Forbes: Drug Truths
DECEMBER 15, 2023
These renewed attacks on biopharma continue to erode its reputation, thereby handicapping the industry’s ability to develop new cures and to confront any new pandemic. That will negatively impact us all.
Chemical Biology and Drug Design
DECEMBER 15, 2023
The figure depicts the neuroprotective role of exendin-4 in Alzheimer's disease and Parkinson's disease. Abstract Neurodegenerative disorders, which affect millions worldwide, are marked by a steady decline of neurons that are selectively susceptible. Due to the complex pathological processes underlying neurodegeneration, at present, there is no viable therapy available for neurodegenerative disorders.
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Drug Discovery World
DECEMBER 15, 2023
The Oxford Vaccine Group (OVG), which led the development of the Oxford vaccine for Covid-19, has been awarded a total of £7.8 ($9.8) million by UK Aid for research into the prevention of five diseases with epidemic or pandemic potential. The awards will fund research into vaccines against Chikungunya and mayaro virus, Marburg virus, Plague (Yersinia pestis), Q Fever (Coxiella burneti) and Sudan Ebolavirus.
Chemical Biology and Drug Design
DECEMBER 15, 2023
In an effort to identify new lead compounds with potential anticancer properties for further optimization, in vitro assays combined with in-silico target fishing and docking studies have been used to identify and further map out the antiproliferative and potential mode of action of molecules from a small library of compounds previously prepared in our laboratory.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Drug Discovery World
DECEMBER 15, 2023
News round-up for 11-15 December by DDW Digital Content Editor Diana Spencer. Our news highlights this week focus on haematology, thanks in part to a number of key announcements at the 65th American Society for Hematology meeting (ASH) Annual Meeting, including real-world evidence on the use of CAR-T therapies in blood cancers and new data for myeloma and lymphoma treatments.
Chemical Biology and Drug Design
DECEMBER 15, 2023
This study revealed that dihydromyricetin (DHM) could inhibit hepatic stellate cell activation and ECM deposition in vitro. Through network pharmacology prediction and in vitro cell experiments verification, it was evidenced that DHM protected against liver fibrosis by acting on the MMP2, PDGFRB, PARP1, CYP2E1, SQSTM1, IL6, and ABCB1 genes and their downstream signaling pathways, including the mTOR and MAPK signaling pathways.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Drugs.com
DECEMBER 15, 2023
FRIDAY, Dec. 15, 2023 -- A new melanoma vaccine has shown its mettle in battling the deadly skin cancer in a new trial. People with advanced melanomas who received the vaccine plus Merck's cancer drug Keytruda were 49% less likely to die or have.
Science Daily: Pharmacology News
DECEMBER 15, 2023
A new study suggests that it's not Rudolph's red nose that helps reindeer find food during snowy Arctic winters, but instead a unique adaptation of their eyes to their favorite food. Reindeer may have developed their unique ability to see in the ultraviolet spectrum so they can more easily spot their primary food, the algae-fungus fusion known as lichens -- which absorb UV -- in the winter landscape.
Drugs.com
DECEMBER 15, 2023
FRIDAY, Dec. 15, 2023 -- Low vaccination rates for the flu, RSV and COVID-19 are putting Americans at higher risk for severe illness and hospitalization this winter, a new government alert warned Thursday.There is an “urgent need” to boost.
Drug Patent Watch
DECEMBER 15, 2023
Annual Drug Patent Expirations for RAPIVAB Rapivab is a drug marketed by Biocryst and is included in one NDA. It is available from one supplier. There are three patents protecting… The post New patent expiration for Biocryst drug RAPIVAB appeared first on DrugPatentWatch - Make Better Decisions.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Drugs.com
DECEMBER 15, 2023
FRIDAY, Dec. 15, 2023 -- Federal agents have seized more than 1.4 million illegal vaping products being smuggled into the United States from China. A three-day operation at Los Angeles International Airport resulted in the seizure of 41 shipments.
biobide
DECEMBER 15, 2023
In the realm of modern biology, understanding the intricate machinery of life demands a comprehensive approach. "Omics" technologies, are a suite of methods that enable the study of biological molecules on a grand scale, gathering the complexity of living systems and revolutionizing their comprehension.
Elrig
DECEMBER 15, 2023
In this interview by AZoNetwork, Jordi Carreras Puigvert shares insights into his groundbreaking research, the unique aspects of Phenaros Pharmaceuticals' drug discovery platform, and the synergy between academia and industry. The post From Cells to Drugs: How Cell Painting is Transforming Drug Discovery first appeared on ELRIG.
Drugs.com
DECEMBER 15, 2023
FRIDAY, Dec. 15, 2023 -- American physicians have mixed feelings on the advent of artificial intelligence (AI) into mainstream medical practice, a new survey shows.The survey of nearly 1,100 doctors, conducted by the American Medical Association.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Drug Channels
DECEMBER 15, 2023
This week, I’m rerunning some popular posts while I prepare for today’s Drug Channels Outlook 2024 live video webinar. My topic #9 for 2024: The Battle Over 340B Gets Even Messier. Click here to see the original post from September 2023. Drug Channels has just obtained new details on the size of the 340B Drug Pricing Program. I couldn’t wait to share the news, hence this special Sunday post.
Drugs.com
DECEMBER 15, 2023
FRIDAY, Dec. 15, 2023 -- People who've lost a leg due to injury or disease are often plagued by what's known as phantom limb pain -- discomfort arising in the area, despite the absence of the limb.Now, researchers report that people who wear a.
