Drug Discovery World

AUGUST 17, 2023

DDW’s Diana Spencer speaks to Alok Javali , CSO of dawn-bio, a new addition to BioInnovation Institute’s (BII) Venture Lab acceleration programme, about the lack of innovation in women’s reproductive health and the company’s plans to fill the vacuum. Earlier this year, dawn-bio was one of five drug discovery companies to enter the BioInnovation Institute’s (BII) Venture Lab acceleration programme for early-stage companies.

Cell Biology 130

Cell Biology International Science Drugs 130

BioPharma Drive: Drug Pricing

AUGUST 17, 2023

A combination of Trodelvy and Merck’s Keytruda appears active against lung tumors, but has a high bar to clear and faces competition from AstraZeneca and Daiichi Sankyo.

Drugs 98

Drugs 98

Drug Discovery World

AUGUST 17, 2023

A new forecast predicts global prescription drug sales to be worth $1.6tn by 2028. Global biopharmaceutical revenues are forecast to grow at a compounded annual rate of 5.9% to 2028, according to the latest World Preview report published by Evaluate. The annual report forecasts that while the industry will have to work hard to navigate ‘Pharma’s Age of Uncertainty’ in coming years, the top ten biggest drugs in 2028 will still pull in over $160bn.

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Pharmaceuticals Therapies Drugs Marketing 130

Broad Institute

AUGUST 17, 2023

#WhyIScience Q&A: A computational biologist helps build datasets for genetic disease diagnosis By Corie Lok August 17, 2023 Breadcrumb Home #WhyIScience Q&A: A computational biologist helps build datasets for genetic disease diagnosis Katherine Chao talks about her work managing the Genome Aggregation Database (gnomAD) and the importance of diverse datasets in rare disease diagnosis.

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Disease Production Science Research 98

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

AUGUST 17, 2023

Researchers at the Francis Crick Institute in the UK have found that molecules in vegetables like broccoli or cauliflower help to maintain a healthy barrier in the lung and ease infection. The aryl hydrocarbon receptor (AHR) is a protein found at barrier sites like the gut and the lung. Natural molecules in cruciferous vegetables are dietary ‘ligands’ for AHR , which means they activate AHR to target a number of genes.

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Virus Laboratories Regulations Research 130

Drugs.com

AUGUST 17, 2023

THURSDAY, Aug. 17, 2023 -- Public health officials are warning people about the risks of flesh-eating bacterial infections and how to avoid them after the deaths of three older adults on the northeast coast. Two of the deaths from vibriosis — an.

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Drugs.com

AUGUST 17, 2023

THURSDAY, Aug. 17, 2023 -- A new type of medication, JAK inhibitors, can effectively treat moderate to severe alopecia areata, a hair loss condition that has been historically hard to treat. A study of its effectiveness, by Dr. Brett King and Dr.

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Treatment 98

Drug Patent Watch

AUGUST 17, 2023

Annual Drug Patent Expirations for LUMASON Lumason is a drug marketed by Bracco and is included in one NDA. It is available from one supplier. There are two patents protecting… The post New patent for Bracco drug LUMASON appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs Marketing 98

Drugs.com

AUGUST 17, 2023

THURSDAY, Aug. 17, 2023 -- Despite what you see on TikTok, don’t consume the laundry powder borax to relieve pain and inflammation or boost bone health. Even though videos on the social media site tout it as a treatment, this substance is not safe.

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Treatment 98

Drug Target Review

AUGUST 17, 2023

What is the main focus of the study or research mentioned in the passage? Many therapeutic monoclonal antibodies (mAb), such as Rituximab and Herceptin, deplete target cells (called direct targeting mAbs) and elicit immunotherapy by engaging activating Fc gamma receptors (FcγRs) on host effector cells. These antibodies are negatively regulated by the inhibitory IgG receptor, FcγRIIB (CD32B).

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International Regulations Therapies Clinical Trials 98

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Drugs.com

AUGUST 17, 2023

THURSDAY, Aug. 17, 2023 -- Sometimes patients with pancreatic cancer are prescribed the benzodiazepine lorazepam (Ativan) for anxiety, but that may be harming their health. A new study found this treatment was linked to worse outcomes, with shorter.

