Drug Discovery World
MARCH 27, 2024
Scientists have discovered how breast cancer cells can ‘hibernate’ to avoid treatment and ‘wake up’ years later – causing a relapse that is more difficult to treat. Their research, published in the journal Cancer Discovery , reveals the role of epigenetics in controlling how cancer cells can become dormant – and suggests a strategy to target it before the cells wake up.
Science Daily: Pharmacology News
MARCH 27, 2024
Researchers have used data from UK Biobank participants to reveal that diabetes, traffic-related air pollution and alcohol intake are the most harmful out of 15 modifiable risk factors for dementia.
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Drug Discovery World
MARCH 27, 2024
Join DDW and Cresset for this free event ‘ Enhancing collaboration in drug discovery – a biotech perspective ’. The event will take place on 28 March at 2pm GMT / 3pm CET / 9am EST / 6am PST. Delivery of synthesis targets within small molecule drug discovery often involves many chemists and other collaborators, both internal and external, across multiple locations.
Science Daily: Pharmacology News
MARCH 27, 2024
What would you do if you walked up to a robot with a human-like head and it smiled at you first? You'd likely smile back and perhaps feel the two of you were genuinely interacting. But how does a robot know how to do this? Or a better question, how does it know to get you to smile back?
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Drug Discovery World
MARCH 27, 2024
The vaccines currently in late-stage development hold promise in tackling the disease burden of tuberculosis (TB), says data and analytics company GlobalData on World Tuberculosis Day 2024. World TB Day is marked annually on 24 March, the anniversary of the discovery of the causative mycobacterium by Dr Robert Koch. The day aims to raise awareness about the devastating health, social, and economic consequences of the disease.
Science Daily: Pharmacology News
MARCH 27, 2024
Researchers have recovered remarkably preserved microbiomes from two teeth dating back 4,000 years, found in an Irish limestone cave. Genetic analyses of these microbiomes reveal major changes in the oral microenvironment from the Bronze Age to today. The teeth both belonged to the same male individual and also provided a snapshot of his oral health.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Chemical Biology and Drug Design
MARCH 27, 2024
Diosgenin through downregulation of PI3K, Akt, mTOR and upregulation of PTEN inhibits migration and proliferation of OVCAR-3 cancer cells. Abstract Diosgenin, a natural steroidal sapogenin, has recently attracted a high amount of attention, as an effective anticancer agent in ovarian cancer. However, diosgenin mediated anticancer impacts are still not completely understood.
Science Daily: Pharmacology News
MARCH 27, 2024
Scientists reversed an aggressive cancer, reverting malignant cells towards a more normal state. Rhabdoid tumors are an aggressive cancer which is missing a key tumor suppressor protein. Scientists discovered that removing a second protein from cancer cells already experiencing tumor suppressor loss can reverse cancer cell identity.
Antidote
MARCH 27, 2024
MS is a chronic disease that is estimated to impact over a million Americans. The condition causes damage to the body’s central nervous system, leading to numbness, memory problems, sight issues, and difficulties with coordination.
Science Daily: Pharmacology News
MARCH 27, 2024
Just as you can't make an omelet without breaking eggs, scientists have found that you can't make long-term memories without DNA damage and brain inflammation.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Drugs.com
MARCH 27, 2024
WEDNESDAY, March 27, 2024 -- ADHD stimulant medications like Ritalin or Adderall appear linked to a heightened risk for cardiomyopathy (a weakening of the heart muscle), and the risk grows with time, new research shows. However, researchers were.
Science Daily: Pharmacology News
MARCH 27, 2024
Do you ever find yourself longing for the energy and vitality of your younger years? Feeling young is not just a matter of perception it is actually related to objective health outcomes. Previous studies have shown that feeling younger than one s actual age is associated with longer, healthier lives. There is even support for subjective age to predict actual brain age, with those feeling younger having younger brains.
Drugs.com
MARCH 27, 2024
WEDNESDAY, March 27, 2024 -- Folks who consistently work out two to three times a week are less likely to suffer from insomnia, a new study says. That sort of long-term commitment to exercise also helps people get the recommended amount of sleep.
Science Daily: Pharmacology News
MARCH 27, 2024
Engineers designed an 'architected' reef that can mimic the wave-buffering effects of natural reefs while providing pockets for marine life. The sustainable and cost-saving structure could dissipate more than 95 percent of incoming wave energy using a small fraction of the material normally needed.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Drugs.com
MARCH 27, 2024
WEDNESDAY, March 27, 2024 -- Some folks struggling with obesity appear to be hampered by their own genes when it comes to working off those extra pounds, a new study finds. People with a higher genetic risk of obesity have to exercise more to avoid.
Science Daily: Pharmacology News
MARCH 27, 2024
A new image from the Event Horizon Telescope (EHT) collaboration has uncovered strong and organized magnetic fields spiraling from the edge of the supermassive black hole Sagittarius A* (Sgr A*). Seen in polarized light for the first time, this new view of the monster lurking at the heart of the Milky Way Galaxy has revealed a magnetic field structure strikingly similar to that of the black hole at the center of the M87 galaxy, suggesting that strong magnetic fields may be common to all black ho
Drugs.com
MARCH 27, 2024
WEDNESDAY, March 27, 2024 -- Youngsters might have good cause to think they’re brainier than their parents or grandparents, a new study finds. It turns out that human brains are getting larger with each generation, potentially adding more.
