Drug Discovery World

SEPTEMBER 1, 2023

News round-up for 28 August – 1 September by DDW Digital Content Editor Diana Spencer. This week’s headline news features a stem-cell derived Parkinson’s therapy, a monoclonal antibody for head and neck cancer, an estrogen receptor degrader for breast cancer, a mitochondrial activator for long Covid, and the world’s first AI-designed bispecific T cell engager – reflecting the breadth of innovative approaches to disease being employed by researchers across the globe.

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Drugs.com

SEPTEMBER 1, 2023

FRIDAY, Sept. 1, 2023 -- A growing number of overdose deaths in the United States involve counterfeit pills, health officials reported Thursday. Overdose deaths involving counterfeit pills were twice as common in the latter half of 2021 as they were.

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Drug Discovery World

SEPTEMBER 1, 2023

A new study has provided insights into the biological mechanism that supports survival of hard-to-treat cancers. In the new study, led by scientists at The Institute of Cancer Research and published in Nature Communications , researchers identify a new cellular role of a protein called EXD2 nuclease and, importantly, its role in the so-called ALT (alternative lengthening of telomeres) pathway.

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Science Daily: Pharmacology News

SEPTEMBER 1, 2023

A new study finds that farmers in India have adapted to warming temperatures by intensifying the withdrawal of groundwater used for irrigation. If the trend continues, the rate of groundwater loss could triple by 2080, further threatening India's food and water security. Reduced water availability in India due to groundwater depletion and climate change could threaten the livelihoods of more than one-third of the country's 1.4 billion residents and has global implications.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

SEPTEMBER 1, 2023

This whitepaper discusses evidence-based selection of starting doses in first-in-human clinical trials through the utilisation of humanised mouse models and emphasises the importance of accurate dose prediction to ensure patient safety and trial success. In this whitepaper you will learn about: The significance of selecting appropriate starting doses in clinical trials.

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Clinical Trials Trials Drug Development Drugs 130

BioPharma Drive: Drug Pricing

SEPTEMBER 1, 2023

The Swiss pharma said, without details, that it observed “unprecedented” results that could make Alecensa the first treatment specifically available after surgery for ALK-positive lung tumors.

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NIOSH Science Blog: Drugs

SEPTEMBER 1, 2023

Labor Day often evokes thoughts about the end of summer and start of a new school year. It can be easy to forget that the origins of the holiday lie in the labor movement of the late nineteenth century when workers fought for their rights, including safer working conditions. A lot has changed since then and while we have made significant progress in improving worker safety and health, new challenges continue to arise as work and workplaces evolve.

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Research 107

Drug Discovery World

SEPTEMBER 1, 2023

The BioInnovation Institute (BII) has welcomed three new drug discovery start-ups into its Venture Lab acceleration programme as part of its latest cohort of eight companies. The 12-month Venture Lab programme is designed to support start-up companies with business acceleration, scientific and team development, and provides a founder-friendly convertible loan of €500,000 plus access to labs and offices at the BII in Copenhagen.

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Drugs.com

SEPTEMBER 1, 2023

FRIDAY, Sept. 1, 2023 -- Float therapy, where a patient is suspended in a pool of warm, salty water in a soundproof room, could help ease some aspects of anorexia nervosa, a small new study found. “The idea is that women with anorexia have.

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Drug Discovery World

SEPTEMBER 1, 2023

A Series B financing round has raised Genesis Therapeutics’ total capital to over $280 million, which will be used to bring the company’s artificial intelligence (AI)-enabled pipeline into clinical development. Genesis will also invest in continued development of generative and predictive AI methods, which form the foundation of the Genesis Exploration of Molecular Space (GEMS) platform.

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Drug Target Review

SEPTEMBER 1, 2023

Could you explain the fundamental distinction between autologous and allogeneic cell therapies and how they differ in terms of cell sourcing and application? Autologous immune cell therapy involves the grafting of a patient’s own immune cells. During this approach, immune cells are collected from a patient and expanded ex vivo to produce cells in large numbers that are ideally healthy and highly functional.

