Drug Discovery World

AUGUST 16, 2023

A tiny human heart model could potentially transform cardiovascular research and enable animal-free drug testing. A team of researchers, led by the Hebrew University of Jerusalem (HU), has developed a self-paced, multi-chambered human heart model, approximately half the size of a rice grain. “Integrating our complex human heart model with sensors allowed us to monitor critical physiological parameters in real-time, revealing intricate mitochondrial dynamics that drive cardiac rhythms,” sai

Drugs 130

Drugs Engineering Disease Research 130

Antidote

AUGUST 16, 2023

Primary sclerosing cholangitis (PSC) is a condition that impacts the bile ducts of the liver, causing them to become inflamed and ultimately scar. It primarily affects young and middle-aged men, and 80% of patients with PBC also have inflammatory bowel disease (IBD).

Disease 98

Disease 98

Drug Discovery World

AUGUST 16, 2023

Samir Ounzain , PhD, CEO & Co-Founder of HAYA Therapeutics, looks at how a better understanding of our DNA can lead to increased activity for RNA therapeutics. The whole world realised the power of RNA when the Covid-19 pandemic brought us the first mRNA-based vaccines. Over the next two decades, it is quite possible that most new drugs approved could be based on some form of RNA, whether it be through its delivery or targeting the molecule itself.

RNA 130

RNA DNA Therapies Small Molecule 130

Drugs.com

AUGUST 16, 2023

WEDNESDAY, Aug. 16, 2023 -- Do you have COVID-19? With a little training, your dog might be more effective at figuring that out than even at-home antigen or sophisticated hospital tests.

Hospitals 98

Hospitals Research 98

Advertisement

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

AUGUST 16, 2023

Join DDW for this exclusive free event, Are in vitro metabolism and drug-drug interaction studies critical for an investigational new drug application? which is supported by BioIVT. Expert Dr Andrew G Taylor, PhD, ADME Technical Sales Specialist, BioIVT, will present this event which will take place on 5 September 2023, 4PM BST, 11AM EST, 5PM CEST, 8AM PDT.

Drug Development 130

Drug Development Drugs 130

Drugs.com

AUGUST 16, 2023

WEDNESDAY, Aug. 16, 2023 -- New hospitalizations for Americans with severe COVID are climbing once again. The number of patients being admitted to hospitals has grown for each of the past four weeks, U.S. Centers for Disease Control and Prevention.

Hospitals 98

Hospitals Disease 98

Drugs.com

AUGUST 16, 2023

WEDNESDAY, Aug. 16, 2023 -- Some patients with acute brain injuries can’t respond to verbal commands, making them appear to be unconscious though they still have some level of awareness. Researchers recently studied this hidden consciousness to.

Research 98

Research 98

Drug Discovery World

AUGUST 16, 2023

Researchers have shown that a novel antibody has greater activity and potentially fewer side effects than existing biological therapies for conditions such as rheumatoid arthritis (RA), psoriasis, and inflammatory bowel disease (IBD). The antibody, called Ab-IPL-IL-17, targets a specific section of signalling proteins IL-17A and IL-17F which play a central role in sustaining inflammation during onset and progression of autoimmune diseases.

Immune Response 130

Immune Response Disease Therapies Treatment 130

Drugs.com

AUGUST 16, 2023

WEDNESDAY, Aug. 16, 2023 -- Genetically engineered pig kidneys are nearing the point where they could provide a government-approved, sustainable supply of organs for sick humans awaiting a transplant, a pair of new studies argue. A lightly modified.

Engineering 98

Engineering Government 98

Drug Patent Watch

AUGUST 16, 2023

Annual Drug Patent Expirations for REMODULIN Remodulin is a drug marketed by United Therap and is included in two NDAs. It is available from one supplier. There are nine patents… The post New patent for United Therap drug REMODULIN appeared first on DrugPatentWatch - Make Better Decisions.

Drugs 98

Drugs Marketing 98

Advertisement

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Drugs.com

AUGUST 16, 2023

WEDNESDAY, Aug. 16, 2023 -- When teens vape, their lungs pay a price, researchers report. The warning stems from a detailed analysis of smoking habit histories shared by just over 2,000 U.S. teens during a series of recent annual surveys. The.

