Drug Hunter

SEPTEMBER 18, 2023

A First-in-Class TRPA1 Antagonist Overcomes Toxicity Hurdles to Become Cough Candidate Genentech’s GDC-6599 is the first oral TRP Ankyrin 1 (TRPA1) antagonist to reach Ph. IIa ( NCT05660850 ) for chronic cough after preclinical studies and a Ph. I trial showed it was well-tolerated, in contrast to prior molecules. The transient receptor potential (TRP) family of ion channels has been the subject of intensive drug discovery efforts due to their critical role in the development and progression of

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Trials Drugs 315

Forbes: Drug Truths

SEPTEMBER 18, 2023

At a time when the opportunities for discovering and developing new medicines is the greatest in our history, we will be doing less. What we really should be doing is investing more in order to generate new medicines thus reducing downstream healthcare costs.

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Drugs 264

BioPharma Drive: Drug Pricing

SEPTEMBER 18, 2023

Public health officials, as well as drugmakers, are trying to raise awareness of RSV among older adults at risk, and convince them to get an additional respiratory shot alongside those for COVID and flu.

Vaccine 130

Vaccine 130

Chemical Biology and Drug Design

SEPTEMBER 18, 2023

Some 2-[4-( 1H -benzimidazol-1-yl) phenyl]- 1H -benzimidazole derivatives decreased cell viability of CML cells dramatically. Compounds induced apoptosis through activation of Caspase3/7 activity and increasing the proapoptotic genes expression levels in CML cell lines. They also decreased the P-gp transport activity in CML cells. Abstract Imatinib (IMA) is a tyrosine kinase inhibitor (TKI) introduced for the chronic myeloid leukemia (CML) therapy.

Therapies 100

Therapies Drugs Research 100

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drugs.com

SEPTEMBER 18, 2023

MONDAY, Sept. 18, 2023 -- Emergency medicine doctors someday might rely on consultation from artificial intelligence (AI) programs like ChatGPT to help them quickly and accurately diagnose patients’ ailments. A new study found that ChatGPT.

Doctors 119

Doctors 119

Chemical Biology and Drug Design

SEPTEMBER 18, 2023

RAGE activation promotes proinflammatory or proapoptotic cell responses. LRP1 regulates the clearance of Aβ in Alzheimer's disease. Formononetin ameliorates Aβ/RAGE-mediated inflammatory and oxidative stress cascade in neuronal cells. It also upregulates the clearance of Aβ by ApoJ-mediated activation of LRP1. Formononetin inhibits the NF-κB nuclear translocation by increasing the expression of Nrf-2.

Government 100

Government Regulations Disease 100

Perficient: Drug Development

SEPTEMBER 18, 2023

Background Excel is the most used spreadsheet software in today’s era, used by every level of organization. Quite a huge amount of unorganized data is maintained in Excel workbooks, owing to ease of quick creation, storage & sharing of Excel files over database. Resultant many of the Power BI reports / dashboards are based on Excel as data-source.

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Drugs.com

SEPTEMBER 18, 2023

MONDAY, Sept. 18, 2023 -- Before pouring another drink, consider this sobering new research: Heavy drinkers can develop fat around the heart, leading to heart failure and other cardiac problems. This so-called pericardial fat is associated with.

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Research 116

BioPharma Drive: Drug Pricing

SEPTEMBER 18, 2023

With the rise of ChatGPT and artificial intelligence (AI), there are many ways the clinical staffing industry can use AI advantageously while removing the stigma that the rise of technology can be dehumanizing.

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Drugs.com

SEPTEMBER 18, 2023

MONDAY, Sept. 18, 2023 -- CPR could save your life if you suffer cardiac arrest in a public place, but you're less likely to receive it if you're a woman, a new study finds. The findings were presented Monday at the European Emergency Medicine.

