Chemical Biology and Drug Design

DECEMBER 11, 2023

The paper reviews the structure and peptide-like inhibitors of SARS-CoV-2 M pro , also the binding mode and structure—activity relationship between the inhibitors and M pro are introduced in detail. It is hoped that this review can provide ideas and help for the development of anti-coronavirus drugs such as COVID-19, and help to develop broad-spectrum antiviral drug for the treatment of coronavirus diseases as soon as possible.

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BioPharma Drive: Drug Pricing

DECEMBER 11, 2023

AbbVie’s blockbuster medicine topped a list of treatments that, combined, elevated U.S. healthcare spending by $1.3 billion in 2022, according to the price watchdog’s latest yearly report.

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Treatment 117

NIOSH Science Blog: Drugs

DECEMBER 11, 2023

♪ Frosty the Worker, Is a jolly happy soul, With his big warm boots and his warm-up breaks, The cold cannot take its toll. ❄ ♪Hypothermia and chilblains, May be fairy tales one day, Cuz’ with training and prevention, Frostbite can be kept at bay.❄ ♪It really isn’t magic when, A warm wool hat is worn, For with proper gear there is no fear, When an employer plan is formed.❄ ♪Oh, Frosty the Worker, We’ll keep you warm when you’re outside, Take breaks and layer your clothing, And we’re sure that you

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Drugs.com

DECEMBER 11, 2023

MONDAY, Dec. 11, 2023 -- Loss of the “happiness” brain hormone serotonin might play a role in the decline of brain function as a person ages, a new study reports.People with mild cognitive impairment (MCI) had up to 25% lower levels of.

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Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Perficient: Drug Development

DECEMBER 11, 2023

Why Okta? Who can forget Okta ? It is basically a household name at many enterprise companies. Even if you don’t know about Okta, you probably recognize the name. Okta is a cloud-based identity and access management platform that provides secure user authentication and authorization services. It enables organizations to manage and control access to various software applications, systems, and data resources across multiple devices and networks.

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Drugs.com

DECEMBER 11, 2023

MONDAY, Dec. 11, 2023 -- The holidays are all about parties, and parties are all about drinking wine. But if you're a red wine lover, how do you avoid stained teeth?“When you drink red wine, you’re encountering a triple threat to your teeth’s.

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Drugs.com

DECEMBER 11, 2023

MONDAY, Dec. 11, 2023 -- An outbreak of deadly tick-borne disease is occurring among people who’ve recently been to Baja California in Mexico, the U.S. Centers for Disease Control and Prevention warns. Three out of five patients have died.

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SCIENMAG: Medicine & Health

DECEMBER 11, 2023

Considerable attention has focused on mental illness as a major contributor to homicides in the United States. Serious mental illness affects more than 14 million Americans ages 18 and older and nearly 58 million people reported having a mental illness.

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Research 91

Drugs.com

DECEMBER 11, 2023

MONDAY, Dec. 11, 2023 -- In response to the ongoing crisis of opioid misuse, U.S. doctors had already cut the amount of opioids they gave patients after surgery by 2022 to just a third of the amount given in 2016, new research shows.Much of the.

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SCIENMAG: Medicine & Health

DECEMBER 11, 2023

On December 11, 2023, UC San Diego Health successfully completed the purchase of Alvarado Hospital Medical Center from Prime Healthcare. The acquisition of the 302-bed medical facility greatly expands the university’s growing network of clinics and hospitals to better serve patients with safe, timely and equitable access to high-quality health care.

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Hospitals 89

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Collaborative Drug

DECEMBER 11, 2023

Explore key insights from the Pistoia Alliance's FAIR Data & Assay Annotation webinar. Discover the latest in bioassay data management and standardization.

