Mon.Apr 15, 2024

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Physical activity reduces stress-related brain activity to lower cardiovascular disease risk

Science Daily: Pharmacology News

Over a ten-year period, biobank participants who met recommended levels of physical activity had a 23% lower risk of cardiovascular disease, and the protective effects were even more pronounced in individuals with depression.

Disease 137
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Identification of 1,3,8-triazaspiro[4.5]decane-2,4-dione Derivatives as a Novel Delta Opioid Receptor-Selective Agonist Chemotype [Drug Discovery and Translational Medicine]

ASPET

Delta opioid receptors hold potential as a target for neurological and psychiatric disorders, yet no delta opioid receptor agonist has proven efficacious in critical phase II clinical trials. The exact reasons for the failure to produce quality drug candidates for the delta opioid receptor is nuclear. However, it is known that certain delta opioid receptor agonists can induce seizures and exhibit tachyphylaxis.

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Can animals count?

Science Daily: Pharmacology News

Researchers have made a groundbreaking discovery regarding number sense in animals by confirming the existence of discrete number sense in rats, offering a crucial animal model for investigating the neural basis of numerical ability and disability in humans.

Research 136
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Ultragenyx says Angelman therapy is working, but safety questions remain

BioPharma Drive: Drug Pricing

Treatment appeared to result in functional and cognitive gains in people with the neurological disorder. Three participants experienced lower extremity weakness, however.

Therapies 124
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Microplastics make their way from the gut to other organs

Science Daily: Pharmacology News

Researchers have found that microplastics -- are having a significant impact on our digestive pathways, making their way from the gut and into the tissues of the kidney, liver and brain.

Research 132
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Antibiotics Probably Won't Ease Your Cough, Even If Infection is Bacterial: Study

Drugs.com

MONDAY, April 15, 2024 -- Doctors sometimes prescribe antibiotics to help treat a cough, but a new study shows the drugs won’t help reduce the severity or duration of coughing -- even if a bacterial infection is the culprit. Lower respiratory.

Doctors 111

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U.S. Medical Drug Shortages Reach Record High

Drugs.com

MONDAY, April 15, 2024 -- Americans are facing more shortages of the drugs they need for medical care than ever before, a national pharmacy database shows.The American Society of Health-System Pharmacists (ASHSP) and the University of Utah Drug.

Pharmacy 111
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Pyrite, also known as fool's gold, may contain valuable lithium, a key element for green energy

Science Daily: Pharmacology News

The technology revolution and development of new renewable energy resources is driving demand for lithium to new heights, but it is not a common mineral. Scientists say they have found lithium in an unexpected place; fool's gold, or pyrite, deposits.

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OrganoidXplore™: Routine and Rapid Compound Testing in a Large Panel of Organoids

Crown Bioscience

Organoid Xplore ™, developed by Crown Bioscience, is a large-scale organoid panel screen, executed every three months, in which clients can include their compounds for testing on organoid viability. It comprises a genetically characterized heterogeneous panel of tumor organoids and matching organoids derived from healthy epithelium from the same patients.

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Epilepsy drug prevents brain tumors in mice with NF1

Science Daily: Pharmacology News

Researchers have discovered that an FDA-approved epilepsy drug can prevent or slow the growth of NF1-linked optic gliomas in mice, laying the groundwork for a clinical trial.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Mastering Blue Prism Debugging Techniques

Perficient: Drug Development

Introduction: In the world of robotic process automation (RPA), Blue Prism stands out as a leading platform that empowers organizations to automate their business processes. While designing and developing automated solutions using Blue Prism is essential, debugging plays a crucial role in ensuring smooth operation and efficient execution. In this blog, we will explore some invaluable debugging techniques in Blue Prism that can help you identify and resolve issues, ultimately optimizing your auto

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The joy of sports: How watching sports can boost well-being

Science Daily: Pharmacology News

Sports, beyond entertainment, foster community and belonging, benefiting both individuals and society. Despite its recognized positive effects, limited evidence exists on the link between watching sports and well-being. To address this gap, a team of researchers conducted a multi-method research and found that sports viewing activates brain reward circuits, leading to improved well-being.

Research 128
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Keeping cleanrooms clean: Choosing the right laboratory equipment is key

BioPharma Drive: Drug Pricing

Because live cell and tissue products are extremely sensitive to contamination from microorganisms, viral particles or other airborne impurities, research and manufacturing involving these materials needs to be conducted in a cleanroom environment.

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How Pluto got its heart

Science Daily: Pharmacology News

The mystery of how Pluto got a giant heart-shaped feature on its surface has finally been solved by an international team of astrophysicists. The team is the first to successfully reproduce the unusual shape with numerical simulations, attributing it to a giant and slow oblique-angle impact.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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The growing role for cfHPV-DNA testing in OPSCC therapeutic development

BioPharma Drive: Drug Pricing

Learn about why access to robust biomarkers such as cfHPV-DNA is pivotal in determining eligibility, assessing treatment response and detecting recurrence early to improve patient outcomes.

DNA 104
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Hidden threat: Global underground infrastructure vulnerable to sea-level rise

Science Daily: Pharmacology News

As sea levels rise, coastal groundwater is lifted closer to the ground surface while also becoming saltier and more corrosive. A recent study compiled research from experts worldwide showing that in cities where there are complex networks of buried and partially buried infrastructure, interaction with this shallower and saltier groundwater exacerbates corrosion and failure of critical systems such as sewer lines, roadways, and building foundations.

