Chemical Biology and Drug Design

JANUARY 4, 2024

Curcumin activates ATF6-regulated endoplasmic reticulum (ER) stress, promotes ATF6 nuclear translocation, activates Chop/Bax/Bcl-2/Caspase-3 apoptosis pathway, and promotes apoptosis of CRC cells. Abstract Colorectal cancer (CRC) is the main cause of cancer-associated death. Herein, we treated SW620 and HT-29 CRC cells with different curcumin concentrations, followed by treatment with the half maximal inhibitory concentration (IC50) curcumin/endoplasmic reticulum stress (ERS) inhibitor 4-phenyl

Regulations 189

Regulations Treatment Research 189

BioPharma Drive: Drug Pricing

JANUARY 4, 2024

Moonwalk Biosciences, the latest biotech cofounded by the gene editing scientist, joins other startups aiming to alter gene expression without changing DNA.

DNA 140

DNA 140

Drugs.com

JANUARY 4, 2024

THURSDAY, Jan. 4, 2024 -- The U.S. Food and Drug Administration is investigating reports of additional dangers linked to several wildly popular weight-loss drugs.In a quarterly report issued this week, the agency said it is investigating.

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FDA Drugs 126

Chemical Biology and Drug Design

JANUARY 4, 2024

PLD exerted a protective role in ammonia-induced pulmonary fibrosis by suppressing the activation of TGF-β1/SMAD3 pathway, thereby reducing the deposition of ECM and subsequent fibrosis. Abstract Ammonia can induce pulmonary fibrosis in humans and animals. Platycodin D (PLD) possesses various bioactive activities including anti-fibrotic properties. In this study, we aimed to explore the activity and mechanism of PLD in pulmonary fibrosis induced by ammonia.

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RNA Disease Research 100

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

BioPharma Drive: Drug Pricing

JANUARY 4, 2024

The company plans to restructure and will start a new late-stage study testing whether its “off-the-shelf” therapy can boost cure rates when used early on.

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Therapies 126

Chemical Biology and Drug Design

JANUARY 4, 2024

We found that NXT played a function role in treating hypertension through the regulation of multi-targets, multi-channels and multi-components based on the network pharmacology and molecular docking. In addition, in vitro experiments validated that NXT can increase cell viability and reduce apoptosis and intracellular oxidative stress. Abstract Naoxintong capsule (NXT) is a clinical drug for the treatment of cardiovascular diseases, but its pharmacological mechanism against hypertension remains

Regulations 100

Regulations Treatment Disease Drugs 100

Chemical Biology and Drug Design

JANUARY 4, 2024

Applying astragaloside IV (AS-IV) might repress the expression of circ_0001615 in colorectal cancer (CRC) cell lines. Furthermore, AS-IV performed a beneficial anti-cancer effect by regulating the circ_0001615/miR-873-5p/LASP1 network in the CRC. Abstract Astragaloside IV (AS-IV) has exhibited pivotal anti-cancer efficacy in multiple types of cancer, including colorectal cancer (CRC).

Regulations 100

Regulations RNA Treatment Research 100

Drugs.com

JANUARY 4, 2024

THURSDAY, Jan. 4, 2024 -- Researchers report that a new type of antibiotic has proved its mettle against a deadly superbug.Acinetobacter baumannii, a bacteria goes by the nickname CRAB, can trigger serious infections in the lungs, urinary tract and.

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Trials Research 116

Science Daily: Pharmacology News

JANUARY 4, 2024

With a split-second muscle contraction, the greater blue-ringed octopus can change the size and color of the namesake patterns on its skin for purposes of deception, camouflage and signaling. Researchers have drawn inspiration from this natural wonder to develop a technological platform with similar capabilities for use in a variety of fields, including the military, medicine, robotics and sustainable energy.

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Engineering Research 112

BioPharma Drive: Drug Pricing

JANUARY 4, 2024

The new program, dubbed LillyDirect, will help patients connect with telehealth providers and deliver medicines like the company’s obesity treatment Zepbound.

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Treatment Drugs 111

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Science Daily: Pharmacology News

JANUARY 4, 2024

Animals reproduce in one of two distinct ways: egg-laying or live birth. By studying an evolutionarily recent transition from egg-laying to live-bearing in a marine snail, collaborative research has shed new light on the genetic changes that allow organisms to make the switch.

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Research 105

BioPharma Drive: Drug Pricing

JANUARY 4, 2024

The agency could soon clear important new drugs from Eli Lilly and Merck, as well as the first treatment for a common liver disease.

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FDA Treatment Disease Drugs 122

Drugs.com

JANUARY 4, 2024

THURSDAY, Jan. 4, 2024 -- People who are early risers appear to be at greater risk of developing anorexia, a new study claims. This differs from other disorders like depression, binge eating and schizophrenia, all of which appear to be associated.

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Drug Target Review

JANUARY 4, 2024

What distinguishes Alder Therapeutics’ approach to regenerative cell therapy development from traditional methods, and how does it aim to reduce risks in the preclinical phase? Traditional approaches to regenerative cell therapy development are defined by several challenges. First, getting from the starting material to the end therapeutic product is often long and slow, as well as tricky to do consistently and repeatedly.

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Therapies Small Molecule Production Disease 98

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Clinical Trials

Drugs.com

JANUARY 4, 2024

THURSDAY, Jan. 4, 2024 -- The fluid-filled spaces around the brain's blood vessels need proper waste "clearance" every few hours. When that fails to happen, a baby's risk for autism appears to rise, new research shows.It's too early to say that.

