Drug Discovery World

SEPTEMBER 7, 2023

Researchers have discovered a new avenue of cell death in Alzheimer’s disease and vascular dementia. A new study, led by scientists at Oregon Health & Science University (OHSU), has revealed that a form of cell death known as ferroptosis – caused by a build-up of iron in cells – destroys microglia cells, a type of cell involved in the brain’s immune response, in cases of Alzheimer’s and vascular dementia.

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Immune Response Laboratories Drugs Science 163

Drugs.com

SEPTEMBER 7, 2023

THURSDAY, Sept. 7, 2023 -- The blockbuster drug Ozempic has become a household name for its ability to spur weight loss. Now an early study hints at an intriguing possibility: The drug might allow people newly diagnosed with type 1 diabetes to drop.

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Treatment Drugs 119

Drug Discovery World

SEPTEMBER 7, 2023

DDW’s Diana Spencer highlights five key clinical studies taking a new therapeutic approach to childhood cancers. Over 100 subtypes of childhood cancer exist today and it represents the most common cause of disease-related death in children. However, despite the fact that children’s response to adult cancer drugs is often poor, due to the challenges of developing medicines for this population, only six drugs are made specifically for childhood cancer. 1 There are a number of challenges face

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Clinical Trials Trials Drugs DNA 148

Drugs.com

SEPTEMBER 7, 2023

THURSDAY, Sept. 7, 2023 -- Some people mistrust the safety and effectiveness of human vaccines for COVID-19 and other diseases, a fact that became abundantly clear during the pandemic. Now, a new survey of 2,200 dog owners shows this mistrust may.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

SEPTEMBER 7, 2023

Following lengthy negotiations, the UK government has announced that the UK will be participating as a fully associated member of Horizon Europe for the remaining life of the programme to 2027. UK researchers can now apply for grants and bid to take part in projects under the Horizon programme. They will also be able to lead consortia in the next work programme of Horizon Europe projects.

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Research Government International Science 148

Drugs.com

SEPTEMBER 7, 2023

THURSDAY, Sept. 7, 2023 -- Emergency room visits for injuries related to driving under the influence of cannabis skyrocketed in Canada after the drug was legalized there, a new study reports. In October 2018, Canada became the second country to.

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Drugs 116

Drugs.com

SEPTEMBER 7, 2023

THURSDAY, Sept. 7, 2023 -- Respiratory syncytial virus (RSV) is a common viral infection that affects people of all ages, with infants and older adults being particularly vulnerable to severe complications. Preventing the spread of RSV requires a.

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Virus 116

Drug Discovery World

SEPTEMBER 7, 2023

In the Phase III innovaTV 301 trial in recurrent or metastatic cervical cancer patients with disease progression on or after front-line therapy, Tivdak (tisotumab vedotin-tftv), compared with chemotherapy alone, met its primary endpoint of overall survival (OS). An independent data monitoring committee determined that OS crossed the pre-specified efficacy boundary at interim analysis.

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Drugs.com

SEPTEMBER 7, 2023

THURSDAY, Sept. 7, 2023 -- New COVID-19 booster shots could soon pass the needed hurdles for vaccinations to begin next week. Sources familiar with U.S. Food and Drug Administration plans say boosters could be approved as soon as Friday, NBC News.

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FDA Approval FDA Vaccine Drugs 116

Drug Discovery World

SEPTEMBER 7, 2023

Cell migration assays can be time-consuming and challenging, from identifying and ensuring assays are imaged at the appropriate time, to properly measuring wound closure. In this new App Note, discover the benefits of Evident’s CM cell culture monitors, which provide label-free, quantitative results, consistent results throughout your lab, and are cost-effective.

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Research Drugs 130

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Clinical Trials

Drugs.com

SEPTEMBER 7, 2023

THURSDAY, Sept. 7, 2023 -- A new test detects a type of cervical cancer often missed by a standard Pap test, providing an important advance in detection. The test was developed by scientists at Montefiore Einstein Cancer Center in New York.

