Drug Discovery World

NOVEMBER 29, 2023

DDW’s Megan Thomas speaks to Jennifer Cann, Director of Pathology at Virscio, a company solving human health challenges through biomedical research. MT: Can you provide a top line summary of your research? JC: As Virscio’s Director of Pathology, I provide exploratory and translational pathology support for drug development research at all stages of the pipeline from pre-clinical through life cycle management, including clinical trial biopsy analysis to demonstrate pharmacodynamic effects wit

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Research Clinical Trials Trials Drug Development 174

Science Daily: Pharmacology News

NOVEMBER 29, 2023

We humans are fixated on big brains as a proxy for smarts. But headless animals called brittle stars have no brains at all and still manage to learn through experience, new research reveals. These shy marine creatures have no brain to speak of -- just nerve cords running down each of their five wiggly arms. But that seems to be enough to learn by association, researchers report.

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Research 128

Drug Discovery World

NOVEMBER 29, 2023

MIRA Pharmaceuticals and MIRALOGX have formed a new partnership to develop and commercialise oral ketamine analog Ketamir-2, hoping to change the landscape of depressive disorder treatments. Ketamir-2 is a patent-pending compound under investigation to potentially deliver ultra-rapid antidepressant effects as early as four hours after dosing. After making its scientific review of Ketamir-2, the DEA concluded that Ketamir-2 is not a controlled substance or listed chemical under the Controlled Sub

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Clinical Trials Government Pharmaceuticals Regulations 130

Chemical Biology and Drug Design

NOVEMBER 29, 2023

The co-administration of fenchone and sodium hyaluronate improved the body weight, number of fecal pellets, and fecal moisture in IBS-C rats. The ability of fenchone combined with sodium hyaluronate to regulate SCF/c-Kit signaling pathway, enhance intestinal barrier function, and modulate gut microbiota contributes to their efficacy in managing IBS-C.

Regulations 100

Regulations Research 100

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

NOVEMBER 29, 2023

Researchers have created a mathematical model that can accurately depict Alzheimer’s disease progression in individual patients, paving the way for personalised treatment and faster development of therapies. According to the model, the disease onset and rate of progression varies on a case by case basis, meaning that some patients will be more likely to benefit from certain therapies than others.

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Drug Development Pharmaceutical Companies Drugs FDA Approval 130

Chemical Biology and Drug Design

NOVEMBER 29, 2023

An undescribed pyrrole alkaloid, Paphlagonicanin B and an undescribed flavonoid glycoside, Paphlagonicanin A. The most cytotoxic compound is 8 α - O -(2′,3′-dihydroxyisobutyryl) desacylcynaropicrin. Abstract Centaurea paphlagonica (Bornm.) Wagenitz is an endemic plant in Turkey. Pyrocatechol, vanillic acid, 3,4-dihydroxy benzoic acid, 5- O -caffeoylshikimic acid, tamarixetin, chlorogenic acid methyl ester, quercetin, 1,3-dicaffeoylquinic acid, tamarixetin-7- O - β -D-glucopyranoside, quercimetri

Research 100

Research 100

BioPharma Drive: Drug Pricing

NOVEMBER 29, 2023

Bumpus, a former Johns Hopkins professor, named “creating a new model” for the FDA’s Office of Regulatory Affairs as one of her priorities when she steps into the role.

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FDA 117

Perficient: Drug Development

NOVEMBER 29, 2023

The Core of Efficiency: Choosing the Right ERP Choosing the right Enterprise Resource Planning (ERP) system is critical for ensuring optimal efficiency and future growth of your business. It is important to choose a system that seamlessly integrates with your unique processes and objectives, acting as the driving force behind your business operations.

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Research 115

FDA Law Blog: Biosimilars

NOVEMBER 29, 2023

By Lisa M. Baumhardt, Senior Medical Device Regulation Expert — In October 2021, FDA and MHRA (United Kingdom’s Medicines and Healthcare products Regulatory Agency) jointly developed 10 guiding principles for the development of Good Machine Learning Practice (GMLP) with the goal of promoting “safe, effective, and high-quality medical devices” that are based on Artificial Intelligence/Machine Learning (AI/ML) technologies.

