Tue.Nov 14, 2023

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Insurers Should Start Paying For Life-Changing Weight Loss Drugs

Forbes: Drug Truths

Ultimately, these drugs will also lower the nation’s healthcare bill. They should be made available to all who need them. Insurance companies need to make this happen as soon as possible.

Drugs 216
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Which diseases are poised to benefit from therapeutic antibody development

Drug Discovery World

DDW’s Megan Thomas looks at how different diseases will benefit from the success of therapeutic antibodies. Cancer Monoclonal antibodies (mAbs) are a type of targeted drug therapy, and as such are often used to treat cancer. Alongside surgery, radiation and chemotherapy, antibody-based immunotherapy is considered to be a main component of cancer therapy 1.

Disease 148
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A researcher's perspective: Linking scientific discovery to clinical medicine

Antidote

For Carla Greenbaum, M.D., growing up in the era of space travel and the moon landing kindled a lifelong interest in science. That interest influenced her career trajectory, and she’s now a leading investigator at Benaroya Research Institute where she has studied the natural history of type 1 diabetes (T1D) since 2000. Her work focuses on finding the cause of autoimmunity and developing targets for treatment, which she finds “incredibly exciting and inspiring—like landing on the moon!

Research 121
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Semaglutide reduces major cardiovascular events by 20%

Drug Discovery World

Semaglutide 2.4mg (Wegovy), a drug approved for weight loss, can reduce the risk of major adverse cardiovascular events (MACE) by 20%, according to new data released by Novo Nordisk. SELECT is a Phase III cardiovascular outcomes trial investigating the effects of once-weekly semaglutide 2.4mg in adults with established cardiovascular disease (CVD) and overweight or obesity without diabetes.

Trials 130
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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#WhyIScience Q&A: A computational biologist uses physics to find hidden patterns in cells

Broad Institute

#WhyIScience Q&A: A computational biologist uses physics to find hidden patterns in cells By Allessandra DiCorato November 14, 2023 Breadcrumb Home #WhyIScience Q&A: A computational biologist uses physics to find hidden patterns in cells Niranj Chandrasekaran talks about his work developing a large image-based cell profiling dataset and his long-standing fascination with physics and astronomy.

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First therapy for very rare blood clotting disorder gets US greenlight

Drug Discovery World

Takeda’s Adzynma has become the first recombinant protein product approved in the US for prophylactic or on-demand enzyme replacement therapy (ERT) for congenital thrombotic thrombocytopenic purpura (cTTP). A very rare, inherited blood clotting disorder, cTTP is caused by a disease-causing mutation in the ADAMTS13 gene, which is responsible for making an enzyme, also named ADAMTS13, that regulates blood clotting.

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Just two days till DDW’s Cancer Research Summit

Drug Discovery World

Don’t forget to register for the DDW Turning Science into Business Summit, ‘Cancer research opportunities and advances’, to hear insight and expertise from leading international figures. The event, which will be sponsored by Taconic Biosciences, will take place online on 16 November at 7AM PST / 10AM EST / 3PM GMT / 4PM CET and will also be available on-demand.

Research 130
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Wegovy Cuts Heart Risks by 20% in Large Trial

Drugs.com

MONDAY, Nov. 13, 2023 (Healthday News) -- In a finding that could change the landscape of heart disease care, the wildly popular weight-loss drug Wegovy has proved its mettle in protecting the heart after lowering the risk of cardiac problems in.

Trials 111
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Single-course in vivo base editing therapy proven to lower cholesterol

Drug Discovery World

A Phase Ib trial has shown low-density lipoprotein cholesterol (LDL-C) reductions up to 55% and blood PCSK9 protein reductions up to 84% after a single infusion of Verve Therapeutics’ Verve-101. The trial participants have heterozygous familial hypercholesterolemia (HeFH), a life-threatening inherited disease characterised by lifelong elevations in blood LDL-C and accelerated atherosclerotic cardiovascular disease (ASCVD).

