Wed.Sep 04, 2024

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A decade of cancer immunotherapy: Keytruda, Opdivo and the drugs that changed oncology

BioPharma Drive: Drug Pricing

Over the past 10 years, PD1-blocking medicines have transformed cancer care. But the steady expansion of their use has slowed and, despite much trying, pharmaceutical companies have largely failed to top the drugs’ successes.

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Fungus-controlled robots tap into the unique power of nature

Science Daily: Pharmacology News

In creating a pair of new robots, researchers cultivated an unlikely component, one found on the forest floor: fungal mycelia. By harnessing mycelia's innate electrical signals, the researchers discovered a new way of controlling 'biohybrid' robots that can potentially react to their environment better than their purely synthetic counterparts.

Research 137
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ArsenalBio raises $325M in one of the year’s largest biotech funding rounds

BioPharma Drive: Drug Pricing

The funding comes amid a slowdown in venture investment for gene and cell therapy startups, and will support development of multiple solid tumor programs.

Therapies 130
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'Forever chemicals' influence the development and function of the brain

Science Daily: Pharmacology News

Some per- and polyfluoroalkyl substances (PFAS) are poorly degradable and are also known as 'forever chemicals'. They adversely affect health and can lead to liver damage, obesity, hormonal disorders, and cancer. A research team has investigated the effects of PFAS on the brain. Using a combination of modern molecular biology methods and the zebrafish model, the researchers revealed the mechanism of action and identified the genes involved.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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3-in-1 Blood Pressure Pill Could Be Treatment Advance

Drugs.com

WEDNESDAY, Sept. 4, 2024 -- An experimental three-in-one blood pressure pill works better than layering on meds one at a time, a new clinical trial shows.After a month on the combo pill, 81% of patients had their blood pressure under control.

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Novel immunotherapy improves recovery from spinal cord injury

Science Daily: Pharmacology News

Researchers have designed, in mice, an approach to minimizing the damage from a spinal cord injury through the use of engineered immune cells. Mice given the treatment had improved recovery from injuries, demonstrating potential for developing the therapy for people.

More Trending

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Uncollected waste and open burning leading causes of the plastic pollution crisis

Science Daily: Pharmacology News

A new study shines a light on the enormous scale of uncollected rubbish and open burning of plastic waste in the first ever global plastics pollution inventory. Researchers used A.I. to model waste management in more than 50,000 municipalities around the world. This model allowed the team to predict how much waste was generated globally and what happens to it.

Research 124
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No Link Between Cellphone Use, Brain Cancer, Major Report Finds

Drugs.com

WEDNESDAY, Sept. 4, 2024 -- In news that should reassure folks glued to their cellphones all day, a new international review finds no link between cellphone use and brain cancer.Commissioned by the World Health Organization (WHO), the review.

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Chemists explain why dinosaur collagen may have survived for millions of years

Science Daily: Pharmacology News

Chemists offer a new explanation for how collagen in dinosaur bones may have survived millions of years: An atomic-level interaction prevents its bonds from being broken down by water.

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Folks Who Cope, Adapt Do Well in Old Age: Study

Drugs.com

WEDNESDAY, Sept. 4, 2024 -- People who can cope with challenges as they grow older are more likely to live longer, a new study shows.Seniors with higher levels of mental resilience are 53% less likely to die within the next 10 years than those with.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Researchers identify mechanism underlying allergic itching, and show it can be blocked

Science Daily: Pharmacology News

Researchers identified a mechanism for why some people will itch from an allergen or mosquito bite exposure, while others will not in a new study, and showed this pathway can be targeted to prevent allergic responses in preclinical models.

Research 116
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Could Your Cellphone Be Harming Your Heart?

Drugs.com

WEDNESDAY, Sept. 4, 2024 -- Your cellphone might be harming your heart, a new study warns.People who regularly use a cellphone have a higher risk of heart disease, researchers found in a large-scale study.And the more time someone spends on their.

Disease 105
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How Earth's most intense heat wave ever impacted life in Antarctica

Science Daily: Pharmacology News

An atmospheric river brought warm, moist air to the coldest and driest corner of the planet in 2022, pushing temperatures 70 degrees above average. A new study reveals what happened to Antarctica's smallest animals.

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Your Health Monitored at the Touch of a Finger

Drugs.com

WEDNESDAY, Sept. 4, 2024 -- A sweat-powered finger wrap could make monitoring a person’s health as easy as wearing a Band-Aid, researchers report.The electronic wrap measures blood levels of sugar, vitamins, drugs and other substances by analyzing t.

Research 105
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Agriculture accelerated human genome evolution to capture energy from starchy foods

Science Daily: Pharmacology News

Scientists have suspected that modern humans have more genes to digest starch than our hunter-gatherer ancestors, but the amylase locus of the genome is hard to study. Researchers have now developed new methods to isolate the multiple amylase genes and compare the locus to ancient genomes. They found that amylase gene number has increased from an average of eight to more than 11 over the past 12,000 years.

Research 110
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California's Drought Cycles Raise Threat of Dangerous Airborne Fungus

Drugs.com

WEDNESDAY, Sept. 5, 2024 -- Weather patterns in California that have been exacerbated by climate change could be fueling more cases of a dangerous fungal infection, scientists warn.The Coccidioides fungus lives in soil, where it can be picked up by.

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Newly discovered gene may influence longevity

Science Daily: Pharmacology News

It turns out that a particular gene has a great influence on longevity, a new study concludes. This may pave the way for new treatment.

