Chemical Biology and Drug Design

JANUARY 29, 2024

A series of 1,3-thiazolidine- amide derivatives were synthesized via two different methods (microwave irradiation and conventional). These derivatives exhibited in vitro good to excellent antimicrobial activity. Molecular docking study performed on the crucial antifungal target 4WMZ. Quantitative structure toxicity relationship (QSTR) study pointed out the slight toxic nature of compounds.

Pharmacokinetics 100

Pharmacokinetics Production Drugs Research 100

Antidote

JANUARY 29, 2024

For individuals living with a condition like melanoma, volunteering to participate in a clinical trial can be a rewarding experience. Not only will patients be able to gain access to potential new treatments, but they will also be directly contributing to research that can save lives — something that Jamie Troil Goldfarb has experienced firsthand. Jamie received a diagnosis of stage IV melanoma in 2011, only 11 weeks after giving birth to her child.

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Clinical Trials Trials Doctors Treatment 122

Chemical Biology and Drug Design

JANUARY 29, 2024

MGMT mRNA expression was significantly increased in CD138+ myeloma cells compared with their matched CD138-nontumorigenic cells and inhibition of MGMT by its specific inhibitor lomeguatrib in MM cells reduced DNA repair, cell viability, and S phase entry and increased DNA damage and apoptosis. Apoptosis and DNA damage were further elevated in melphalan-treated RPMI 8226 cells, where MGMT expression is absent.

DNA 100

DNA Treatment Disease Research 100

BioPharma Drive: Drug Pricing

JANUARY 29, 2024

The FDA is reviewing the companies’ application for a “tumor agnostic” indication for their drug Enhertu, which would break new ground for antibody-drug conjugates.

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FDA Drugs 121

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Chemical Biology and Drug Design

JANUARY 29, 2024

Crocin enhances the sensitivity of breast cancer cells to PTX by suppressing BIRC5 expression. Our data identified crocin as a novel promising therapeutic agent in sensitizing breast cancer cells to PTX, and highlighted the potential role of BIRC5 in the development of PTX resistance in breast cancer. Abstract Paclitaxel (PTX) is one of the first-line chemotherapeutic agents for treating breast cancer.

Therapies 100

Therapies Research 100

Drugs.com

JANUARY 29, 2024

MONDAY, Jan. 29, 2024 -- Five of eight British children who received human growth hormone from the pituitary glands of deceased donors went on to develop early-onset Alzheimer's disease many decades later, researchers report.Researchers at.

Disease 111

Disease Research 111

Drugs.com

JANUARY 29, 2024

MONDAY, Jan. 29, 2024 -- Following a recall of millions of its breathing machines that began in mid-2021, Philips Respironics announced Monday that it would halt sales of all such machines within the United States.The machines include continuous.

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Chemical Biology and Drug Design

JANUARY 29, 2024

An account on the currently limited knowledge generated with a still thin repertoire of genetic/chemical tools on the (patho)physiological roles of the individual deacylase activities of sirtuins is presented, calling for an expanded research to ultimately sort out the (patho)physiological roles of all the deacylase activities indicated in this figure.

Regulations 100

Regulations Research 100

Drugs.com

JANUARY 29, 2024

MONDAY, Jan. 29, 2024 -- Stuart Douglas, 78, has played the accordion all his long life.“I learned to play the accordion as a boy living in a mining village in Fife and carried on throughout my career in the police force and beyond,” said.

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111

Science Daily: Pharmacology News

JANUARY 29, 2024

A new study, which centers on evidence from skulls of a 6-million-year-old fossil ape, Lufengpithecus, offers important clues about the origins of bipedal locomotion courtesy of a novel method: analyzing its bony inner ear region using three-dimensional CT-scanning. The inner ear appears to provide a unique record of the evolutionary history of ape locomotion.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Perficient: Drug Development

JANUARY 29, 2024

We like being lied to. If you don’t believe that, then you’re not being honest with yourself! In this article I’ll cover some of the common self-deceptions, biases, and societal pleasantries we entertain. Then, I’ll cover why transparency, even when uncomfortable, is always the better option. Self-Deception: We Lie to Ourselves From ancient society working out tedious and sometimes harmful ways to look more attractive, to the carefully curated social media accounts and “virtue signaling” of toda

Production 102

Production Marketing 102

Drugs.com

JANUARY 29, 2024

MONDAY, Jan. 29, 2024 -- High school students who smoke, drink or use weed are more likely to be emotionally troubled and have suicidal thoughts, a new study finds.Teens who turn to nicotine, alcohol or marijuana are more likely to think about.

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Science Daily: Pharmacology News

JANUARY 29, 2024

The James Webb Space Telescope observed 19 nearby face-on spiral galaxies in near- and mid-infrared light as part of its contributions to the Physics at High Angular resolution in Nearby GalaxieS (PHANGS) program.

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Drugs.com

JANUARY 29, 2024

MONDAY, Jan. 29, 2024 -- It’s not easy to lose weight, especially when facing a world filled with the temptation of tasty treats and rich, delicious meals.But being kind to yourself can make the difference when it comes to sticking to a diet, a.

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Science Daily: Pharmacology News

JANUARY 29, 2024

Artificial intelligence using neural networks performs calculations digitally with the help of microelectronic chips. Physicists have now created a type of neural network that works not with electricity but with so-called active colloidal particles.The researchers describe how these microparticles can be used as a physical system for artificial intelligence and the prediction of time series.