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Science Daily: Pharmacology News

SEPTEMBER 18, 2023

Exposure to endocrine-disrupting chemicals like PFAS and phenols are implicated in hormone-mediated cancers of the breast, ovaries, skin and uterus. To learn more about the environmental exposures experienced by women who developed these cancers, researchers analyzed data from NHANES and found that women who reported having cancer had significantly higher levels of these chemicals in their bodies.

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Research 107

Drugs.com

SEPTEMBER 18, 2023

MONDAY, Sept. 18, 2023 -- As people age, health issues tend to mount, but roughly a quarter of low-income adults over 65 have no medical insurance. That’s the age when most Americans become eligible for Medicare, the federal health insurance for.

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Drug Patent Watch

SEPTEMBER 18, 2023

The article “Maximizing the Value of Drug Patents Before Losing Exclusivity” discusses strategies for biomedical companies to maximize the value of their drug patents before the exclusivity period expires. In… The post Maximizing Drug Patents’ Value: Strategies for Biomedical Companies appeared first on DrugPatentWatch - Make Better Decisions.

Drugs 94

Drugs 94

BioPharma Drive: Drug Pricing

SEPTEMBER 18, 2023

Three years after gaining European approval, Libmeldy is now under U.S. review with a deadline set for March.

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Therapies Disease FDA 117

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Science Daily: Pharmacology News

SEPTEMBER 18, 2023

Engineers designed an implantable device that carries hundreds of thousands of islet cells along with its own on-board oxygen factory to keep the cells healthy. Such a device could help Type 1 diabetes patients eliminate the need for insulin injections.

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Engineering 95

Drugs.com

SEPTEMBER 18, 2023

MONDAY, Sept. 18, 2023 -- It's an important health topic, but both adult patients and their primary care doctors shy away from discussing firearms and gun safety, a new survey finds. While they may discuss a variety of health risks, firearm safety.

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Doctors 89

BioPharma Drive: Drug Pricing

SEPTEMBER 18, 2023

The drug, known scientifically as momelotinib, is now cleared to treat myelofibrosis and will compete against rival medicines sold by Incyte and Bristol Myers Squibb.

FDA Approval 76

FDA Approval FDA Drugs 76

Drugs.com

SEPTEMBER 18, 2023

MONDAY, Sept. 18, 2023 -- Low-carb diets may be all the rage, but they're not for kids with diabetes, according to the American Academy of Pediatrics (AAP). In a new report, the AAP says that low-carbohydrate diets cannot be recommended for children.

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Drug Channels

SEPTEMBER 18, 2023

Informa Connect’s Patient Support Services Congress November 7-9, 2023 | The Inn at Penn, Philadelphia, PA [link] Exclusive Offer – Be sure to use your exclusive promo code 23DC10 to save 10% off* of your registration. The Patient Support Services Congress is a dialogue-driven meeting that arms the industry with innovative trends and next-generation approaches to patient services for optimal performance.

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Compliance Pharmaceuticals Drugs Disease 75

Drugs.com

SEPTEMBER 18, 2023

MONDAY, Sept. 18, 2023 -- Perhaps succumbing to fraudsters or facing mounting bills, older Americans begin losing wealth in the years preceding a definitive dementia diagnosis, new research shows. For example, the median household net worth of the.

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Research 89

Science Daily: Pharmacology News

SEPTEMBER 18, 2023

Researchers discover excellent thermoelectric properties of nickel-gold alloys. These can be used to efficiently convert heat into electrical energy.

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Research 96

Drugs.com

SEPTEMBER 18, 2023

MONDAY, Sept. 18, 2023 -- A clinical trial designed to test repurposed medications for their impact on fighting COVID-19 has found no benefit to taking the antidepressant fluvoxamine (Luvox) to ease coronavirus symptoms. The study, led by Duke.