Science Daily: Pharmacology News
MARCH 27, 2024
Researchers have developed an organic photovoltaic film that is both waterproof and flexible, allowing a solar cell to be put onto clothes and still function correctly after being rained on or even washed.
Drugs.com
MARCH 27, 2024
WEDNESDAY, March 27, 2024 -- Migraines in young adults appear to increase their risk of stroke more than traditional risk factors like high blood pressure, a new study reports. Results show that migraine is the most important non-traditional risk.
Science Daily: Pharmacology News
MARCH 27, 2024
The interior of the Sun does not rotate at the same rate at all latitudes. The physical origin of this differential rotation is not fully understood. It turns out, long-period solar oscillations discovered in 2021 play a crucial role in controlling the Sun's rotational pattern. The long-period oscillations are analogous to the baroclinically unstable waves in Earth's atmosphere that shape the weather.
Drugs.com
MARCH 27, 2024
WEDNESDAY, March 27, 2024 -- A major review of data confirms that getting less than the recommended amount of sleep each night is a risk factor for high blood pressure. Data collected in 16 studies conducted from 2000 through 2023, involving over 1.
Science Daily: Pharmacology News
MARCH 27, 2024
The Antarctic Circumpolar Current plays an important part in global overturning circulation, the exchange of heat and CO2 between the ocean and atmosphere, and the stability of Antarctica's ice sheets. An international research team has now used sediments taken from the South Pacific to reconstruct the flow speed in the last 5.3 million years. Their data show that during glacial periods, the current slowed; during interglacials, it accelerated.
Drugs.com
MARCH 27, 2024
WEDNESDAY, March 27, 2024 -- The odds in the United States that a well-functioning donor heart will go to a Black man are lower than for white transplant candidates of either gender, new research shows. The news is troubling, since "Black patients.
Science Daily: Pharmacology News
MARCH 27, 2024
Scientists created a highly accurate reference genome for one of the most important modern crops and found a rare example of how genes confer disease resistance in plants. Exploring sugarcane's genetic code could help researchers develop more resilient and productive crops, with implications for both sugar production and biofuels.
Drugs.com
MARCH 27, 2024
WEDNESDAY, March 27, 2024 -- Fried foods not only wreck the waistline, but they could also be harming the brain, a new study of lab rats suggests. Fed chow that was fried in sesame or sunflower oil, the rodents developed liver and colon problems.
Science Daily: Pharmacology News
MARCH 27, 2024
Scientists have uncovered a key step in the wound healing process that becomes disabled in diseases like diabetes and aging, contributing to a global healthcare cost of managing poorly healing wounds exceeding $250 billion a year. Importantly, the research reveals a molecule involved in the healing of tissues that -- when injected into animal models -- leads to a drastic acceleration of wound closure, up to 2.5 times faster, and 1.6 times more muscle regeneration.
sptlabtech
MARCH 27, 2024
Biological research hinges on the collection and preservation of often precious samples for future analysis. Preserving sample integrity over time is crucial to avoiding degradation. Loss of integrity can lead to data loss or unreliable results, potentially jeopardizing research outcomes and incurring significant costs. Implementing robust and reliable sample management practices is key to giving you security in the integrity of your sample library and preventing costly disasters. arktic ® is ou
Science Daily: Pharmacology News
MARCH 27, 2024
Researchers found that the double-lobed object, which is officially named Kuiper Belt Object 486958 Arrokoth and resembles a snowman, may have ancient ices stored deep within it from when the object first formed billions of years ago.
BioPharma Drive: Drug Pricing
MARCH 27, 2024
The failure of a medicine known as TUDCA is yet another disappointment for ALS patients, as it comes just after Amylyx’s therapy Relyvrio proved unsuccessful in confirmatory testing.
Science Daily: Pharmacology News
MARCH 27, 2024
Engineers have uncovered an unexpected pattern in how neural networks -- the systems leading today's AI revolution -- learn, suggesting an answer to one of the most important unanswered questions in AI: why these methods work so well. The result not only illuminates the inner workings of neural networks, but gestures toward the possibility of developing hyper-efficient algorithms that could classify images in a fraction of the time, at a fraction of the cost.
BioPharma Drive: Drug Pricing
MARCH 27, 2024
An arm of the private equity firm pledged up to $750 million in funding for Moderna’s flu shot development, in exchange for milestones and royalties.
Science Daily: Pharmacology News
MARCH 27, 2024
Astronomers have measured the speed of fast-moving jets in space, crucial to star formation and the distribution of elements needed for life. The jets of matter, expelled by stars deemed 'cosmic cannibals', were measured to travel at over one-third of the speed of light -- thanks to a groundbreaking new experiment.
BioPharma Drive: Drug Pricing
MARCH 27, 2024
The startup’s performance will test investors’ appetite for early-stage drugmakers, as Boundless has only advanced as far as Phase 1 clinical trials.
Science Daily: Pharmacology News
MARCH 27, 2024
In a remarkable discovery, whole milk powder manufactured in New Zealand in 1907 and transported to Antarctica with explorers seeking the South Pole was unveiled after more than a century. The find has allowed dairy researchers to answer the question: Is the milk we enjoy today different from the milk consumed in previous generations? Now, a new comparative study has peered back in time to demonstrate that -- despite advancements in selective breeding and changes to farm practices -- milk of the
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