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SCIENMAG: Medicine & Health

DECEMBER 11, 2023

In agricultural and remote sensing research, accurately estimating wheat’s Leaf Area Index (LAI) using unmanned aerial vehicle-based multispectral data is essential for monitoring crop health and growth. Traditionally, LAI measurement is accurate but laborious. Recent advancements have introduced hybrid methods combining radiative transfer models with machine learning, showing promise due to their efficiency and applicability.

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Research 87

Drugs.com

DECEMBER 11, 2023

MONDAY, Dec. 11, 2023 -- Nurses are less likely to discharge still-recovering Black patients to home health care than white patients, a new study has found.About 22% of Black patients are referred to home health care by discharge nurses, compared.

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SCIENMAG: Medicine & Health

DECEMBER 11, 2023

Jacques Morcos, MD, a renowned neurosurgeon from University of Miami Health System, will join UTHealth Houston as the new chair of the Vivian L. Smith Department of Neurosurgery with McGovern Medical School at UTHealth Houston, effective today.

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Medical Schools 85

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Clinical Trials

Science Daily: Pharmacology News

DECEMBER 11, 2023

A striking and extremely rare half-female, half-male bird has been spotted by a zoologist.

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SCIENMAG: Medicine & Health

DECEMBER 11, 2023

BUFFALO, N.Y. – University at Buffalo research has identified how a misstep in the genesis of a key component of the kidney causes infantile cystinosis, a rare disease that significantly shortens the lifespan of patients. Published Nov.

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Drugs.com

DECEMBER 11, 2023

MONDAY, Dec. 11, 2023 -- When an HIV-infected child known as the 'Mississippi baby' was given powerful antiretroviral drugs within hours of birth in 2013 and then appeared to be rid of HIV, people wondered if it might be replicated in other.

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Drugs 75

SCIENMAG: Medicine & Health

DECEMBER 11, 2023

WASHINGTON (Dec. 11, 2023)–A new study published in Proceedings of the National Academy of Sciences Nexus provides a better understanding of how the brain responds to injuries. Researchers at the George Washington University discovered that a protein called Snail plays a key role in coordinating the response of brain cells after an injury.

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Science Research 77

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

FDA Law Blog: Biosimilars

DECEMBER 11, 2023

By Allyson B. Mullen — With comments due on the proposed LDT rule last week, FDA wasted no time updating the Unified Agenda to indicate that a final rule may be published in April ( here ). We take this date with a grain of salt given the frequency with which these dates are missed and given the volume of comments filed. (It is not entirely clear how many comments were actually logged in; on December 7, FDA showed 19,655 comments, and the next day 6,732.

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Drug Patent Watch

DECEMBER 11, 2023

Annual Drug Patent Expirations for AUSTEDO+XR Austedo Xr is a drug marketed by Teva and is included in one NDA. It is available from one supplier. There are nine patents… The post New patent for TEVA drug AUSTEDO XR appeared first on DrugPatentWatch - Make Better Decisions.

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Covalent Modifiers

DECEMBER 11, 2023

Qianni Peng, Eranthie Weerapana Cell Chemical Biology , 2023 DOI: [link] The nucleus controls cell growth and division through coordinated interactions between nuclear proteins and chromatin. Mutations that impair nuclear protein association with chromatin are implicated in numerous diseases. Covalent ligands are a promising strategy to pharmacologically target nuclear proteins, such as transcription factors, which lack ordered small-molecule binding pockets.

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Small Molecule DNA Regulations Disease 63

Agency IQ

DECEMBER 11, 2023

As we round the corner into the last few weeks of 2023, AgencyIQ has taken a look back at a very busy year for the FDA’s oncology staff, and for sponsors. By our count, the FDA’s Oncologic Drugs Advisory Committee held seven meetings in 2023; additionally, the Oncology Center of Excellence authored nine new (draft) and six final guidance documents. Read on for a deep dive into the major themes in oncology this past year.

