Drug Discovery World
AUGUST 14, 2024
AstraZeneca’s Imfinzi (durvalumab) and Lynparza (olaparib) have been approved in the European Union (EU) as treatment for certain patients with primary advanced or recurrent endometrial cancer. Imfinzi plus chemotherapy as first-line treatment followed by Lynparza and Imfinzi has been approved for patients with mismatch repair proficient (pMMR) disease.
Science Daily: Pharmacology News
AUGUST 14, 2024
A new brain-computer interface translates brain signals into speech with up to 97 percent accuracy. Researchers implanted sensors in the brain of a man with severely impaired speech due to amyotrophic lateral sclerosis (ALS). The man was able to communicate his intended speech within minutes of activating the system.
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Drug Discovery World
AUGUST 14, 2024
DDW’s Diana Spencer caught up with Dr Patrick Short , CEO and Co-Founder, Sano Genetics, about the challenges facing personalised medicine development and his own personal experience of genetic conditions. DS: You and your co-founders met at the University of Cambridge. Can you tell us about the founding of the company? What challenges did you have to overcome to turn a scientific idea into a profitable business?
Science Daily: Pharmacology News
AUGUST 14, 2024
Researchers have developed a smart fabric that can convert body heat and solar energy into electricity, potentially enabling continuous operation with no need for an external power source. Different sensors monitoring temperature, stress, and more can be integrated into the material.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Drug Discovery World
AUGUST 14, 2024
The US Food and Drug Administration (FDA) has approved a Phase II clinical trial for Biosyngen’s BRG01, an EBV-specific CAR-T cell therapy. This marks the first cell therapy to enter Phase lI trials in both the US and China for the treatment of relapsed/metastatic EBV-positive nasopharyngeal carcinoma. The Center for Drug Evaluation (CDE) of the National Medicinal Product Administration (NMPA) in China had previously granted approval for the pivotal Phase II clinical trial of BRG01.
Science Daily: Pharmacology News
AUGUST 14, 2024
New research found that brain scans can detect consciousness in some patients with brain injury who are unresponsive. In the study, 241 participants with severe brain injury who do not respond when given a simple instruction were assessed with functional MRI (fMRI), electroencephalography (EEG), or both tests, while hearing instructions, such as 'imagine opening and closing your hand.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Science Daily: Pharmacology News
AUGUST 14, 2024
A new study has identified diet-derived molecules called metabolites as main drivers of young-onset colorectal cancer risk, especially those associated with red and processed meat. The report, which analyzed metabolite and microbiome datasets, highlighted that one of the best ways a younger (less than 60 years) adult can prevent colorectal cancer is to discuss their diet with their doctor.
Drugs.com
AUGUST 14, 2024
WEDNESDAY, Aug. 14, 2024 -- A new implant could help prevent overdose deaths by automatically administering the OD-reversing drug naloxone, a new study shows. The implant, about the size of a stick of gum, is placed under the skin, where it.
Science Daily: Pharmacology News
AUGUST 14, 2024
The coordinated activity of brain cells, like birds flying in formation, helps us behave intelligently in new situations, according to a new study. The work is the first to illuminate the neurological processes known as abstraction and inference in the human brain.
Drugs.com
AUGUST 14, 2024
WEDNESDAY, Aug. 14, 2024 -- Americans continue to rank dead last in life expectancy among English-speaking countries, a new study finds.People in the United States more often fall prey at younger ages to accidental deaths, homicides and chronic.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Science Daily: Pharmacology News
AUGUST 14, 2024
A major international study has explained how bread wheat helped to transform the ancient world on its path to becoming the iconic crop that today helps sustain a global population of eight billion.
Drugs.com
AUGUST 14, 2024
WEDNESDAY, Aug. 14, 2024 -- Aging Americans, you're not imagining things: Big shifts in physical well-being do occur at certain points in the life span, new research shows.A team at Stanford University has found "massive" changes during a person's.
Science Daily: Pharmacology News
AUGUST 14, 2024
In the fight against Alzheimer's, researchers have developed a promising, preventative therapeutic approach. They specifically targeted the amyloid beta biomolecule, which triggers the hyperactivity of nerve cells typical of the brain disease in its early stages. They succeeded in developing and using a protein drug that can suppress the effects of the harmful molecule.
Drugs.com
AUGUST 14, 2024
WEDNESDAY, Aug. 14, 2024 -- Parvovirus B19, a seasonal respiratory virus that subsided during the pandemic, is making a comeback, U.S. health officials warned Tuesday.In a health alert issued by the U.S. Centers for Disease Control and.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Science Daily: Pharmacology News
AUGUST 14, 2024
An unchartered area in the foothills of the Southern Pyrenees in Spain is providing insights into a poorly known period of Neanderthal history, offering clues that could help archaeologists uncover the mystery of their downfall, according to new research.
Drugs.com
AUGUST 14, 2024
WEDNESDAY, Aug. 14, 2024 -- Older voters are keenly interested in the cost of health care, a new survey has found. Five of the top six health issues among older adults have to do with health care costs, according to new data from the University of.
Science Daily: Pharmacology News
AUGUST 14, 2024
Early life exposure to 'forever chemicals' in the environment permanently disrupts the gut microbiome in mice, contributing to the development of metabolic disease in later life, according to new research. The results suggest that human exposure to these chemicals during early childhood may be contributing to the recent epidemic of metabolic disorders, including obesity and type 2 diabetes among adults.