Research 98

Research 98

Science Daily: Pharmacology News

JANUARY 4, 2024

Scientists have engineered the microbiome of plants for the first time, boosting the prevalence of 'good' bacteria that protect the plant from disease. The findings could substantially reduce the need for environmentally destructive pesticides.

Engineering 95

Engineering Disease 95

Drugs.com

JANUARY 4, 2024

THURSDAY, Jan. 4, 2023 (HeathDay News) -- Muscle cells' "power stations" function less effectively in people with long COVID, potentially explaining the persistent fatigue that's a hallmark of the condition. That's the finding of a Dutch study.

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Science Daily: Pharmacology News

JANUARY 4, 2024

People often keep adverse information about themselves secret because they worry that others will judge them harshly. But those fears are overblown, according to new research.

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Research 98

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drugs.com

JANUARY 4, 2024

THURSDAY, Jan. 4, 2023 -- A hearing aid’s first purpose is fairly obvious, but a new study argues that the devices also provide an important second benefit -- a longer life.“We found that adults with hearing loss who regularly used hearing aids.

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SCIENMAG: Medicine & Health

JANUARY 4, 2024

University of California San Diego School of Medicine has received a $5 million, five-year grant from the Agency for Healthcare Research and Quality (AHRQ) to establish a Center for Learning Health Systems Science.

Science 85

Science Research 85

Drug Channels

JANUARY 4, 2024

Paula and I have some exciting news to share with you: Drug Channels Institute is joining the HMP Global family! HMP is a leading omnichannel healthcare education, events, and market insights company. It’s a great fit for DCI. Here’s the press release: HMP Global Expands Market Reach with Strategic Acquisition of Drug Channels Institute; Launches Market Intelligence Unit Paula and I will continue to lead DCI as part of HMP.

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Drugs Marketing 75

SCIENMAG: Medicine & Health

JANUARY 4, 2024

Researchers have uncovered evidence hinting that the most common bug spray ingredient, DEET, might cause reproductive problems by affecting the formation of egg cells during pregnancy. Credit: Rick Groleau Researchers have uncovered evidence hinting that the most common bug spray ingredient, DEET, might cause reproductive problems by affecting the formation of egg cells during pregnancy.

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Research 79

BioPharma Drive: Drug Pricing

JANUARY 4, 2024

The CRISPR specialist joins some of its genetic medicine peers in trimming staff, announcing an “organizational streamlining” to focus resources on prioritiy drug programs.

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Research Drugs 73

SCIENMAG: Medicine & Health

JANUARY 4, 2024

Detecting malaria in people who aren’t experiencing symptoms is vital to public health efforts to better control this tropical disease in places where the mosquito-borne parasite is common. Asymptomatic people harboring the parasite can still transmit the disease or become ill later, after initially testing negative.

Disease 78

Disease 78

Perficient: Drug Development

JANUARY 4, 2024

As we step into 2024, the transformative impact of Artificial Intelligence (AI) and generative AI on enterprise-level organizations has reshaped the business landscape in profound ways. The continual evolution of these technologies has empowered businesses to leverage advanced algorithms, predictive modeling, and generative capabilities, driving unprecedented innovation and efficiency.

Engineering 72

Engineering Pharmaceuticals Production Research 72

SCIENMAG: Medicine & Health

JANUARY 4, 2024

Surface electromyography (sEMG) is a traditional method used to measure the electrical activity of muscles during physical activity. This method has remained unchanged for over 70 years and involves the use of two standard approaches.

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Drugs.com

JANUARY 4, 2024

THURSDAY, Jan. 4, 2024 -- Three twenty-somethings in Chicago took a street drug they thought was a harmless form of Xanax. All three were found collapsed and unresponsive eight hours later by one of their mothers, who had them rushed to the.

Drugs 75

Drugs 75

Science Daily: Pharmacology News

JANUARY 4, 2024

New research indicates that the eating disorder anorexia nervosa is associated with being an early riser, unlike many other disorders that tend to be evening-based such as depression, binge eating disorder and schizophrenia.

Research 70

Research 70

Drug Patent Watch

JANUARY 4, 2024

Annual Drug Patent Expirations for HETLIOZ Hetlioz is a drug marketed by Vanda Pharms Inc and is included in two NDAs. It is available from one supplier. There are twenty-four… The post New patent for Vanda Pharms drug HETLIOZ appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs Marketing 59

Agency IQ

JANUARY 4, 2024

In a long-anticipated draft report, the FDA has offered a vision for a series of potential improvements to the way it currently publishes guidance documents. But while the ideas proposed by the agency are likely of interest to regulators, the report doesn’t spend much time thinking about how it might improve its processes to benefit external stakeholders.

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FDA Regulations 59

Drug Patent Watch

JANUARY 4, 2024

Annual Drug Patent Expirations for SYNJARDY Synjardy is a drug marketed by Boehringer Ingelheim and is included in two NDAs. It is available from one supplier. There are eight patents… The post New patent for Boehringer Ingelheim drug SYNJARDY appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs Marketing 59

Agency IQ

JANUARY 4, 2024

In this returning feature, AgencyIQ looks at public data to determine what the Environmental Protection Agency is planning to do in the month ahead, including deadlines, meetings, events, planned regulations, comment periods, and more. Fill out the form to read the full article.

Regulations 59

Regulations 59

Drug Patent Watch

JANUARY 4, 2024

Annual Drug Patent Expirations for JARDIANCE Jardiance is a drug marketed by Boehringer Ingelheim and is included in one NDA. It is available from four suppliers. There are eight patents… The post New patent for Boehringer Ingelheim drug JARDIANCE appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs Marketing 59