Drug Discovery World

JULY 16, 2024

Scientists at the University of Sydney and Liverpool School of Tropical Medicine have revealed that a commonly used blood thinner, heparin, can be repurposed as an inexpensive antidote for cobra venom. Cobras kill thousands of people a year worldwide and many more are seriously maimed by necrosis caused by the venom, which can lead to amputation. The World Health Organization has announced a goal of reducing the global burden of snakebite in half by 2030.

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Chemical Biology and Drug Design

JULY 16, 2024

This study provides preliminary elucidation of multiple pharmacological targets, biological processes and signaling pathways of VD against TC. These findings offer valuable insights for future therapeutic strategies targeting TC. Abstract Thyroid cancer (TC) is one of the most common endocrine malignancies worldwide. Increasing evidence suggests that vitamin D (VD) has potential benefits in the treatment of TC.

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Drug Discovery World

JULY 16, 2024

Younger workers in the UK are increasingly choosing careers in pharmaceuticals over other industries like technology or finance due to perceptions of better work life balance and social purpose in the sector. This is according to a new report ‘Young people’s perceptions of careers in the pharmaceutical industry’, commissioned by the Association of the British Pharmaceutical Industry (ABPI).

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Chemical Biology and Drug Design

JULY 16, 2024

Several Bruton's tyrosine kinase (BTK) inhibitors have been shown in studies to be effective in the inhibition of biological activity analysis and in animal models. This review focuses on the BTK inhibition mechanism and its possible impact on immune-mediated disease, as well as the types being investigated for RA, preclinical and clinical investigations and future research opportunities.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

JULY 16, 2024

There is limitless scope for generative AI to transform regulatory processes. But where to start? ArisGlobal’s Agnes Cwienczek and Renato Rjavec describe use cases where AI is already delivering tangible everyday benefits. As life sciences companies’ investments in regulatory data capture, enrichment and exchange continue to rise in line with agency mandates, the potential scope for artificial intelligence (AI) and generative AI seems limitless in its promise to transform labour-intensive proces

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Science Daily: Pharmacology News

JULY 16, 2024

For the first time, scientists have found that sleep can be detected by patterns of neuronal activity just milliseconds long, 1000 times shorter than a second, revealing a new way to study and understand the basic brain wave patterns that govern consciousness.

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BioPharma Drive: Drug Pricing

JULY 16, 2024

The well-funded startup says drugs AbbVie abandoned last year could form a combination regimen with “superior efficacy” to Vertex’s market-leading medicines.

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Drugs.com

JULY 16, 2024

TUESDAY, July 16, 2024 -- Being regular is good for you, a new study shows.Predictable bowel movements could be tied to your long-term health, allowing your body to absorb essential nutrients without producing harmful organ-damaging toxins.

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Drug Patent Watch

JULY 16, 2024

Introduction Patent oppositions are a crucial tool in the pharmaceutical industry, allowing civil society to challenge the validity of patents […] Source

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Drugs.com

JULY 16, 2024

TUESDAY, July 16, 2024 -- As millions of American teens continue to struggle with their mental health, a new survey reveals a sizable gap between how much support teens say they get and how much support their parents think they are getting. In the.

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Clinical Trials

Science Daily: Pharmacology News

JULY 16, 2024

A strange 'garden sprinkler-like' jet coming from a neutron star has been pictured for the first time. The S-shaped structure is created as the jet changes direction due to the wobbling of the disc of hot gas around the star -- a process called precession, which has been observed with black holes but, until now, never with neutron stars.

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Drugs.com

JULY 16, 2024

TUESDAY, July 16, 2024 -- An experimental blood test might be able to predict whether glaucoma patients will continue to lose their vision following treatment, researchers report.A biochemical called nicotinamide adenine dinucleotide (NAD) tends to.

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Science Daily: Pharmacology News

JULY 16, 2024

Tantalizing evidence of potential dark matter objects has been detected with the help of the Universe's 'timekeepers'. These pulsars -- neutron stars which rotate and emit lighthouse-like beams of radio waves that rapidly sweep through space -- were used to identify mysterious hidden masses. Pulsars earned their nickname because they send out electromagnetic radiation at very regular intervals, ranging from milliseconds to seconds, making them extremely accurate timekeepers.

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Drugs.com

JULY 16, 2024

TUESDAY, July 16, 2024 -- The stress of living in a poor neighborhood might contribute to higher rates of aggressive prostate cancer in Black men, a new study warns.Black men are more than twice as likely to die from prostate cancer than white men.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Science Daily: Pharmacology News

JULY 16, 2024

Astronomers have uncovered what appear to be 21 neutron stars in orbit around stars like our Sun. The discovery is surprising because it is not clear how a star that exploded winds up next to a star like our Sun.

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BioPharma Drive: Drug Pricing

JULY 16, 2024

In the suit, Vertex argues HHS’ stance forces a “Hobson’s choice” on people with sickle cell seeking to undergo the potentially curative treatment.

