Mon.Mar 25, 2024

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Read the Spring issue of DDW now

Drug Discovery World

The Spring issue of Drug Discovery World (DDW) is out now. It looks at where we are in the fight against antimicrobial resistance, explores how structural biology is informing vaccine design, and offers advice on approaching dealmaking in biopharma. Read the digital version here. Other features in the Spring issue include: A market report on the drug discovery hotspots in Europe.

Therapies 163
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Persian plateau unveiled as crucial hub for early human migration out of Africa

Science Daily: Pharmacology News

A new study combining genetic, palaeoecological, and archaeological evidence has unveiled the Persian Plateau as a pivotal geographic location serving as a hub for Homo sapiens during the early stages of their migration out of Africa. It highlights the period between 70,000 to 45,000 years ago when human populations did not uniformly spread across Eurasia, leaving a gap in our understanding of their whereabouts during this time frame.

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Novo Nordisk acquires cardiovascular therapies developer Cardior

Drug Discovery World

Novo Nordisk has acquired Cardior Pharmaeuticals for up to €1.025 billion, including an upfront payment and additional payments if certain milestones are achieved. Cardior is focused on the discovery and development of therapies that target RNA to prevent, repair and reverse diseases of the heart. The company seeks to advance a novel class of antisense oligonucleotides (ASOs) targeting non-coding RNAs (ncRNAs) that act on several key disease pathways simultaneously.

Therapies 130
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The world is one step closer to secure quantum communication on a global scale

Science Daily: Pharmacology News

Researchers have brought together two Nobel prize-winning research concepts to advance the field of quantum communication. Scientists can now efficiently produce nearly perfect entangled photon pairs from quantum dot sources.

Research 120
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Six March 2024 deals advancing drug discovery

Drug Discovery World

Allogene Therapeutics and Arbor Biotechnologies Biotechnology companies Allogene Therapeutics and Arbor Biotechnologies entered a non-exclusive, global gene editing licensing agreement for use of Arbor’s proprietary CRISPR gene-editing technology in Allogene’s AlloCAR T platform for the treatment of autoimmune disease (AID). “The potential for CAR T as a therapeutic option for autoimmune disease has captured the collective imagination of the scientific community,” said Zachary Roberts, Executive

Drugs 130
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A self-cleaning wall paint

Science Daily: Pharmacology News

Beautiful white wall paint does not stay beautiful and white forever. Often, various substances from the air accumulate on its surface. This can be a desired effect because it makes the air cleaner for a while -- but over time, the color changes and needs to be renewed. Now, special titanium oxide nanoparticles have been developed that can be added to ordinary, commercially available wall paint to establish self-cleaning power: The nanoparticles are photocatalytically active, they can use sunlig

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Common household chemicals pose new threat to brain health, study finds

Science Daily: Pharmacology News

Researchers have provided fresh insight into the dangers some common household chemicals pose to brain health. They suggest that chemicals found in a wide range of items, from furniture to hair products, may be linked to neurological conditions.

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Eli Lilly Warns That 2 Insulin Products Will Be in Short Supply

Drugs.com

MONDAY, March 25, 2024 -- Drugmaker Eli Lilly & Co is announcing a temporary shortage of two of its insulin products."The 10 mL [millilter] vials of Humalog® and Insulin Lispro Injection are or will be temporarily out of stock at wholesalers.

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#WhyIScience Q&A: A cell biologist now helps recent college graduates launch their scientific careers

Broad Institute

#WhyIScience Q&A: A cell biologist now helps recent college graduates launch their scientific careers By Leah Eisenstadt March 25, 2024 Breadcrumb Home #WhyIScience Q&A: A cell biologist now helps recent college graduates launch their scientific careers Alex Navarro draws from her scientific and personal experiences to guide young researchers toward their professional goals in the Broad’s post-baccalaureate program.

Science 111
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FDA May Ban Electroshock Devices Used on Some Psychiatric Patients

Drugs.com

MONDAY, March 25, 2024 -- Federal regulators are taking a second stab at banning the controversial use of electroshock devices to manage the behavior of patients with intellectual and developmental disorders.The devices deliver electric shocks to a.

