Tue.Nov 21, 2023

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Neanderthals were the world's first artists, research reveals

Science Daily: Pharmacology News

Recent research has shown that engravings in a cave in La Roche-Cotard (France), which has been sealed for thousands of years, were actually made by Neanderthals. The findings reveal that the Neanderthals were the first humans with an appreciation of art.

Research 143
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Ropivacaine inhibits the proliferation and metastasis of gastric cancer cells via the SNX10/SRC/STAT3 pathway

Chemical Biology and Drug Design

SNX10 shRNA expression was transfected into AGS cells, and Rop intervention was given. qRT-PCR, CCK8, wound healing assay, transwell assay, and western blot were used to clarify the effects of Rop on the proliferation and metastasis of SNX10/SRC/STAT3 pathway in gastric cancer cells. Our results suggest that Rop shows a potential role in preventing proliferation and metastasis of gastric cancer.

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Roche’s Genentech partners with Nvidia in AI drug deal

BioPharma Drive: Drug Pricing

The partnership is another investment by the biotech subsidiary in artificial intelligence for drug discovery and development, continuing an industry trend.

Drugs 131
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Many Primary Care Docs Unaware of Biologic Asthma Meds

Drugs.com

TUESDAY, Nov. 21, 2023 -- Biologic drugs to treat asthma have been around for two decades, but a surprising number of family doctors still aren’t prescribing them to kids and adults. A new survey found that more than two in five primary care.

Doctors 119
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Introduction to My Spring Boot Blog Series: Embarking on a Learning Journey Together

Perficient: Drug Development

Greetings, Fellow Developers, Enthusiasts, and Friends! I am thrilled to embark on a journey of exploration and learning with you as I dive into the fascinating world of Spring Boot. As I navigate this powerful framework, I’ve decided to document my experiences, insights, and newfound knowledge in a blog series. The Motivation Behind the Series: The primary motivation for initiating this blog series stems from a desire to not only solidify my understanding of Spring Boot but also to create

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Quotient emerges from Flagship with plan to explore somatic mutations

BioPharma Drive: Drug Pricing

Studying somatic mutations could be “the next wave of opportunity” to develop more precise medicines, said Mike Stratton, one of Quotient’s scientific co-founders.

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One Death, 10 Hospitalizations in Listeria Outbreak Tied to Peaches, Plums

Drugs.com

TUESDAY, Nov. 21, 2023 -- Peaches, nectarines and plums tainted with Listeria have caused one death and put 10 people in the hospital with food poisoning across seven states, federal officials say. The Listeria outbreak also has caused one.

Hospitals 116
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Medtronic CEO downplays impact of obesity drugs on procedures, devices

BioPharma Drive: Drug Pricing

Surging demand for GLP-1 agonists has put medtech firms like Medtronic under pressure, even as they argue the hit to their businesses will be minimal.

Drugs 111
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Our brains are not able to 'rewire' themselves, despite what most scientists believe, new study argues

Science Daily: Pharmacology News

Contrary to the commonly-held view, the brain does not have the ability to rewire itself to compensate for the loss of sight, an amputation or stroke, for example, say scientists. The researchers argue that the notion that the brain, in response to injury or deficit, can reorganize itself and repurpose particular regions for new functions, is fundamentally flawed -- despite being commonly cited in scientific textbooks.

Research 106
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Most Americans Know Little About Harmful PFAS 'Forever Chemicals'

Drugs.com

TUESDAY, Nov. 21, 2023 -- Nearly half of Americans have never heard of health-threatening PFAS “forever chemicals,” a new survey has found. PFAS (perfluoroalkyl and polyfluoroalkyl substances) are a category of thousands of manufactured.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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First comprehensive look at effects of 2020-2021 California megafires on terrestrial wildlife habitat

Science Daily: Pharmacology News

In 2020 and 2021, California experienced fire activity unlike anything recorded in the modern record. When the smoke cleared, the amount of burned forest totaled ten times more than the annual average going back to the late 1800s. We know that wildlife in western forests evolved with changing habitat and disturbances like wildfire. Each species responds differently, some benefiting from openings, others losing critical habitat.