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FDA Drugs 64

Drug Channels

DECEMBER 11, 2023

This week, I’m rerunning some popular posts while I prepare for Friday’s Drug Channels Outlook 2024 live video webinar. Click here to see the original post from September 2023. One update: CVS Caremark's 2024 formulary for patient-administered autoimmune products prefers: Humira Hyrimoz (the high WAC Sandoz biosimilar) adalimumab-adaz (the unbranded, low WAC Sandoz biosimilar) Perhaps coincidentally, Sandoz products are marketed by Cordavis, the new business described in today's rerun.

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BioPharma Drive: Drug Pricing

DECEMBER 11, 2023

A return to profitable growth is on the horizon—organizations that take advantage of the following key trends can thrive in 2024 and beyond.

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Drug Patent Watch

DECEMBER 11, 2023

This chart shows the pharmaceutical companies with the most supplementary protection certificates (SPCs) in Sweden. SPCs are used in European Union and select others to encourage pharmaceutical innovation by compensating… The post Which pharmaceutical companies have the most SPCs in Sweden? appeared first on DrugPatentWatch - Make Better Decisions.

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Pharmaceutical Companies Pharmaceuticals 59

Agency IQ

DECEMBER 11, 2023

A variety of cities and municipalities have rejected a proposed settlement with several producers of per- and polyfluoroalkyl substances. This AgencyIQ analysis reviews some of the reasons that the cities and municipalities have rejected the settlement, and what could be next for PFAS litigation in the United States. Fill out the form to read the full article.

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Drug Patent Watch

DECEMBER 11, 2023

Annual Drug Patent Expirations for PRADAXA Pradaxa is a drug marketed by Boehringer Ingelheim and is included in two NDAs. It is available from four suppliers. There are four patents… The post New patent for Boehringer Ingelheim drug PRADAXA appeared first on DrugPatentWatch - Make Better Decisions.

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Reprocell

DECEMBER 11, 2023

Finding a suitable human iPSC (hiPSCs) line is the first step of many disease modeling and cell therapy projects. Once a suitable donor has been found and hiPSCs have been generated, certain quality control (QC) measures of the cell culture to verify its identity and quality are crucial. If portions of the QC are missing or deviate from the standard, the results acquired with these cells may be unusable or may produce misleading conclusions.

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Therapies Disease Research 59

Drug Patent Watch

DECEMBER 11, 2023

Annual Drug Patent Expirations for AUVI-Q Auvi-q is a drug marketed by Kaleo Inc and is included in one NDA. It is available from three suppliers. There are thirty-one patents… The post New patent for Kaleo Inc drug AUVI-Q appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs Marketing 59

BioPharma Drive: Drug Pricing

DECEMBER 11, 2023

Research from Everest Group shows how life sciences leaders are investing in process mining to speed time-to-market, improve regulatory compliance and drive innovation.

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Drug Patent Watch

DECEMBER 11, 2023

Annual Drug Patent Expirations for AUSTEDO Austedo is a drug marketed by Teva Branded Pharm and Teva and is included in two NDAs. It is available from one supplier. There… The post New patent for Teva Branded drug AUSTEDO appeared first on DrugPatentWatch - Make Better Decisions.

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Covalent Modifiers

DECEMBER 11, 2023

Nathalie M. Grob, Clint Remarcik, Simon L. Rössler, Jeffrey Y. K. Wong, John C. K. Wang, Jason Tao, Corey L. Smith, Andrei Loas, Stephen L. Buchwald, Dan L. Eaton, Magdalena Preciado López, and Bradley L. Pentelute ACS Chemical Biology 2023 DOI: 10.1021/acschembio.3c00538 Protein–protein interactions (PPIs) are intriguing targets in drug discovery and development.

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Drug Patent Watch

DECEMBER 11, 2023

Annual Drug Patent Expirations for WINLEVI Winlevi is a drug marketed by Sun Pharm and is included in one NDA. It is available from one supplier. There are eight patents… The post New patent for Sun Pharm drug WINLEVI appeared first on DrugPatentWatch - Make Better Decisions.

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