FDA 115
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Wild bird gestures 'after you'

Science Daily: Pharmacology News

A small-bird species, the Japanese tit (Parus minor), uses wing movements as a gesture to convey the message 'after you,' according to new research. When a mating pair arrives at their nest box with food, they will wait outside on perches. One will then often flutter its wings toward the other, apparently indicating for the latter to enter first. The researchers say that this discovery challenges the previous belief that gestural communication is prominent only in humans and great apes, signific

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Do You Need to Take Supplements If You Eat a Healthy Diet?

Drugs.com

MONDAY, March 25, 2024 -- Vitamin supplements are a big business, with Americans spending roughly $45 billion out of more than $177 billion worldwide on pills, gummies and powders meant to boost health.About 59 million Americans regularly use some.

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Unintended consequences of fire suppression

Science Daily: Pharmacology News

A new study reveals how fire suppression ensures that wildfires will burn under extreme conditions at high severity, exacerbating the impacts of climate change and fuel accumulation.

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Mouse Study Yields Clues to Why Psoriasis Worsens

Drugs.com

MONDAY, March 25, 2024 -- Australian researchers say they have identified a gene mutation that causes the skin disease psoriasis.A chronic inflammatory condition, psoriasis causes red, scaly, itchy patches on the skin. Some patients also develop.

Disease 105
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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More exposure to artificial, bright, outdoor night-time light linked to higher stroke risk

Science Daily: Pharmacology News

Air pollution and night-time outdoor light each were associated with harmful effects on brain health, finds new study.

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Even Slight Rise in One Gut Microbe Might Keep You Out of the Hospital

Drugs.com

MONDAY, March 25, 2024 -- Even a slight rise in a specific type of beneficial gut bacteria can help people ward off serious infections, a new study reports.For every 10% increase in butyrate-producing bacteria in a patient’s gut, their risk of.

Hospitals 105
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Cool paint coatings help pedestrians feel up to 1.5 degrees Celsius cooler in urban setting

Science Daily: Pharmacology News

A real-world study has shown that the use of cool paint coatings in cities can help pedestrians feel up to 1.5 degrees Celsius cooler, making the urban area more comfortable for work and play.

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Tally of Infant SIDS Deaths Shows Many Unsafe Sleep Practices

Drugs.com

MONDAY, March 25, 2024 -- Babies who die unexpectedly in their sleep often are subjected to many hazards that could have contributed to their deaths, a new study reports.Multiple unsafe sleep practices are at play in three-quarters (76%) of Sudden.

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Axsome drug succeeds in narcolepsy symptoms trial

BioPharma Drive: Drug Pricing

Despite the late-stage victory, shares of the New York-based biotech dipped more than 3%. One analyst argued that Axsome’s drug has “largely been falling under investor radars.

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Survey Finds Americans Conflicted About Plant-Based Diets

Drugs.com

MONDAY, March 25, 2024 -- Most folks know they’d be healthier if they ate more plant-based foods, but only a quarter are willing to follow through and do it, a new study shows.Surveys reveal that Americans' beliefs about eating more plants for.

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Common household chemicals pose new threat to brain health

SCIENMAG: Medicine & Health

CLEVELAND—A team of researchers from the Case Western Reserve University School of Medicine has provided fresh insight into the dangers some common household chemicals pose to brain health. They suggest that chemicals found in a wide range of items, from furniture to hair products, may be linked to neurological diseases like multiple sclerosis and autism spectrum disorders.

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Most New Doctors Have Faced Sexual Harassment, Study Shows

Drugs.com

MONDAY, March 25, 2024 -- The #MeToo movement has done little to blunt sexual harassment among health care professionals, a pair of new studies report.More than half of all new doctors are subjected to sexual harassment during their first year on.

Doctors 105
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Drug Channels News Roundup, March 2024: My $0.02 of CarelonRx/Kroger & CVS, Provider-Owned Pharmacies, Shady AFPs, 340B Deception, and Lilly’s GLP-1 Ad

Drug Channels

It’s finally spring in Philadelphia, home of Drug Channels. Along with sunshine and fine weather, the vernal equinox has ushered in a crop of new and noteworthy stories: What the CarelonRx/Kroger specialty pharmacy deal means for CVS Health Provider-owned specialty pharmacies expand in Medicare Payers are not keen on shady alternative funding programs (AFP) Hospitals’ association spreads 340B misinformation Plus, Lilly trolls our nation’s celebrities.

