Chemical Biology and Drug Design

NOVEMBER 27, 2023

Compound ZYZ384 could selectively inhibit the growth of gefitinib-resistant (G-R) lung cancer cells by activating JNK/MAPK signaling pathway, without affecting that of normal lung epithelial cells. Abstract The emergency of tyrosine kinase inhibitors has remarkably enhanced the clinical outcomes of cancer therapy, especially the use of EGFR inhibitors for non-small cell lung cancer (NSCLC).

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Science Daily: Pharmacology News

NOVEMBER 27, 2023

The intensity and frequency of extreme rainfall increases exponentially with global warming, a new study finds. The analysis shows that state-of-the-art climate models significantly underestimate how much extreme rainfall increases under global warming -- meaning that extreme rainfall could increase quicker than climate models suggest.

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Chemical Biology and Drug Design

NOVEMBER 27, 2023

A new AChE inhibitor named A6 with antitumor activity was identified. A6 significantly disrupted the amino acid metabolism, inhibited migration and invasion and induced apoptosis of MCF-7. A6 affected the whole genome pattern. A6 play anticancer role by regulating Best1 and HIST1H2BJ. Abstract Acetylcholinesterase (AchE) is a serine hydrolase with classical function to degrade acetylcholine and terminate neurotransmission.

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Antidote

NOVEMBER 27, 2023

The cornea is the outermost layer of the human eye, serving both as a protective covering and allowing light into the retina. To perform this function, the cornea is made up of several layers, the outermost of which is known as the epithelium.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Chemical Biology and Drug Design

NOVEMBER 27, 2023

Bruceine A (BA) inhibits breast cancer proliferation and metastasis through inducing autophagy by targeting PI3K-AKT pathway. Abstract Although there have been significant advances in cancer treatment, the urgent need to inhibit breast cancer metastasis remained unmet. Bruceine A (BA) is a natural compound extracted from Bruceae Fructus and has long been recognized to have antitumor effects with high safety and biocompatibility.

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Treatment Therapies Research 100

BioPharma Drive: Drug Pricing

NOVEMBER 27, 2023

One year after the U.K. drugmaker withdrew the multiple myeloma drug from the U.S. market because of negative data, new study results might crack open the door to a relaunch.

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FDA Law Blog: Biosimilars

NOVEMBER 27, 2023

By Riëtte van Laack & Anne K. Walsh — Although the Consumer Product Safety Act (CPSA) has been around for over 50 years to “protect the public against unreasonable risks of injury associated with consumer products,” it was not until 2008 that the statute was amended to authorize the Consumer Product Safety Commission (“CPSC”) to impose criminal liability against individual directors, officers, or agents of a corporation for violating the CPSA.

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Production Government Trials Marketing 104

Drugs.com

NOVEMBER 27, 2023

MONDAY, Nov. 27, 2023 (Healthday News) -- Three more brands of cantaloupe have been recalled by U.S. health officials after salmonella infections linked to the fruit more than doubled in just a week.The case count now includes nearly 100 people in.

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On Medicine

NOVEMBER 27, 2023

On the International Day of Persons with Disabilities , it is important to make sure that we think about ALL people with disabilities. Children and young people with Profound and Multiple Learning Disabilities (PMLD) are some of the most vulnerable young people in our society. Children and young people with PMLD usually have complex health conditions and need help with many areas of daily life.

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Drugs.com

NOVEMBER 27, 2023

MONDAY, Nov. 27, 2023 -- People with long COVID exhibit brain changes that are different from the brains of fully recovered COVID-19 patients, a new brain scan study reports.COVID-19 induced a specific pattern of microscopic structural changes in.

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SCIENMAG: Medicine & Health

NOVEMBER 27, 2023

An innovative stem cell-based treatment for Type 1 diabetes can meaningfully regulate blood glucose levels and reduce dependence on daily insulin injections, according to new clinical trial results from the University of British Columbia (UBC) and Vancouver Coastal Health (VCH).

