacology News

The movement of carbon dioxide (CO2) from the surface of the ocean, where it is in active contact with the atmosphere, to the deep ocean, where it can be sequestered away for decades, centuries, or longer, depends on a number of seemingly small processes. A key microscale process in the ocean is the dietary preferences of bacteria that feed on organic molecules called lipids.

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