Treatment 98

Treatment 98

SCIENMAG: Medicine & Health

AUGUST 17, 2023

According to the World Health Organization, globally, infectious disease is a leading cause of death among children. Furthermore, children are more likely than adults to contract infectious illnesses. However, there’s a gap in research measuring children’s responses to sick faces.

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Disease Research 95

Drugs.com

AUGUST 17, 2023

THURSDAY, Aug. 17, 2023 -- When Daniel Cooney and his husband Patrick Key adopted Rothko, a coonhound mix, from a shelter eight years ago, it took time to get used to his quirks. Rothko doesn’t always jell with other pups, which means the dog park.

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SCIENMAG: Medicine & Health

AUGUST 17, 2023

In an experiment on how turbulent boundary layers respond to acceleration in the flow around them, aerospace engineers at the University of Illinois Urbana-Champaign observed an unexpected internal boundary layer.

Engineering 91

Engineering International 91

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drugs.com

AUGUST 17, 2023

THURSDAY, Aug. 17, 2023 -- The U.S. Food & Drug Administration has approved Akeega (niraparib and abiraterone acetate) for the treatment of BRCA-positive metastatic castration-resistant prostate cancer. The approval makes Akeega the first and.

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FDA Approval FDA Treatment Drugs 98

SCIENMAG: Medicine & Health

AUGUST 17, 2023

Bias in the collection of data on which Artificial Intelligence (AI) computer programmes depend can limit the usefulness of this rapidly growing tool for climate scientists predicting future scenarios and guiding global action, according to a new paper by researchers at the University of Cambridge published in Nature’s npj |Climate Action series.

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Research 89

Drugs.com

AUGUST 17, 2023

THURSDAY, Aug. 17, 2023 (American Heart Association News) -- Researchers have long understood that people with chronic health conditions, such as heart disease, are at increased risk for depression. The same may be true for people with COVID-19.

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Disease Research 98

SCIENMAG: Medicine & Health

AUGUST 17, 2023

A new study of the PhyloBone project of the University of Turku, Finland, identifies hundreds of non-collagenous proteins in the bone matrix that may play regulatory roles in bone formation and regeneration. The study opens the door to new treatments and preventive measures for bone regeneration and osteoporosis research.

Treatment 88

Treatment Research 88

Drugs.com

AUGUST 17, 2023

THURSDAY, Aug. 17, 2023 -- Two recently approved treatments offer newfound hope for patients in the early stages of Alzheimer’s disease, but most people who could benefit will likely be deemed ineligible, a new study finds. Alzheimer's affects.

Treatment 96

Treatment Disease Drugs 96

SCIENMAG: Medicine & Health

AUGUST 17, 2023

Somatostatin, a signaling molecule produced by many inhibitory neurons in the brain, broadly dampens communication among a variety of cell types in the prefrontal cortex and promotes exploratory and risk-taking-like behavior in mice, according a Penn State-led research team.

Research 87

Research Science 87

Drugs.com

AUGUST 17, 2023

THURSDAY, Aug. 17, 2023 -- Vaping CBD (cannabidiol) is on the rise among middle and high school students, according to a national U.S. survey, and health experts warn there can be serious risks involved. More than 1 in 5 students who use electronic.

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SCIENMAG: Medicine & Health

AUGUST 17, 2023

Credit: Brian Maffly, University of Utah Earth’s rapidly changing climate is taking an increasingly heavy toll on landscapes around the world in the form of floods, rising sea levels, extreme weather, drought and wildfire.

Science 86

Science 86

Drugs.com

AUGUST 17, 2023

THURSDAY, Aug. 17, 2023 -- It’s fun to playfully toss a toddler into the air, or tote a kid piggyback-style on your shoulders. But those delightful giggles may come with a risk of head injury from a typically overlooked hazard -- the room’s.