Therapies 130
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Major Study Confirms Salt's Deadly Effect on Blood Pressure

Drugs.com

MONDAY, Nov. 13, 2023 -- Cutting out just one teaspoon of salt every day lowers blood pressure almost as much as medication does, new research shows. Investigators said theirs is one of the largest studies ever to include people taking high blood.

Research 105
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Troubleshooting Sitecore Image Update Issue

Perficient: Drug Development

Troubleshooting image update issues in Sitecore can prove to be a complex task, as various factors could contribute to the problem. We recently encountered an issue where, after updating the “Sitecore Images,” our local project instance stopped working. In order to resolve the issue, we attempted multiple possible solutions, including those available on the internet, but initially were not able to identify the root cause of the problem.

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Forbion-backed biotech raises $138M to develop ALS drug

BioPharma Drive: Drug Pricing

The Series A round for three-year-old startup VectorY is one of the largest private financings in Europe this year, Forbion said.

Drugs 119
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Consent Management for Compliance and Customer Experience Benefits 

Perficient: Drug Development

Data privacy has become an increasingly complex subject, especially with the introduction of the California Consumer Privacy Act (CCPA) and similar regulations emerging in other states. Non-compliance with these regulations can result in hefty fines, as seen with Sephora’s recent $1.2 million penalty. The Growing Need for Consent Management The proliferation of privacy laws and regulations worldwide has led to a multitude of compliance deadlines.

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Food Allergies Might Pose 'Silent' Threat to the Heart

Drugs.com

MONDAY, Nov. 13, 2023 -- In an unexpected finding, new research suggests that antibodies arising from common food allergies may also raise risks for heart trouble. These IgE antibodies didn't even have to be present in quantities high enough to.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Drug Channels Outlook 2024 (NEW Live Video Webinar)

Drug Channels

It’s time for our most popular event of the year! Dr. Adam J. Fein, CEO of Drug Channels Institute (DCI) and the author of Drug Channels , invites you to join him for DCI’s new live video webinar: Drug Channels Outlook 2024 This event will be broadcast live on Friday, December 15, 2023 12:00 p.m. to 1:30 p.m. ET. This post describes the event, outlines the pricing options, and explains how to purchase a registration.

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CDC Tells Docs to Look for Lead Poisoning in Kids, as Fruit Puree Investigation Continues

Drugs.com

TUESDAY, Nov. 14, 2023 (Healthday News) -- Doctors need to be on the lookout for lead poisoning in children as the latest tally of kids exposed to the toxin after consuming pouches of cinnamon-flavored apple puree climbed to 22, the U.S. Centers for.

Doctors 98
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Great results with emergency care adapted for pregnant women

SCIENMAG: Medicine & Health

Increased vigilance for high blood pressure and diffuse stomach pain. These are some of the characteristics of emergency care adapted for pregnant women and new mothers. The model, which could become clinical routine throughout Sweden, is described in a thesis at the University of Gothenburg.

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Controlled Fires Cut Wildfire Risk by 60%, Study Shows

Drugs.com

TUESDAY, Nov. 14, 2023 -- Controlled forest burns can prevent the sort of high-intensity wildfires that have plagued the Western U.S. and Canada as a result of climate change, a new study argues. A low-intensity fire in the mixed conifer forests of.

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A sweet solution: turning winery waste into jelly

SCIENMAG: Medicine & Health

Researchers in Turkey have proposed a new sustainable solution for winery waste. Credit: Dr Gülce Bedis Kaynarca Researchers in Turkey have proposed a new sustainable solution for winery waste.

Science 89
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Subtle Changes Could Predict Inflammatory Bowel Disease Years Before Symptoms Hit

Drugs.com

MONDAY, Nov. 13, 2023 (Healthday News) -- Inflammatory bowel disease starts to develop years before patients come down with symptoms, a new study suggests. Gut changes can be detected in blood tests up to eight years before a diagnosis of.

Disease 98
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New study finds association between insecticide exposure and lower sperm concentration in adult men

SCIENMAG: Medicine & Health

EMBARGOED until November 15, 2023 Credit: George Mason University College of Public Health EMBARGOED until November 15, 2023 Contact: Michelle Thompson George Mason University mthomp7@gmu.