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Drugs.com

NOVEMBER 27, 2023

MONDAY, Nov. 27, 2023 -- Squats and lunges aren’t the most fun exercises, but a new study says they’ll help save your knees.Folks with strong quads building up their thighs appear to be less likely to require a total knee replacement, according.

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Drug Target Review

NOVEMBER 27, 2023

What role does the eIF4F complex play in cancer, and how do your STRIs target it? eIF4F is a critical biomolecular complex that plays a central role in cancer development and progression. It is responsible for initiating the translation of specific messenger RNAs (mRNAs) into proteins within cells. These proteins are often oncogenes or other factors that have a profound effect on cells, including driving cancer cell growth, proliferation, and survival.

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Drugs.com

NOVEMBER 27, 2023

MONDAY, Nov. 27, 2023 — In a disease cluster last year, one infected but asymptomatic man spread a rare form of syphilis that affects the eyes to five Michigan women, a new report finds.Since ocular syphilis remains very rare, researchers believe.

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SCIENMAG: Medicine & Health

NOVEMBER 27, 2023

If you’ve had a near miss accident in your car or suffered the intimidation of a menacing person, you’ve probably felt it — a psychological reaction to a threat called a fight or flight response. Your heart rate climbs, anxiety washes over you, you might shake or sweat.

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Drugs.com

NOVEMBER 27, 2023

MONDAY, Nov. 27, 2023 -- When it comes to the ultra-fine particles you may breathe in from polluted air, all is not created equal as it affects your health. Fine particle pollutants known PM2.5 -- particles that are 2.5 microns or less in.

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SCIENMAG: Medicine & Health

NOVEMBER 27, 2023

Osaka, Japan – The global impact of the coronavirus pandemic has ignited a renewed focus on emerging and re-emerging infectious diseases. Researchers at Osaka Metropolitan University are making great strides in combating pneumococcal pneumonia, one of the leading causes of respiratory deaths worldwide.

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Conversations in Drug Development Trends

NOVEMBER 27, 2023

By: Amy Raymond, PMP, PhD, Senior Director, Therapeutic Strategy Lead, Cellular & Genetic Medicines On November 16, the British regulatory body, Medicines and Healthcare products Regulatory Agency (MHRA) approved exagamglogene autotemcel (exa-cel) to treat severe sickle cell disease for patients ages 12 and up, becoming the first gene editing treatment to receive regulatory approval.

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SCIENMAG: Medicine & Health

NOVEMBER 27, 2023

Dietary food intake has a major influence on health indicators, including Body Mass Index (BMI), blood pressure, serum cholesterol and glucose. Previous research has shown that decisions to purchase specific food items are primarily based on taste and cost.

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Research 80

NIOSH Science Blog: Drugs

NOVEMBER 27, 2023

Law enforcement officers (LEOs) face many workplace hazards. Current research does not include a complete picture of nonfatal injuries that officers sustain while on-duty. Workers’ compensation (WC) data are an underutilized source for occupational injury surveillance in the law enforcement field. A recently published research article explored patterns and characteristics of workers’ compensation injury claims over a 19-year period among LEOs in Ohio.

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Science Daily: Pharmacology News

NOVEMBER 27, 2023

An international team has shown that the injection of a type of stem cell into the brains of patients living with progressive multiple sclerosis (MS) is safe, well tolerated and has a long-lasting effect that appears to protect the brain from further damage.

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SCIENMAG: Medicine & Health

NOVEMBER 27, 2023

PITTSBURGH, Nov. 27, 2023 – Common neuropsychiatric symptoms that doctors see in Alzheimer’s disease patients originate from brain inflammation rather than amyloid and tau proteins, report University of Pittsburgh School of Medicine researchers today in JAMA Network Open. Credit: UPMC PITTSBURGH, Nov.

