Drug Discovery World

AUGUST 1, 2023

Researchers from the University of Liverpool, UK, have created a biomedical compound that has the potential to stop the spread of breast cancer. Scientists from the Chemistry and Biochemistry Departments at the University of Liverpool and Nanjing Medical School in China have discovered a possible way to block proteins that cause metastasis. The major problem hindering the successful treatment of commonly occurring cancers is not the primary tumour which can usually be removed by surgery, but its

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Medical Schools Clinical Trials Research Treatment 246

Chemical Biology and Drug Design

AUGUST 1, 2023

A series of pyrimido[4,5- b ]quinoline derivatives synthesized, showed good cytotoxic activity on MCF-7 cells. 5b was the most active (IC 50 : 1.67 μM), HER2 inhibitor (IC 50 : 0.073 μM) and promoted apoptosis. Abstract A series of N -arylpyrimido[4,5- b ]quinolines 3a–e and 2-aryl-2,3-dihydropyrimido[4,5- b ]quinoline-4(1 H )-ones 5a–e was designed and synthesized as potential anticancer agents against breast cancer.

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Research 100

Drug Discovery World

AUGUST 1, 2023

Investigators at the Icahn School of Medicine at Mount Sinai have designed an RNA-based strategy to activate dendritic cells that eradicated tumours and prevented their recurrence in mouse models of melanoma. The findings, which suggest that the approach has the potential to be effective against tumours that have already spread to other parts of the body and against different cancer types, were reported in Nature Nanotechnology.

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RNA Clinical Trials Research Trials 130

Drugs.com

AUGUST 1, 2023

TUESDAY, Aug. 1, 2023 -- One dose of the hallucinogenic ingredient in "magic mushrooms" may help some people with anorexia move past their preoccupation with body image, an early study suggests. The study, of just 10 women with anorexia, tested the.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

AUGUST 1, 2023

Synthetic biology is increasingly important to drug discovery and development. Reece Armstrong examines recent activity within the sector and highlights some of the key advancements and innovation. Partnerships Earlier this year cell-engineering company MaxCyte signed a strategic platform license (SPL) with biotechnology company Catamaran Bio. The agreement will see Catamaran gain access to MaxCyte’s technology platforms which enable the complex engineering of cells.

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Licensing Licensing Drugs Engineering 130

Drugs.com

AUGUST 1, 2023

TUESDAY, Aug. 1, 2023 -- A micronutrient in human breast milk may provide significant benefit to developing newborn brains, according to new research that sheds light on the link between nutrition and brain health. Scientists looked at this sugar.

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Research 98

Drugs.com

AUGUST 1, 2023

TUESDAY, Aug. 1, 2023 -- Pediatricians have suspected it for years, and now a new study may be proving them right: Cold air really can help ease children's croup symptoms. Croup is a common childhood illness that usually starts as an ordinary cold.

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Drug Channels

AUGUST 1, 2023

In my most recent video webinar , I explored how plans and PBMs are turning to novel—and highly controversial—benefit design tools that access manufacturers’ patient support spending: copay accumulators, maximizers, and alternative funding programs. In the video excerpt below, I describe these new approaches that plans offset specialty drug expenses.

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Marketing Drugs 98

Drugs.com

AUGUST 1, 2023

TUESDAY, Aug. 1, 2023 -- Cervical cells from Henrietta Lacks, a cancer patient who died more than 70 years ago, are a cornerstone of modern medicine, but her family has never been compensated for the cells taken without her knowledge. Until.

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SCIENMAG: Medicine & Health

AUGUST 1, 2023

ATLANTA, August 1, 2023 – A new study from researchers at the American Cancer Society (ACS) found monthly adult cancer diagnoses decreased by half in April 2020 during the COVID-19 pandemic in the United States. The largest decrease was for stage I cancers, resulting in a higher proportion of late-stage diagnoses.