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Drug Discovery World

SEPTEMBER 7, 2023

AI drug discovery company Intelligent OMICS and Janssen Research & Development have agreed a target discovery collaboration to evaluate novel biological targets for the treatment of haematological cancers. The collaboration will combine Intelligent OMICS’ AI platform, which uses multi-omics data and deep learning algorithms to uncover therapeutic opportunities for treatment, with Janssen’s expertise in data science, oncology research and development. “We are thrilled to be workin

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Research Science Treatment Production 130

BioPharma Drive: Drug Pricing

SEPTEMBER 7, 2023

Fresh off a Series C fundraise, Kriya has acquired the privately held Tramotane Therapeutics and its preclinical candidate for the widely prevalent liver disease.

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Therapies Disease 117

Drug Discovery World

SEPTEMBER 7, 2023

Apollo Therapeutics, a biopharmaceutical company focused on translating fundamental medical research into medicines through a hub-and-spoke approach, has closed $226.5 million in a Series C financing, led by lead investor Patient Square Capital. Financing significantly adds to the $195 million previously raised by the company, and to Apollo’s pipeline of over 20 programmes with multiple near and medium-term value catalysts and uncorrelated risk.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drugs.com

SEPTEMBER 7, 2023

THURSDAY, Sept. 7, 2023 -- For the first time ever, a solid humanized organ has been grown from scratch in an animal — a first step in a process that could potentially solve organ shortages and save countless lives. Chinese researchers grew.

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Research 111

Drug Discovery World

SEPTEMBER 7, 2023

This is the latest episode of the free DDW narrated podcast, “How is mass spectrometry advancing drug discovery?”, which covers two articles written for Volume 23, Issue 3 – Summer 2022 of DDW. They are called “ Native mass spectrometry: Drug discovery’s new kid on the block ”, and “ Addressing the developability gap in pharma ”. In the first article, you will hear from Id-leer Liko, klee-tos Sokratous & Miguel Silva at OMass Therapeutics.

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Drugs.com

SEPTEMBER 7, 2023

THURSDAY, Sept. 7, 2023 – Game show host Bob Barker died in late August from Alzheimer’s disease. The longtime host of “The Price Is Right” died at age 99 of the memory-robbing condition, his death certificate now shows, NBC News.

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Disease 111

Drug Discovery World

SEPTEMBER 7, 2023

This is the latest episode of the free DDW narrated podcast, “How is mass spectrometry advancing drug discovery?”, which covers two articles written for Volume 23, Issue 3 – Summer 2022 of DDW. They are called “ Native mass spectrometry: Drug discovery’s new kid on the block ”, and “ Addressing the developability gap in pharma ”. In the first article, you will hear from Id-leer Liko, klee-tos Sokratous & Miguel Silva at OMass Therapeutics.

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Drugs Marketing Drug Development 130

Drugs.com

SEPTEMBER 7, 2023

THURSDAY, Sept. 7, 2023 -- Most American men think they’re leading a healthy lifestyle, possibly picturing themselves as a Hollywood leading man type. But their actual health habits are those of a schlubby sidekick, a new Cleveland Clinic survey.

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Perficient: Drug Development

SEPTEMBER 7, 2023

Sitecore has form elements OOB that meet practically all form requirements. But in some scenarios, we may need to create a custom element to fulfill the requirement like the Cascading Dropdown List. We had a scenario where we needed to load all Products of selected Categories in dropdown lists. We intended to utilize the Sitecore SXA Filter. However, after selecting Category from the list, it loads the associated Products in the Products dropdown list while removing the other Category item from

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Production 105

Drugs.com

SEPTEMBER 7, 2023

THURSDAY, Sept. 7, 2023 -- Your thinking and memory skills may take a hit decades after recovering from a concussion, a new study indicates. Scientists who studied male twins, from an average age of 67, found that earlier concussions were tied to.

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ProRelix Research

SEPTEMBER 7, 2023

Autoimmune disorders comprise several diseases in which the immune system mistakenly attacks and destroys the body’s own healthy cells instead of destroying bacteria and viruses to keep the body healthy. […] The post Autoimmune disorders and current developments of novel treatments under clinical trials appeared first on ProRelix Research.