SCIENMAG: Medicine & Health
DECEMBER 15, 2023
EMBARGOED UNTIL FRI, DEC. 15 – 5:00 A.M. Eastern Credit: Medical College of Wisconsin NEWS RELEASE EMBARGOED UNTIL FRI, DEC. 15 – 5:00 A.M. Eastern Contact Colleen McDonald – Sr. Consultant, Earned Media 414.801.3146 | cmcdonald@mcw.edu Trip or Treat?
Drugs.com
DECEMBER 15, 2023
FRIDAY, Dec. 15, 2023 -- Hours plunked down in front of the TV or staring at a phone screen in childhood could bring poor heart health decades later, a new study shows. Finnish researchers say kids who were largely sedentary tended to turn into.
SCIENMAG: Medicine & Health
DECEMBER 15, 2023
In a first-of-its-kind study for North America, scientists accumulated a list of potential invasive species for Florida, and researchers deemed 40 pose the greatest threat. Credit: UF/IFAS In a first-of-its-kind study for North America, scientists accumulated a list of potential invasive species for Florida, and researchers deemed 40 pose the greatest threat.
Drugs.com
DECEMBER 15, 2023
FRIDAY, Dec. 15, 2023 -- Patients with advanced heart failure can benefit from stem cell therapy, a large, new clinical trial has found.Injections of stem cells programmed to heal damaged heart tissue wound up improving overall quality of life for.
SCIENMAG: Medicine & Health
DECEMBER 15, 2023
BALTIMORE, December 14, 2023– In a landmark study led by the University of Maryland School of Medicine, researchers discovered for the first time that a certain kind of protein similar to hemoglobin, called cytoglobin, plays an important role in the development of the heart.
Drugs.com
DECEMBER 15, 2023
FRIDAY, Dec. 15, 2023 -- Smoking shrinks the human brain, and once that brain mass is lost then it’s gone for good, a new study warns.Brain scans from more than 32,000 people strongly link a history of smoking with a gradual loss of brain volume.
SCIENMAG: Medicine & Health
DECEMBER 15, 2023
Major depressive disorder affects 16.1 million adults in the United States and costs $210 billion annually. While the primary symptoms of depression are psychological, scientists and doctors have come to understand that depression is a complex disease with physical effects throughout the body.
Science Daily: Pharmacology News
DECEMBER 15, 2023
A team of astronomers has used asteroseismology, or the study of stellar oscillations, to accurately measure the distance of stars from the Earth. Their research examined thousands of stars and checked the measurements taken during the Gaia mission to study the near Universe.
Drug Patent Watch
DECEMBER 15, 2023
Dasatinib is the generic ingredient in two branded drugs marketed by Apotex and Bristol Myers Squibb and is included in three NDAs. There are two patents protecting this compound. Drug… The post New tentative approval for Teva Pharms drug dasatinib appeared first on DrugPatentWatch - Make Better Decisions.
SCIENMAG: Medicine & Health
DECEMBER 15, 2023
Cerebral organoids are three-dimensional, in vitro cultured brains that mimic the activities of the human brain. They have emerged as invaluable tools to comprehend evolution, disease pathogenesis, and neurodevelopmental processes. However, the development of these organoids is still in nascent stages with several limitations that hinder their broad applications.
BioPharma Drive: Drug Pricing
DECEMBER 15, 2023
Welireg, which Merck got through its purchase of Peloton Therapeutics, can now be used to treat an advanced form of kidney cancer, adding to an earlier clearance in a rare genetic disease.
Drug Patent Watch
DECEMBER 15, 2023
Icosapent ethyl is the generic ingredient in two branded drugs marketed by Apotex, Dr Reddys, Hikma, Strides Pharma, Teva Pharms Usa, Zydus, and Amarin Pharms and, and is included in… The post New tentative approval for Ascent Pharms drug icosapent ethyl appeared first on DrugPatentWatch - Make Better Decisions.
BioPharma Drive: Drug Pricing
DECEMBER 15, 2023
While a positive recommendation for the gene editing treatment Casgevy was expected, a clearance for Biogen’s Skyclaris, acquired through a recent acquisition, was no sure bet.
Drugs.com
DECEMBER 15, 2023
FRIDAY, Dec. 15, 2023 -- “Long COVID” has become a well-known potential consequence of COVID infection, with symptoms that can last weeks, months or even years.Now it appears that “long flu” is also possible, with some patients developing.
BioPharma Drive: Drug Pricing
DECEMBER 15, 2023
Jay Bradner, a well-known physician-scientist who left Novartis last year amid an organizational shakeup, will now serve a Amgen’s chief scientific officer and head of R&D.
SCIENMAG: Medicine & Health
DECEMBER 15, 2023
Frontiers for Young Minds, the award-winning, open-access scientific journal for kids, has published the first articles in a new collection in collaboration with CERN, one of the world’s largest centers for scientific research. The collection, entitled SPARK-ing big questions: what is the future of health technology?, addresses key questions on how ground-breaking health technologies and science can improve human health for future generations.
Drug Patent Watch
DECEMBER 15, 2023
Annual Drug Patent Expirations for TRULANCE Trulance is a drug marketed by Salix and is included in one NDA. It is available from two suppliers. There are eight patents protecting… The post New patent for SALIX drug TRULANCE appeared first on DrugPatentWatch - Make Better Decisions.
Agency IQ
DECEMBER 15, 2023
The 60-day comment period on the FDA’s proposed rule to revamp the way that laboratory developed tests (LDTs) are regulated ended on December 4th, 2023. Based on AgencyIQ’s review of available comments, it’s clear that key stakeholders are generally opposed to the rule for a wide range of significant reasons. We have some high-level takeaways for our readers in the piece below.
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