Chemical Biology and Drug Design

AUGUST 24, 2023

Resveratrol alleviated Aβ-induced neuronal apoptosis, inflammatory reaction, oxidative stress, and endoplasmic reticulum stress via circ_0050263/miR-361-3p/PDE4A axis. Abstract Resveratrol (Res) has been identified to reduce neurodegeneration. Circular RNAs (circRNAs) are stable noncoding RNAs that are considered to be ideal biomarkers for molecular targeting treatment.

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FDA Law Blog: Biosimilars

AUGUST 24, 2023

Hyman, Phelps & McNamara, P.C. (“HP&M”) is is proud to announce that 14 of the Firm’s attorneys have been selected to the 2024 edition of The Best Lawyers in America®. Newly recognized this year are attorneys Josephine M. Torrente (FDA Law), Michelle L. Butler (FDA Law), Sara W. Koblitz (FDA Law), Allyson B. Mullen (FDA Law), and Anne K. Walsh (FDA Law), as well as McKenzie E.

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Chemical Biology and Drug Design

AUGUST 24, 2023

Key mitochondrial folate enzyme, methylene tetrahydrofolate dehydrogenase 2 (MTHFD2) plays crucial role in targeting folate cycle in cancer. Formate flux from mitochondria to cytosol cause folate trap-induced toxicity to kill MTHFD2-expressing cancer cell, with the MTHFD1 inhibitor. Metabolomics studies show ambiguity in data analysis if growth media is not chosen properly.

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Perficient: Drug Development

AUGUST 24, 2023

The transition from a wholesale-centric business model to include a new direct-to-consumer (D2C) approach presents lucrative opportunities alongside a suite of technical and operational intricacies to consider. While the move brings manufacturing companies closer to end consumers, it also requires several considerations spanning content creation, post-purchase support, and overall brand experience.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Target Review

AUGUST 24, 2023

The focus of this study is on Growth Differentiation Factor-15 (GDF-15), a cytokine known for its critical role in feto-maternal tolerance, which has now been found to be hijacked by tumours to evade immune attack. We will explore how GDF-15 impacts the tumour microenvironment and hinders the infiltration of T cells into the tumour, as well as the implications of neutralising GDF-15 to reverse its inhibitory effects and sensitise tumours to anti-PD-1 treatment.

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Drugs.com

AUGUST 24, 2023

THURSDAY, Aug. 24, 2023 -- Cancer patients with immune systems weakened by treatment are among the groups most concerned about the continued spread of COVID-19 and the chance of the infection becoming severe. New research suggests more guidance on.

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Drugs.com

AUGUST 24, 2023

THURSDAY, Aug. 24, 2023 -- Stroll past the supplements in any drugstore and you’ll find broad claims about fish oil helping everything from heart and brain health, to joints, eyes and immune systems.

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BioPharma Drive: Drug Pricing

AUGUST 24, 2023

Bristol Myers Squibb is among those backing the startup, which claims the manufacturing capacity at its New Jersey plant can surpass that of conventional CDMO facilities.

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Drugs.com

AUGUST 24, 2023

THURSDAY, Aug. 24, 2023 -- Anyone who has quickly slurped up a milkshake or chomped on a snow cone knows the sharp, brief pain of "brain freeze." Its cause is a mystery, but it’s not harmful, according to experts at University of Texas.

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BioPharma Drive: Drug Pricing

AUGUST 24, 2023

The subsidiary, called Cordavis, will work directly with manufacturers to market or co-produce low-cost biologic drugs, starting with Novartis’ Humira copy.

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Drugs.com

AUGUST 24, 2023

THURSDAY, Aug. 24, 2023 -- Public health officials have detected the new BA.2.86 variant of COVID-19 in U.S. wastewater, giving rise to concerns about the highly mutated variant in the United States. The U.S. Centers for Disease Control and.

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BioPharma Drive: Drug Pricing

AUGUST 24, 2023

The deal, worth up to $500 million, is a bet by the drug rights dealmaker on the uncertain commercial prospects of Ferring's gene therapy Adstiladrin.

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Drugs.com

AUGUST 24, 2023

THURSDAY, Aug. 24, 2023 -- With 2023 predicted to be the hottest year on record, a new study is pointing to another potential consequence of heat waves: faster declines in older adults' memory and thinking skills. The study, of nearly 9,500 older.

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Science Daily: Pharmacology News

AUGUST 24, 2023

The first three weeks of July 2023 have been the hottest global three-week period so far. Researchers report that the European population's exposure to heat was highest in Italy.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drugs.com

AUGUST 24, 2023

THURSDAY, Aug. 24, 2023 -- The American middle-class squeeze has grown even worse in recent years, with many in the “forgotten middle” facing financial pressure and poor health as they near retirement age, a new study.

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Science Daily: Pharmacology News

AUGUST 24, 2023

Emperor penguin colonies experienced unprecedented breeding failure in a region of Antarctica where there was total sea ice loss in 2022. The discovery supports predictions that over 90% of emperor penguin colonies will be quasi-extinct by the end of the century, based on current global warming trends.

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Drugs.com

AUGUST 24, 2023

THURSDAY, Aug. 24, 2023 -- AI might not always be your most accurate source of health information, especially when it comes to cancer care, new research finds. Two new studies assessed the quality of responses offered by AI chatbots to a variety of.

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Science Daily: Pharmacology News

AUGUST 24, 2023

Scientists have developed a flexible battery as thin as a human cornea, which stores electricity when it is immersed in saline solution, and which could one day power smart contact lenses.