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Total Solar Eclipse in 2017 Linked to Brief Rise in Traffic Accidents

Drugs.com

MONDAY, March 25, 2024 -- Ahead of a total solar eclipse arriving April 8, new research finds there was a temporary rise in U.S. traffic accidents around the time of a solar eclipse back in 2017.The area in the United States covered by the total.

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The future of companion diagnostic (CDx) development: Why commercialization is key

BioPharma Drive: Drug Pricing

As precision medicine expands into a growing number of therapeutic areas, the “one size fits all” approach to drug development is becoming less common.

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AgencyIQ Guidance Tracker: European medical device and diagnostics guidance documents

Agency IQ

BY COREY JASEPH, MS, RAC With the many moving parts of the European medical device and IVD regulations, it can be difficult to keep up on planned guidance and other publications, published documents and document revisions. Our new resource aims to help make this a little bit easier. Europe enacted the medical device (MDR) and IVD regulations (IVDR) in May 2017 but gave manufacturers and other stakeholders, including the regulators themselves, time for implementation.

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Introducing Salesforce Einstein Copilot for AI

Perficient: Drug Development

Do you struggle to optimize user experience and maximize productivity? If so, your team is spending valuable time on repetitive tasks like data entry, locating the right information, and follow-ups, limiting time for core functions and strategic initiatives. What if an AI assistant could streamline workflows and unlock hidden efficiencies? Enter Salesforce’s Einstein Copilot , a game-changer that surpasses basic AI suggestions.

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ECHA flags 28 substances for evaluation over next three years

Agency IQ

BY SCOTT STEPHENS, MPA This week, ECHA finalized its annual update to the Community Rolling Action Plan (CoRAP), listing 28 substances that will be assessed under the REACH Regulation’s substance evaluation procedure during the 2024-2026 period. Ten substances have been prioritized for evaluation this year, including dioctyltin oxide, tetrasodium glutamate diacetate, and tribromophenol.

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Your Dog May Understand Words for Certain Objects

Drugs.com

MONDAY, March 25, 2024 -- It’s well-known that dogs can learn words for spoken commands like “sit,” “stand” and “heel.”But a new study has found they also can tell their “ball-ball” from their “dolly,” “teddy,” “chewy”.

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Updates from IMDRF: What’s next for the working groups

Agency IQ

BY LAURA DIANGELO, MPH At the International Medical Device Regulators Forum (IMDRF) annual meeting in Washington, DC, regulators presented updates on the work underway within all seven IMDRF working groups. Here, AgencyIQ provides highlights from these updates, including current and future project plans. Fill out the form to read the full article.

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Helping Poorer Patients Pay for Prostate Cancer Meds Keeps Them on Treatment

Drugs.com

MONDAY, March 25, 2024 — Men with prostate cancer treated at hospitals participating in a special drug-pricing program were more likely to stick to their therapy than patients elsewhere, new research reveals.The federal 340B Drug Program requires.

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Senate hearing on hazardous substance listing for PFAS finds common ground, but disagreements on implementation tactics

Agency IQ

BY WALKER LIVINGSTON, ESQ The Senate Committee on Environment and Public Works held a hearing on March 20, 2024, reviewing the issues and possibilities for designating PFAS as hazardous substances under the federal Superfund law. The testimony of witnesses and the Senators themselves largely agreed on the designation, but diverged on questions of liability exemptions.

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Novo to acquire heart failure drug in $1B deal for Cardior

BioPharma Drive: Drug Pricing

Cardior’s therapy is currently in mid-stage testing and should the deal close, Novo plans to start another Phase 2 trial in heart failure.

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In proposed rule, FDA offers up a (surprisingly sparse) list of drugs that present demonstrable compounding difficulties

Agency IQ

BY CHELSEY MCINTYRE, PHARMD FDA yesterday released a long-awaited proposed rule on a list of drug products that present demonstrable difficulties for compounding. This proposed rule has been in the works for over 20 years, during which time the regulation of drug compounding has gone through many changes. Now, the proposed list is out, and its limited length may be a surprise to stakeholders.

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