Drug Discovery World

SEPTEMBER 4, 2024

The European Commission has granted orphan medicinal product designation (OMPD) to Cereno Scientific’s lead drug candidate CS1 for pulmonary arterial hypertension (PAH). CS1 is an HDAC inhibitor that works through epigenetic modulation, being developed to offer improved quality of life and prolonged life for patients with PAH. Companies that obtain orphan designation benefit from protocol assistance, a type of scientific advice specific for designated orphan drugs, and market exclusivity once th

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Drugs FDA Marketing Treatment 264

BioPharma Drive: Drug Pricing

SEPTEMBER 4, 2024

Over the past 10 years, PD1-blocking medicines have transformed cancer care. But the steady expansion of their use has slowed and, despite much trying, pharmaceutical companies have largely failed to top the drugs’ successes.

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Pharmaceutical Companies Pharmaceuticals Drugs 140

Drug Discovery World

SEPTEMBER 4, 2024

Cancer Research Horizons and AstraZeneca have signed a five-year renewal of the Functional Genomics Centre, a facility dedicated to advancing drug discovery with genome-altering technologies such as CRISPR. The Functional Genomics Centre was established in 2019 to explore the function and interaction of genes and proteins in cancer and create sophisticated models of the disease for research.

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Research Therapies Disease Drugs 130

Science Daily: Pharmacology News

SEPTEMBER 4, 2024

In creating a pair of new robots, researchers cultivated an unlikely component, one found on the forest floor: fungal mycelia. By harnessing mycelia's innate electrical signals, the researchers discovered a new way of controlling 'biohybrid' robots that can potentially react to their environment better than their purely synthetic counterparts.

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Research 134

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

SEPTEMBER 4, 2024

The first patient has been treated in a Phase II trial of EVO756 in adults with chronic inducible urticaria (CIndU). EVO756 is a highly selective small molecule antagonist of mas-related G-protein coupled receptor X2 (MRGPRX2) and could offer the potential for once-daily oral administration without the side effects observed with other therapies. MRGPRX2 can trigger IgE-independent activation (degranulation) via multiple ligands, which can lead to a variety of symptoms depending on the tissue tha

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Clinical Trials Trials Small Molecule Clinical Development 130

Science Daily: Pharmacology News

SEPTEMBER 4, 2024

Researchers have designed, in mice, an approach to minimizing the damage from a spinal cord injury through the use of engineered immune cells. Mice given the treatment had improved recovery from injuries, demonstrating potential for developing the therapy for people.

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Engineering Therapies Treatment Research 125

Science Daily: Pharmacology News

SEPTEMBER 4, 2024

Some per- and polyfluoroalkyl substances (PFAS) are poorly degradable and are also known as 'forever chemicals'. They adversely affect health and can lead to liver damage, obesity, hormonal disorders, and cancer. A research team has investigated the effects of PFAS on the brain. Using a combination of modern molecular biology methods and the zebrafish model, the researchers revealed the mechanism of action and identified the genes involved.

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Molecular Biology Research 125

Drugs.com

SEPTEMBER 4, 2024

WEDNESDAY, Sept. 4, 2024 -- An experimental three-in-one blood pressure pill works better than layering on meds one at a time, a new clinical trial shows.After a month on the combo pill, 81% of patients had their blood pressure under control.

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Treatment Clinical Trials Trials 107

Science Daily: Pharmacology News

SEPTEMBER 4, 2024

A new study shines a light on the enormous scale of uncollected rubbish and open burning of plastic waste in the first ever global plastics pollution inventory. Researchers used A.I. to model waste management in more than 50,000 municipalities around the world. This model allowed the team to predict how much waste was generated globally and what happens to it.

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Research 122

Drugs.com

SEPTEMBER 4, 2024

TUESDAY, Sept. 4, 2024 -- An overgrowth of gut microorganisms that produce methane could be a cause of severe constipation in many people, a new review finds.These gut bugs belong to a class of microbe called archaea, and when they flourish too.