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FDA Production Regulations Marketing 115

Drug Target Review

NOVEMBER 29, 2023

As the Director of Neuroscience Alchemab Therapeutics, how do you navigate neuroscientific research to propel the company’s future objectives? Michelle: The key is keeping up-to-date on research advancements and technological innovations, while keeping an eye on the therapeutic landscape. By doing this, we ensure we are well-positioned to take advantage of the latest findings and technologies that can help propel our research and development efforts forward, with the ultimate goal of deliv

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Engineering Drug Development Disease Research 111

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Science Daily: Pharmacology News

NOVEMBER 29, 2023

Astronomers have found a key new system of six transiting planets orbiting a bright star in a harmonic rhythm. This rare property enabled the team to determine the planetary orbits which initially appeared as an unsolvable riddle.

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Drugs.com

NOVEMBER 29, 2023

WEDNESDAY, Nov. 29, 2023 (Healthday News) -- Your neck muscles could be giving you headaches, claims new German research that used special MRI scans to spot the connection.“Our imaging approach provides [the] first objective evidence for the very.

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Research 105

BioPharma Drive: Drug Pricing

NOVEMBER 29, 2023

Drawn-out negotiations led to a lower price than initially expected, but analysts called the agreement a step forward for the biotech company.

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Therapies 117

Drugs.com

NOVEMBER 29, 2023

WEDNESDAY, Nov. 29, 2023 -- With fewer Americans dying from COVID in 2022, U.S. life expectancy rebounded a bit from declines experienced during the pandemic.According to provisional data from the U.S. Centers for Disease Control and Prevention on.

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Disease 105

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drug Target Review

NOVEMBER 29, 2023

What does Ochre Bio do, can you give me an overview of your work? Our primary focus is to design and develop RNA therapies for liver diseases. Using humans as the model, we use an approach called deep phenotyping to explore the relationships between cells, genes, biological pathways and patterns of disease. Our team of chemists then uses this information to develop novel therapies.

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Therapies Disease RNA Engineering 102

Drugs.com

NOVEMBER 29, 2023

WEDNESDAY, Nov. 29, 2023 -- People can walk away their risk of developing type 2 diabetes – but only if they walk fast enough, a new report finds.Folks who walk at least 2.5 miles an hour appear to have a significantly lower risk of type 2.

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BioPharma Drive: Drug Pricing

NOVEMBER 29, 2023

The cuts will impact 7% of the cancer drug division’s employees, although about 90 new roles will be created around “areas of growth.

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Therapies Drugs 113

Drugs.com

NOVEMBER 29, 2023

WEDNESDAY, Nov. 29, 2023 -- U.S. suicide numbers reached a grim new high in 2022. The increase was most acute among women over the age of 24, according to provisional data from the U.S. Centers for Disease Control and Prevention. Overall, almost.

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Disease 98

Science Daily: Pharmacology News

NOVEMBER 29, 2023

While life on Earth is relatively new, geologically speaking, the ingredients that combined to form it might be much older than once thought. The simplest amino acid, carbamic acid, could have formed alongside stars or planets within interstellar ices. The findings could be used to train deep space instruments like the James Webb Space Telescope to search for prebiotic molecules in distant, star-forming regions of the universe.

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Drugs.com

NOVEMBER 29, 2023

WEDNESDAY, Nov. 29, 2023 -- It's not just bumper-to-bumper highway traffic that's causing your blood pressure to spike during your daily commute.New research shows that the exhaust fumes spewing from all those vehicles triggers a significant.

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Research 98

SCIENMAG: Medicine & Health

NOVEMBER 29, 2023

Bacterial vaginosis is a common condition in which the natural microbiome of the vagina falls out of balance, sometimes leading to complications in sexual and reproductive health. But exactly how these bacterial populations disrupt vaginal health has remained unclear.

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Science 91

Drugs.com

NOVEMBER 29, 2023

WEDNESDAY, Nov. 29, 2023 -- Dreary, chilly winter days might cause some year-round runners to think twice about their jog, but recent research suggests the benefits of cold weather running outweigh those of running in warmer.

