Mon.Nov 18, 2024

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Diabetes Meds Metformin, GLP-1s Can Also Curb Asthma

Drugs.com

MONDAY, Nov. 18, 2024 -- Drugs already taken by millions of diabetes patients appear to also help slash asthma attacks by up to 70%, new British research shows.The two drugs are metformin, one of the most widely used diabetes medications, and the.

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Scientists recreate mouse from gene older than animal life

Science Daily: Pharmacology News

An international team of researchers has achieved an unprecedented milestone: the creation of mouse stem cells capable of generating a fully developed mouse using genetic tools from a unicellular organism, with which we share a common ancestor that predates animals. This breakthrough reshapes our understanding of the genetic origins of stem cells, offering a new perspective on the evolutionary ties between animals and their ancient single-celled relatives.

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Accelerate Drug and Material Discovery with New Math Library NVIDIA cuEquivariance

Nvidia Developer: Drug Discovery

AI models for science are often trained to make predictions about the workings of nature, such as predicting the structure of a biomolecule or the properties of. AI models for science are often trained to make predictions about the workings of nature, such as predicting the structure of a biomolecule or the properties of a new solid that can become the next battery material.

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New idea may crack enigma of the Crab Nebula's 'zebra' pattern

Science Daily: Pharmacology News

A theoretical astrophysicist may have solved a nearly two-decade-old mystery over the origins of an unusual 'zebra' pattern seen in high-frequency radio pulses from the Crab Nebula.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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FDA endorses speedy approval path for Regenxbio Duchenne gene therapy

BioPharma Drive: Drug Pricing

The agency's openness to a targeted pivotal study shows it’s still willing to consider accelerated clearance for Duchenne gene therapies despite questions about their effectiveness.

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Redefining net zero will not stop global warming

Science Daily: Pharmacology News

An international group of authors who developed the science behind net zero demonstrate that relying on 'natural carbon sinks' like forests and oceans to offset ongoing CO2 emissions from fossil fuel use will not actually stop global warming. The science of net zero, developed over 15 years ago, does not include these natural carbon sinks in the definition of net human-induced CO2 emissions.

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Effortless robot movements

Science Daily: Pharmacology News

Humans and animals move with remarkable economy without consciously thinking about it by utilizing the natural oscillation patterns of their bodies. A new tool can now utilize this knowledge for the first time to make robots move more efficiently.

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New Prolapse Surgery Uses Women's Own Tissues to Restore Function

Drugs.com

MONDAY, Nov. 18, 2024 -- It’s possible to correct a woman’s pelvic prolapse using her own muscle tissue in robot-assisted surgery, a new study demonstrates.In the procedure, tendon muscle is transferred from the thigh to the uterus or cervix, rep.

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New fossil reveals the evolution of flying reptiles

Science Daily: Pharmacology News

A newly discovered pterosaur fossil is shedding light on the evolutionary journey of these ancient flying reptiles. This complete specimen, named Skiphosoura bavarica, provides crucial insights into how pterosaurs transitioned from early, smaller forms to the later, gigantic species. By analysing the unique features of Skiphosoura, paleontologists can now trace the step-by-step evolution of pterosaurs, including changes in head size, neck length, wing structure, and tail length.

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Certain Painkillers Can Raise Bleeding Risks for People on Blood Thinners

Drugs.com

MONDAY, Nov. 18, 2024 -- People on blood thinners have a doubled risk of dangerous internal bleeding if they also take a non-steroidal anti-inflammatory drug (NSAID) like ibuprofen or naproxen, a new study warns.People typically are prescribed.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Gaming for the good!

Science Daily: Pharmacology News

It turns out gaming is good for you! New research indicates massive multiplayer online gamers learn by gaming and their skills in the workplace are enriched by those seemingly endless hours previously thought of as frittering away time.

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First U.S. Case of New Mpox Strain Spotted in Traveler

Drugs.com

MONDAY, Nov. 18, 2024 -- As Africa continues to battle an outbreak of the newer "clade Ib" strain of mpox, California officials have confirmed the first known U.S. case of this strain of the virus.The subtype of clade I mpox virus has already.

