Wed.Jan 17, 2024

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Kyverna sets plans for IPO in test of biotech market

BioPharma Drive: Drug Pricing

The offering is the fifth outlined by a biotech startup this month, suggesting companies are becoming more willing to gauge investors’ appetite for new stock offerings.

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FDA Clears Sickle Cell Drug, Casgevy, to Treat Transfusion-Dependent Beta-Thalassemia

Drugs.com

WEDNESDAY, Jan. 17, 2024 -- Casgevy, a groundbreaking treatment that was approved to treat sickle cell disease in December, was given the U.S. Food and Drug Administration's blessing on Tuesday to treat another inherited blood disorder. Casgevy is.

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Tr1x, a new biotech, joins ‘Treg’ chase with $75M fundraise

BioPharma Drive: Drug Pricing

The startup is focusing on immune cells called Tr1 cells, which it claims could be important in treating autoimmune conditions like graft-versus-host disease.

Disease 124
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Chemists create a 2D heavy fermion

Science Daily: Pharmacology News

Researchers have synthesized the first 2D heavy fermion. The material, a layered intermetallic crystal composed of cerium, silicon, and iodine (CeSiI), has electrons that are 1000x heavier and is a new platform to explore quantum phenomena.

Research 101
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Optimizely CMS – Custom form element with dependencies

Perficient: Drug Development

Optimizely CMS comes with a package called Episerver.Forms that enables you to incorporate easy to build forms within a CMS website. There is a built in form container that supports standard built in form elements like input fields, checkboxes, radio buttons, select lists, buttons etc. And just like any other feature, Episerver Forms also come with the capability to customize, where you can customize existing elements, or create new ones and more.

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The heat is on: Scientists discover southern Africa's temps will rise past the rhinos' tolerance

Science Daily: Pharmacology News

Southern Africa contains the vast majority of the world's remaining populations of both black and white rhinoceroses (80% and 92%, respectively). The region's climate is changing rapidly as a result global warming. Traditional conservation efforts aimed at protecting rhinos have focused on poaching, but until now, there has been no analysis of the impact that climate change may have on the animals.

Research 101

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Artificial 'power plants' harness energy from wind and rain

Science Daily: Pharmacology News

Fake plants are moving into the 21st century! Researchers developed literal 'power plants' -- tiny, leaf-shaped generators that create electricity from a blowing breeze or falling raindrops. The team tested the energy harvesters by incorporating them into artificial plants.

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Mothers with high levels of dental plaque are 8 times more likely to transfer Candida albicans, involved in tooth decay, to their babies, underlining the need for moms to keep their own teeth clean

SCIENMAG: Medicine & Health

Mothers with high levels of dental plaque are 8 times more likely to transfer Candida albicans, involved in tooth decay, to their babies, underlining the need for moms to keep their own teeth clean Credit: jennyfriedrichs, Pixabay, CC0 ([link] Mothers with high levels of dental plaque are 8 times more likely to transfer Candida albicans, […]

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Astronomers detect oldest black hole ever observed

Science Daily: Pharmacology News

Researchers have discovered the oldest black hole ever observed, dating from the dawn of the universe, and found that it is 'eating' its host galaxy to death.

Research 105
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Getting Protein From Plant-Based Foods Might Extend Women's Lives

Drugs.com

WEDNESDAY, Jan. 17, 2024 -- Women who consume more plant-based protein tend to age more gracefully, a new study reports.Women with diets rich in protein -- especially from plant-based sources -- develop fewer chronic diseases and enjoy healthier.

Disease 97
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Big dogs versus small dogs: Which sizes face higher risks of which diseases?

SCIENMAG: Medicine & Health

A study of more than 25,000 U.S. dogs and 238 breeds has linked dog size to varying patterns of risk for health conditions over the course of a dog’s lifespan. Yunbi Nam of the University of Washington, U.S., and colleagues present these findings in the open-access journal PLOS ONE on January 17.