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Clinical Trials Trials Treatment Virus 105

Drugs.com

SEPTEMBER 7, 2023

THURSDAY, Sept. 7, 2023 -- “Vain” isn’t a word normally associated with football players, but many wide receivers believe they look slim and fleet-footed with a lower number on their jersey rather than a higher one. New research shows these.

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Research 105

Drug Target Review

SEPTEMBER 7, 2023

Anchored by the TCX-101 Program, the company targets high-risk leukaemia’s by enhancing graft-vs.-leukaemia effects and reducing graft-vs.-host disease risks. TCX-102 complements this effort by focusing on TCRs against NPM1 gene mutations. The first clinical candidate, BSB-1001, aims to transform leukemia treatment by targeting minor histocompatibility antigen-1.

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SCIENMAG: Medicine & Health

SEPTEMBER 7, 2023

New York, NY (September 7, 2023)—Researchers at the Icahn School of Medicine at Mount Sinai have identified the structure of a special transporter found in red blood cells and how it interacts with drugs. Details on the findings, which were reported in the September 7 issue of Nature Structural & Molecular Biology [DOI: 10.

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Molecular Biology Drugs Research 96

Drugs.com

SEPTEMBER 7, 2023

THURSDAY, Sept. 7, 2023 -- Bruce Springsteen has again postponed shows for illness, this time while he is treated for symptoms of peptic ulcer disease.

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Disease 105

SCIENMAG: Medicine & Health

SEPTEMBER 7, 2023

Guangzhou Institutes of Biomedicine and Health researchers have successfully created chimeric embryos containing a combination of human and pig cells. When transferred into surrogate pig mothers, the developing humanized kidneys had normal structure and tubule formation after 28 days.

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Research 96

Science Daily: Pharmacology News

SEPTEMBER 7, 2023

Researchers have successfully created chimeric embryos containing a combination of human and pig cells. When transferred into surrogate pig mothers, the developing humanized kidneys had normal structure and tubule formation after 28 days. This is the first time that scientists have been able to grow a solid humanized organ inside another species, though previous studies have used similar methods to generate human tissues such as blood or skeletal muscle in pigs.

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Research 102

SCIENMAG: Medicine & Health

SEPTEMBER 7, 2023

With the help of a new grant from the National Institute of Health for more than $2.6 million, Assistant Professor Timothy Huang, Ph.D., will continue his research on the role of the brain’s immune cells on the risk of developing Alzheimer’s disease.

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Disease Research 93

Science Daily: Pharmacology News

SEPTEMBER 7, 2023

Crustaceans, insects and mushrooms are rich sources of the dietary fiber chitin, which activates the immune system and benefits metabolism, according to a new study in mice.

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SCIENMAG: Medicine & Health

SEPTEMBER 7, 2023

Analysis of data from more than 1 million Danish inpatients identifies nearly 4,000 drug pairings that are associated with more frequent dosage adjustments when prescribed together—potentially hinting at previously undiscovered drug interactions. Søren Brunak of the University of Copenhagen, Denmark, and colleagues present these findings in the open-access journal PLOS Digital Health.

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Drugs 89

Science Daily: Pharmacology News

SEPTEMBER 7, 2023

An international consortium of scientists is using an unprecedentedly large database of canine DNA to take an unbiased look at how our furry friends evolved into the various breeds we know and love.

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DNA International 97

SCIENMAG: Medicine & Health

SEPTEMBER 7, 2023

Milan, Italy: Women exposed to air pollution give birth to smaller babies, according to research that will be presented at the European Respiratory Society International Congress in Milan, Italy [1]. The research also shows that women living in greener areas give birth to bigger babies and this may help counteract the effects of pollution.

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International Research 87

Science Daily: Pharmacology News

SEPTEMBER 7, 2023

The climate-driven advance of beavers into the Arctic tundra is causing the release of more methane -- a greenhouse gas -- into the atmosphere. Beavers, as everyone knows, like to make dams. Those dams cause flooding, which inundates vegetation and turns Arctic streams and creeks into a series of ponds. Those beaver ponds and surrounding inundated vegetation can be devoid of oxygen and rich with organic sediment, which releases methane as the material decays.

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