Thu.Aug 22, 2024

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Hydrogels can play Pong by 'remembering' previous patterns of electrical simulation

Science Daily: Pharmacology News

Non-living hydrogels can play the video game Pong and improve their gameplay with more experience, researchers report. The researchers hooked hydrogels up to a virtual game environment and then applied a feedback loop between the hydrogel's paddle -- encoded by the distribution of charged particles within the hydrogel -- and the ball's position -- encoded by electrical stimulation.

Research 141
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Thymoquinone reversed doxorubicin resistance in U87 glioblastoma cells via targeting PI3K/Akt/mTOR signaling

Chemical Biology and Drug Design

TQ enhanced DOX sensitivity in U87 glioblastoma cells via targeting PI3K/Akt/mTOR signaling. Abstract Natural compounds such as thymoquinone (TQ) have recently gained increasing attention in treating glioblastoma (GBM). However, the effects of TQ in reversing drug resistance are not completely understood. Therefore, we aimed to examine TQ impacts on GBM cells with doxorubicin (DOX) resistance and the involvement of the PI3K/Akt/mTOR pathway.

Treatment 100
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Mitochondria are flinging their DNA into our brain cells

Science Daily: Pharmacology News

A new study finds that mitochondria in our brain cells frequently fling their DNA into the cells' nucleus, where the mitochondrial DNA integrates into chromosomes, possibly causing harm.

DNA 137
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KLS-13019, a novel structural analogue of cannabidiol (CBD) and GPR55 receptor antagonist, Prevents and Reverses Chemotherapy-Induced Peripheral Neuropathy (CIPN) in Rats. [Behavioral Pharmacology]

ASPET

Neuropathic pain is a form of chronic pain that develops because of damage to the nervous system. Treatment of neuropathic pain is often incompletely effective, and most available therapeutics have only moderate efficacy and present side effects that limit their use. Opioids are commonly prescribed for the management of neuropathic pain despite equivocal results in clinical studies and significant abuse potential.

Treatment 100
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Mosquitoes sense infrared from body heat to help track humans down

Science Daily: Pharmacology News

While a mosquito bite is often no more than a temporary bother, in many parts of the world it can be scary. One mosquito species, Aedes aegypti, spreads the viruses that cause over 100,000,000 cases of dengue, yellow fever, Zika and other diseases every year. Another, Anopheles gambiae, spreads the parasite that causes malaria. The World Health Organization estimates that malaria alone causes more than 400,000 deaths every year.

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FDA Approves Updated COVID Shots for Fall

Drugs.com

THURSDAY, Aug. 22, 2024 -- Updated shots to shield against COVID-19 infection were approved by the U.S. Food and Drug Administration on Thursday.This year's approval for the updated mRNA vaccines comes much sooner than happened in 2023, when fall.

More Trending

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Universal Flu Vaccine Blocks Infection in Mice

Drugs.com

THURSDAY, Aug. 22, 2024 -- A universal flu vaccine that would protect against all influenza strains -- and that people might not need to take every year -- could be close at hand, researchers report.An experimental vaccine candidate produced a.

Vaccine 115
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New gels could protect buildings during wildfires

Science Daily: Pharmacology News

Researchers have developed a sprayable gel that creates a shield to protect buildings from wildfire damage. It lasts longer and is more effective than existing commercial options.

Research 115
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Government Report Links Excessive Fluoride in Water to Lowered IQs in Kids

Drugs.com

THURSDAY, Aug. 22, 2024 -- High levels of fluoride in drinking water may dim the intelligence of children, a new U.S. government report shows. Based on an analysis of published research, the potentially controversial report marks the first time a.

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Catalyst for 'one-step' conversion of methane to methanol

Science Daily: Pharmacology News

Scientists have engineered a highly selective catalyst that can convert methane, a major component of natural gas, into methanol, an easily transportable liquid fuel, in a single, one-step reaction. This direct process for methane-to-methanol conversion runs at a temperature lower than required to make tea and exclusively produces methanol without additional byproducts.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Women Could Have New Medical Option to Ease Hot Flashes

Drugs.com

THURSDAY, Aug. 22, 2024 -- A drug under development could provide a much needed option for women seeking relief from hot flashes and other menopausal symptoms, new research shows.The drug, elinzanetant, cut the frequency of hot flashes by an.

Research 111
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Fighting coastal erosion with electricity

Science Daily: Pharmacology News

New research has systematically demonstrated that a mild zap of electricity can strengthen a marine coastline for generations -- greatly reducing the threat of erosion in the face of climate change and rising sea levels. The new process forms natural cement between grains of sand, transforming it into solid, immoveable rock. Mollusks use a similar process to turn naturally occurring minerals into shells.

Research 106
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Number of Americans With Type 2 Diabetes Jumped by 20% in a Decade

Drugs.com

THURSDAY, Aug. 21, 2024 -- Type 2 diabetes increased by nearly 20% in the United States between 2012 and 2022, with age, race, income level, obesity and lack of exercise all playing a role in the metabolic disease’s spread, a new study r.

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DNA tech offers both data storage and computing functions

Science Daily: Pharmacology News

Researchers have demonstrated a technology capable of a suite of data storage and computing functions -- repeatedly storing, retrieving, computing, erasing or rewriting data -- that uses DNA rather than conventional electronics. Previous DNA data storage and computing technologies could complete some but not all of these tasks.

DNA 106
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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One Diet Might Cut Your Odds for COVID-19

Drugs.com

THURSDAY, Aug. 22, 2024 -- COVID cases have surged this summer, but a new study suggests that following the Mediterranean diet might spare you from infection.In a review published Wednesday in the journal PLOS One, Indonesian researchers discovered.