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Drug Patent Watch

SEPTEMBER 1, 2023

Annual Drug Patent Expirations for SPY+AGENT+GREEN+KIT Spy Agent Green Kit is a drug marketed by Novadaq Tech and is included in one NDA. It is available from one supplier. There… The post New patent for Novadaq Tech drug SPY AGENT GREEN KIT appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs.com

SEPTEMBER 1, 2023

FRIDAY, Sept. 1, 2023 -- Red tape is getting in the way of cancer patients receiving the treatment they crucially require, a new study has found. Patients were 18% more likely to experience cancer care delays or be unable to stick to a treatment.

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biobide

SEPTEMBER 1, 2023

Angiogenesis is a dynamic process by which blood vessels grow from pre-existing ones. The initial network is set up by vasculogenesis, the process of de novo formation of vessels, and becomes modified and grows by angiogenesis. Unlike most other organs, vasculature has a remarkable capacity to regenerate, and grow also in the adult organism, to efficiently repair damaged tissues.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

BioPharma Drive: Drug Pricing

SEPTEMBER 1, 2023

The settlement between Amgen and the FTC may reassure those in the industry who feared a more activist regulator would gum up dealmaking.

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Antidote

SEPTEMBER 1, 2023

As part of our efforts to better understand patients and their motivations to participate in clinical trials, Antidote and SCORR Marketing partnered on a survey to gain a deeper understanding of how patients think about the medical research process. Survey participants were recruited by eight of Antidote’s partners, including the American Kidney Fund, Allergy & Asthma Network, Healthline, JDRF, Lung Cancer Alliance, Lupus Research Alliance, Melanoma Research Alliance, and the Multiple Sclero

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On Medicine

SEPTEMBER 1, 2023

“I’d consider myself low risk now, because I’ve got my sugars under control and I don’t wear sandals anymore” (Nick, 55-year-old male, had T1 diabetes for 32 years, two toes amputated, and a third under treatment for an infected cut). Awareness of diabetic foot ulcer risk is often limited and underestimated, even in those at the highest risk. One problem associated with diabetes is changes in nerve function (neuropathy).

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Engineering Production Treatment Research 92

SCIENMAG: Medicine & Health

SEPTEMBER 1, 2023

EAST LANSING, Mich. – Backed by a $26 million federal grant, researchers at three Michigan universities, a leading health care system, and a state agency will continue a long-term study of how exposure to environmental factors during pregnancy and early childhood can impact health for a lifetime. Credit: Courtesy photo Michigan State University.

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Science Daily: Pharmacology News

SEPTEMBER 1, 2023

New research by an international team of scientists explains what's behind a stalled trend in Arctic Ocean sea ice loss since 2007. The findings indicate that stronger declines in sea ice will occur when an atmospheric feature known as the Arctic dipole reverses itself in its recurring cycle. The many environmental responses to the Arctic dipole are described in a recent article.

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SCIENMAG: Medicine & Health

SEPTEMBER 1, 2023

People without a secure job contract can reduce their risk of premature death by 20 per cent if they gain permanent employment, a study from Karolinska Institutet published in The Journal of Epidemiology and Community reports. According to the researchers, the results indicate that job security on the Swedish labour market needs to improve.

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Marketing Research 88

Drugs.com

SEPTEMBER 1, 2023

FRIDAY, Sept. 1, 2023 -- Nursing homes will soon have to meet federal minimum staffing requirements, the U.S. Department of Health and Human Services (HHS) announced Friday. "Establishing minimum staffing standards for nursing homes will improve.

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Nurses Government Regulations 85

SCIENMAG: Medicine & Health

SEPTEMBER 1, 2023

We are constantly exposed to phthalates in our environment through plastic products such as storage containers, medical devices, packages, fabrics, and toys. Specifically, di-isononyl phthalate is inevitably becoming a part of our lives. Unfortunately, the impact of DiNP on the establishment and maintenance of pregnancy is largely unknown.

