NIOSH Science Blog: Drugs
NOVEMBER 20, 2023
In May, the U.S. Surgeon General, Vice Admiral Vivek Murthy, MD, MBA, released Our Epidemic of Loneliness and Isolation: The U.S. Surgeon General’s Advisory on the Healing Effects of Social Connection and Community calling for a whole-of-society approach to address the epidemic of loneliness and isolation.1 Below we briefly highlight information from the Advisory and its implications for worker well-being.
Chemical Biology and Drug Design
NOVEMBER 20, 2023
GAA slows the progression of osteoarthritis by blocking the ER stress and NF-κB pathway. Abstract Osteoarthritis (OA) is a prevalent degenerative pathology, however, there exists a lack of cost-effective pharmacological interventions that efficaciously inhibit its progression. ganoderic acid A (GAA), a triterpenoid derived from Ganoderma lucidum, possesses antiapoptotic and -inflammatory effects.
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BioPharma Drive: Drug Pricing
NOVEMBER 20, 2023
Called Evinova, the unit will operate as a separate business within AstraZeneca, which sees digital health solutions as a market primed for growth.
Chemical Biology and Drug Design
NOVEMBER 20, 2023
We employed a combined strategy involving molecular docking-based virtual screening, molecular dynamics (MD) simulation, and MM/GBSA free energy calculation on existing FDA-approved drugs. Sorafenib and glimepiride simultaneously downregulated c-Maf protein expression to induce G1 phase arrest and apoptosis in myeloma cells. Abstract Multiple myeloma (MM) is a prevalent plasma cell malignancy in the blood system that remains incurable.
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The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Drug Target Review
NOVEMBER 20, 2023
A team of scientists at Mass General Brigham in the US has developed a visualisation tool combining high-speed cameras, that can detect changes happening in a billionth of a second, and FDA-approved fluorescent injections to distinguish tumour tissue from normal tissue across several cancer types. The researchers reported that this technique was over 97 percent accurate across tumour types.
Chemical Biology and Drug Design
NOVEMBER 20, 2023
The HIV-1 Gag MA domain binds not only to phosphatidylinositol 4,5-bisphosphate (Di-C 7 -PIP2 derivative is in use), a cell membrane component but also to another phospholipid, cardiolipin (Tetra-C 7 -CL derivative), with two phosphate ester bonds and four fatty acid moieties. Abstract The human immunodeficiency virus type 1 (HIV-1) Gag protein is responsible for facilitating HIV-1 virion assembly and budding.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Drugs.com
NOVEMBER 20, 2023
MONDAY, Nov. 20, 2023 -- The song says ‘tis the season to be jolly, but many Americans find it to be more the season of stress and worry, a new survey reports. The strain of inflation and world affairs this year are adding to the other.
Science Daily: Pharmacology News
NOVEMBER 20, 2023
Scientists have shown that placing physical constraints on an artificially-intelligent system -- in much the same way that the human brain has to develop and operate within physical and biological constraints -- allows it to develop features of the brains of complex organisms in order to solve tasks.
Drugs.com
NOVEMBER 20, 2023
MONDAY, Nov. 20, 2023 -- A minimally invasive procedure that's long been used to ease headaches and irregular heartbeats might also restore a sense of smell to people who lost it after COVID, new research shows. The 10-minute procedure is called a.
SCIENMAG: Medicine & Health
NOVEMBER 20, 2023
CHAPEL HILL, N.C. – The Centers for Disease Control and Prevention report that autism is becoming more common in young children. In an effort to improve the challenges young autistic children face as part of their early development, researchers have focused on developing and evaluating nonpharmaceutical interventions that can be provided in early childhood.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Drugs.com
NOVEMBER 20, 2023
MONDAY, Nov. 20, 2023 -- Middle-aged folks with lots of belly fat surrounding their internal organs appear to be at higher risk for Alzheimer’s disease later in life, a new study suggests. This hidden abdominal fat -- known as visceral fat --.
Science Daily: Pharmacology News
NOVEMBER 20, 2023
Using 700 years' worth of wave data from more than a billion waves, scientists have used artificial intelligence to find a formula for how to predict the occurrence of these maritime monsters. Long considered myth, freakishly large rogue waves are very real and can split apart ships and even damage oil rigs.
Drugs.com
NOVEMBER 20, 2023
MONDAY, Nov. 20, 2023 -- It’s not simple traveling if you have heart disease, but a chronic condition needn’t keep someone from seeing friends and family during the holidays, the American Heart Association (AHA) says. Most people only.
Science Daily: Pharmacology News
NOVEMBER 20, 2023
New research combined both physiological and archaeological evidence to argue that not only did prehistoric women engage in the practice of hunting, but their female anatomy and biology would have made them intrinsically better suited for it.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Drugs.com
NOVEMBER 20, 2023
MONDAY, Nov. 20, 2023 -- Lab-grown blood vessels are providing new insight into how damage to the tiny vessels in the brain can cause them to leak, contributing to dementia and stroke. Even better, this research has identified a drug target that.
SCIENMAG: Medicine & Health
NOVEMBER 20, 2023
A global study of major crops has found that farmworkers are being increasingly exposed to combinations of extreme heat and humidity during planting and harvest seasons that can make it hard for them to function. Such conditions have nearly doubled across the world since 1979, the authors report, a trend that could eventually hinder cultivation.
