Wed.Aug 14, 2024

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New brain-computer interface allows man with ALS to 'speak' again

Science Daily: Pharmacology News

A new brain-computer interface translates brain signals into speech with up to 97 percent accuracy. Researchers implanted sensors in the brain of a man with severely impaired speech due to amyotrophic lateral sclerosis (ALS). The man was able to communicate his intended speech within minutes of activating the system.

Research 144
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Chemicals in Makeup, Sunscreen May Raise Odds for Dangerous Pregnancy Complication

Drugs.com

WEDNESDAY, Aug. 14, 2024 -- Chemicals commonly found in sunscreen, makeup and other personal care products could be putting pregnancies at risk, a new study warns. Phenols and parabens in these products increase a pregnant woman’s risk of.

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Smart fabric converts body heat into electricity

Science Daily: Pharmacology News

Researchers have developed a smart fabric that can convert body heat and solar energy into electricity, potentially enabling continuous operation with no need for an external power source. Different sensors monitoring temperature, stress, and more can be integrated into the material.

Research 137
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Implant Automatically Releases Naloxone to Reverse Opioid Overdose

Drugs.com

WEDNESDAY, Aug. 14, 2024 -- A new implant could help prevent overdose deaths by automatically administering the OD-reversing drug naloxone, a new study shows. The implant, about the size of a stick of gum, is placed under the skin, where it.

Drugs 105
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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International study detects consciousness in unresponsive patients

Science Daily: Pharmacology News

New research found that brain scans can detect consciousness in some patients with brain injury who are unresponsive. In the study, 241 participants with severe brain injury who do not respond when given a simple instruction were assessed with functional MRI (fMRI), electroencephalography (EEG), or both tests, while hearing instructions, such as 'imagine opening and closing your hand.

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US Still Last for Life Expectancy Among English-Speaking Countries

Drugs.com

WEDNESDAY, Aug. 14, 2024 -- Americans continue to rank dead last in life expectancy among English-speaking countries, a new study finds.People in the United States more often fall prey at younger ages to accidental deaths, homicides and chronic.

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Your Body's 'Biomolecular' Makeup Shifts in Your 40s and 60s

Drugs.com

WEDNESDAY, Aug. 14, 2024 -- Aging Americans, you're not imagining things: Big shifts in physical well-being do occur at certain points in the life span, new research shows.A team at Stanford University has found "massive" changes during a person's.

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How bread dough gave rise to civilization

Science Daily: Pharmacology News

A major international study has explained how bread wheat helped to transform the ancient world on its path to becoming the iconic crop that today helps sustain a global population of eight billion.

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CDC Warns of Resurgence of Common Respiratory Virus, With Risks for Particular Groups

Drugs.com

WEDNESDAY, Aug. 14, 2024 -- Parvovirus B19, a seasonal respiratory virus that subsided during the pandemic, is making a comeback, U.S. health officials warned Tuesday.In a health alert issued by the U.S. Centers for Disease Control and.

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Stopping and reversing Alzheimer's at an early stage

Science Daily: Pharmacology News

In the fight against Alzheimer's, researchers have developed a promising, preventative therapeutic approach. They specifically targeted the amyloid beta biomolecule, which triggers the hyperactivity of nerve cells typical of the brain disease in its early stages. They succeeded in developing and using a protein drug that can suppress the effects of the harmful molecule.

Disease 117
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Cost of Health Care Is Big Concern for Voters Over 50

Drugs.com

WEDNESDAY, Aug. 14, 2024 -- Older voters are keenly interested in the cost of health care, a new survey has found. Five of the top six health issues among older adults have to do with health care costs, according to new data from the University of.

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Early life exposure to common chemical permanently disrupts gut microbiome, study suggests

Science Daily: Pharmacology News

Early life exposure to 'forever chemicals' in the environment permanently disrupts the gut microbiome in mice, contributing to the development of metabolic disease in later life, according to new research. The results suggest that human exposure to these chemicals during early childhood may be contributing to the recent epidemic of metabolic disorders, including obesity and type 2 diabetes among adults.

Disease 115
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One Key to Better Parenting: Laughter

Drugs.com

WEDNESDAY, Aug. 14, 2024 -- Want to be a better, more effective mom or dad? Trying sharing a good laugh with your kid.New research among folks ages 18 to 45 found many citing humor as one of the reasons they had, and continue to have, a positive.

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Patterns of intelligence

Science Daily: Pharmacology News

The coordinated activity of brain cells, like birds flying in formation, helps us behave intelligently in new situations, according to a new study. The work is the first to illuminate the neurological processes known as abstraction and inference in the human brain.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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The Role of Oncology Biomarkers in Personalizing Hematology Treatment Plans

Conversations in Drug Development Trends

By: Simran Padam, Medical Director, Medical Affairs Personalized treatment approaches have emerged as pivotal in improving outcomes for hematological cancers. Central to this advancement are biomarkers, which are measurable indicators that signal biological processes or pathological changes within the body. They play a crucial role in tailoring hematology oncology therapeutic strategies to individual patients and have transformed personalized medicine in oncology.

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Rare archaeological site reveals 'surprising' Neanderthal behaviour at Pyrenees foothills

Science Daily: Pharmacology News

An unchartered area in the foothills of the Southern Pyrenees in Spain is providing insights into a poorly known period of Neanderthal history, offering clues that could help archaeologists uncover the mystery of their downfall, according to new research.