Disease 94
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CDD Co-Sponsoring Buzzed For Biotech Morning Event- Vester Cambridge

Collaborative Drug

Date: Jan 25th, 9:00 AM - 12:00 pm EST Location: VESTER Cambridge, Ames Street, Cambridge, MA, USA Free RSVP (Walk-ins Welcome as well!) The Buzzed for Biotech morning networking event, organized by Dovetail Biopartners , is just around the corner! It's a great opportunity to connect with peers in the biotech community over coffee and pastries. Joining us will be Ralf Fesner , ready and eager to have a chat, share insights, and contribute to our local biotech landscape's growth and knowledge.

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Add Some Impact to Your Exercise to Keep Aging Bones Strong

Drugs.com

WEDNESDAY, Jan. 17, 2024 -- Putting a little pressure on your bones during exercise or daily activities might pay off in stronger bones as you age, new research suggests.The study focused on a crucial part of the hip joint anatomy called the.

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Diets rich in plant protein may help women stay healthy as they age

SCIENMAG: Medicine & Health

Women who consume higher amounts of protein, especially protein from plant-based sources, develop fewer chronic diseases and are more likely to be healthier overall as they age, according to a study led by researchers at the Jean Mayer USDA Human Nutrition Research Center on Aging (HNRCA) at Tufts University and published Jan.

Disease 81
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Woolly mammoth movements tied to earliest Alaska hunting camps

Science Daily: Pharmacology News

Researchers have linked the travels of a 14,000-year-old woolly mammoth with the oldest known human settlements in Alaska, providing clues about the relationship between the iconic species and some of the earliest people to travel across the Bering Land Bridge. Isotopic data, along with DNA from other mammoths at the site and archaeological evidence, indicates that early Alaskans likely structured their settlements to overlap with areas where mammoths congregated.

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U.S. Cancer Death Rates Are Falling, But News Isn't All Good

Drugs.com

WEDNESDAY, Jan. 17, 2024 -- Cancer deaths continue to decline in the United States, with more than 4 million deaths prevented since 1991, a new report shows.But more people are developing cancers than ever, making the dreaded disease a continued.

Disease 91
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Online versus reality: Social media influences perceptions

Science Daily: Pharmacology News

People may form inaccurate impressions about us from our social media posts, finds new research that is the first to examine perceptions of our personalities based on online posts.

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'Default' Orders for Palliative Care Speed Relief for Hospital Patients in Pain

Drugs.com

WEDNESDAY, Jan 17, 2024 -- Palliative care is meant to ease suffering at any stage of disease, but too often many patients wait too long for this type of care to be ordered. Now, researchers at the University of Pennsylvania may have come up with a.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Surprisingly simple model explains how brain cells organize and connect

Science Daily: Pharmacology News

A new study by physicists and neuroscientists describes how connectivity among neurons comes about through general principles of networking and self-organization, rather than the biological features of an individual organism.

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Winding down the window, drinking tea and coffee, turning the radio up and singing while driving could be signs of a dangerous snoring condition

SCIENMAG: Medicine & Health

Frequently using more than three strategies to stay alert while driving could be a sign of excessive sleepiness due to obstructive sleep apnoea (OSA), according to a study published today (Thursday) in ERJ Open Research [1].

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Revealing the mechanism of action of a first-in-class covalent inhibitor of KRASG12C (ON) and other functional properties of oncogenic KRAS by 31P NMR

Covalent Modifiers

Alok K. Sharma,Jun Pei,Yue Yang,Marcin Dyba,Brian Smith,Dana Rabara,Erik Larsen,Felice C. Lightstone,Dominic Esposito,Andrew G. Stephen,Bin Wang,Pedro J. Beltran,Eli Wallace,Dwight V. Nissley,Frank McCormick,Anna E. Maciag Journal of Biological Chemistry , 2024 [link] Individual oncogenic KRAS mutants confer distinct differences in biochemical properties and signaling for reasons that are not well understood.

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Keys to aging hidden in the leaves

SCIENMAG: Medicine & Health

Scientists have known about a particular organelle in plant cells for over a century. However, UC Riverside scientists have only now discovered that organelle’s key role in aging. Credit: Katie Dehesh/UCR Scientists have known about a particular organelle in plant cells for over a century.