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Drugs.com

NOVEMBER 27, 2023

MONDAY, Nov. 27, 2023 — Repeated COVID-19 outbreaks in nursing homes have had a stark and lasting impact on vulnerable older residents, a new study reports.Long COVID has left many residents of these facilities relying more and more on staff to.

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BioPharma Drive: Drug Pricing

NOVEMBER 27, 2023

Yet, the company believes there were enough positive findings in the mid-stage trial to warrant further study of its drug, called XEN1101, in depression.

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Drug Patent Watch

NOVEMBER 27, 2023

Annual Drug Patent Expirations for TWINJECT+0.15 Twinject 0.15 is a drug marketed by Impax and is included in one NDA. It is available from four suppliers. There are two patents… The post New patent for IMPAX drug TWINJECT 0.15 appeared first on DrugPatentWatch - Make Better Decisions.

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BioPharma Drive: Drug Pricing

NOVEMBER 27, 2023

Results from the second of two Phase 3 trials testing the blockbuster drug in the respiratory condition showed treatment could reduce attacks and improve lung function.

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Drug Patent Watch

NOVEMBER 27, 2023

Annual Drug Patent Expirations for ADRENACLICK Adrenaclick is a drug marketed by Impax and is included in one NDA. It is available from four suppliers. There are two patents protecting… The post New patent for IMPAX drug ADRENACLICK appeared first on DrugPatentWatch - Make Better Decisions.

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Agency IQ

NOVEMBER 27, 2023

Today, more than a decade after Congress required the FDA to publish such a regulation, the FDA finalized a rule that will require direct-to-consumer drug advertisements to ensure that the “major statement” of drug risks and side effects is presented in a “clear, conspicuous, and neutral manner.” The changes, which should take effect in mid-2024, should result in drug ads with fewer distracting elements and more emphasis on the major risks of the drug.

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Drug Patent Watch

NOVEMBER 27, 2023

Annual Drug Patent Expirations for TWINJECT+0.3 Twinject 0.3 is a drug marketed by Impax and is included in one NDA. It is available from four suppliers. There are two patents… The post New patent for IMPAX drug TWINJECT 0.3 appeared first on DrugPatentWatch - Make Better Decisions.

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Agency IQ

NOVEMBER 27, 2023

The European Chemicals Agency is attempting to guide scientific research toward topics with regulatory relevance. Its latest report serves as a powerful indicator for what EU chemical regulation is likely to resemble in the coming years should the agency receive sufficient scientific support to meet four regulatory challenges ECHA just can’t solve without further progress from the scientific community.

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BioPharma Drive: Drug Pricing

NOVEMBER 27, 2023

The planned $2.3 billion investment follows an earlier $6 billion commitment to expand manufacturing for drugs like its in-demand medicine Wegovy.

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Production Drugs 62

Agency IQ

NOVEMBER 27, 2023

A new FDA-commissioned report provides recommendations on the next steps in managing cybersecurity risks for medical devices. The FDA, industry and international regulators have been working to determine which policies may mitigate cybersecurity risks for “legacy” medical devices no longer supported by manufacturers. The report offers recommendations that focus more on filling knowledge and infrastructure gaps and less on potential guidance for device manufacturers.

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Broad Institute

NOVEMBER 27, 2023

Sam Peng - Core Institute Member By Rose Circeo November 27, 2023 Breadcrumb Home Sam Peng - Core Institute Member Sam Peng , a core member at the Broad Institute, describes his lab's work developing novel probes and microscopy techniques that enable long-term imaging in living systems. Peng talks about his multidisciplinary approach to research, and the opportunity his lab's probes offer for improved understanding of how molecules interact in disease.

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Agency IQ

NOVEMBER 27, 2023

The California Office of Environmental Health Hazard Assessment has added coal-tar pitch, fluoro-edenite fibrous amphibole, and silicon carbide whiskers to the Proposition 65 list. Fill out the form to read the full article.

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