Drug Discovery World

JULY 19, 2024

News round-up for 15-19 July by DDW Senior Digital Content Editor Diana Spencer. The chosen news stories this week all feature therapies that could have significant impact on the future treatment of cancer, particularly haematological malignancies, but also solid tumours. The top stories: Bacteriophage study offers new hope in treating GVHD Researchers from Japan have identified a bacteriophage-derived enzyme that holds promise for future applications in preventing or treating acute graft-versus

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Science Daily: Pharmacology News

JULY 19, 2024

A new study describes a chemical reaction that can convert Styrofoam into a high-value conducting polymer known as PEDOT:PSS. Researchers also noted that the upgraded plastic waste can be successfully incorporated into functional electronic devices, including silicon-based hybrid solar cells and organic electrochemical transistors.

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Drug Discovery World

JULY 19, 2024

Biotechnology company Draupnir Bio has received equity investments totalling €12 million to support the company’s work in the field of targeted protein degradation (TPD). TPD is a rapidly emerging field in drug development, exploiting a cell’s own destruction machinery to tackle disease-causing proteins that have historically been highly challenging to target with conventional therapies.

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Chemical Biology and Drug Design

JULY 19, 2024

Demethylcantharidin (DEM) is a widely used antitumor drug; however, its poor tumor targeting and serious organotoxicity limit its application. The aim of this study was to develop a new drug delivery system for efficient delivery of DEM. DEM, demethylcalcin; DNLNs, nanoemulsion based lipid nanoparticles containing demethylcantharidin; EPR, enhanced permeability and retention; PEG-400, polyethylene glycol 400.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

JULY 19, 2024

Dr Gloria Gonzalez-Aseguinolaza, Co-Founder & Chief Scientific Officer of Vivet Therapeutics, has been awarded the Rosalind Franklin Society (RFS) Special Award in Science given by Mary Ann Liebert, Inc. and the Rosalind Franklin Society. The award recognises Dr Gonzalez-Aseguinolaza’s remarkable contributions and dedication to advancing scientific knowledge.

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Science Daily: Pharmacology News

JULY 19, 2024

A new species of fossil snake unearthed in Wyoming is rewriting our understanding of snake evolution. The discovery, based on four remarkably well-preserved specimens found curled together in a burrow, reveals a new species named Hibernophis breithaupti. This snake lived in North America 34 million years ago and sheds light on the origin and diversification of boas and pythons.

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Drugs.com

JULY 19, 2024

FRIDAY, July 19, 2024 -- A German man has become the seventh person to apparently be cured of HIV, researchers report.The 60-year-old man, referred to as the “next Berlin Patient,” was treated with a stem cell transplant in October 2015 for acute my.

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Drug Discovery World

JULY 19, 2024

Scientists have created the first bioengineered bone marrow model which can support the type of human stem cells that are crucial for bone marrow transplants and in vitro study work. The research – published in Nature Communications and led by the University of Glasgow – replicates key aspects of the human bone marrow microenvironment, to enable the support of rare long-term hematopoietic stem cells, or LT-HSCs.

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Drugs.com

JULY 19, 2024

FRIDAY, July 19, 2024 -- It's long been known that popping the antibiotic doxycycline within 72 hours of a risky sexual encounter can greatly reduce a person's risk for a sexually transmitted infection (STI). In fact, the U.S. Centers for Disease.

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Disease 116

Broad Institute

JULY 19, 2024

An immune factor in the brain plays critical roles in neuron function and aging By Tom Ulrich July 19, 2024 Breadcrumb Home An immune factor in the brain plays critical roles in neuron function and aging Study highlights unexpected interactions between innate immune system and neurons, raises questions about additional roles for immune system in the brain with aging.

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Drugs.com

JULY 19, 2024

FRIDAY, July 19, 2024 -- Cancer growth can be fueled by flecks of ancient viral DNA lodged into the genetics of modern humans, a new study says.Overall, about 8% of the human genome is made of bits of DNA left behind by viruses that infected our.

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Fierce BioTech

JULY 19, 2024

InMed’s INM-901 Demonstrates Potential as a Multi-factorial Approach to Treating Alzheimer’s Disease jpiatt Fri, 07/19/2024 - 09:56

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Drugs.com

JULY 19, 2024

FRIDAY, July 19, 2024 -- Pudgy with a purpose: Fat cats could help humans better understand the way gut bacteria influences conditions like obesity and type 2 diabetes, a new study claims.Food-related changes in obese cats’ gut microbiome have s.

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BioPharma Drive: Drug Pricing

JULY 19, 2024

Federal filings showed no companies other than Lilly made an offer to buy Morphic, while Novartis executives said they’re still waiting for more data on pelabresib.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drugs.com

JULY 19, 2024

FRIDAY, July 19, 2024 -- Looking for a brand new smile?Many people with chipped, worn or indelibly stained teeth may ponder the possibility of veneers. They're wholly cosmetic, typically aren't covered by dental insurance and can cost thousands of.