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Research 96

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Drugs.com

AUGUST 1, 2023

TUESDAY, Aug. 1, 2023 -- Kombucha is a fermented tea that many folks believe offers numerous health benefits — and new research suggests they may be right. Though the study was small -- 12 participants -- it found that kombucha may help lower.

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Research 98

SCIENMAG: Medicine & Health

AUGUST 1, 2023

It created something of a stir when, back in 2022, researchers from Aarhus University announced a new and inexpensive way of breaking down polyurethane (PU) plastic into its original components, which can then be recycled into new PU material instead of ending up in landfills or incinerators.

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Research 94

Drugs.com

AUGUST 1, 2023

TUESDAY, Aug. 1, 2023 -- In a study of families that have multiple children with autism, researchers have unearthed new insights into genes that might drive the disorder. “Study design is critical, and not enough attention has been paid to.

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Research 98

SCIENMAG: Medicine & Health

AUGUST 1, 2023

“We have discussed in detail the clinical implications of ER in avoiding overtreatment and undertreatment in DCIS.” Credit: 2023 Thorat. “We have discussed in detail the clinical implications of ER in avoiding overtreatment and undertreatment in DCIS.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drugs.com

AUGUST 1, 2023

TUESDAY, Aug. 1, 2023 – The family of a mother of four who collapsed and died while cooking breakfast has been awarded $11 million in a wrongful death lawsuit. The cause of death for Krystal Talavera, 39, involved the opioid-like herb known as.

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SCIENMAG: Medicine & Health

AUGUST 1, 2023

Silicon-based materials are currently the undisputed leaders in the field of semiconductors. Even so, scientists around the world are actively trying to find superior alternatives for next-generation electronics and high-power systems. Interestingly, diamonds are among the most promising materials for applications such as fast telecommunications and power conversion in electric vehicles and power plants.

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Science Daily: Pharmacology News

AUGUST 1, 2023

When a fragrance wafted through the bedrooms of older adults for two hours every night for six months, memories skyrocketed. Participants in this study reaped a 226% increase in cognitive capacity compared to the control group. The researchers say the finding transforms the long-known tie between smell and memory into an easy, non-invasive technique for strengthening memory and potentially deterring dementia.

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Research 76

SCIENMAG: Medicine & Health

AUGUST 1, 2023

Can one see through a scattering medium like ground glass? Conventionally, such a feat would be deemed impossible. As light travel through an opaque medium, the information contained in the light becomes “jumbled up”, almost as if undergoes complex encryption.

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Drugs.com

AUGUST 1, 2023

TUESDAY, Aug. 1, 2023 -- Taking the stairs rather than an elevator. Raking leaves. Toting heavy grocery bags. Pushing a vacuum. Playing hard with your kids or pets. Short bursts of vigorous physical activity during everyday events like these —.

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SCIENMAG: Medicine & Health

AUGUST 1, 2023

August 1, 2023, Mountain View, CA – The SETI Institute is proud to announce that Dr. John Rummel will receive the prestigious 2023 Drake Award, recognizing his extraordinary and innovative programmatic contributions and unwavering advocacy for SETI and astrobiology.

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Science 87

Science Daily: Pharmacology News

AUGUST 1, 2023

Royal Ontario Museum announces the oldest swimming jellyfish in the fossil record with the newly named Burgessomedusa phasmiformis. This 505-million-year-old swimming jellyfish from the Burgess Shale highlights diversity in the Cambrian ecosystem.

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SCIENMAG: Medicine & Health

AUGUST 1, 2023

The public funding of science is responsible for many of the biomedical and other scientific breakthroughs on which our lives depend. However, the process through which funding decisions are made, the peer review of grant proposals, has been historically understudied, and current approaches can lead to undesirable outcomes.

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Research Science 85

addgene Blog

AUGUST 1, 2023

If you’ve ever used Golden Gate Assembly for cloning, you might be familiar with the rules of thumb for designing your overhang sets. But are those rules the best way to design GGA overhang sets, particularly for high-complexity reactions?