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Dieting: Cause of the yo-yo effect deciphered

Science Daily: Pharmacology News

Researchers have discovered a mechanism behind the yo-yo effect: fat cells have a memory that is based on epigenetics.

Research 116
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E. Coli Spurs Nationwide Organic Carrots Recall

Drugs.com

MONDAY, Nov. 18, 2024 -- An E. coli outbreak linked to organic carrots has sickened 39 people in 18 states, U.S. health officials reported Sunday.Supplied by California-based Grimmway Farms and sold under popular brand names such as Nature’s P.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Tiny worm makes for big evolutionary discovery

Science Daily: Pharmacology News

The history of a major animal group, composed of millions of species of insects, arachnids, and nemotodes, has been elusive -- until now. A team has now identified the oldest known ecdysozoan in the fossil record and the only one from the Precambrian period.

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Can drugs be blockbusters without relying on US sales?

Drug Patent Watch

The concept of a blockbuster drug, defined as a medication generating at least $1 billion in annual sales, has long been a cornerstone of the pharmaceutical industry. However, the question arises whether a drug can achieve blockbuster status without heavily relying on U.S. sales.

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Reducing variability in gene expression: bottlenecks and solutions

BioPharma Drive: Drug Pricing

Explore solutions to reduce variability in gene expression during cell line development.

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Atlas Venture 2024 Year In Review

LifeSciVC

“May you live in interesting times” – or so goes the phrase. In 1966, RFK Jr’s father famously used that quote to capture the turbulence of the times, and continued: “Like it or not, we live in interesting times. They are times of danger and uncertainty, but they are also the most creative of any time in the history of mankind.” Ironically, this is how biotech feels right now in November 2024, dealing with the shockwaves of Trump’s nomination of RFK Jr as the nation’s new health czar.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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New research explores volcanic caves, advancing the search for life on Mars

Science Daily: Pharmacology News

Through the intricate study of lava tubes -- caves formed following volcanic eruptions when lava cools down -- an international team of researchers has uncovered clues about Earth's ancient environments that could be significant in the search for life on Mars.

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AI Helps Spot Liver Disease Early

Drugs.com

MONDAY, Nov. 18, 2024 -- AI can help doctors diagnose early cases of fatty liver disease, a new study says.An AI program trained to spot a leading type of the disease, called metabolic-associated steatotic liver disease (MASLD), unearthed hundreds.

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Syndax secures FDA OK for new kind of leukemia drug

BioPharma Drive: Drug Pricing

Revuforj is the first so-called menin inhibitor cleared in the U.S., securing FDA approval for use in adults and certain pediatric patients with an aggressive form of acute leukemia.

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When Schools Give Kids Time in Nature, Anxiety and Behavior Issues Ease

Drugs.com

MONDAY, Nov. 18, 2924 -- A dose of green may be just what school kids with anxiety, depression and other mental health issues need, new research shows.Canadian investigators found that a school program that let 10- to 12-year-olds spend a little.

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The Future of Generic Drug Development in Emerging Markets

Drug Patent Watch

The pharmaceutical industry is undergoing a significant shift, with emerging markets offering the next growth opportunity. This growth is driven by several factors, including the increasing prevalence of chronic diseases, cost-effectiveness, and patent expirations of branded drugs.

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Your Heart's Shape Could Affect Your Health

Drugs.com

MONDAY, Nov. 18, 2024 -- It's long been known that certain structural qualities of the human heart -- its size, chamber volume -- can influence cardiovascular health.British scientists say they're now discovering that the gene-directed shape of a.

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CRISPR therapy from Intellia may ameliorate rare heart disorder, data suggest

BioPharma Drive: Drug Pricing

Phase 1 data indicate Intellia’s medicine could be a powerful treatment for a cardiac form of ATTR amyloidosis. But rival drugs are further ahead.

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Cocoa, Green Tea Might Counter Effects of 'Stress Eating' Fatty Foods

Drugs.com

MONDAY, Nov. 18, 2024 -- Folks who stress-eat fatty foods like cookies, chips and ice cream might be able to protect their health with a nice cup of cocoa or green tea, a new study says.Drinking cocoa that’s high in healthy flavanols along with a f.