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Science Daily: Pharmacology News

JULY 16, 2024

Researchers have developed a new technique that pairs artificial intelligence and X-ray science.

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BioPharma Drive: Drug Pricing

JULY 16, 2024

The Merck KGaA spinout has a tau-regulating medicine it claims could be an “ideal therapy” for Alzheimer’s. The pitch has intrigued both healthcare investors and pharma venture arms.

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Science Daily: Pharmacology News

JULY 16, 2024

A new study of radar experiment data from the Cassini-Huygens mission to Saturn has yielded fresh insights related to the makeup and activity of the liquid hydrocarbon seas near the north pole of Titan, the largest of Saturn's 146 known moons.

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Drugs.com

JULY 16, 2024

TUESDAY, July 16, 2024 -- Early exposure to antibiotics might increase a kid’s risk of asthma by altering their gut bacteria, a new mouse study finds.Antibiotics could specifically lower gut production of indole propionic acid (IPA), a biochemical t.

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Production 59

Science Daily: Pharmacology News

JULY 16, 2024

A new global assessment of scientific literature finds that nature-based solutions (NbS) are an economically effective method to mitigate risks from a range of disasters -- from floods and hurricanes to heatwaves and landslides -- which are only expected to intensify as Earth continues to warm.

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BioPharma Drive: Drug Pricing

JULY 16, 2024

The deal gives Vertex rights to use Orum’s ADC-like technology to discover gentler preparatory regimens for patients receiving intensive treatments like Casgevy.

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addgene Blog

JULY 16, 2024

There are several facilities nationwide where you can obtain excellent quality, high titer rAAV ( including Addgene! ), but you can also generate rAAVs in your own lab with standard molecular biology tools and tissue culture experience. Here, we’ll go over the basics of rAAV production.

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BioPharma Drive: Drug Pricing

JULY 16, 2024

The financing, which ranks as one of the year’s larger private rounds, will help the startup advance a pair of drugs and potentially acquire other medicines.

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Drug Patent Watch

JULY 16, 2024

Dabigatran etexilate mesylate is the generic ingredient in two branded drugs marketed by Alkem Labs Ltd, Apotex, Hetero Labs Ltd Iii, and Boehringer Ingelheim and, and is included in five NDAs.

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Fierce BioTech

JULY 16, 2024

Launching a Product in Europe: Understanding Supply Chain Cost Drivers This paper explores the costs of setting up a supply chain in Europe for a new biopharma therapy. It outlines key cost drivers & the various levers decision makers can use to affect those costs. lbarrick Tue, 07/16/2024 - 14:15 This paper explores the costs of setting up a supply chain in Europe for a new biopharma therapy.

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Drugs.com

JULY 16, 2024

TUESDAY, July 16, 2024 -- Women who've undergone stem cell treatments for blood cancers, or for illnesses such as sickle cell disease, can successfully bring a pregnancy to term, new research shows.The German findings run counter to the perceived.

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Drug Channels

JULY 16, 2024

Last week, the Federal Trade Commission (FTC) released its interim report on pharmacy benefit managers (PBMs). The report’s unsubtle subtitle revealed how the agency views PBMs: The Powerful Middlemen Inflating Drug Costs and Squeezing Main Street Pharmacies. ICYMI, the FTC's report relied extensively on the Drug Channels Institute's (DCI's) 2024 Economic Report on U.S.

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Drugs.com

JULY 16, 2024

TUESDAY, July 16, 2024 -- There's good news and bad for stroke survival in the United States: New research shows that Americans are now more likely to survive long-term, but that's more true for whites than for Black Americans.At least for a sample.

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thought leadership

JULY 16, 2024

The key to successful drug development in the US is directional and focused navigation of FDA’s Investigational New Drug (IND) process. The Chemistry, Manufacturing, and Controls (CMC) section is a critical component of an IND submission and is integral to US regulatory applications.

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Drugs.com

JULY 16, 2024

TUESDAY, July 16, 2024 -- An experimental blood test could help detect pregnant women at increased risk for preeclampsia, a serious high blood pressure condition that can harm both mother and child.Researchers report the test looks at genetic.

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Drug Patent Watch

JULY 16, 2024

This chart shows the pharmaceutical drugs with the greatest number of patents still in force.

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Drugs.com

JULY 16, 2024

TUESDAY, July 16, 2024 -- People's odds for Long COVID appear to be declining with the advent of new variants of the virus, along with repeat infections and vaccinations, new research shows.That suggests that the average person's chances of.

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PPD

JULY 16, 2024

Our recent white paper explores the many ways in which a functional service provider (FSP) engagement delivers key pharmacovigilance (PV) capabilities necessary across the product life span and across different geographical regions. Many pharma, biotech and medical device companies rely on FSP partnerships for comprehensive and cost-effective PV regulatory intelligence (RI), including: Monitoring for changes Analyzing and interpreting regulations and guidance Communicating requirements and opera

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