Drugs.com
NOVEMBER 20, 2023
MONDAY, Nov. 20, 2023 -- A new 'technopill' can safely monitor a person’s vital signs from inside their bodies, researchers report. The vitals-monitoring (VM) Pill works by tracking the small vibrations in the body associated with lungs.
Science Daily: Pharmacology News
NOVEMBER 20, 2023
Psychologists used music to manipulate emotions of volunteers and found the dynamics of their emotions molded otherwise neutral experiences into memorable events. The tug of war between integrating memories and separating them helps to form distinct memories, allowing people to understand and find meaning in their experiences, and retain information.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
BioPharma Drive: Drug Pricing
NOVEMBER 20, 2023
Biopharma companies capture data across a variety of different fronts and, so this data must be managed effectively in order to unlock business efficiencies and drive improvements.
SCIENMAG: Medicine & Health
NOVEMBER 20, 2023
A groundbreaking study recently published in JAMA indicates that aspirin may not be necessary as part of an antithrombotic regimen for patients with a fully magnetically levitated left ventricular assist device (LVAD). Ochsner Health surgical director for the Mechanical Assist Device Circulatory Support Program, Dr.
Drugs.com
NOVEMBER 20, 2023
MONDAY, Nov. 20, 2023 -- A new round of four free COVID-19 tests is available for order from the federal government, the U.S. Postal Service announced Monday. The free additional tests are being made available as health officials prepare for an.
SCIENMAG: Medicine & Health
NOVEMBER 20, 2023
According to Thailand’s Ministry of Public Health, approximately 18-24 million or 30-40 percent of the Thai population carries the thalassemia gene, with moderately severe thalassemia patients requiring regular treatment, including blood transfusion and chelation therapy to remove excess iron from the blood.
Science Daily: Pharmacology News
NOVEMBER 20, 2023
Using the James Webb Space Telescope, CECILIA Survey receives first data from galaxies forming two-to-three billion years after the Big Bang. By examining light from these 33 galaxies, researchers discovered their elemental composition and temperature. The ultra-deep spectrum revealed eight distinct elements: Hydrogen, helium, nitrogen, oxygen, silicon, sulfur, argon and nickel.
SCIENMAG: Medicine & Health
NOVEMBER 20, 2023
Falls are the leading cause of both fatal and nonfatal injuries in the United States for adults ages 65 and older. With 1 in 4 older adults falling annually, 27,000 deaths, 8 million emergency department (ED) visits, and 800,000 hospitalizations have occurred.
BioPharma Drive: Drug Pricing
NOVEMBER 20, 2023
Company shares fell by one-fifth after study monitors called for halting a planned 18,000-person trial because Bayer’s experimental drug wasn’t working as well as Eliquis.
Drugs.com
NOVEMBER 20, 2023
MONDAY, Nov. 20, 2023 (Healthday News) -- Expert advice and self-help books are officially passé: Social media is where nearly all new parents now go for guidance on potty training, sleep issues and toddler tantrums, a new poll shows. Four.
biobide
NOVEMBER 20, 2023
Background on the Cosmetics industry In 2022, the value of the global cosmetics market was estimated to be worth USD 262.21 billion, with an annual growth of 4.2% projected by the year 2030. The justification for this growth projection lies in the increased popularity and demand for skincare and personal care products, joined by the aging of global population.
Drugs.com
NOVEMBER 20, 2023
MONDAY, Nov. 20, 2023 -- It's been around for a century, and electroconvulsive therapy -- formerly known as electroshock therapy -- has helped countless people with psychiatric conditions feel better. But even the physicians who've used it have had.
Drug Patent Watch
NOVEMBER 20, 2023
This chart shows the drugs with the most patents in Chile. Patents must be filed in each country (or, in some cases regional patent office) where patent protection is desired.… The post Which pharmaceutical drugs have the most drug patents in Chile? appeared first on DrugPatentWatch - Make Better Decisions.
Agency IQ
NOVEMBER 20, 2023
FDA’s Sentinel Initiative, the post-market, real-world data surveillance system, is nearing the end of its current five-year strategic plan. During an annual update on the program and its various workstreams, regulators and researchers discussed ongoing projects at Sentinel, its work under the current Prescription Drug User Fee authorization (PDUFA) program and next steps in using active surveillance for regulatory purposes.
Drug Patent Watch
NOVEMBER 20, 2023
Annual Drug Patent Expirations for PROMACTA+KIT Promacta Kit is a drug marketed by Novartis and is included in one NDA. It is available from one supplier. There are three patents… The post New patent expiration for Novartis drug PROMACTA KIT appeared first on DrugPatentWatch - Make Better Decisions.
Agency IQ
NOVEMBER 20, 2023
The EPA’s Office of Pesticide Programs (OPP) is in the developmental stage of creating a structured pesticide and digital pesticide label. Both labels would provide the framework for the consistent placement and order of the regulated portions of pesticide label information, with the digital label organizing the contents as data. EPA asserts the adoption of these labels will streamline the submission and review processes thereby saving time and resources.
Drug Patent Watch
NOVEMBER 20, 2023
Annual Drug Patent Expirations for PROMACTA Promacta is a drug marketed by Novartis and is included in two NDAs. It is available from one supplier. There are eight patents protecting… The post New patent expiration for Novartis drug PROMACTA appeared first on DrugPatentWatch - Make Better Decisions.
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