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Comprehensive Exploration of Isocitrate Dehydrogenase (IDH) Mutations: Tumorigenesis, Drug Discovery, and Covalent Inhibitor Advances

Covalent Modifiers

Conghao Gai, Hairong Zeng , Haoming Xu, Xiaoyun Chai, Yan Zou, Chunlin Zhuang, Guangbo Ge, Qingjie Zhao European Journal of Medicinal Chemistry, 2024 [link] Isocitrate dehydrogenase (IDH) is an enzyme that catalyses the oxidative decarboxylation of isocitrate, producing α-ketoglutarate (α-KG) relative to the hydroxylation of substrates. However, IDH mutants can further reduce α-KG to 2-hydroxyglutarate (2-HG) which competitively inhibits α-KG dependent enzymes, leading to the downregulation of n

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Poll Finds Many Parents Struggling to Manage Kids' Anger

Drugs.com

MONDAY, Nov. 18, 2024 -- Angry outbursts are common among children, as siblings squabble and kids protest the unfairness of rules like screen time limits.Now, a new survey shows that many parents struggle to manage their kids’ anger, and some even s.

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Cancer Immunotherapy Data Science Challenge - Lecture 3, Part B - Data - Data Overview

Broad Institute

Cancer Immunotherapy Data Science Challenge - Lecture 3, Part B - Data - Data Overview By Rose Circeo November 18, 2024 Breadcrumb Home Cancer Immunotherapy Data Science Challenge - Lecture 3, Part B - Data - Data Overview The "Cancer Immunotherapy Data Science Challenge: Reprogramming T Cells to Combat Tumors" was born of the desire to leverage rapid advances in single-cell sequencing technologies and the power of machine learning to improve cancer treatment.

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ACTO JOINS VEEVA AI PARTNER PROGRAM TO STRENGTHEN FIELD TEAM MESSAGING DURING FACE-TO-FACE HCP INTERACTIONS

ACTO

Helping Mutual Customers Elevate the “Human Touch” Element of Their Omnichannel Engagement Strategies MADRID, Spain – Veeva Commercial Summit – November 19, 2024 – ACTO today announced it expanded its product partnership with Veeva by joining the Veeva AI Partner Program to help advance the use of Generative AI (GenAI) in life sciences. ACTO offers GenAI products that help field-based representatives with messaging during face-to-face interactions with healthcare providers (HCPs).

Science 52
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Cancer Immunotherapy Data Science Challenge - Lecture 3, Part A - Data - Experiment Overview

Broad Institute

Cancer Immunotherapy Data Science Challenge - Lecture 3, Part A - Data - Experiment Overview By Rose Circeo November 18, 2024 Breadcrumb Home Cancer Immunotherapy Data Science Challenge - Lecture 3, Part A - Data - Experiment Overview The "Cancer Immunotherapy Data Science Challenge: Reprogramming T Cells to Combat Tumors" was born of the desire to leverage rapid advances in single-cell sequencing technologies and the power of machine learning to improve cancer treatment.

Science 52
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Maximizing Site Performance: The Hidden Benefits of Unified eConsent and EDC

Crucial Data Solutions

Let’s be real: managing clinical trials is tough enough without juggling multiple disconnected systems. Yet for many research teams, that’s. The post Maximizing Site Performance: The Hidden Benefits of Unified eConsent and EDC appeared first on Crucial Data Solutions.

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Cancer Immunotherapy Data Science Challenge - Lecture 2, Part C - Tech - Measuring Perturbations in Cells

Broad Institute

Cancer Immunotherapy Data Science Challenge - Lecture 2, Part C - Tech - Measuring Perturbations in Cells By Rose Circeo November 18, 2024 Breadcrumb Home Cancer Immunotherapy Data Science Challenge - Lecture 2, Part C - Tech - Measuring Perturbations in Cells The "Cancer Immunotherapy Data Science Challenge: Reprogramming T Cells to Combat Tumors" was born of the desire to leverage rapid advances in single-cell sequencing technologies and the power of machine learning to improve cancer treatmen

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