Fri.Jan 10, 2025

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Can Elderberry Juice Help You Lose Weight?

Drugs.com

FRIDAY, Jan. 10, 2025 -- Ozempic? Wegovy? Zepbound?How about elderberry juice?Elderberry juice might help people lose weight and improve their blood sugar control, a new small-scale study says.People who drank 12 ounces of elderberry juice daily.

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Patrizia Cavazzoni, key FDA official, to leave agency

BioPharma Drive: Drug Pricing

The director of the FDA's main drug review office will exit on Jan. 18, according to an email sent to staff. Her departure is one of several announced by high-ranking FDA leaders ahead of the coming administration change.

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Feeding your good gut bacteria through fiber in diet may boost body against infections

Science Daily: Pharmacology News

A new study has found that the composition of your gut microbiome helps predict how likely you are to succumb to potentially life-threatening infection with Klebsiella pneumoniae, E.coli and other bugs -- and it may be altered by changing your diet.

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Being Told to 'Calm Down,' Other Microaggressions May Raise Risk for Postpartum Hypertension

Drugs.com

FRIDAY, Jan. 10, 2025 -- The words calm down are worse than unhelpful -- they actually can increase blood pressure among new mothers of color, a study has found.Gender-based racism through such microaggressions significantly increased a new moms.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Ouro, backed by GSK, joins hunt to bring bispecifics to autoimmune disease

BioPharma Drive: Drug Pricing

“Practice of medicine could fundamentally change with these types of therapies,” said CEO Jaideep Dudani, of T cell engagers now being tested in inflammatory conditions.

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Can Doctors Estimate Life Expectancy After a Dementia Diagnosis?

Drugs.com

FRIDAY, Jan. 10, 2025 -- The clock is running for people whove been diagnosed with dementia, but the time they have left depends on their age.Average life expectancy for people with dementia is largely based on their age at diagnosis, researchers f.

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Access to Green Space May Help Reduce Kids' Screen Time

Drugs.com

SATURDAY, Jan. 11, 2025 -- Want to help your child cut back on their screen time?Make sure you live near parks and other open spaces where they can frolic outside.New research underlines the importance of green space access as an alternative to.

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A fast-moving belly flop: Researchers unveil the unique skills of cricket frogs

Science Daily: Pharmacology News

The way cricket frogs move across the surface of water has long been thought to resemble walking on water, but researchers have now discovered a different reality.

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The Best Ways to Quit Vaping

Drugs.com

FRIDAY, Jan. 10, 2025 -- Text-based support programs are one of the best ways to help young people quit vaping, a new evidence review says.These texts offer motivational messages and tips for quitting vaping.I think its clear that this approach he.

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Magma composition may drive volcanic tremor

Science Daily: Pharmacology News

A new study based on the sampling and analysis of volcanic ash at Cumbre Vieja volcano in the Canary Islands, located off Africa's northwest coast, suggests that the composition of magma could drive tremors during volcanic eruptions. The findings highlight the potential of volcanic ash analysis as a monitoring and forecasting tool.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Pfizer’s PD-1 drug succeeds; AbbVie writes down $3.5B in Cerevel assets

BioPharma Drive: Drug Pricing

Sasanlimab, a subcutaneous immunotherapy developed by Pfizer, could help treat bladder cancer. Elsewhere, Royalty Pharma moved to simplify its corporate structure and Biogen made another hire.

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Can Carrots Help Treat Type 2 Diabetes?

Drugs.com

FRIDAY, Jan. 10, 2025 -- Munching on carrots may help benefit your health, especially if you live with type 2 diabetes. At least, that is the hope of researchers in Denmark."We see carrots as a potential component of future dietary strategies for.

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Intellia to stop work on rare disease therapy, lay off staff

BioPharma Drive: Drug Pricing

The CRISPR gene editing company will reduce its workforce by 27% over the course of the year as it discontinues a treatment for alpha-1 antitrypsin deficiency.

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Job Strain Can Worsen Sleep Longterm, Data Suggests

Drugs.com

FRIDAY, Jan. 10, 2025 -- Ever woke in the night with your thoughts racing about work problems, co-worker disputes, or heavy career decisions?Well, its more common than you think.Job stress is robbing U.S. workers of the sleep they need, r.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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AAV Packaged on Request is Here!

addgene Blog

AAV Packaged on Request, an expansion of our viral vectors service, has officially launched! As of today, you can request any of over 3,000 eligible AAV cargo plasmids in the Addgene repository to be packaged in your choice of five different serotypes.

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Avoiding Isolation By Volunteering Offers Mental Health Benefits to Seniors

Drugs.com

FRIDAY, Jan. 10, 2025 -- Delivering meals to the infirm. Tutoring a student. Patrolling a city park. Helping out at a local library.All these activities not only serve the community, but also can help seniors avoid depression related to social.

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Debugging and Error Handling in VBA for Excel

Perficient: Drug Development

Debugging and Error Handling in VBA After setting up VBA in Excel, you can start automating tasks and creating your macros. This blog will guide you through what comes next after the setup processwriting, running, and debugging VBA code in Excel. Debugging and error handling are crucial for writing effective and reliable VBA (Visual Basic for Applications) code.

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Childhood Smoking Ups COPD Risk

Drugs.com

FRIDAY, Jan. 10, 2025 -- Young teens might think smoking makes them look cool, but its likely to take their breath away in adulthood, a new study says.Children who start smoking prior to age 15 have a 27% increased risk of developing chronic o.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Hepatocellular Carcinoma Cells in Humans Exhibit Resistance to Suberoylanilide Hydroxamic Acid (SAHA) Owing to the Diminished Level of Hsa‐miR‐125a‐5p

Chemical Biology and Drug Design

The presence of hsa-miR-125a-5p diminishes TRAF6 expression, enhancing the therapeutic effectiveness of suberoylanilide hydroxamic acid in the original HA22T hepatocellular carcinoma cells. Conversely, inhibiting hsa-miR-125a-5p expression leads to increased TRAF6 levels, consequently fostering resistance to suberoylanilide hydroxamic acid in HA22T-HDACi resistant cells.

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Cleopatra's sister remains missing

Science Daily: Pharmacology News

anthropologists have analyzed a skull that was found in the ruins of Ephesos (Turkey) in 1929. It was long speculated that it could be the remains of Arsino IV, the sister of the famous Cleopatra. However, the latest anthropological analyses show that the remains are those of a boy between the ages of 11 and 14 who suffered from pathological developmental disorders.

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Evaluation of Larger Side‐Group Functionalities and the Side/End‐Group Interplay in Ritonavir‐Like Inhibitors of CYP3A4

Chemical Biology and Drug Design

Structureactivity relationship of 13 rationally designed CYP3A4 inhibitors differing in side- and end-groups was investigated using spectral, functional, and structural approaches. The impact of the side/end-group interplay on the ligand binding mode, K s and IC50, was found to be multidirectional and largely dependent on the size/stereochemistry of the side group.

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Selective Protein (Post-)modifications through Dynamic Covalent Chemistry: Self-activated SNAr Reactions

Covalent Modifiers

Ferran Esteve, Jean-Louis Schmitt, Sergii Kolodych, Oleksandr Koniev, and Jean-Marie Lehn Journal of the American Chemical Society 2025 DOI: 10.1021/jacs.4c15421 SNAr reactions were remarkably accelerated using a pretargeting and activating unit based on dynamic covalent chemistry (DCvC). A Cys attack at the CF bond on the aromatic ring of salicylaldehyde derivatives was only observed upon iminium formation with a neighboring Lys residue of model small peptides.