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Ethical, Regulatory, and Operational Considerations for Cell and Gene Therapy Research in Children

Fierce BioTech

Cell and Gene Therapy (CGT) has the potential to transform the life trajectory of children with genetic conditions amendable to gene modification with advances in treatment and possible cures. | Pediatric CGT trials have the potential to cure diseases and prolong lives. Discover steps to protect safety and enhance operations in your CGT trials.

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National Heart Centre Singapore partners Medera’s Novoheart to develop Asia’s first bioengineered human heart-in-a-jar with heart failure for precision medicine

SCIENMAG: Medicine & Health

NATIONAL HEART CENTRE SINGAPORE PARTNERS MEDERA’S NOVOHEART TO DEVELOP ASIA’S FIRST BIOENGINEERED HUMAN HEART-IN-A-JAR WITH HEART FAILURE FOR PRECISION MEDICINE Credit: National Heart Centre Singapore NATIONAL HEART CENTRE SINGAPORE PARTNERS MEDERA’S NOVOHEART TO DEVELOP ASIA’S FIRST BIOENGINEERED HUMAN HEART-IN-A-JAR WITH HEART FAILURE FOR PRECISION MEDICINE SINGAPORE/ BOSTON, MASSACHUSETTS, UNITED STATES, 21 November 2023 – National […]

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Teen With Multiple Concussions Face Higher Risk of Suicidal Thoughts

Drugs.com

TUESDAY, Nov. 21, 2023 — A year after suffering a concussion, teens, especially boys, are more likely than their peers to think about, plan and even attempt suicide, new research finds. With more concussions, the risk grows. Teen boys.

Research 104
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Nuclear physics traineeship program offers launchpad for research careers

SCIENMAG: Medicine & Health

Associate Professor of physics Benjamin Jones has received a $341,571 grant from the U.S. Department of Energy to continue his successful traineeship program at The University of Texas at Arlington. Credit: University of Texas at Arlington Associate Professor of physics Benjamin Jones has received a $341,571 grant from the U.S.

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Massive Antarctic ozone hole over past 4 years: What is to blame?

Science Daily: Pharmacology News

Despite public perception, the Antarctic ozone hole has been remarkably massive and long-lived over the past four years; researchers believe chlorofluorocarbons (CFCs) aren't the only things to blame.

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Mount Sinai Health System names Brendan Carr, MD, MA, MS, as next Chief Executive Officer

SCIENMAG: Medicine & Health

Mount Sinai Health System announced that Brendan Carr, MD, MA, MS, a nationally recognized leader in academic medicine and health policy, will be its next Chief Executive Officer.

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Hate Driving Your Cat to the Vet? FDA Just Approved a Drug for That

Drugs.com

TUESDAY, Nov. 21, 2023 -- If you belong to one of the 46 million American households with a cat, you already know how stressful a trip to the vet can be for your feline -- and you. Rescue might be on the way: The U.S. Food and Drug Administration.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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New study shows swapping pulses for common proteins and grains improves American diet

SCIENMAG: Medicine & Health

MOSCOW, Idaho (November 21, 2023): A recently published study[i] in Nutrients, an open-access peer-reviewed scientific journal, demonstrates that exchanging pulses for small amounts of typical protein sources and refined grains significantly improves the nutritional profile of the American diet.

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How Worldwide and Every Cure Are Using AI To Unlock New Rare Disease Treatments

Conversations in Drug Development Trends

Since the advent of modern medicine, the scientific community has developed more than 3,000 drugs for thousands of diseases. Despite significant progress, there are more than 6,500 rare diseases without a single approved treatment. We recently partnered with Every Cure , a nonprofit organization, to help them advance their mission of unlocking the full potential of every existing medicine to treat as many diseases as possible — with a specific focus on rare diseases.

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Dwarf galaxies use 10-million-year quiet period to churn out stars

Science Daily: Pharmacology News

If you look at massive galaxies teeming with stars, you might be forgiven in thinking they are star factories, churning out brilliant balls of gas. But actually, less evolved dwarf galaxies have bigger regions of star factories, with higher rates of star formation. Now, University of Michigan researchers have discovered the reason underlying this: These galaxies enjoy a 10-million-year delay in blowing out the gas cluttering up their environments.