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Science Daily: Pharmacology News

SEPTEMBER 4, 2024

Chemists offer a new explanation for how collagen in dinosaur bones may have survived millions of years: An atomic-level interaction prevents its bonds from being broken down by water.

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Perficient: Drug Development

SEPTEMBER 4, 2024

Did you ever feel tense while taking your exams? Or you must have watched the Olympics or other sports events like cricket, football, etc. When you focus on national players during significant events, you can observe stress and anxiety in performing at that level. Similar is the situation of an IT professional during a production deployment call. This moment is crucial because it represents the end of months or years of effort, the results of which will be evaluated by those involved.

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Production 105

Science Daily: Pharmacology News

SEPTEMBER 4, 2024

Researchers identified a mechanism for why some people will itch from an allergen or mosquito bite exposure, while others will not in a new study, and showed this pathway can be targeted to prevent allergic responses in preclinical models.

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Research 116

Drugs.com

SEPTEMBER 4, 2024

WEDNESDAY, Sept. 4, 2024 -- In news that should reassure folks glued to their cellphones all day, a new international review finds no link between cellphone use and brain cancer.Commissioned by the World Health Organization (WHO), the review.

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International 101

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Science Daily: Pharmacology News

SEPTEMBER 4, 2024

An atmospheric river brought warm, moist air to the coldest and driest corner of the planet in 2022, pushing temperatures 70 degrees above average. A new study reveals what happened to Antarctica's smallest animals.

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Drugs.com

SEPTEMBER 4, 2024

WEDNESDAY, Sept. 4, 2024 -- Your cellphone might be harming your heart, a new study warns.People who regularly use a cellphone have a higher risk of heart disease, researchers found in a large-scale study.And the more time someone spends on their.

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Disease Research 98

Science Daily: Pharmacology News

SEPTEMBER 4, 2024

Nuclear clocks would measure time based on changes inside an atom's nucleus, which would make them less sensitive to external disturbances and potentially more accurate than atomic clocks. These clocks could lead to improved timekeeping and navigation, faster internet speeds, and advances in fundamental physics research. Scientists have demonstrated key components of a nuclear clock, such as precise frequency measurements of an energy jump in a thorium-229 nucleus.

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Research 107

Drugs.com

SEPTEMBER 4, 2024

WEDNESDAY, Sept. 4, 2024 -- A sweat-powered finger wrap could make monitoring a person’s health as easy as wearing a Band-Aid, researchers report.The electronic wrap measures blood levels of sugar, vitamins, drugs and other substances by analyzing t.

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Research Drugs 97

Science Daily: Pharmacology News

SEPTEMBER 4, 2024

It turns out that a particular gene has a great influence on longevity, a new study concludes. This may pave the way for new treatment.

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Treatment 122

Drug Patent Watch

SEPTEMBER 4, 2024

Optimizing API manufacturing is crucial for ensuring the consistent production of high-quality APIs. The pharmaceutical industry has learned valuable lessons from various strategies and technologies that have significantly improved the efficiency, precision, and sustainability of API manufacturing processes. De-risking involves minimizing the uncertainty and unknowns in an API strategy.

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Pharmaceuticals Production 97

Science Daily: Pharmacology News

SEPTEMBER 4, 2024

Resting brain stem cells hardly differ from normal astrocytes, which support the nerve cells in the brain. How can almost identical cells perform such different functions? The key lies in the methylation of their genetic material, which endowes these special astrocytes with stem cell properties. In mice, the researchers showed that experimentally induced lack of blood supply in the brain epigenetically reprograms astrocytes into brain stem cells, which in turn can give rise to nerve progenitor c

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Research 105

Drugs.com

SEPTEMBER 4, 2024

WEDNESDAY, Sept. 4, 2024 -- People who can cope with challenges as they grow older are more likely to live longer, a new study shows.Seniors with higher levels of mental resilience are 53% less likely to die within the next 10 years than those with.