Drugs.com
AUGUST 14, 2024
WEDNESDAY, Aug. 14, 2024 -- Want to be a better, more effective mom or dad? Trying sharing a good laugh with your kid.New research among folks ages 18 to 45 found many citing humor as one of the reasons they had, and continue to have, a positive.
Science Daily: Pharmacology News
AUGUST 14, 2024
A new study has found galaxies with more neighbors tend to be larger than their counterparts that have a similar shape and mass, but reside in less dense environments. The team, which used a machine-learning algorithm to analyze millions of galaxies, reports that galaxies found in denser regions of the universe are as much as 25% larger than isolated galaxies.
Covalent Modifiers
AUGUST 14, 2024
Nickolas J. Serniuck, Eden Kapcan, Duane Moogk,Allyson E. Moore,Benjamin P.M. Lake, Galina Denisova,Joanne A. Hammill,Jonathan L. Bramson, Anthony F. Rullo Molecular Therapy 2024 DOI: [link] Proximity-induction of cell-cell interactions via small molecules represents an emerging field in basic and translational sciences. Covalent anchoring of these small molecules represents a useful chemical strategy to enforce proximity; however, it remains largely unexplored for driving cell-cell interactions
Science Daily: Pharmacology News
AUGUST 14, 2024
An international team of researchers analyzed beluga whale bones retrieved from archaeological sites in the Mackenzie Delta, Northwest Territories, Canada, to shed light on the sustainability of centuries of Inuvialuit beluga whale subsistence harvests.
BioPharma Drive: Drug Pricing
AUGUST 14, 2024
Less than two months after splitting from Illumina, the liquid biopsy maker is refocusing resources as it pursues an FDA submission for the Galleri multi-cancer early detection test.
Science Daily: Pharmacology News
AUGUST 14, 2024
Scientists have sequenced the largest genome of all animals, the lungfish genome. Their data help to explain how the fish-ancestors of today's land vertebrates were able to conquer land.
FDA Law Blog: Biosimilars
AUGUST 14, 2024
By Alan M. Kirschenbaum & Michelle L. Butler & Faraz Siddiqui & Sophia R. Gaulkin — Enacted in 2022, the Inflation Reduction Act (IRA) amended the Medicare provisions of the Social Security Act to impose several discount requirements on pharmaceutical manufacturers. In addition to the widely publicized drug price negotiation program, the IRA established inflation rebate programs under Medicare Part B and Part D.
Science Daily: Pharmacology News
AUGUST 14, 2024
With 2D cameras and space robotics algorithms, astronautics engineers have created a navigation system able to manage multiple satellites using visual data only. They just tested it in space for the first time.
Drug Target Review
AUGUST 14, 2024
Early drug discovery involves conducting experiments, data generation, and testing scientific hypotheses. For scientists in early drug discovery, their success is heavily dependent on the quality of the data generated. For example, the following questions must be considered: are we generating the right data from the right experiments, and are we applying the best methods for data analysis and interpretation?
Science Daily: Pharmacology News
AUGUST 14, 2024
A new milestone has been set for levitated optomechanics as a group of scientists observed the Berry phase of electron spins in nano-sized diamonds levitated in vacuum.
BioPharma Drive: Drug Pricing
AUGUST 14, 2024
The company's new CEO announced layoffs that will affect about 7% of company’s workforce.
Science Daily: Pharmacology News
AUGUST 14, 2024
Scientists report that rock samples from Mars' Jezero Crater contain minerals that are typically formed in water. While the presence of organic matter is inconclusive, the rocks could be scientists' best chance at finding remnants of ancient Martian life.
Drug Patent Watch
AUGUST 14, 2024
Dabigatran etexilate mesylate is the generic ingredient in two branded drugs marketed by Alkem Labs Ltd, Apotex, Hetero Labs Ltd Iii, and Boehringer Ingelheim and, and is included in five NDAs.
Science Daily: Pharmacology News
AUGUST 14, 2024
A team of researchers has made strides in understanding the formation of massif-type anorthosites, enigmatic rocks that only formed during the middle part of Earth's history. These plagioclase-rich igneous rock formations, which can cover areas as large as 42,000 square kilometers and host titanium ore deposits, have puzzled scientists for decades due to conflicting theories about their origins.
Perficient: Drug Development
AUGUST 14, 2024
As Dreamforce 2024 approaches, we had the opportunity to sit down with Chelsea Monda, Practice Director for go-to-market strategy and execution at Perficient. With an impressive 16-year tenure at Perficient, including 14 years focused on Salesforce, Chelsea brings a wealth of experience to her role. In this exclusive interview, she shares her thoughts on attending her first Dreamforce conference and how she plans to leverage the experience for Perficient and its clients.
Science Daily: Pharmacology News
AUGUST 14, 2024
A new class of fat cells makes people healthier. The cells consume energy and produce heat through seemingly pointless biochemical reactions.
thought leadership
AUGUST 14, 2024
One of the big questions pharmaceutical, biotech and medical device companies often ask, is: “When is the optimal time to seek strategic regulatory consulting assistance?”. Traditionally, the need for regulatory consulting support is inversely proportional to the availability of expertise within the companies’ own regulatory department. This blog explains the three elements required for developing a successful regulatory strategy.
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