Tue.Dec 26, 2023

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Key industry partnerships advancing drug discovery

Drug Discovery World

Otsuka Pharmaceutical and Ionis Pharmaceuticals Otsuka Pharmaceutical and RNA therapy company Ionis have entered into a licence agreement for Otsuka to acquire exclusive marketing rights to Ionis’ hereditary angioedema (HAE) drug candidate donidalorsen in Europe. Donidalorsen is an investigational ligand-conjugated antisense (LICA) medicine designed to target the prekallikrein, or PKK, pathway.

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Decision tree?based identification of important molecular fragments for protein?ligand binding

Chemical Biology and Drug Design

Identifying important molecular fragments through ECFP fingerprints for fragment encoding and decision tree algorithms for feature importance assessment. Abstract Fragment-based drug design is an emerging technology in pharmaceutical research and development. One of the key aspects of this technology is the identification and quantitative characterization of molecular fragments.

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Suspend Reality – 6 Steps to Move from Fantasy to Execution

Perficient: Drug Development

We’re just now finishing up the holiday season. At this time of year, I’m always intrigued by the magic of the holidays we celebrate, and the optimistic goals we set for the new year. It amazes me how we collectively like to suspend reality for a bit, reflect, and forecast. And I wonder why we don’t drift into thoughts of the extraordinary more often.

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Many Young People at Risk for Psychosis Are Torn About Using Marijuana

Drugs.com

TUESDAY, Dec. 26, 2023 -- Even after they've experienced episodes of psychosis, many young people who use marijuana are unsure they want to quit the drug, new research shows.Cannabis has long been linked to a heightened risk for psychosis -- a.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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New patent for Purdue Pharma drug HYSINGLA ER

Drug Patent Watch

Annual Drug Patent Expirations for HYSINGLA+ER Hysingla Er is a drug marketed by Purdue Pharma Lp and is included in one NDA. It is available from one supplier. There are… The post New patent for Purdue Pharma drug HYSINGLA ER appeared first on DrugPatentWatch - Make Better Decisions.

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In Rare Cases, Measles Mutates in Brain and Kills

Drugs.com

TUESDAY, Dec. 26, 2023 -- Measles is incredibly contagious, and outbreaks are more common now as people decide against vaccinating their kids. Now, a case involving a rare but fatal brain disease caused by the measles virus may make some rethink.

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Brain Plaques, Not Just Age, Point to Who'll Get Alzheimer's Disease

Drugs.com

TUESDAY, Dec. 26, 2023 -- Are you necessarily at higher risk of Alzheimer's disease just because you're 80, and not 75? New research shows it's more complex than that. The findings suggest that it's the pace of buildup in the brain of.

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New patent expiration for Woodward drug COREG CR

Drug Patent Watch

Annual Drug Patent Expirations for COREG+CR Coreg Cr is a drug marketed by Woodward and is included in one NDA. It is available from four suppliers. There are two patents… The post New patent expiration for Woodward drug COREG CR appeared first on DrugPatentWatch - Make Better Decisions.

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Healthy Twins Born to Woman Who Was Pregnant in Each of Her Two Uteruses

Drugs.com

TUESDAY, Dec. 26, 2023 -- When Kelsey Hatcher’s twins share their birth story someday, their tale will truly be one in a million.Hatcher, who gave birth at the University of Alabama at Birmingham (UAB), has a rare double uterus and was pregnant.

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End of Year Enhancements for Oracle Enterprise Data Management (2023)

Perficient: Drug Development

Earlier this month Oracle released a long list of new features for EDM (Oracle Enterprise Data Management ). The enhancements address several areas that great improve the tool for both administrators and business users. Follow below as we take a look at a few of the features which we believe are most beneficial. Customized Navigation and Information Since the initial release of EDM, the home page has contained been the same layout and options for both administrators and business users.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Winter Is Prime Time for Indoor Allergies

Drugs.com

TUESDAY, Dec. 26, 2023 -- Folks with allergies might want to breathe a deep, sneeze-free sigh of relief when winter rolls around.Unfortunately, the cold weather that puts pollen-producing trees and grass to sleep can also keep a person cooped up.

