Thu.Aug 01, 2024

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Retreat of tropical glaciers foreshadows changing climate's effect on the global ice

Science Daily: Pharmacology News

As they are in many places around the globe, glaciers perched high in the Andes Mountains are shrinking. Now, researchers have uncovered evidence that the high-altitude tropical ice fields are likely smaller than they've been at any time since the last ice age ended 11,700 years ago.

Research 136
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Lilly obesity drug shows heart benefit in late-stage trial

BioPharma Drive: Drug Pricing

The drug led to a 38% reduction in the risk of death or complications from a type of heart failure, a finding that compared favorably to available treatments.

Trials 122
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Key to rapid planet formation

Science Daily: Pharmacology News

Researchers have developed a new model to explain the formation of giant planets such as Jupiter, which furnishes deeper insights into the processes of planet formation and could expand our understanding of planetary systems.

Research 135
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Moderna shares fall amid lower sales outlook for RSV, COVID shots

BioPharma Drive: Drug Pricing

The biotech cited competitive pressure and “very low” expected sales in Europe for its latest guidance cut, which sent shares down by nearly 20%.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Modern behavior explains prehistoric economies

Science Daily: Pharmacology News

What if the 'Market Economy' always existed? Archaeologists tried to answer this question by researching how much Bronze Age people used to spend to sustain their daily lives. Their results show that, starting at least 3,500 years ago, the spending habits of prehistoric Europeans were not substantially different from what they are today.

Marketing 122
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Daily Aspirin Cuts Odds for Colon Cancer: Who Benefits Most?

Drugs.com

THURSDAY, Aug. 1, 2024 -- It's long been known that a daily dose of low-dose aspirin helps keep colon cancer at bay.But new research suggests that those who benefit most are folks whose lifestyles up their odds for the disease in the first.

Disease 111

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FDA Warns of Danger From At-Home Chemical Peels

Drugs.com

THURSDAY, Aug. 1, 2024 -- Don't use a chemical peel to help rejuvenate your skin unless it's done under the supervision of a trained professional, the U.S. Food and Drug Administration has advised. "FDA is warning consumers not to purchase or use.

FDA 111
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Half a billion-year-old spiny slug reveals the origins of mollusks

Science Daily: Pharmacology News

Exceptional fossils with preserved soft parts reveal that the earliest mollusks were flat, armored slugs without shells. The new species, Shishania aculeata, was covered with hollow, organic, cone-shaped spines. The fossils preserve exceptionally rare detailed features which reveal that these spines were produced using a sophisticated secretion system that is shared with annelids (earthworms and relatives).

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UniQure restructuring to claim 300 jobs

BioPharma Drive: Drug Pricing

The job cuts affects 65% of UniQure’s workforce and include the gene therapy developer’s recent sale of a manufacturing plant to Genezen.

Therapies 113
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When it comes to DNA replication, humans and baker's yeast are more alike than different

Science Daily: Pharmacology News

Humans and baker's yeast have more in common than meets the eye, including an important mechanism that helps ensure DNA is copied correctly, reports a pair of studies. The findings visualize for the first time a molecular complex -- called CTF18-RFC in humans and Ctf18-RFC in yeast -- that loads a 'clamp' onto DNA to keep parts of the replication machinery from falling off the DNA strand.

DNA 112
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Nasal COVID Vaccine Stops Infection in Animal Trials

Drugs.com

THURSDAY, Aug. 1, 2024 -- A next-generation nasal vaccine for COVID-19 appears to do what injectable vaccines can’t -- actually stop the spread of the virus from person to person.Hamsters that received the nasal vaccine didn’t pass the virus on to.

Vaccine 110
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Engineering researchers crack the code to boost solar cell efficiency and durability

Science Daily: Pharmacology News

Photovoltaic (PV) technologies, which convert light into electricity, are increasingly applied worldwide to generate renewable energy. Researchers have now developed a molecular treatment that significantly enhances the efficiency and durability of perovskite solar cells. Their breakthrough will potentially accelerate the large-scale production of this clean energy.

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Most Americans Don't Know About Lung Cancer Screening: Survey

Drugs.com

THURSDAY, Aug. 1, 2024 -- People who've had a history of smoking can get a lung cancer spotted early -- when it's most treatable -- through annual CT screening. Unfortunately, most Americans polled in a new survey didn't know this potentially.

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Judging your own happiness could backfire

Science Daily: Pharmacology News

Judging how happy you are could backfire and negatively impact life satisfaction and psychological well-being, according to new research.

Research 123
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Common Medical Billing Errors Keep Many Americans From Care: Report

Drugs.com

THURSDAY, Aug. 1, 2024 -- Insured working-age adults are frequently being hit with medical bills for services that should have been covered, a new Commonwealth Fund survey has found.Close to half (45%) of insured workers have received a bill or.

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Climate change may lead to shifts in vital Pacific Arctic fisheries

Science Daily: Pharmacology News

Commercially important marine fish and invertebrate species will likely shift northwards under a warmer climate, according to new research.

Research 114
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14 Risk Factors Raise Your Odds for Odds for Dementia

Drugs.com

THURSDAY, AUG. 1, 2024 -- New research has added two conditions to the list of 12 risk factors that boost the chances of a dementia diagnosis.The good news? You can guard against the development of both and researchers offer advice on exactly how.

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When Nanoparticles Blow Up— Explosion Hazards of Nanoparticles

NIOSH Science Blog: Drugs

This blog is part of a series to commemorate the 20th anniversary of the Nanotechnology Research Center. Click here for additional blogs in the series and on other nanotechnology topics. Engineered nanoparticles are synthesized materials with at least one dimension smaller than 100 nanometers. Reactive nanoparticles pose a special hazard. The heat released by the rapid oxidation of aerosolized combustible nanoparticles increases the temperature and pressure of the suspending gas.