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SCIENMAG: Medicine & Health

AUGUST 1, 2023

Only 19% of Saudi Arabian women are diagnosed at stage I of cervical cancer where survival rates are highest, according to a study published by the King Abdulaziz University. To further motivate action to combat cervical cancer, BGI Genomics today released its State of Cervical Cancer Awareness Report in Saudi Arabia.

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Drugs.com

AUGUST 1, 2023

TUESDAY, Aug. 1, 2023 -- As Americans continue to grapple with the effects of long COVID, the Biden administration on Monday announced the creation of a new office focused on research about the condition that will be part of the U.S. Department of.

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Research 75

SCIENMAG: Medicine & Health

AUGUST 1, 2023

Smoking in pregnancy can harm developing babies, especially their growth . Current guidelines recommend that pregnant smokers who find quitting difficult should be provided with nicotine replacements products and stop-smoking services usually recommend nicotine patches. This research published in NIHR Journals Library, suggests that pregnant women should also consider e-cigarettes.

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Production Research 84

Drugs.com

AUGUST 1, 2023

TUESDAY, Aug. 1, 2023 -- Children who have a chronic immune system disease that can prevent them from eating may eventually have a new treatment, decades after the condition was first identified. “Parents and doctors may not be aware of this, but.

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Disease Doctors Treatment 74

SCIENMAG: Medicine & Health

AUGUST 1, 2023

Can the humble feijoa help the world tackle type 2 diabetes? University of Auckland scientists are investigating. With more than 200,000 people in New Zealand living with type 2 diabetes, prevention is key to tackling this important health issue. Could a solution be found growing in New Zealand backyards?

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Drug Patent Watch

AUGUST 1, 2023

Annual Drug Patent Expirations for PATANASE Patanase is a drug marketed by Novartis and is included in one NDA. It is available from two suppliers. There are two patents protecting… The post New patent expiration for Novartis drug PATANASE appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs Marketing 52

SCIENMAG: Medicine & Health

AUGUST 1, 2023

Molecules that act as connected wheels can hold long molecular chains together to modify the properties of soft polymers. Credit: Minami Ebe, et al. Angewandte Chemie International Edition. July 17, 2023 Molecules that act as connected wheels can hold long molecular chains together to modify the properties of soft polymers.

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International 82

Drug Patent Watch

AUGUST 1, 2023

Obeticholic acid is the generic ingredient in one branded drug marketed by Intercept Pharms Inc and is included in one NDA. There are ten patents protecting this compound. Drug patent… The post New tentative approval for Optimus Pharma drug obeticholic acid appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs Marketing 52

SCIENMAG: Medicine & Health

AUGUST 1, 2023

Atomic nuclei consist of nucleons such as protons and neutrons, which are bound together by nuclear force or strong interaction. This force allows protons and neutrons to form bound states; however, when only two neutrons are involved, the attractive force is slightly insufficient to create such a state.

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Drug Patent Watch

AUGUST 1, 2023

Annual Drug Patent Expirations for SOTALOL+HYDROCHLORIDE Sotalol Hydrochloride is a drug marketed by Altathera Pharms Llc, Apotex, Aurobindo Pharma Usa, Beximco Pharms Usa, Epic Pharma Inc, Impax Pharms, Mylan, Oxford… The post New patent for Altathera Pharms drug SOTALOL HYDROCHLORIDE appeared first on DrugPatentWatch - Make Better Decisions.

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SCIENMAG: Medicine & Health

AUGUST 1, 2023

Decades of research have left knowledge gaps about cells that regulate the immune system: Purdue and NIH Credit: Purdue University photo/Jessica Kerkhoff Decades of research have left knowledge gaps about cells that regulate the immune system: Purdue and NIH Four decades of research have produced a vast pool of knowledge about regulatory T cells, a […]

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Regulations Research 82