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Cooking Up a New Year: How a Seamless Ecommerce Experience Influenced My New Year Resolution

Perficient: Drug Development

How an Ecommerce Experience Transformed My New Year’s Resolution As the New Year approaches I find myself, like many others, contemplating a New Year resolution that I could do. I struggled to figure out what my resolution was going to be and did not think I would have one this year. However, out of left field, an unexpected source influenced my resolution.

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One Gender Loses More Muscle During Space Flight

Drugs.com

TUESDAY, Dec. 26, 2023 -- Women are more likely to lose more muscle mass during space flight than men, a new lab study suggests.Females participating in the extended bed rest study lost more leg muscle mass at two months than the men had lost at.

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Kubernetes Testing Approaches and Best Practices

Perficient: Drug Development

Introduction Kubernetes has emerged as a key player, providing a robust platform for deploying and managing containerized applications. This blog aims to explore Kubernetes testing approaches, focusing on best practices, and underscore their significance in the software development lifecycle. Kubernetes Testing Approaches Unit Testing: Definition: Unit testing is a software testing approach that focuses on evaluating individual components of a system in isolation.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Many Americans Are Resolving to Boost Their Mental Health in 2024

Drugs.com

TUESDAY, Dec. 26, 2023 -- Three-quarters of Americans plan to start the New Year with a resolution to be more healthy, including 28% who want to focus on improving their mental health, a new survey has found.These folks plan to exercise more.

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A Guide to Security Testing and Test Frameworks in Kubernetes Environments

Perficient: Drug Development

Introduction In the dynamic landscape of software development, where Kubernetes has become the linchpin of modern application deployment, ensuring robust security measures is non-negotiable. This comprehensive guide explores the indispensable realm of security testing methods and the influential power of test frameworks in the Kubernetes environment.

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Your Microbiome Could Be Setting You Up for Kidney Stones

Drugs.com

TUESDAY, Dec. 26, 2023 -- The pain of kidney stones seemingly arises out of nowhere, but new research suggests the body's microbiomes might help create the noxious granules.In the Canadian study, people who had kidney stones appeared to share.

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Understanding the HCL Commerce Ajax Framework: Exploring Requests and Responses

Perficient: Drug Development

Introduction: In today’s fast-paced world of e-commerce, providing a seamless and responsive user experience is essential. This is where Ajax ( A synchronous J avaScript A nd X ML) comes into play. Ajax allows web applications to communicate with a server in the background without disrupting the user’s experience. HCL Commerce, a popular e-commerce platform, includes a robust Ajax framework that facilitates these interactions.

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Skin Conditions Flare Up When Wildfires Nearby

Drugs.com

TUESDAY, Dec. 26, 2023 -- The smoke billowing from this summer’s devastating wildfires wasn’t just bad for your lungs.Skin problems also seem to worsen, with dermatology visits rising as air quality deteriorates, a new study says.Visits for.

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Which pharmaceutical companies have the most emulsion dosed drugs?

Drug Patent Watch

This chart shows the pharmaceutical companies with the most emulsion dosed drugs. For a different perspective, see the most popular dosage types. The companies with the most emulsion dosed drugs… The post Which pharmaceutical companies have the most emulsion dosed drugs? appeared first on DrugPatentWatch - Make Better Decisions.

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Pediatricians Offer 8 Goals to Parents to 'Start the Year Strong'

Drugs.com

TUESDAY, Dec. 26, 2023 -- New Year's resolutions often center on weight loss and personal lifestyle changes, but setting good parenting goals is also well worth the effort, pediatricians say.“This is a great time to take a step back, take a.

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DDW readers’ top drug discovery developments of 2023

Drug Discovery World

DDW’s Diana Spencer takes a look at the breaking news stories that were most popular with DDW readers over the last year. Representing a dominant field of drug discovery, it isn’t surprising that breakthroughs in cancer research were popular with DDW readers in 2023, particularly strategies to overcome treatment resistance and prevent the spread of disease.

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New Fed. R. Evid. 702 – Use This Stuff To Update Your Briefs

Drug & Device Law

As readers of the Blog undoubtedly know , the amendments toughening up Fed. R. Evid. 702 became effective on December 1, 2023. Here are the precise changes again: Rule 702. Testimony by expert witnesses. A witness who is qualified as an expert by knowledge, skill, experience, training, or education may testify in the form of an opinion or otherwise if the proponent demonstrates to the court that it is more likely than not that: a) the expert’s scientific, technical, or other specialized knowled