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Science Daily: Pharmacology News

SEPTEMBER 4, 2024

Some of the butterflies most in danger of fluttering out of existence fare better when their habitats are actively managed by humans, a recent study found. Scientists have long warned that insect populations worldwide are falling rapidly due to the combined effects of climate change, habitat loss and pesticides. The study analyzed data on 114 populations of 31 butterfly species in 10 U.S. states.

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Research 104

Drugs.com

SEPTEMBER 4, 2024

WEDNESDAY, Sept. 5, 2024 -- Weather patterns in California that have been exacerbated by climate change could be fueling more cases of a dangerous fungal infection, scientists warn.The Coccidioides fungus lives in soil, where it can be picked up by.

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Science Daily: Pharmacology News

SEPTEMBER 4, 2024

A new study has found that regular mobile phone use was positively associated with incident cardiovascular diseases risk. In addition, this association was partly attributed to poor sleep, psychological distress, and neuroticism.

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Disease 96

Drugs.com

SEPTEMBER 4, 2024

WEDNESDAY, Sept. 4, 2024 -- Current vaccines against mpox were designed to fight an older, rarer cousin of the virus, smallpox.Now, new research from the drug company Moderna suggests its new mpox vaccine, based on mRNA technology, might do a.

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Vaccine Trials Virus Research 84

Science Daily: Pharmacology News

SEPTEMBER 4, 2024

Researchers have developed a model that captures the dynamics of human dispersal across the continent during the last Ice Age in unprecedented detail.

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Research 105

Drugs.com

SEPTEMBER 4, 2024

WEDNESDAY, Sept. 4, 2024 -- A new brain imaging study has concluded that autism likely isn’t caused by faulty connections to the amygdala.A prevailing hypothesis of autism spectrum disorder has held that people with the condition have poorer neural.

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Science Daily: Pharmacology News

SEPTEMBER 4, 2024

Scientists have suspected that modern humans have more genes to digest starch than our hunter-gatherer ancestors, but the amylase locus of the genome is hard to study. Researchers have now developed new methods to isolate the multiple amylase genes and compare the locus to ancient genomes. They found that amylase gene number has increased from an average of eight to more than 11 over the past 12,000 years.

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Research 102

LifeSciVC

SEPTEMBER 4, 2024

By Ankit Mahadevia, chairman of Spero Therapeutics, as part of the From The Trenches feature of LifeSciVC A common theme in startup literature is that by cutting a range of unnecessary tasks, a step-change in results will follow. I’ve found most suggestions on achieving this state of prioritization nirvana unhelpful. Most of us know how to prioritize the obvious things, and after that, everything on one’s plate still feels justifiably important.

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Clinical Trials Production Government International 67

Science Daily: Pharmacology News

SEPTEMBER 4, 2024

It's 7 billion years ago, and the universe's heyday of star formation is beginning to slow. What might our Milky Way galaxy have looked like at that time? Astronomers have found clues in the form of a cosmic question mark, the result of a rare alignment across light-years of space.

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BioPharma Drive: Drug Pricing

SEPTEMBER 4, 2024

A new dose regimen of Biogen's spinal muscular atrophy drug appeared promising, while Denali Therapeutics and Regenxbio charted plans for drug approval applications.

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Drugs 60

Science Daily: Pharmacology News

SEPTEMBER 4, 2024

Fruit flies walking on minature treadmills are helping scientists learn how the nervous system enables animals to move in an unpredictable and complex world. The researchers engineered these small-scale machines from inexpensive parts. The treadmills are used in studies of how fruit flies recognize and deal with unexpected changes underfoot while they are walking.

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Engineering Research 76

Perficient: Drug Development

SEPTEMBER 4, 2024

90% of Fortune 500 companies use Salesforce as their Customer Relations Management tool. I have ingested data from Salesforce into almost every database using almost every ETL tool. Every integration tool out there has a Salesforce connector; Salesforce even owns Mulesoft. The integration always worked, but it was rarely smooth. Its just something that you accepted.

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