Research 105
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Updated COVID shots from Pfizer, Moderna cleared by FDA

BioPharma Drive: Drug Pricing

The approval of both reformulated messenger RNA vaccines, which are designed to target the KP.2 virus strain, comes just ahead of the fall and winter seasons.

RNA 110
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Fisheries research overestimates fish stocks

Science Daily: Pharmacology News

The state of fish stocks in the world's ocean is worse than previously thought. While overfishing has long been blamed on fisheries policies that set catch limits higher than scientific recommendations, a new study reveals that even these scientific recommendations were often too optimistic. The result? Far more global fish stocks are overfished or have collapsed than we thought.

Research 103
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Here's What Long COVID Looks Like in Kids

Drugs.com

THURSDAY, Aug. 22, 2024 -- Kids and teens are vulnerable to Long COVID just as adults are, with a set of distinct symptoms showing long-term health effects, a new study shows.Ten symptoms in school-age children and 8 in teenagers indicate the.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Physicists shine new light on ultra-fast atomic processes

Science Daily: Pharmacology News

Scientists report incredibly small time delays in a molecule's electron activity when the particles are exposed to X-rays. To measure these tiny high-speed events, known as attoseconds, researchers used a laser to generate intense X-ray flashes that allowed them to map the inner workings of an atom.

Research 101
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Vaccination Could Shield Against Mental Issues Following Severe COVID

Drugs.com

THURSDAY, Aug. 22, 2024 -- People stricken with a severe case of COVID-19 have a higher risk of mental illness in the year following their infection, a new study warns.However, vaccination appears to ward off these effects on mental health.

Vaccine 103
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Colorful traits in primates ease tensions between groups

Science Daily: Pharmacology News

Primate ornamentation plays a crucial role in communication not only within social groups but also between them, according to a new study. The research reveals that the males of species with overlapping home ranges often display vibrant colors or elaborate features, traits that may help reduce intergroup aggression by enabling quick assessments of potential rivals.

Research 100
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Marriage Gives Health Boost to Older Men, But Not Women

Drugs.com

THURSDAY, Aug. 22, 2024 -- A wedding band may be good medicine for men as they age, but not so much for women, new research shows. A three-year study of over 7,600 Canadians aged 60 and older found that men who got hitched were twice as likely to.

Research 102
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Technical Design of a Western Blot

addgene Blog

If you’ve ever run a western blot , or thought about running one, you’ll know there’s a lot of choices to make when designing the experiment. What detection method? What membrane? What should you block with?

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Collaborative Drug Discovery Introduces CDD AI Support ChatBot

Collaborative Drug

Burlingame, California – August 22, 2024 – Collaborative Drug Discovery (CDD), provider of CDD Vault, a web-based scientific research informatics platform, is excited to announce the launch of the CDD AI Support ChatBot, a cutting-edge capability to enhance the user support experience by offering immediate responses to common customer support inquiries.

Drugs 100
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Universal flu vaccine candidate protects against infection in mice

Science Daily: Pharmacology News

A new flu vaccine candidate incorporates proteins from 8 strains of influenza.

Vaccine 108
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Women in Coal Mining

NIOSH Science Blog: Drugs

When thinking of mining, many picture male coal miners. This is because most miners are men, and many depictions of coal miners are of men wearing hardhats and dusty reflective coveralls. Women have been working in various capacities above ground in coal mining since coal was first commercially used in the U.S. in the early 1700s. However, it wasn’t until 1974 that women were formally recognized and included in the underground coal mining workforce.

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FDA defends med device chief’s tenure after report raises ethics concerns

BioPharma Drive: Drug Pricing

The FDA backed Jeff Shuren, the agency’s former CDRH leader, amid questions raised by The New York Times. Still, a spokesperson said the FDA has advised Shuren to take greater caution in managing recusal obligations.

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State Laws Strongly Affect Mental Health of Trans People, Study Finds

Drugs.com

THURSDAY, Aug. 22, 2024 (HeathDay News) -- There's a strong association between a state's policies and laws around the rights of transgender people and the mental health of transgender residents, a new study shows."Trans individuals who were worried.

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Versant reimagines its Chinook success with newest startup launch

BioPharma Drive: Drug Pricing

Borealis Biosciences launches with money from Novartis, which last year bought the biotech’s predecessor for a pair of drugs that treat a rare kidney disorder.

Drugs 64
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CDMO Project Management: Tips and Tricks for Success

Drug Patent Watch

Effective project management is crucial for the success of any contract development and manufacturing organization (CDMO). As a dedicated CDMO, we understand the importance of providing outstanding services, solutions, and support to our clients.

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UK approves Leqembi, but reimbursement may not follow

BioPharma Drive: Drug Pricing

Leqembi’s benefits are “too small to justify the significant cost to the NHS,” said the head of a UK agency in charge of determining medicine reimbursement.

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Female Doctors Face Higher Risk for Suicide

Drugs.com

THURSDAY, Aug. 22, 2024 -- Suicide rates among female doctors are significantly higher than those of the general population, a new study finds.Female doctors have a 76% higher suicide risk than average folks, researchers found.Male doctors had.

Doctors 59
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How baleen whales have adapted over the past 50 million years

Science Daily: Pharmacology News

The largest dataset of cetacean genes ever collated has helped scientists deep dive 'into the blue' to fathom the 'triumph' of baleen whale evolution. The new study explores the key genetic adaptations of these diverse whale species around the world's vast oceans -- giving new insights into the risks and opportunities for their survival.

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