Treatment 124
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Production Deployment and its Basics: Known to Many, Followed by Few

Perficient: Drug Development

Did you ever feel tense while taking your exams? Or you must have watched the Olympics or other sports events like cricket, football, etc. When you focus on national players during significant events, you can observe stress and anxiety in performing at that level. Similar is the situation of an IT professional during a production deployment call. This moment is crucial because it represents the end of months or years of effort, the results of which will be evaluated by those involved.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Major leap for nuclear clock paves way for ultraprecise timekeeping

Science Daily: Pharmacology News

Nuclear clocks would measure time based on changes inside an atom's nucleus, which would make them less sensitive to external disturbances and potentially more accurate than atomic clocks. These clocks could lead to improved timekeeping and navigation, faster internet speeds, and advances in fundamental physics research. Scientists have demonstrated key components of a nuclear clock, such as precise frequency measurements of an energy jump in a thorium-229 nucleus.

Research 106
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Study Debunks Theory Linking Autism to Changes in Brain's Amygdala

Drugs.com

WEDNESDAY, Sept. 4, 2024 -- A new brain imaging study has concluded that autism likely isn’t caused by faulty connections to the amygdala.A prevailing hypothesis of autism spectrum disorder has held that people with the condition have poorer neural.

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Epigenetic changes reprogram astrocytes into brain stem cells

Science Daily: Pharmacology News

Resting brain stem cells hardly differ from normal astrocytes, which support the nerve cells in the brain. How can almost identical cells perform such different functions? The key lies in the methylation of their genetic material, which endowes these special astrocytes with stem cell properties. In mice, the researchers showed that experimentally induced lack of blood supply in the brain epigenetically reprograms astrocytes into brain stem cells, which in turn can give rise to nerve progenitor c

Research 105
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Moderna's mRNA- Based Mpox Vaccine Shows Promise in Monkey Trial

Drugs.com

WEDNESDAY, Sept. 4, 2024 -- Current vaccines against mpox were designed to fight an older, rarer cousin of the virus, smallpox.Now, new research from the drug company Moderna suggests its new mpox vaccine, based on mRNA technology, might do a.

Vaccine 98
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New population model identifies phases of human dispersal across Europe

Science Daily: Pharmacology News

Researchers have developed a model that captures the dynamics of human dispersal across the continent during the last Ice Age in unprecedented detail.

Research 113
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Meeting the Challenge of Evolving Site Models

PPD

Over the last decade, the clinical research industry has seen investigator site models evolve, pushing contract research organizations (CROs) to think and collaborate more creatively. Today’s sites span a full spectrum — from traditional sites dedicated exclusively to research, all the way to new community practices and decentralized options. Their unique characteristics can sometimes create complexities when executing clinical research and therefore need careful attention when planning for a st

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At-risk butterflies more likely to survive with human help

Science Daily: Pharmacology News

Some of the butterflies most in danger of fluttering out of existence fare better when their habitats are actively managed by humans, a recent study found. Scientists have long warned that insect populations worldwide are falling rapidly due to the combined effects of climate change, habitat loss and pesticides. The study analyzed data on 114 populations of 31 butterfly species in 10 U.S. states.

Research 103
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Keeping It Simple: What Really Matters For Emerging Enterprises  

LifeSciVC

By Ankit Mahadevia, chairman of Spero Therapeutics, as part of the From The Trenches feature of LifeSciVC A common theme in startup literature is that by cutting a range of unnecessary tasks, a step-change in results will follow. I’ve found most suggestions on achieving this state of prioritization nirvana unhelpful. Most of us know how to prioritize the obvious things, and after that, everything on one’s plate still feels justifiably important.

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Distorted galaxy forming cosmic question mark

Science Daily: Pharmacology News

It's 7 billion years ago, and the universe's heyday of star formation is beginning to slow. What might our Milky Way galaxy have looked like at that time? Astronomers have found clues in the form of a cosmic question mark, the result of a rare alignment across light-years of space.

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Optimizing API Manufacturing: Lessons from the Industry

Drug Patent Watch

Optimizing API manufacturing is crucial for ensuring the consistent production of high-quality APIs. The pharmaceutical industry has learned valuable lessons from various strategies and technologies that have significantly improved the efficiency, precision, and sustainability of API manufacturing processes. De-risking involves minimizing the uncertainty and unknowns in an API strategy.

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Regular mobile phone use may increase the risk of cardiovascular diseases, study suggests

Science Daily: Pharmacology News

A new study has found that regular mobile phone use was positively associated with incident cardiovascular diseases risk. In addition, this association was partly attributed to poor sleep, psychological distress, and neuroticism.

Disease 94
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High-dose Spinraza meets study goal; Top Dyne executives exit

BioPharma Drive: Drug Pricing

A new dose regimen of Biogen's spinal muscular atrophy drug appeared promising, while Denali Therapeutics and Regenxbio charted plans for drug approval applications.

Drugs 60
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Miniature treadmills accelerate studies of insects walking

Science Daily: Pharmacology News

Fruit flies walking on minature treadmills are helping scientists learn how the nervous system enables animals to move in an unpredictable and complex world. The researchers engineered these small-scale machines from inexpensive parts. The treadmills are used in studies of how fruit flies recognize and deal with unexpected changes underfoot while they are walking.

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Integrate Salesforce and Databricks

Perficient: Drug Development

90% of Fortune 500 companies use Salesforce as their Customer Relations Management tool. I have ingested data from Salesforce into almost every database using almost every ETL tool. Every integration tool out there has a Salesforce connector; Salesforce even owns Mulesoft. The integration always worked, but it was rarely smooth. Its just something that you accepted.

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Wearable Heart Monitor Ups Detection of A-fib by More Than 50%

Drugs.com

WEDNESDAY, Sept. 4, 2024 -- A wearable heart monitor raises the detection rate of the dangerous irregular heartbeat known as atrial fibrillation (A-fib) by more than 50%, a new study finds.Unfortunately, there was no increase observed in the number.

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