Research 117
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Electrophilic proximity-inducing synthetic adapters enhance universal T cell function by covalently enforcing immune receptor signaling [@RulloLab]

Covalent Modifiers

Nickolas J. Serniuck, Eden Kapcan, Duane Moogk,Allyson E. Moore,Benjamin P.M. Lake, Galina Denisova,Joanne A. Hammill,Jonathan L. Bramson, Anthony F. Rullo Molecular Therapy 2024 DOI: [link] Proximity-induction of cell-cell interactions via small molecules represents an emerging field in basic and translational sciences. Covalent anchoring of these small molecules represents a useful chemical strategy to enforce proximity; however, it remains largely unexplored for driving cell-cell interactions

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Galaxies in dense environments tend to be larger, settling one cosmic question and raising others

Science Daily: Pharmacology News

A new study has found galaxies with more neighbors tend to be larger than their counterparts that have a similar shape and mass, but reside in less dense environments. The team, which used a machine-learning algorithm to analyze millions of galaxies, reports that galaxies found in denser regions of the universe are as much as 25% larger than isolated galaxies.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Grail to shed 350 workers in restructuring

BioPharma Drive: Drug Pricing

Less than two months after splitting from Illumina, the liquid biopsy maker is refocusing resources as it pursues an FDA submission for the Galleri multi-cancer early detection test.

FDA 61
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Decoding the world's largest animal genome

Science Daily: Pharmacology News

Scientists have sequenced the largest genome of all animals, the lungfish genome. Their data help to explain how the fish-ancestors of today's land vertebrates were able to conquer land.

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Part one: an introduction to data quality

Drug Target Review

Early drug discovery involves conducting experiments, data generation, and testing scientific hypotheses. For scientists in early drug discovery, their success is heavily dependent on the quality of the data generated. For example, the following questions must be considered: are we generating the right data from the right experiments, and are we applying the best methods for data analysis and interpretation?

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Engineers conduct first in-orbit test of 'swarm' satellite autonomous navigation

Science Daily: Pharmacology News

With 2D cameras and space robotics algorithms, astronautics engineers have created a navigation system able to manage multiple satellites using visual data only. They just tested it in space for the first time.

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CMS Issues Proposed Rule on the Medicare Part B and Part D Inflation Rebate Program; HPM Issues Detailed Summary

FDA Law Blog: Biosimilars

By Alan M. Kirschenbaum & Michelle L. Butler & Faraz Siddiqui & Sophia R. Gaulkin — Enacted in 2022, the Inflation Reduction Act (IRA) amended the Medicare provisions of the Social Security Act to impose several discount requirements on pharmaceutical manufacturers. In addition to the widely publicized drug price negotiation program, the IRA established inflation rebate programs under Medicare Part B and Part D.

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Physicists throw world's smallest disco party

Science Daily: Pharmacology News

A new milestone has been set for levitated optomechanics as a group of scientists observed the Berry phase of electron spins in nano-sized diamonds levitated in vacuum.

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Evotec, citing research spending slowdown, cuts jobs and exits gene therapy

BioPharma Drive: Drug Pricing

The company's new CEO announced layoffs that will affect about 7% of company’s workforce.

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Rocks from Mars' Jezero Crater, which likely predate life on Earth, contain signs of water

Science Daily: Pharmacology News

Scientists report that rock samples from Mars' Jezero Crater contain minerals that are typically formed in water. While the presence of organic matter is inconclusive, the rocks could be scientists' best chance at finding remnants of ancient Martian life.

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Which pharmaceutical drugs have the most drug patents in Philippines?

Drug Patent Watch

This chart shows the drugs with the most patents in Philippines. Patents must be filed in each country (or, in some cases regional patent office) where patent protection is desired.

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Researchers unveil mysteries of ancient Earth

Science Daily: Pharmacology News

A team of researchers has made strides in understanding the formation of massif-type anorthosites, enigmatic rocks that only formed during the middle part of Earth's history. These plagioclase-rich igneous rock formations, which can cover areas as large as 42,000 square kilometers and host titanium ore deposits, have puzzled scientists for decades due to conflicting theories about their origins.

Research 113
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New tentative approval for Alembic drug dabigatran etexilate mesylate

Drug Patent Watch

Dabigatran etexilate mesylate is the generic ingredient in two branded drugs marketed by Alkem Labs Ltd, Apotex, Hetero Labs Ltd Iii, and Boehringer Ingelheim and, and is included in five NDAs.

Drugs 52
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Beige fat cells with a 'Sisyphus mechanism'

Science Daily: Pharmacology News

A new class of fat cells makes people healthier. The cells consume energy and produce heat through seemingly pointless biochemical reactions.

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Perficient Insights: Dreamforce 2024 with Chelsea Monda

Perficient: Drug Development

As Dreamforce 2024 approaches, we had the opportunity to sit down with Chelsea Monda, Practice Director for go-to-market strategy and execution at Perficient. With an impressive 16-year tenure at Perficient, including 14 years focused on Salesforce, Chelsea brings a wealth of experience to her role. In this exclusive interview, she shares her thoughts on attending her first Dreamforce conference and how she plans to leverage the experience for Perficient and its clients.

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Great Scott! Stonehenge's Altar Stone origins reveal advanced ancient Britain

Science Daily: Pharmacology News

New research has revealed Stonehenge's monumental six-ton Altar Stone, long believed to originate from Wales, actually hails from Scotland.

Research 114
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How a Strong Regulatory Strategy Supports Your Product’s Success

thought leadership

One of the big questions pharmaceutical, biotech and medical device companies often ask, is: “When is the optimal time to seek strategic regulatory consulting assistance?”. Traditionally, the need for regulatory consulting support is inversely proportional to the availability of expertise within the companies’ own regulatory department. This blog explains the three elements required for developing a successful regulatory strategy.