Drug Hunter
AUGUST 9, 2023
This month features big announcements from Biogen on their acquisition of Reata and their Nrf2 activator for Friedreich’s ataxia and from BridgeBio on their TTR stabilizer with positive Ph. III data for their ATTR-CM treatment. A pair of KRAS inhibitors from Chugai (macrocycle) and AstraZeneca (brain-penetrant) also makes the list for their notable pharmacology.
Chemical Biology and Drug Design
AUGUST 9, 2023
We found plumbagin can inhibit the viability of LoVo cells by multiple mechanisms. Proteomic analysis may provide new insights that plumbagin can inhibit protein transcription process by decreasing eukaryotic initiation factor expression. Abstract Extracted from the roots of Plumbago zeylanica L., plumbagin is a natural naphthoquinone with potential as an anticancer compound.
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Drug Hunter
AUGUST 9, 2023
To help drug discovery professionals get the most out of your trip to ACS San Francisco 2023, we compiled a table of sessions that are likely to be of high interest to industry scientists here. Click here to access the live version of the calendar where you can expand each card for details on each session. You can filter by conference day, time, and see descriptions of the talks and key topics all in one place.
Drugs.com
AUGUST 9, 2023
WEDNESDAY, Aug. 9, 2023 -- If you’re one of the millions of folks bent on racking up at least 10,000 steps a day, read on. A new study finds that heart health starts to improve with as few as 2,300 steps a day. The research also indicates.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Perficient: Drug Development
AUGUST 9, 2023
In today’s web development, being fast and responsive is really important. Users want smooth experiences, and developers work hard to make apps that do just that. This is where Node.js and Redis come in. When used together, they can make your apps work much faster and better. In this article, we’ll look at how to use Redis with Node.js to make applications that are super quick and responsive.
Drugs.com
AUGUST 9, 2023
WEDNESDAY, Aug. 9, 2023 -- It’s already known that the “healthy glow” of a tan actually represents damage to skin cells. But a new study of people on vacation has found that sunbathing also can disrupt the skin’s microbiome, altering the.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Drugs.com
AUGUST 9, 2023
WEDNESDAY, Aug. 9, 2023 -- The U.S. Food and Drug Administration has approved Izervay (avacincaptad pegol intravitreal solution) for the treatment of geographic atrophy secondary to age-related macular degeneration. The approval was based on two.
SCIENMAG: Medicine & Health
AUGUST 9, 2023
NASA’s James Webb Space Telescope has followed up on observations by the Hubble Space Telescope of the farthest star ever detected in the very distant universe, within the first billion years after the big bang.
Drugs.com
AUGUST 9, 2023
WEDNESDAY, Aug. 9, 2023 -- New research shows hard-to-diagnose blood disorders called myelodysplastic syndromes/neoplasms (MDS) are often misdiagnosed and a second opinion may be needed. The difficulty of diagnosis and frequent misdiagnosis puts.
SCIENMAG: Medicine & Health
AUGUST 9, 2023
Currently, hydrogen is mainly produced by natural gas, which, unfortunately, also generates greenhouse gases such as carbon dioxide as by-products. Scientists argue that hydrogen produced this way, while economical, is not truly sustainable, and thus requires a more eco-friendly approach for its generation.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Drugs.com
AUGUST 9, 2023
WEDNESDAY, Aug. 9, 2023 -- Following a four-day raid, Mexico has closed 23 pharmacies in Caribbean resorts of Cancun, Playa del Carmen and Tulum for irregular pill sales. Last spring, the United States warned of dangerous pill sales to foreigners.
SCIENMAG: Medicine & Health
AUGUST 9, 2023
Tropical forests like the Amazon lock away vast amounts of carbon, but that carbon is not equally distributed. The largest 1% of trees store half of the carbon in these forests, and release it back into the atmosphere after they die.
Drugs.com
AUGUST 9, 2023
WEDNESDAY, Aug. 9, 2023 -- About 1 in 5 newborns hospitalized for surgery to treat a life-threatening bowel infection are given opioids for pain relief and some then need methadone to wean off the addictive drugs. But there is wide variability in.
SCIENMAG: Medicine & Health
AUGUST 9, 2023
Immunothrombosis, or the formation of microscopic blood clots during inflammation, is a major cause of morbidity among patients with sepsis or severe COVID-19. A key enzyme in this process is thrombin. To date, no method exists for early detection of immunothrombosis in a living organism.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Drugs.com
AUGUST 9, 2023
WEDNESDAY, Aug. 9, 2023 -- Astronauts aboard the International Space Station (ISS) are living in an environment that contains higher levels of potentially harmful chemicals than seen in American homes, new research reveals. The discovery is.
SCIENMAG: Medicine & Health
AUGUST 9, 2023
Dam constructions have flooded over 1.13 million acres of tribal land in the US contributing to the historic and ongoing struggle against land dispossession for Indigenous peoples in the United States.
BioPharma Drive: Drug Pricing
AUGUST 9, 2023
Third Rock-founded Decibel, which has shed much of its value since a 2021 IPO, expected to run out of money within a year.