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Low-fat Diets Battle Fatigue for Folks With MS

Drugs.com

TUESDAY, Nov. 14, 2023 — Researchers have found a remedy for the debilitating fatigue faced by many patients with multiple sclerosis (MS): A low-fat diet. "The results reinforced what we had seen before," said study leader Dr. Vijayshree.

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US men die 6 years before women, as life expectancy gap widens

Science Daily: Pharmacology News

We've known for more than a century that women outlive men. But new research shows that, at least in the United States, the gap has been widening for more than a decade.

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New AMA policies target GLP-1 coverage, corporate medicine

BioPharma Drive: Drug Pricing

The lobbying group urged broader health insurance coverage for treating obesity, including with GLP-1 agonists like Wegovy.

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When we see what others do, our brain sees not what we see, but what we expect

Science Daily: Pharmacology News

When we engage in social interactions, like shaking hands or having a conversation, our observation of other people's actions is crucial. But what exactly happens in our brain during this process: how do the different brain regions talk to each other? Researchers provide an intriguing answer: our perception of what others do depends more on what we expect to happen than previously believed.

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Allison Institute hosts inaugural scientific symposium

SCIENMAG: Medicine & Health

HOUSTON ― The James P. Allison Institute at The University of Texas MD Anderson Cancer Center hosted its inaugural scientific symposium on Nov. 10 at the TMC3 Collaborative Building in the Texas Medical Center’s Helix Park.

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Most Kids With the Flu Miss Out on Antiviral Tamiflu

Drugs.com

TUESDAY, Nov. 14, 2023 -- Children stricken with influenza aren’t receiving the flu-busting antiviral drug Tamiflu even though it’s recommended for them, a new study says. Three of five children with the flu aren’t prescribed.

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University of Kentucky researcher helps solve 60-year mystery inside heart, publishes in Nature

SCIENMAG: Medicine & Health

LEXINGTON, Ky. (Nov. 14, 2023) — One University of Kentucky researcher has helped solve a 60-year-old mystery about one of the body’s most vital organs: The heart. Credit: Jeremy Blackburn | University of Kentucky Research Communications. LEXINGTON, Ky. (Nov.

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Any Activity, Even Sleeping, Is Healthier Than Sitting

Drugs.com

TUESDAY, Nov. 14, 2023 (Healthday News) -- There is nothing worse for your heart than sitting, a new study confirms.

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Current uses of asbestos exceed exposure limits

SCIENMAG: Medicine & Health

San Francisco, November 14, 2023 – A new study summarizing exposures to asbestos during the installation and removal of asbestos cement products demonstrates that these construction activities almost always exceed U.S. occupational limits. The study focused on airborne asbestos exposures from existing uses of asbestos that are still allowed in most countries.

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'Bouncing' comets could deliver building blocks for life to exoplanets

Science Daily: Pharmacology News

How did the molecular building blocks for life end up on Earth? One long-standing theory is that they could have been delivered by comets. Now, researchers have shown how comets could deposit similar building blocks to other planets in the galaxy.

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Many Clinics Are Selling Ketamine as Bogus 'Cure' for Illnesses

Drugs.com

TUESDAY, Nov. 14, 2023 -- The party drug and anesthetic ketamine is starting to show promise in trials as a treatment for depression. But new research also suggests that hundreds of U.S. clinics may be misleading consumers, hawking off-label and.

Trials 81
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Downloading NASA's dark matter data from above the clouds

Science Daily: Pharmacology News

Data from a NASA mission to map dark matter around galaxy clusters has been saved by a new recovery system. The system allowed the retrieval of gigabytes of information, even after communication failed and the balloon-based telescope was damaged in the landing process.

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U.S. Men Are Dying Much Earlier Than Women, as Death 'Gender Gap' Widens

Drugs.com

MONDAY, Nov. 13, 2024 -- The gap in life expectancy between American men and women is now the biggest it has been since the mid-1990s -- almost six years. The pandemic and opioid overdoses are key factors in the gender difference in longevity, said.

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