Research 98

Research 98

Perficient: Drug Development

AUGUST 16, 2023

In today’s rapidly evolving tech landscape, staying ahead of the curve is crucial, but so is selecting the right platform. If you find yourself overwhelmed by the multitude of options and the complexities involved in the selection process, you’re not alone. To help you make an informed decision and find the ultimate technology platform for your organization, here are the top five factors you need to consider: Prioritize Your Requirements: To ensure seamless alignment with your orga

Production 98

Production 98

Drugs.com

AUGUST 16, 2023

WEDNESDAY, Aug. 16, 2023 -- America’s emergency rooms are being flooded by children suffering from psychiatric emergencies like anxiety, depression and suicidal thoughts or attempts, a new joint report from three leading medical associations.

Doctors 98

Doctors 98

BioPharma Drive: Drug Pricing

AUGUST 16, 2023

The decision stands in contrast to the agency’s plans for a would-be rival gene editing treatment from Vertex Pharmaceuticals and CRISPR Therapeutics that is also under a regulatory review.

Therapies 98

Therapies FDA Pharmaceuticals Treatment 98

Advertisement

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drugs.com

AUGUST 16, 2023

WEDNESDAY, Aug. 16, 2023 -- Having good fitness while young can really pay off when it comes to cancer risk later in life. New research found that cardiorespiratory fitness -- the ability to do aerobic exercise -- was associated with up to 42% lower.

Research 98

Research 98

PPD

AUGUST 16, 2023

The COVID-19 pandemic rapidly accelerated the adoption of hybrid and decentralized clinical trial (DCT) models. However, as the world settles into its post-pandemic state and returns to pre-pandemic paradigms in many areas, the pharmaceutical industry remains dedicated to moving beyond traditional, centralized clinical trial constructs. At the end of 2022, the PPD clinical research business of Thermo Fisher Scientific surveyed key leadership and staff on the frontline of clinical trial execution

Clinical Trials 98

Clinical Trials Trials Clinical Research FDA 98

Drugs.com

AUGUST 16, 2023

WEDNESDAY, Aug. 16, 2023 -- All infants should receive the new long-acting preventive monoclonal antibody for respiratory syncytial virus (RSV), the nation’s leading pediatrics group said. The American Academy of Pediatrics (AAP) urged that access.

Virus 98

Virus 98

Drug Target Review

AUGUST 16, 2023

Cancer remains a major global health concern, often diagnosed at advanced stages when treatment options and survival rates are limited. Early detection and intervention are likely to be the most effective means of reducing morbidity and mortality of human cancer. 1 Early-stage cancers are typically asymptomatic, making routine screening challenging with traditional methods due to cost and clinical constraints.

DNA 98

DNA Disease Therapies Treatment 98

Drugs.com

AUGUST 16, 2023

WEDNESDAY, Aug. 16, 2023 (American Heart Association News) -- After a seven-hour drive back home with his family to Woodbury, Minnesota, Dave Ogle planned to do what he always did: haul his suitcases upstairs to unpack and do laundry.

98

98

FDA Law Blog: Biosimilars

AUGUST 16, 2023

By Douglas B. Farquhar — Francis Godwin, Director of the Office of Manufacturing Quality of the Office of Compliance at FDA’s Center for Drug Evaluation and Research provided useful information (presentation attached here ) Tuesday at the GMP by the Sea Conference. He talked about regulatory discretion being exercised for drug manufacturing facilities with serious compliance problems, about how firms should respond to FDA inspectional observations, and about an upcoming guidance that will be of

Compliance 97

Compliance FDA Drugs Pharmaceuticals 97

Drugs.com

AUGUST 16, 2023

WEDNESAY, Aug. 16, 2023 -- Research into a possible link between childhood health problems and natural gas wells in western Pennsylvania is wrapping up with some answers.

Research 98

Research 98

SCIENMAG: Medicine & Health

AUGUST 16, 2023

HAMILTON, ON (August 16, 2023) – Some women with early-stage, low-risk breast cancer may not need radiotherapy after breast conserving surgery according to new research led by McMaster University, BC Cancer, Hamilton Heath Sciences, and the University of British Columbia.