Research 123
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Roche reports survival data for new dual-acting lymphoma drug

BioPharma Drive: Drug Pricing

The results could give Roche’s Columvi an edge over a rival medicine from AbbVie and Genmab, while Regeneron awaits an approval of its own therapy.

Therapies 111
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Chemicals Stored in Your Garage Could Raise Odds for ALS

Drugs.com

MONDAY, April 15, 2024 -- Volatile and toxic chemicals commonly stored in garages can increase the risk of amyotrophic lateral sclerosis (ALS).Gasoline or kerosene, gas-powered equipment and lawn care chemicals represented the top three risk.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Even the simplest marine organisms tend to be individualistic

Science Daily: Pharmacology News

Sport junkie or couch potato? Always on time or often late? The animal kingdom, too, is home to a range of personalities, each with its own lifestyle. Biologists report on a surprising discovery: even simple marine polychaete worms shape their day-to-day lives on the basis of highly individual rhythms. This diversity is of interest not just for the future of species and populations in a changing environment, but also for medicine.

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Pets Are Passing Drug-Resistant 'Superbugs' to Their Owners

Drugs.com

MONDAY, April 15, 2024 -- Dogs and cats can pass antibiotic-resistant bacteria to their owners, raising concerns that household pets could be contributing to the world’s antibiotics crisis, a new study says.Cases of these “superbugs” being.

Drugs 98
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Switch to green wastewater infrastructure could reduce emissions and provide huge savings according to new research

Science Daily: Pharmacology News

Researchers have shown that a transition to green wastewater-treatment approaches in the U.S. that leverages the potential of carbon-financing could save a staggering $15.6 billion and just under 30 million tons of CO2-equivalent emissions over 40 years.

Research 120
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'Feeling Like a Burden' Can Be Motivator for Suicide in Preteens

Drugs.com

MONDAY, April 15, 2024 -- Quiet preteens who feel they're a burden on others are more likely to have suicidal thoughts and behaviors, a new study reports.Criticism from parents or caregivers also increased the likelihood of suicidal thoughts and.

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Tropical forests can't recover naturally without fruit-eating birds

Science Daily: Pharmacology News

Natural forest regeneration is hailed as a cost-effective way to restore biodiversity and sequester carbon. However, the fragmentation of tropical forests has restricted the movement of large birds limiting their capacity to disperse seeds and restore healthy forests.

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One in 3 Women With Migraines Say Attacks Occur During Periods

Drugs.com

MONDAY, April 15, 2024 -- Among U.S. women with migraine, a third say the attacks tend to coincide with their periods, a new survey finds. Migraines that occur during menstruation are often frequent and severe, but only about one in five.

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Newly sequenced genome reveals coffee's prehistoric origin story -- and its future under climate change

Science Daily: Pharmacology News

The study charts the family history of Arabica, the world's most popular coffee species, through Earth's heating and cooling periods over the last millennia.

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Americans Short on Sleep, Stressed Out About It: Poll

Drugs.com

MONDAY, April 15, 2024 -- While more than half of Americans say they would feel better with more sleep, only 42% say they are getting as much shut-eye as they need, a new poll finds.

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Supporting Mental Health in the Workplace

NIOSH Science Blog: Drugs

Work plays a significant role in workers’ mental health. This impact is so substantial that managers impact workers’ mental health more than doctors or therapists do, according to the Workforce Institute’s Mental Health at Work study. The U.S. Surgeon General even emphasizes the role of workplaces in shaping our mental and physical well-being, noting that the average full-time U.S. worker spends about half of their waking life at work.

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Exercise Could Help Your Heart by Calming the Brain: Study

Drugs.com

MONDAY, April 15, 2024 -- You know exercise is great for your cardiovascular health, but new research suggests that your brain has a lot to do with it.It's all about physical activity's ability to lower stress levels within the brain, explained a.

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Which pharmaceutical drugs have the most drug patents in Slovenia?

Drug Patent Watch

This chart shows the drugs with the most patents in Slovenia. Patents must be filed in each country (or, in some cases regional patent office) where patent protection is desired.

Drugs 59
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Data-Centric Approaches to Streamline the Clinical Workload

Cytel

In the context of clinical trials, reducing the workload of the clinical team without compromising data quality is imperative for efficiency and cost-effectiveness. One key area that demands attention is the approach to Source Data Verification (SDV) and data review. Typically, the industry relies on 100% SDV, a resource-intensive quality assurance method that often leads to higher costs and staff turnover without necessarily improving data quality.

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Neumora’s schizophrenia drug hit with clinical hold

BioPharma Drive: Drug Pricing

Shares of the biotech dipped by double digits following disclosure the FDA had paused an early-stage study of Neumora’s muscarinic-targeting drug.

Drugs 65
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Alopecia Areata: Types, Symptoms, and Triggers

Olympian Clinical Research

Alopecia areata is a condition that causes hair loss in patches on the scalp, face, or other parts of the body. Nearly 700,000 Americans have alopecia areata, which may occur at any age and affects both men and women equally. Currently, this condition has no cure, but treatments are available to help manage the symptoms. Recognizing the different types of alopecia areata, understanding the symptoms, and identifying triggers can help individuals better manage their condition.

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Regeneron commits $500M to new venture capital fund

BioPharma Drive: Drug Pricing

While corporate venture arms are commonplace among pharmaceutical companies, the new fund announced Monday is Regeneron’s first.