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High Blood Pressure Might Help Spur Migraines

Drugs.com

THURSDAY, Aug. 1, 2024 -- High blood pressure might increase a woman’s odds of suffering migraines, a new study finds.Specifically, high diastolic blood pressure is linked to a slightly higher risk of women ever having a migraine, researchers r.

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Cigna CEO promises ‘aggressive’ defense of pharmacy benefit managers

BioPharma Drive: Drug Pricing

David Cordani’s comments to investors Thursday come as the payer blew past Wall Street’s expectations for the second quarter, helped by significant growth in its health services division — including PBM Express Scripts.

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Wildfire Smoke Exposure Linked With Higher Dementia Risk

Drugs.com

THURSDAY, Aug. 1, 2024 -- The wildfires thats are increasing with climate change could harm the future brain health of humanity, a new study suggests.Wildfire smoke appears to increase people’s risk of a dementia diagnosis even more than other t.

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Antibodies 101: Stripping and Reprobing Western Blots

addgene Blog

Western blots are a great tool to identify a protein of interest in a complicated solution like cell lysate. But they can be a lot of work — and what if you want to detect more than one protein in your sample? Or what if something weird happened during your western and your results look… funky? Do you need to start a whole new blot? Never fear: membrane stripping is here!

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Why Are Cancer Rates Rising Among Gen X, Millennials?

Drugs.com

THURSDAY, Aug. 1, 2024 -- Cancer rates are rising among Gen Xers and millennials, a new study reports.Successively younger generations are more frequently being diagnosed half of the 34 known cancer types, researchers found.For example, people.

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As sales climb, Biogen ‘convinced’ the worst is over for Leqembi

BioPharma Drive: Drug Pricing

On a call with reporters, CEO Chris Viehbacher pointed to trends showing the Alzheimer’s drug is “on the right path” to becoming the lucrative product the company envisioned.

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Scientists revolutionize microscopy by reimagining the logic of imaging

Science Daily: Pharmacology News

Scientists have devised an innovative imaging method using state-of-the-art microscopes that significantly reduces the time and radiation required. Their work represents a significant breakthrough that will benefit several disciplines, from materials science to medicine, as the method promises to deliver improved imaging for sensitive materials such as biological tissues that are especially vulnerable to damage.

Science 81
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Jim Wilson, prominent gene therapy researcher, to depart UPenn

BioPharma Drive: Drug Pricing

Wilson, who founded UPenn’s gene therapy program three decades ago, will step down to start two new spinouts, Gemma Bio and Franklin Biolabs.

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Crafting AEP Schemas: A Practical Guide

Perficient: Drug Development

Welcome to the world of Adobe Experience Platform (AEP) , where digital transformation becomes a reality. If you’ve landed here, you’re already on your way to making significant strides in your organization or your career. In a digital era where data reigns supreme, and the Customer Data Platform (CDP) landscape is ever-evolving, businesses strive to maximize their investments to thrive in a fiercely competitive market.

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Looking back at Pride Month

BenchSci

Every year, in the month of June, communities around the world gather together to commemorate the persistence of the LGBTQIA2+ spirit. This spirit emphasizes the respect and dignity innate across all diverse expressions of the human experience and celebrates that diversity. This time of year is fittingly referred to as Pride, as it’s a reminder to take pride in and bond with others as our authentic selves.

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Breaking Through Supply Chain Bottlenecks in CGT

Fierce BioTech

Breaking Through Supply Chain Bottlenecks in CGT pesurya Thu, 08/01/2024 - 17:20 Wed, 09/25/2024 - 11:00 Resource Type Webinar Matthew L. Plaud Dr. Mike Scott Matthew Frazzetta Amy Hendricks Robert S. Jones Promotion Start Wed, 08/14/2024 - 13:35 Promotion End Fri, 02/14/2025 - 13:35 Duration 60 Minutes In the fast-evolving field of cell and gene therapy, overcoming bottlenecks at every stage of the process – both upstream and downstream of manufacturing – is crucial to ensure timely and effecti

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New tentative approval for Alembic drug dabigatran etexilate mesylate

Drug Patent Watch

Dabigatran etexilate mesylate is the generic ingredient in two branded drugs marketed by Alkem Labs Ltd, Apotex, Hetero Labs Ltd Iii, and Boehringer Ingelheim and, and is included in five NDAs.

Drugs 52
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Antidote Partner Profile: A Q&A with Breakthrough T1D (formerly JDRF)

Antidote

Enabling medical advancements is one of Antidote’s chief missions, and one way we do this is through our robust partner network. By providing our clinical trial search tool, Antidote Match , to these organizations at no cost, we can build relationships with condition experts, reach patient communities effectively, and aid individuals during their search for clinical trials.

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New patent expiration for Mayne Pharma drug RHOFADE

Drug Patent Watch

Annual Drug Patent Expirations for RHOFADE Rhofade is a drug marketed by Mayne Pharma and is included in one NDA. It is available from one supplier. There are eight patents protecting this drug.

Drugs 52
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Drop Ship Business Challenges and Solutions By Technology

Perficient: Drug Development

What is drop ship? Drop shipping is a one-of-its-kind retail business model where a seller accepts customer orders without keeping inventory on hand. Instead, the seller forwards the order and payment details to a supplier, who then ships the product directly to the customer. This model is popular because it allows retailer to avoid investing in warehouse space, operational cost, or unsold inventory, and instead focus on other areas like marketing.

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New patent for Vertical Pharms drug DSUVIA

Drug Patent Watch

Annual Drug Patent Expirations for DSUVIA Dsuvia is a drug marketed by Vertical Pharms and is included in one NDA. It is available from one supplier. There are twenty patents protecting this drug.

Drugs 52