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Research 98

SCIENMAG: Medicine & Health

NOVEMBER 29, 2023

A senior biology student at The University of Texas at Arlington recently earned an award for her research about antimicrobial drug resistance. Credit: The University of Texas at Arlington A senior biology student at The University of Texas at Arlington recently earned an award for her research about antimicrobial drug resistance.

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Research Drugs 86

Drugs.com

NOVEMBER 29, 2023

WEDNESDAY, Nov. 29, 2023 -- Alzheimer’s patients are notoriously irritable, agitated and anxious – and researchers now think they know why.Brain inflammation appears to influence the mood problems of Alzheimer’s patients, rather than.

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Research 95

Science Daily: Pharmacology News

NOVEMBER 29, 2023

A new study provides compelling evidence that music preferences can serve as a window into an individual's moral values. It has uncovered an important link between music and morality, paving the way for a deeper understanding of the psychological dimensions of our musical experiences.

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SCIENMAG: Medicine & Health

NOVEMBER 29, 2023

Exercise may reduce postpartum depression, with moderate intensity exercises three to four times a week being especially effective, per meta-analysis Credit: Xu et al., CC-BY 4.

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Science Daily: Pharmacology News

NOVEMBER 29, 2023

New research links soccer heading -- where players hit the ball with their head -- to a measurable decline in the microstructure and function of the brain over a two-year period.

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Research 87

SCIENMAG: Medicine & Health

NOVEMBER 29, 2023

Doctors managing deceased organ donors routinely treat the donors’ bodies with thyroid hormones in a bid to preserve heart function and increase the quantity and quality of hearts and other organs available for transplantation. However, according to a recent clinical trial led by researchers at Washington University School of Medicine in St.

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Treatment Clinical Trials Doctors Trials 82

Science Daily: Pharmacology News

NOVEMBER 29, 2023

Researchers have uncovered a mechanism that safeguards the biallelic expression of haploinsufficient genes, shedding light on the importance of having two copies of each chromosome. A study identified the epigenetic regulator MSL2 an 'anti-monoallelic' factor that maintains biallelic gene dosage. This discovery not only reveals a communication system between parental alleles but also points to potential therapeutic strategies for diseases associated with haploinsufficient genes.

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Regulations Disease Research 85

Drugs.com

NOVEMBER 29, 2023

WEDNESDAY, Nov. 29, 2023 (Healthday News) -- The diabetes drug Mounjaro prompted more weight loss among overweight and obese adults than Ozempic did in a real-world setting, researchers report.Both Mounjaro (tirzepatide) and Ozempic (semaglutide).

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Trials Research Drugs 85

SCIENMAG: Medicine & Health

NOVEMBER 29, 2023

Microgels form a thin protective shell around a droplet until the temperature rises above 32 degrees. Then the microgels shrink and the droplet dissolves in the surrounding liquid. A study by researchers from the University of Gothenburg now reveals the underlying mechanism behind this process.

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Research 79

Drugs.com

NOVEMBER 29, 2023

WEDNESDAY, Nov. 29, 2023 -- The world is being flooded with internet-driven misinformation, but there are ways to counter fake news with the facts, a new report says.These include aggressive fact-checking, preemptively debunking lies before they.

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SCIENMAG: Medicine & Health

NOVEMBER 29, 2023

The ARIES-HM3 Randomized Clinical Trial assessed the safety and efficacy of excluding aspirin from the antithrombotic regimen in patients with advanced heart failure who have undergone implantation of a fully magnetically levitated left ventricular assist device (LVAD).

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Clinical Trials Trials 76

Science Daily: Pharmacology News

NOVEMBER 29, 2023

In a remarkable discovery, astronomers have found a disc around a young star in the Large Magellanic Cloud, a galaxy neighboring ours. It's the first time such a disc, identical to those forming planets in our own Milky Way, has ever been found outside our galaxy. The new observations reveal a massive young star, growing and accreting matter from its surroundings and forming a rotating disc.

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