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Packaging Production Research 87

Drugs.com

SEPTEMBER 1, 2023

FRIDAY, Sept. 1, 2023 -- A continuous positive airway pressure (CPAP) machine can relieve not only sleep apnea but the heartburn and chronic cough that often accompanies it, a new study finds. People who suffer from sleep apnea are three times more.

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SCIENMAG: Medicine & Health

SEPTEMBER 1, 2023

UMC Utrecht will lead an international consortium that will try to answer a key question that’s in the mind of many pediatricians, infectiologists, pulmonologists and other health professionals: “Why are children that had an RSV infection in early childhood at increased risk of developing asthma later in life?

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Cytel

SEPTEMBER 1, 2023

Data is the cornerstone of any clinical trial, driving the decision-making process of drug development, and is a fundamental requirement for approval of new therapies by regulatory agencies like the FDA or EMA. But generating high-quality data is far from straightforward, and a gap in quality could negatively impact clinical development timelines and add additional costs for sponsors.

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BioPharma Drive: Drug Pricing

SEPTEMBER 1, 2023

The newly posted documents show the agency had concerns about the side effects experienced by people with clinical depression who took Sage’s drug, Zurzuvae.

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Drug Patent Watch

SEPTEMBER 1, 2023

Annual Drug Patent Expirations for NUMBRINO Numbrino is a drug marketed by Cody Labs Inc and is included in one NDA. It is available from one supplier. The generic ingredient… The post New patent for Cody Labs drug NUMBRINO appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs.com

SEPTEMBER 1, 2023

FRIDAY, Sept. 1, 2023 -- Infants born three to six weeks early -- considered late preterm -- are at risk for learning problems, but they can be overcome, researchers say. Preschool attendance and sensitive parenting can help them bridge the gap.

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Drug Patent Watch

SEPTEMBER 1, 2023

Annual Drug Patent Expirations for REZZAYO Rezzayo is a drug marketed by Cidara Theraps and is included in one NDA. It is available from one supplier. There are five patents… The post New patent for Cidara Theraps drug REZZAYO appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs.com

SEPTEMBER 1, 2023

FRIDAY, Sept. 1, 2023 – Along with having to deal with the social stigma of having a parent who is incarcerated, young adults in that situation may be more likely to develop signs of heart trouble, a new study finds. The health impacts of having a.

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Perficient: Drug Development

SEPTEMBER 1, 2023

Introduction: In today’s world, we see that many businesses are emerging everywhere. It can be of any type. It establishes and grows. And, to grow, it requires customers and customers require satisfaction. Both things are interdependent. To keep a healthy relationship with customers, businesses use CRM (Customer Relationship Management) tool. Collecting feedbacks from customers is a smart way to keep good relationship with customers.

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Production 59

Predictive Oncology

SEPTEMBER 1, 2023

“Pamela’s unwavering passion for a cancer cure paved the way for an incredible opportunity to directly make a difference in the lives of countless people,” Molecule to Market podcast. In this episode of Molecule to Market, host Raman Sehgal talks with Pamela Bush, Ph.D., MBA, Chief Business Officer of Predictive Oncology, about the breakthrough technology that Predictive Oncology offers.

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Perficient: Drug Development

SEPTEMBER 1, 2023

Are you ready to unlock the full potential of B2B commerce? Mark your calendar for September 7 th as Perficient participates in Optimizely’s virtual B2B Commerce Summit 2023. Across 2022 and 2023, economic headwinds have affected the growth of B2B vendors. Specifically, vendors are struggling with the rising cost of inflation, supply chain disruptions, and labor shortages, all while tasked with launching and increasing results from online commerce.

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Agency IQ

SEPTEMBER 1, 2023

FDA finalizes guidance on oversight of RWE studies, making several significant changes The FDA today finalized a much-anticipated guidance document on how sponsors of drugs and biologics can oversee and make use of their non-interventional studies involving real-world data and evidence. While the FDA mostly ignored suggestions from more than two dozen companies and trade groups, it managed to make several significant changes to the guidance that seem to solve one major problem and create a poten

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