Research 93

Research Science 93

BioPharma Drive: Drug Pricing

AUGUST 16, 2023

The struggling biotech also plans to offload other cell therapy assets, including a multiple myeloma therapy, and focus exclusively on gene editing medicines.

Therapies 98

Therapies Research Drugs 98

SCIENMAG: Medicine & Health

AUGUST 16, 2023

MIAMI, FLORIDA (Aug. 17, 2023) – Researchers with Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine have been awarded a grant from the U.S. Department of Defense (DoD)’s Congressionally Directed Medical Research Program to target chemotherapy resistance in pancreatic cancer. Credit: Photo by Sylvester. MIAMI, FLORIDA (Aug.

Research 93

Research 93

Eye on FDA

AUGUST 16, 2023

In what has been a long period of relative low activity, FDA’s OPDP has taken the opportunity to remind us that low enforcement does not mean no enforcement when it comes to promotional speech by pharmaceutical companies. This past June FDA posted an Untitled Letter , the first regulatory action letter in a year, reported on here regarding a website communication.

FDA 84

FDA Pharmaceutical Companies Doctors Pharmaceuticals 84

SCIENMAG: Medicine & Health

AUGUST 16, 2023

What if artificial intelligence (AI) could be used to spur discovery in areas such as biotechnology, drug discovery and fluid dynamics? Using geometric graphs and innovative methodologies, AI can solve fundamental problems in basic natural science. The possibilities are endless in this relatively new field known as AI for science.

Science 92

Science Engineering Drugs 92

Science Daily: Pharmacology News

AUGUST 16, 2023

A new study shows that trapping light inside magnetic materials may dramatically enhance their intrinsic properties. Strong optical responses of magnets are important for the development of magnetic lasers and magneto-optical memory devices, as well as for emerging quantum transduction applications.

75

75

SCIENMAG: Medicine & Health

AUGUST 16, 2023

About The Study: Paternal depression was associated with subsequent offspring depression in this systematic review and meta-analysis including 7.1 million father-child dyads from 16 observational studies.

92

92

Drugs.com

AUGUST 16, 2023

WEDNESDAY, Aug. 16, 2023 -- Breast, colon and pancreatic cancer rates are increasing at concerning rates among America's young adults, a new study finds. Breast cancer accounted for the most cases in adults under 50 between 2010 and 2019, but.

75

75

SCIENMAG: Medicine & Health

AUGUST 16, 2023

SAN FRANCISCO, Aug. 16, 2023 — Indoor air pollution may have met its match. Today, scientists will report that they have designed catalyst-coated lampshades that transform indoor air pollutants into harmless compounds.

Engineering 92

Engineering 92

Drugs.com

AUGUST 16, 2023

WEDNESDAY, Aug. 16, 2023 -- Death rates skyrocket during extreme weather events among the most vulnerable Americans, especially those from minority groups. A study looking at hurricanes over more than three decades showed that their impacts varied.

75

75

SCIENMAG: Medicine & Health

AUGUST 16, 2023

Osaka, Japan – What if “looking your age” refers not to your face, but to your chest? Osaka Metropolitan University scientists have developed an advanced artificial intelligence (AI) model that utilizes chest radiographs to accurately estimate a patient’s chronological age. More importantly, when there is a disparity, it can signal a correlation with chronic disease.

Disease 91

Disease Engineering 91

Science Daily: Pharmacology News

AUGUST 16, 2023

People who adhere to a Mediterranean lifestyle -- which includes a diet rich in fruits, vegetables, and whole grains; healthy eating habits like limiting added salts and sugars; and habits promoting adequate rest, physical activity, and socialization -- have a lower risk of all-cause and cancer mortality, according to a new study. People who adhered to the lifestyle's emphasis on rest, exercise, and socializing with friends had a lower risk of cardiovascular disease mortality.

Disease 75

Disease 75

SCIENMAG: Medicine & Health

AUGUST 16, 2023

Drawing on UMass Lowell’s expertise in spacecraft design and track record of successful missions, the university has secured $5.5 million in state funding to launch a research center where scientists, industry leaders and startups can build and test miniature satellites and components essential to spaceflight.

Research 90

Research Science 90