Research 97

Research 97

Drugs.com

JANUARY 29, 2024

MONDAY, Jan. 29, 2024 -- 'Young folk don't write in cursive anymore' is a common complaint of older folks in this keyboard-obsessed age.Now, new research suggests that kids who ignore handwriting are, in fact, missing out: By the time they reach.

Research 98

Research 98

Science Daily: Pharmacology News

JANUARY 29, 2024

Researchers found that when mice were fed a high-fat diet, mitochondria within their fat cells broke apart and were less able to burn fat, leading to weight gain. They also found they could reverse the effect by targeting a single gene, suggesting a new treatment strategy for obesity.

Treatment 96

Treatment Research 96

Drugs.com

JANUARY 29, 2024

MONDAY, Jan. 29, 2024 -- Marijuana has a reputation for being harmless, but frequent tokers are more likely to suffer from asthma, a new study shows.Asthma is more common among U.S. adults who’ve used weed within the past 30 days, researchers.

Research 98

Research 98

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Science Daily: Pharmacology News

JANUARY 29, 2024

The next generation of advanced telescopes could sharpen the hunt for potential extraterrestrial life by closely scrutinizing the atmospheres of nearby exoplanets, new research suggests.

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Research 85

Drugs.com

JANUARY 29, 2024

MONDAY, Jan 29, 2024 -- Fatty liver disease can cause liver damage and can be one health effect of long-term heavy drinking. Now, research shows that the illness can prove even more deadly for women who drink than for men.Also called steatotic.

Disease 98

Disease Research 98

SCIENMAG: Medicine & Health

JANUARY 29, 2024

Respiratory syncytial virus (RSV) is one of the main reasons leading to hospitalisation among young children worldwide and each year, an estimated 101,000 children below the age of 5 years die due to RSV infections [1].

Virus 87

Virus 87

Drugs.com

JANUARY 29, 2024

MONDAY, Jan. 29, 2024 -- It’s long been known that people with immune deficiencies are at increased risk for severe COVID.But a new study shows the threat varies dramatically based on how severe that immune suppression is and the reason behind.

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SCIENMAG: Medicine & Health

JANUARY 29, 2024

Researchers mapped genetic blueprints for 51 species including cats, dolphins, kangaroos, penguins, sharks, and turtles, a discovery that deepens our understanding of evolution and the links between humans and animals. Credit: Delphine Larivière, Penn State University.

Research 86

Research 86

Drugs.com

JANUARY 29, 2024

MONDAY, Jan. 29, 2024 -- Imagine being subjected to domestic violence in your home, wanting to escape -- but there's no place you can go that will accept a beloved pet.

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SCIENMAG: Medicine & Health

JANUARY 29, 2024

Previous studies focused on cocaine use have found that women are more likely than men to develop an addiction, try cocaine at a younger age, use larger amounts of the drug, and suffer from overdose.

Research 84

Research Drugs 84

Science Daily: Pharmacology News

JANUARY 29, 2024

The first analysis results now confirm that the grave in Tiarp is one of the oldest stone burial chambers in Sweden. The researchers noted that some parts of the people buried in the grave are missing, such as skulls and thigh bones, posing intriguing questions for archaeologists.

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Research 82

SCIENMAG: Medicine & Health

JANUARY 29, 2024

January is a time when many people are looking for new diet routines, and intermittent fasting is trending, as are traditional calorie cutting programs. Credit: Pennington Biomedical January is a time when many people are looking for new diet routines, and intermittent fasting is trending, as are traditional calorie cutting programs.

Research 84

Research 84

BioPharma Drive: Drug Pricing

JANUARY 29, 2024

An under-the-skin Opdivo shot produced similar results to an intravenous formulation in kidney cancer, giving Bristol Myers a chance at sustaining sales past a key patent expiration in 2028.

Trials 70

Trials 70

SCIENMAG: Medicine & Health

JANUARY 29, 2024

LA JOLLA, CA — Nerve cells in the brain demand an enormous amount of energy to survive and maintain their connections for communicating with other nerve cells.

Disease 89

Disease 89

Covalent Modifiers

JANUARY 29, 2024

Zifeng Tang, Jie Li, Lijie Peng, Fang Xu, Yi Tan, Xiaoqiang He, Chengjun Zhu, Zhi-Min Zhang, Zhang Zhang, Pinghua Sun, Ke Ding, and Zhengqiu Li Journal of Medicinal Chemistry 2024 DOI: 10.1021/acs.jmedchem.3c01608 Glutathione peroxidase 4 (GPX4) emerges as a promising target for the treatment of therapy-resistant cancer through ferroptosis. Thus, there is a broad interest in the development of GPX4 inhibitors.

Therapies 68

Therapies Pharmacokinetics Treatment 68

SCIENMAG: Medicine & Health

JANUARY 29, 2024

A University of Houston optometry researcher is warning against the use of low-level red light (LLRL) therapy as a method to control myopia, or nearsightedness, especially in children.

Therapies 72

Therapies Treatment Research 72

Covalent Modifiers

JANUARY 29, 2024

Trevor T. Dean, Juliet Jelú-Reyes, A’Lester C. Allen, and Terry W. Moore Journal of Medicinal Chemistry 2024 DOI: 10.1021/acs.jmedchem.3c01835 Building on recent advances in peptide science, medicinal chemists have developed a hybrid class of bioconjugates, called peptide–drug conjugates, that demonstrate improved efficacy compared to peptides and small molecules independently.

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Small Molecule Drugs Science Disease 68

Science Daily: Pharmacology News

JANUARY 29, 2024

Great whites, the largest predatory sharks in the world with the most fatal attacks on humans, are tough to imagine as newborn babies. That is partially because no one has seen one in the wild, it seems, until now.

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