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Perficient: Drug Development

JULY 19, 2024

Customers are demanding a personalized experience, and manufacturing is no different. One-size-fits-all manufacturing is now becoming a thing of the past. Today, we are seeing a decline in the mass production of identical products in exchange for personalization and niche products. As consumers intensify their expectations for on-demand personalization and delivery within days of purchase, marketplaces that offer wide ranges of options without sacrificing price or availability, like Amazon, have

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Drugs.com

JULY 19, 2024

FRIDAY, July 19, 2024 -- The U.S. Food and Drug Administration on Thursday authorized the sale of the country's best-selling e-cigarette.The agency's decision only applies to several tobacco-flavored versions of the reusable product, sold as Vuse.

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Drug Patent Watch

JULY 19, 2024

Dabigatran etexilate mesylate is the generic ingredient in two branded drugs marketed by Alkem Labs Ltd, Apotex, Hetero Labs Ltd Iii, and Boehringer Ingelheim and, and is included in five NDAs.

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Drugs.com

JULY 19, 2024

FRIDAY, July 19, 2024 -- Mushroom gummies being sold to promote brain function might instead contain harmful ingredients not listed on the label, including illicit psilocybin, the hallucinogen found in “magic” mushrooms, experts warn in new rep.

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KIF1A

JULY 19, 2024

Megan, Sloane’s mom, writes: Hello KAND Families! Sloane received her second ASO dose on June 6th. We were still in New York City. On the 5th we had her predose blood draws and her research EEG (the PT had a conflict so we had to move that to the 10th but typically there would also be a PT eval predose). Post dose on the 6th we were monitored in a recovery room and then moved to our overnight room.

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Drugs.com

JULY 19, 2024

FRIDAY, July 19, 2024 -- Many breast cancer patients aren’t getting genetic counseling and testing that could help them get the most effective treatment, a new study finds.Only three-quarters of patients eligible for genetic testing after their b.

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Drug Channels

JULY 19, 2024

Today’s guest post comes from Greg Skalicky, President, EVERSANA; Krista Pinto, President, Deployment Solutions, EVERSANA; and Faruk Abdullah, President, Professional Services & Chief Business Officer, EVERSANA Greg, Krista, and Faruk explain how and why integrated delivery networks (IDNs) have become crucial stakeholders for drug commercialization.

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Drugs.com

JULY 19, 2024

FRIDAY, July 19, 2024 -- Boredom is the key emotion behind most teens’ use of Instagram, a new study says.Teens open the app because they’re bored, then sift through its contents looking for interesting bits to relieve their boredom, researchers rep.

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Research 102

BioPharma Drive: Drug Pricing

JULY 19, 2024

At least 11 health systems were experiencing issues Friday after an update by cybersecurity firm CrowdStrike went awry.

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Hospitals 62

Drugs.com

JULY 19, 2024

THURSDAY, July 19, 2024 -- As good as many genetic tests might be, a deeper look at the DNA of over 44,000 people identified many who carried genes that hike their risks for cancer, researchers said."This study is a wake-up call, showing us that.

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Drug Patent Watch

JULY 19, 2024

Annual Drug Patent Expirations for CONTRAVE Contrave is a drug marketed by Nalpropion and is included in one NDA. It is available from one supplier.

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ASPET

JULY 19, 2024

Cardiovascular disease (CVD) remains one of leading causes of death worldwide. Aberrant platelet function mediate fibrin(ogen) rich thrombi that lead to occlusive thrombi associated with mortality. The receptor, TREM-like transcript-1 (TLT-1), stored in the platelet a-granules and released upon platelet activation, binds fibrinogen and von Willebrand factor.

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Drug Patent Watch

JULY 19, 2024

This chart shows the pharmaceutical companies with the most pellets dosed drugs. For a different perspective, see the most popular dosage types.

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ASPET

JULY 19, 2024

Cancer patients have an increased risk of venous thromboembolism (VTE) which is their second cause of death after disease progression itself. Several thrombotic risk factors coexist in cancer patients, including the ability of both cancer and tumoral microenvironment's cells to directly or indirectly activate platelets and the enzymes of the coagulation cascade, resulting in a hyper-coagulable state of blood.

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ASPET

JULY 19, 2024

Advanced-stage endometrial cancer patients typically receive a combination of platinum and paclitaxel chemotherapy. However, limited treatment options are available for those with recurrent disease, and there is a need to identify alternative treatment options for the advanced setting. Our goal was to evaluate the pre-clinical efficacy and mechanism of action of Oklahoma Nitrone 007 (OKN-007) alone and in combination with carboplatin and paclitaxel in endometrial cancer.

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