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NDARC at APSAD 2023

National Drug & Alcohol Research Centre Blog

Olivia Price The reviews are in! “ ★★★★★ – it was a pleasure to see the NDARC PhD candidates and early career researchers do us proud” – Shane Darke, Professor “ ★★★★★ – it was a fantastic experience to learn from a diverse range of speakers and leaders in the alcohol and other drug space; APSAD inspired me to continue working in this field on contemporary challenges that are rising” – Lily Palmer, Research Officer and First Time APSAD Attendee “ ★★★★★ – my favourite APSAD so far” – Michael Farr

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Trilobites rise from the ashes to reveal ancient map

Science Daily: Pharmacology News

Ten newly discovered species of trilobites, hidden for 490 million years in a little-studied part of Thailand, could be the missing pieces in an intricate puzzle of ancient world geography.

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Merck to buy private biotech Caraway in neuroscience deal

BioPharma Drive: Drug Pricing

In a deal worth up to $610 million, Merck will gain a pipeline of neuroscience and rare disease programs from a startup it previously backed.

Disease 78
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Ultra-processed foods and higher risk of mouth, throat and esophagus cancers

Science Daily: Pharmacology News

Eating more ultra-processed foods (UPFs) may be associated with a higher risk of developing cancers of upper aerodigestive tract (including the mouth, throat and esophagus), according to a new study. The authors of this international study, which analyzed diet and lifestyle data on 450,111 adults who were followed for approximately 14 years, say obesity associated with the consumption of UPFs may not be the only factor to blame.

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Evaluating an AI Product in Life Sciences

H1 Blog

The life sciences industry, characterized by stringent regulations, vast data sets, and the critical nature of its decisions, is increasingly turning to Artificial Intelligence (AI) for solutions. AI has the potential to revolutionize drug discovery, clinical trials, and personalized medicine. However, before integrating an AI product into a life sciences workflow , it is crucial to evaluate its effectiveness and reliability rigorously.

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NASA's Webb reveals new features in heart of Milky Way

Science Daily: Pharmacology News

The latest image from NASA's James Webb Space Telescope shows a portion of the dense center of our galaxy in unprecedented detail, including never-before-seen features astronomers have yet to explain. The star-forming region, named Sagittarius C (Sgr C), is about 300 light-years from the Milky Way's central supermassive black hole, Sagittarius A*.

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Solving the Mystery of Why Red Wine Gives Some Folks Headaches

Drugs.com

WEDNESDAY, Nov. 22, 2023 -- Countless corks will pop and wine will flow freely during the upcoming holiday season, but some people will pay a price for even the slightest bit of revelry. For those unlucky folks, drinking red wine even in small.

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Babies as young as four months show signs of self-awareness

Science Daily: Pharmacology News

Babies as young as four months old can make sense of how their bodies interact with the space around them, according to new research.

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AI Might Accurately Spot Autism in Early Childhood

Drugs.com

TUESDAY, Nov. 21, 2023 — University of Louisville researchers say they've developed an artificial intelligence (AI) system with a near-perfect record of diagnosing autism in toddlers. Using specialized MRI scans of the brain, the tool.

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'Triple star' discovery could revolutionize understanding of stellar evolution

Science Daily: Pharmacology News

A ground-breaking new discovery could transform the way astronomers understand some of the biggest and most common stars in the Universe. Research by PhD student Jonathan Dodd and Professor René Oudmaijer, from the University's School of Physics and Astronomy, points to intriguing new evidence that massive Be stars -- until now mainly thought to exist in double stars -- could in fact be 'triples'.

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New patent expiration for Zr Pharma drug RUBRACA

Drug Patent Watch

Annual Drug Patent Expirations for RUBRACA Rubraca is a drug marketed by Zr Pharma and is included in one NDA. It is available from two suppliers. There are twelve patents… The post New patent expiration for Zr Pharma drug RUBRACA appeared first on DrugPatentWatch - Make Better Decisions.

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The Contract Transformation of the Biotech and BioPharma Industry

Fierce BioTech

The Contract Transformation of the Biotech and BioPharma Industry swheeler Tue, 11/21/2023 - 18:43 Tue, 12/19/2023 - 12:00 Resource Type Webinar Angelina Bellanton Simon Jones Duration 60 minutes Either you want to implement a CLM, or you don’t know how to fix the processes of the one you have in place. Either is a tough place to be in. Join us in this webinar to learn from a CLM solution implementation expert in the highly regulated field of pharmaceuticals.