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SCIENMAG: Medicine & Health

AUGUST 17, 2023

In trials, the antipsychotic drug brexpiprazole (Rexulti) failed to provide a clinically meaningful benefit and increased the risk of death. Yet the US Food and Drug Administration (FDA) has fast tracked its approval, making Rexulti the first antipsychotic for treating agitation in elderly patients with dementia.

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FDA Drugs Trials 86

Drugs.com

AUGUST 17, 2023

THURSDAY, Aug. 17, 2023 -- The idea of “doing your own research” didn’t begin with the pandemic, but new research suggests that those who follow that ideology have been more likely to believe COVID misinformation. “We had heard the phrase a.

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Research 75

SCIENMAG: Medicine & Health

AUGUST 17, 2023

Overview Credit: COPYRIGHT (C) TOYOHASHI UNIVERSITY OF TECHNOLOGY. ALL RIGHTS RESERVED. Overview Assistant Professor Yuya Hosoda of the Center for IT-Based Education (CITE), Toyohashi University of Technology developed a method for estimating the pitch of vocal cord vibrations of humans from call audio.

Science 86

Science 86

Science Daily: Pharmacology News

AUGUST 17, 2023

In 1956, theoretical physicists predicted that electrons in a solid can do something strange. While they normally have a mass and an electric charge, Pines asserted that they can combine to form a composite particle that is massless, neutral, and does not interact with light. He called this particle a 'demon.' Since then, it has been speculated to play an important role in the behaviors of a wide variety of metals.

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SCIENMAG: Medicine & Health

AUGUST 17, 2023

ALBUQUERQUE, N.M. — Sandia National Laboratories has produced its first lot of a new world-class ion trap, a central component for certain quantum computers. The new device, dubbed the Enchilada Trap, enables scientists to build more powerful machines to advance the experimental but potentially revolutionary field of quantum computing.

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Laboratories 85

Science Daily: Pharmacology News

AUGUST 17, 2023

Researchers have found an injection of a specific blood factor can replicate the benefits of exercise in the brain. They've discovered that platelets secrete a protein, exerkine CXCL4/Platelet factor 4 or PF4, that rejuvenates neurons in aged mice in a similar way to physical exercise. This protein, which is released from platelets after exercise, results in regenerative and cognitive improvements when injected into aged mice.

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Research 75

SCIENMAG: Medicine & Health

AUGUST 17, 2023

What if we could identify the earliest warning signs of cardiovascular disease from a simple saliva sample? Scientists think they have found a way to do so. Gum inflammation leads to periodontitis, which is linked with cardiovascular disease.

Disease 84

Disease 84

Science Daily: Pharmacology News

AUGUST 17, 2023

Scientists have developed an AI model that accurately estimates a patient's age, using chest radiographs of healthy individuals collected from multiple facilities. Furthermore, they found a positive relationship between differences in the AI-estimated and chronological ages and a variety of chronic diseases, such as hypertension, hyperuricemia, and chronic obstructive pulmonary disease.

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Disease 75

SCIENMAG: Medicine & Health

AUGUST 17, 2023

Who’s responsible for upholding research integrity, mitigating misinformation or disinformation and increasing trust in research? Everyone – even those reporting on research – says a new article published by leading research integrity experts. Credit: Digital Science Who’s responsible for upholding research integrity, mitigating misinformation or disinformation and increasing trust in research?

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Research Science 82

Science Daily: Pharmacology News

AUGUST 17, 2023

Magnetars are the strongest magnets in the Universe. These super-dense dead stars with ultra-strong magnetic fields can be found all over our galaxy but astronomers don't know exactly how they form. Now, using multiple telescopes around the world, researchers have uncovered a living star that is likely to become a magnetar. This finding marks the discovery of a new type of astronomical object -- massive magnetic helium stars -- and sheds light on the origin of magnetars.

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Research 70

SCIENMAG: Medicine & Health

AUGUST 17, 2023

The University of Arizona College of Nursing was one of 50 institutions nationwide to receive a Health Resources and Services Administration grant to increase the number and diversity of Doctor of Nursing Practice students in clinical rotations at Federally Qualified Health Center partners in southern Arizona.

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Nurses Doctors Science 82