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Fierce BioTech

AUGUST 24, 2023

The MedTech Conference Expand your horizon and register for medtech’s annual reunion, The MedTech Conference! As the leading gathering of the community's brightest, MedTechCon unites executives, innovators, investors, policymakers, and more in the spirit of collaboration. Explore the agenda and plan your MTC journey now! mteefey Thu, 08/24/2023 - 12:45 The MedTech Conference unites global medtech executives and innovators from across the industry to discuss critical topics, share visions for the

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Science Daily: Pharmacology News

AUGUST 24, 2023

Researchers have discovered a novel approach for engrafting engineered cells into injured lung tissue. These findings may lead to new ways for treating lung diseases, such as emphysema, pulmonary fibrosis and COVID-19. The two studies describe the methodologies for engineering lung stem cells and transplanting them into injured experimental lungs without immunosuppression.

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Drug Patent Watch

AUGUST 24, 2023

Annual Drug Patent Expirations for TRINTELLIX Trintellix is a drug marketed by Takeda Pharms Usa and is included in one NDA. It is available from three suppliers. There are ten… The post New patent for Takeda Pharms drug TRINTELLIX appeared first on DrugPatentWatch - Make Better Decisions.

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Science Daily: Pharmacology News

AUGUST 24, 2023

A global team of scientists conducted one of the largest genetic association studies on heart failure to date. Using genomic data from over 90,000 heart failure patients and more than a million controls, the team identified 39 genetic mutations associated with heart failure, 18 of which had not been reported previously.

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Drug Patent Watch

AUGUST 24, 2023

Annual Drug Patent Expirations for LYBALVI Lybalvi is a drug marketed by Alkermes Inc and is included in one NDA. It is available from one supplier. There are ten patents… The post New patent for Alkermes Inc drug LYBALVI appeared first on DrugPatentWatch - Make Better Decisions.

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Science Daily: Pharmacology News

AUGUST 24, 2023

Using ESO's Very Large Telescope (VLT), astronomers have observed a large dark spot in Neptune's atmosphere, with an unexpected smaller bright spot adjacent to it. This is the first time a dark spot on the planet has ever been observed with a telescope on Earth. These occasional features in the blue background of Neptune's atmosphere are a mystery to astronomers, and the new results provide further clues as to their nature and origin.

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Drug Patent Watch

AUGUST 24, 2023

Annual Drug Patent Expirations for LATISSE Latisse is a drug marketed by Abbvie and is included in one NDA. It is available from one supplier. There are eight patents protecting… The post New patent expiration for Abbvie drug LATISSE appeared first on DrugPatentWatch - Make Better Decisions.

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Science Daily: Pharmacology News

AUGUST 24, 2023

A bitter taste in the mouth is often a symptom or side effect of illness, which may be the result of how the body reacts to pathogens. A new study sheds light on the mechanisms involved in the complex interplay between taste perception and immune function. Their work also highlights the potential of a sequencing tool for investigating epigenetic mechanisms that affect taste-cell gene expression.

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Drug Patent Watch

AUGUST 24, 2023

Annual Drug Patent Expirations for EPCLUSA Epclusa is a drug marketed by Gilead Sciences Inc and is included in two NDAs. It is available from two suppliers. There are fifteen… The post New patent for Gilead Sciences drug EPCLUSA appeared first on DrugPatentWatch - Make Better Decisions.

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Broad Institute

AUGUST 24, 2023

Agenda By Rose Circeo August 24, 2023 Breadcrumb Home Machine Learning in Drug Discovery Symposium Agenda 08:00 - 08:50 am Registration/breakfast 08:50 - 09:00 AM Opening Remarks Keynote 09:00 - 10:00 am Keynote Daphne Koller CEO and Founder Insitro Morning session 10:00 - 10:40 am Rethinking molecular modeling Imran Haque Senior Vice President, AI and Digital Sciences Recursion 10:40 - 10:55 am Break and poster viewing 10:55 - 11:15 am Lightning talks from selected poster presenters 11:15 - 11:

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Drugs.com

AUGUST 24, 2023

THURSDAY, Aug. 24, 2023 -- For the first time in a decade, the rate at which American adolescents received the human papillomavirus (HPV) vaccine has not increased, new data show. Current guidelines from the U.S. Centers for Disease Control and.

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Covalent Modifiers

AUGUST 24, 2023

Lara Ibrahim, Caroline Stanton, Kayla Nutsch, Thu Nguyen, Chloris Li-Ma, Yeonjin Ko, Gabriel C. Lander, R. Luke Wiseman, Michael J. Bollong Cell Chemical Biology, 2023 [link] Cross talk between metabolism and stress-responsive signaling is essential for maintaining cellular homeostasis. This cross talk is often achieved through covalent modification of proteins by endogenous, reactive metabolites that regulate key stress-responsive transcription factors like NRF2.

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Drugs.com

AUGUST 24, 2023

THURSDAY, Aug. 24, 2023 (American Heart Association News) -- Holly Page was having a great day. She got her hair done, then enjoyed a long dinner catching up with friend Lisa Stillings. They were walking out of the restaurant when something strange.

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Perficient: Drug Development

AUGUST 24, 2023

Today, we are excited to announce a new partnership with Writer, the leading generative AI platform for enterprises. This collaboration marks a significant milestone for both companies as we join forces to drive unparalleled value for our clients. Every client challenge, use case, and internal dynamics are unique, but most organizations are looking for the right generative AI solution.

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Drugs.com

AUGUST 24, 2023

THURSDAY, Aug. 24, 2023 -- Mothers use sing-song language to talk to their infants. Their dogs respond to it, too, according to a new study. Researchers in Hungary also found that dogs have greater brain sensitivity to the speech directed at them.

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Collaborative Drug

AUGUST 24, 2023

Vault Snack #20 - Manage Protocol/Assay Definitions in CDD Vault

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