SCIENMAG: Medicine & Health
AUGUST 9, 2023
Researchers at the University of Miami and University of California, Irvine were awarded a $1.5 million National Science Foundation grant to make flood risk adaptation faster and more effective to address rapidly escalating flood risks and social inequities in decision-making processes.
Drugs.com
AUGUST 9, 2023
WEDNESDAY, Aug. 9, 2023 -- There are plenty of reasons to steer clear of sugary drinks, and new research highlights yet another one: Women who drink sodas and other sweetened drinks have a higher risk of developing liver cancer and chronic liver.
SCIENMAG: Medicine & Health
AUGUST 9, 2023
Three scientists from the U.S. Department of Energy’s (DOE) Argonne National Laboratory have been named recipients of DOE Early Career Research Awards for 2023. Credit: (Image by Argonne National Laboratory/Mark Lopez.) Three scientists from the U.S. Department of Energy’s (DOE) Argonne National Laboratory have been named recipients of DOE Early Career Research Awards for 2023.
Drugs.com
AUGUST 9, 2023
WEDNESDAY, Aug. 9, 2023 -- New research links air pollution to a variety of cancers, not just lung cancer. Long-term exposure to fine-particulate air pollutants (PM2.
SCIENMAG: Medicine & Health
AUGUST 9, 2023
– By Christina Nunez Credit: Bryngelzon/iStock – By Christina Nunez In rooms where smoking has taken place regularly, tobacco’s imprint lingers on indoor surfaces, even long after regular smoking has stopped. The leftover residues, known as thirdhand smoke, can be a long-term source of indoor pollutants.
Drugs.com
AUGUST 9, 2023
WEDNESDAY, Aug. 9, 2023 -- It seems obvious that texting and walking can be a dangerous duo, but now a new Australian study offers solid evidence of the dangers. Emergency room doctors Dr. Michael Levine and Dr. Matthew Harris, who were not involved.
SCIENMAG: Medicine & Health
AUGUST 9, 2023
LOS ANGELES — Researchers at City of Hope, one of the largest cancer research and treatment organizations in the United States and a leading research center for diabetes and other life-threatening illnesses, were awarded $32.
Science Daily: Pharmacology News
AUGUST 9, 2023
Everywhere scientists look for microplastics, they've found them -- food, water, air and some parts of the human body. But examinations of our innermost organs that aren't directly exposed to the environment are still limited. Now, in a pilot study of people who underwent heart surgery, researchers report that they have found microplastics in many heart tissues.
SCIENMAG: Medicine & Health
AUGUST 9, 2023
Artificial intelligence could hold the key to feeding 10 billion people by 2050 in the face of climate change and rapidly evolving pests and pathogens according to researchers at The University of Queensland.
Science Daily: Pharmacology News
AUGUST 9, 2023
Promising preclinical results show hematopoietic stem cell therapy was effective in rescuing memory loss, neuroinflammation and beta amyloid build-up in a mouse model of Alzheimer's disease.
SCIENMAG: Medicine & Health
AUGUST 9, 2023
A new DNA study has nuanced the picture of how different groups intermingled during the European Stone Age, but also how certain groups of people were actually isolated.
Science Daily: Pharmacology News
AUGUST 9, 2023
A new DNA study has nuanced the picture of how different groups intermingled during the European Stone Age, but also how certain groups of people were actually isolated. Researchers produced new genetic data from 56 Central and Eastern European individuals from the Stone Age.
SCIENMAG: Medicine & Health
AUGUST 9, 2023
First study to measure resilience in biomedical scientists during the pandemic Sixty-one percent of study participants said they experienced a setback during pandemic ‘You can be as resilient as you want, but certain structural factors can hinder your professional advancement’ CHICAGO — When COVID-19 presented the world with the greatest health challenge in modern history, it […]
Science Daily: Pharmacology News
AUGUST 9, 2023
A scientific journey decades in the making has found a new antibiotic strategy to defeat gram-negative bacteria like Salmonella, Pseudomonas and E. coli, the culprits in many urinary tract infections. The synthetic molecule works fast and is durable. It interferes with synthesis of the bacterial outer membrane by jamming an enzyme. When tested against a clinical collection of 285 bacterial strains, including some that were highly resistant to commercial antibiotics, it killed them all.
SCIENMAG: Medicine & Health
AUGUST 9, 2023
It was today (9th August, 2023) announced that Professor Gianluigi Botton has been appointed as the new Chief Executive Officer (CEO) of Diamond Light Source, one of the world’s leading science facilities. He joins Diamond from the Canadian Light Source where he has been its Science Director since May 2019.
Science Daily: Pharmacology News
AUGUST 9, 2023
Breastfeeding has long been used as a method to help keep newborns healthy and protected against a variety of diseases. But certain sugars naturally found in breastmilk could also help prevent infections before a baby arrives. Researchers have found that these sugars can stop a common prenatal infection in human tissues and pregnant mice. This could someday help people avoid preterm births or complications without the need for additional antibiotics.
SCIENMAG: Medicine & Health
AUGUST 9, 2023
MINNEAPOLIS – People who take acid reflux medications called proton pump inhibitors for four-and-a-half years or more may have a higher risk of dementia compared to people who do not take these medications, according to new research published in the August 9, 2023, online issue of Neurology®, the medical journal of the American Academy of […]
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