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Space solar power project ends first in-space mission with successes and lessons

Science Daily: Pharmacology News

A 10-month mission demonstrated three elements of the plan to beam solar power from space to Earth.

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Samsung Electronics Co., Ltd., (Suwon, Republic of Korea) developed hip-assist robot to advance fitness in the elderly

SCIENMAG: Medicine & Health

The natural aging process often results in a notable reduction of muscle mass, particularly in the lower limbs. This decline, in turn, leads to a gradual decrease in physical activity among older adults, as the weakening of lower-limb muscles heightens the risk of falls.

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Biomimetic Synthesis and Chemical Proteomics Reveal the Mechanism of Action and Functional Targets of Phloroglucinol Meroterpenoids

Covalent Modifiers

Amy K. Bracken, Colby E. Gekko, Nina O. Suss, Emma E. Lueders, Qi Cui, Qin Fu, Andy C. W. Lui, Elizabeth T. Anderson, Sheng Zhang, and Mikail E. Abbasov Journal of the American Chemical Society 2024 DOI: 10.1021/jacs.3c10741 Natural products perennially serve as prolific sources of drug leads and chemical probes, fueling the development of numerous therapeutics.

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Certain personality traits linked to college students’ sense of belonging

SCIENMAG: Medicine & Health

In a study of nearly 5,000 North American first-year college students, those who were more extraverted, more agreeable, or less neurotic were more likely to feel a greater sense of belonging at school.

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Comanche Biopharma raises $75M to fund preeclampsia drug testing

BioPharma Drive: Drug Pricing

The biotech is developing an RNA-based therapy for what it describes as a root cause of the pregnancy-related complication, which affects millions of women.

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NIH-developed HIV antibodies protect animals in proof-of-concept study

SCIENMAG: Medicine & Health

WHAT: Three different HIV antibodies each independently protected monkeys from acquiring simian-HIV (SHIV) in a placebo-controlled proof-of-concept study intended to inform development of a preventive HIV vaccine for people.

Vaccine 72
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New study unveils emotional hubs that exist across languages

Science Daily: Pharmacology News

Emotions influence human decision-making and behavior. Therefore, understanding the most salient human emotions can have theoretical and practical implications. By exploiting a feature of words called colexification, researchers from Japan discovered that the emotions 'GOOD,' 'BAD,' 'HAPPY,' and 'WANT' act as emotional hubs across languages. Their findings may provide crucial insights for understanding language evolution and natural language processing.

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$24 million grant to extend Study of Healthy Aging in African Americans (STAR)

SCIENMAG: Medicine & Health

Researchers at UC Davis Health and Kaiser Permanente Division of Research have received a $24 million grant from the National Institute on Aging, part of the National Institutes of Health (NIH), to continue the Study of Healthy Aging in African Americans (STAR) for an additional five years.

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Covalent Targeting of Splicing in T Cells

Covalent Modifiers

Kevin A. Scott, Hiroyuki Kojima, Nathalie Ropek, Charles D. Warren, Tiffany L. Zhang, Simon J. Hogg, Caroline Webster, Xiaoyu Zhang, Jahan Rahman, Bruno Melillo, Benjamin F. Cravatt, Jiankun Lyu, Omar Abdel-Wahab, Ekaterina V. Vinogradova bioRxiv 2023.12.18.572199; doi: [link] Despite significant interest in therapeutic targeting of splicing, few chemical probes are available for the proteins involved in splicing.

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Artificial intelligence helps coronary CT angiography and accelerates the development of precision medicine

SCIENMAG: Medicine & Health

This review was jointly published by Prof. Long-Jiang Zhang (Department of Radiology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University) and Prof. Christian Tesche (Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina and Department of Cardiology, Munich University Clinic, Ludwig-Maximilian-University).

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Study delivers detailed photos of galaxies' inner structures

Science Daily: Pharmacology News

High-resolution images captured by the James Webb Space Telescope are offering powerful insights into the complex dust patterns of nearby star-forming galaxies.

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