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Clinical Trials Trials 69

Cytel

SEPTEMBER 18, 2023

With the ongoing changes inherent in the life sciences industry comes heightened expectations for companies to take accountability for their environmental, social, and governance (ESG) impacts. Click below to read Cytel’s inaugural Sustainability Report, in which you will learn about Cytel’s ESG strategy, objectives, and current state. Drawing from core values of accountability, innovation, and collaboration, Cytel has embraced these expectations as an opportunity to showcase its commitment to i

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Government Science 64

Drugs.com

SEPTEMBER 18, 2023

MONDAY, Sept. 18, 2023 -- Whole-body MRI scans are the latest health fad to be promoted by celebrities, with Kim Kardashian taking to Instagram last month to tout the practice. But doctors are warning that such whole-body scans, while tempting, are.

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Doctors 69

BioPharma Drive: Drug Pricing

SEPTEMBER 18, 2023

As integrated evidence generation takes center stage for driving evidence-based decision making across the product life cycle, automated registries just might be the linchpin that pulls it all together.

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Production 62

Drug Patent Watch

SEPTEMBER 18, 2023

Annual Drug Patent Expirations for ACTOPLUS+MET+XR Actoplus Met Xr is a drug marketed by Takeda Pharms Usa and is included in one NDA. There are five patents protecting this drug… The post New patent expiration for Takeda Pharms drug ACTOPLUS MET XR appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs Marketing 59

Perficient: Drug Development

SEPTEMBER 18, 2023

Chile Independence Day, also known as “Fiestas Patrias,” is a cherished national holiday that captures the heart and soul of Chilean culture. On the 18th of September each year, Chileans come together to commemorate their country’s declaration of independence from Spanish rule in 1810. How does Chile celebrate Independence Day? This lively celebration is a vibrant blend of tradition, history, and patriotism.

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Drug Patent Watch

SEPTEMBER 18, 2023

Annual Drug Patent Expirations for AUVELITY Auvelity is a drug marketed by Axsome and is included in one NDA. It is available from one supplier. There are one hundred and… The post New patent for Axsome drug AUVELITY appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs Marketing 59

Tecan

SEPTEMBER 18, 2023

By Mellisa Enriquez Molecular diagnostics: the never-ending challenge Molecular diagnostics offers researchers and clinicians valuable insights into the mechanisms of disease, allowing them to assess predisposition, as well as to design and implement accurate diagnostic methods and individualized therapies.

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Therapies Disease Research 52

Drug Patent Watch

SEPTEMBER 18, 2023

Annual Drug Patent Expirations for INGREZZA Ingrezza is a drug marketed by Neurocrine and is included in one NDA. It is available from one supplier. There are twenty patents protecting… The post New patent for Neurocrine drug INGREZZA appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs Marketing 59

Perficient: Drug Development

SEPTEMBER 18, 2023

In an increasingly interconnected world, technology continues to transform and improve every aspect of our lives. This includes assistive technologies designed to enhance the quality of life for individuals with diverse needs. Among the many areas of assistive technology, one that plays a vital role in promoting comfort and support is Body Structure Aids.

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Production Research 52

SCIENMAG: Medicine & Health

SEPTEMBER 18, 2023

CAMBRIDGE, MA — One promising approach to treating Type 1 diabetes is implanting pancreatic islet cells that can produce insulin when needed, which can free patients from giving themselves frequent insulin injections.

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Perficient: Drug Development

SEPTEMBER 18, 2023

Cognitive disabilities, often invisible but profoundly impactful, can present unique challenges for individuals and their families. Conditions such as dementia, autism, attention deficit hyperactivity disorder (ADHD), and traumatic brain injury (TBI) can affect memory, communication, problem-solving, and daily functioning. In this blog post, we explore the pivotal role of assistive technologies in empowering individuals with cognitive disabilities and enhancing their quality of life.

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Production 52

SCIENMAG: Medicine & Health

SEPTEMBER 18, 2023

Healthcare organizations, in reviewing care delivery opportunities and providing feedback to staff, often focus on what went wrong, but a new study suggests that reversing this perspective may help organizations improve their work culture by understanding what went right.

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Research 52